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Gene: CHD6 |
Gene summary for CHD6 |
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Gene information | Species | Human | Gene symbol | CHD6 | Gene ID | 84181 |
Gene name | chromodomain helicase DNA binding protein 6 | |
Gene Alias | CHD-6 | |
Cytomap | 20q12 | |
Gene Type | protein-coding | GO ID | GO:0006139 | UniProtAcc | Q8TD26 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
84181 | CHD6 | CCI_2 | Human | Cervix | CC | 9.21e-06 | 7.69e-01 | 0.5249 |
84181 | CHD6 | CCI_3 | Human | Cervix | CC | 6.08e-09 | 8.50e-01 | 0.516 |
84181 | CHD6 | HTA11_3410_2000001011 | Human | Colorectum | AD | 2.16e-20 | -5.75e-01 | 0.0155 |
84181 | CHD6 | HTA11_2487_2000001011 | Human | Colorectum | SER | 9.33e-09 | -5.94e-01 | -0.1808 |
84181 | CHD6 | HTA11_1938_2000001011 | Human | Colorectum | AD | 2.10e-05 | -4.86e-01 | -0.0811 |
84181 | CHD6 | HTA11_78_2000001011 | Human | Colorectum | AD | 3.23e-04 | -4.09e-01 | -0.1088 |
84181 | CHD6 | HTA11_2112_2000001011 | Human | Colorectum | SER | 2.13e-02 | -7.17e-01 | -0.2196 |
84181 | CHD6 | HTA11_3361_2000001011 | Human | Colorectum | AD | 5.64e-07 | -5.59e-01 | -0.1207 |
84181 | CHD6 | HTA11_83_2000001011 | Human | Colorectum | SER | 9.12e-07 | -5.95e-01 | -0.1526 |
84181 | CHD6 | HTA11_696_2000001011 | Human | Colorectum | AD | 4.00e-06 | -4.11e-01 | -0.1464 |
84181 | CHD6 | HTA11_866_2000001011 | Human | Colorectum | AD | 3.77e-07 | -4.39e-01 | -0.1001 |
84181 | CHD6 | HTA11_1391_2000001011 | Human | Colorectum | AD | 5.35e-05 | -4.01e-01 | -0.059 |
84181 | CHD6 | HTA11_5212_2000001011 | Human | Colorectum | AD | 2.20e-04 | -6.79e-01 | -0.2061 |
84181 | CHD6 | HTA11_7862_2000001011 | Human | Colorectum | AD | 1.36e-02 | -5.56e-01 | -0.0179 |
84181 | CHD6 | HTA11_866_3004761011 | Human | Colorectum | AD | 3.51e-05 | -4.02e-01 | 0.096 |
84181 | CHD6 | HTA11_8622_2000001021 | Human | Colorectum | SER | 1.85e-03 | -5.00e-01 | 0.0528 |
84181 | CHD6 | HTA11_10623_2000001011 | Human | Colorectum | AD | 2.61e-03 | -5.27e-01 | -0.0177 |
84181 | CHD6 | HTA11_10711_2000001011 | Human | Colorectum | AD | 7.12e-07 | -3.90e-01 | 0.0338 |
84181 | CHD6 | HTA11_7696_3000711011 | Human | Colorectum | AD | 3.75e-14 | -5.08e-01 | 0.0674 |
84181 | CHD6 | HTA11_99999970781_79442 | Human | Colorectum | MSS | 1.02e-05 | -3.59e-01 | 0.294 |
Page: 1 2 3 4 5 6 7 8 9 10 11 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:000697910 | Cervix | CC | response to oxidative stress | 102/2311 | 446/18723 | 2.99e-10 | 4.36e-08 | 102 |
GO:004361810 | Cervix | CC | regulation of transcription from RNA polymerase II promoter in response to stress | 21/2311 | 47/18723 | 3.85e-08 | 2.53e-06 | 21 |
GO:004362010 | Cervix | CC | regulation of DNA-templated transcription in response to stress | 22/2311 | 53/18723 | 9.29e-08 | 5.19e-06 | 22 |
GO:006219710 | Cervix | CC | cellular response to chemical stress | 76/2311 | 337/18723 | 1.01e-07 | 5.25e-06 | 76 |
GO:003459910 | Cervix | CC | cellular response to oxidative stress | 63/2311 | 288/18723 | 3.58e-06 | 9.50e-05 | 63 |
GO:00063257 | Cervix | CC | chromatin organization | 78/2311 | 409/18723 | 5.40e-05 | 8.02e-04 | 78 |
GO:00360038 | Cervix | CC | positive regulation of transcription from RNA polymerase II promoter in response to stress | 10/2311 | 24/18723 | 3.05e-04 | 3.26e-03 | 10 |
GO:00323923 | Cervix | CC | DNA geometric change | 21/2311 | 90/18723 | 2.71e-03 | 1.85e-02 | 21 |
GO:0006979 | Colorectum | AD | response to oxidative stress | 145/3918 | 446/18723 | 5.16e-09 | 3.23e-07 | 145 |
GO:0062197 | Colorectum | AD | cellular response to chemical stress | 109/3918 | 337/18723 | 5.33e-07 | 1.95e-05 | 109 |
GO:0034599 | Colorectum | AD | cellular response to oxidative stress | 94/3918 | 288/18723 | 2.03e-06 | 6.02e-05 | 94 |
GO:0006325 | Colorectum | AD | chromatin organization | 119/3918 | 409/18723 | 4.85e-05 | 8.33e-04 | 119 |
GO:0043620 | Colorectum | AD | regulation of DNA-templated transcription in response to stress | 23/3918 | 53/18723 | 1.86e-04 | 2.49e-03 | 23 |
GO:0036003 | Colorectum | AD | positive regulation of transcription from RNA polymerase II promoter in response to stress | 13/3918 | 24/18723 | 3.45e-04 | 4.03e-03 | 13 |
GO:0043618 | Colorectum | AD | regulation of transcription from RNA polymerase II promoter in response to stress | 20/3918 | 47/18723 | 6.54e-04 | 6.75e-03 | 20 |
GO:0032392 | Colorectum | AD | DNA geometric change | 31/3918 | 90/18723 | 2.02e-03 | 1.63e-02 | 31 |
GO:0043619 | Colorectum | AD | regulation of transcription from RNA polymerase II promoter in response to oxidative stress | 7/3918 | 11/18723 | 2.59e-03 | 1.96e-02 | 7 |
GO:00069791 | Colorectum | SER | response to oxidative stress | 114/2897 | 446/18723 | 1.75e-08 | 1.28e-06 | 114 |
GO:00621971 | Colorectum | SER | cellular response to chemical stress | 87/2897 | 337/18723 | 5.33e-07 | 2.59e-05 | 87 |
GO:00345991 | Colorectum | SER | cellular response to oxidative stress | 73/2897 | 288/18723 | 8.52e-06 | 2.86e-04 | 73 |
Page: 1 2 3 4 5 6 7 8 9 10 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
CHD6 | insertion | Frame_Shift_Ins | novel | c.1442_1443insA | p.Asn481LysfsTer6 | p.N481Kfs*6 | Q8TD26 | protein_coding | TCGA-CH-5767-01 | Prostate | prostate adenocarcinoma | Male | >=65 | 7 | Unknown | Unknown | SD | ||
CHD6 | insertion | In_Frame_Ins | novel | c.730_731insTAAAGC | p.Lys243_Arg244insLeuLys | p.K243_R244insLK | Q8TD26 | protein_coding | TCGA-KK-A59Y-01 | Prostate | prostate adenocarcinoma | Male | <65 | 9 | Hormone Therapy | leuprolide | CR | ||
CHD6 | SNV | Missense_Mutation | rs879691040 | c.6013G>C | p.Glu2005Gln | p.E2005Q | Q8TD26 | protein_coding | deleterious_low_confidence(0.01) | benign(0.177) | TCGA-BR-4362-01 | Stomach | stomach adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
CHD6 | SNV | Missense_Mutation | c.5714N>G | p.Asn1905Ser | p.N1905S | Q8TD26 | protein_coding | tolerated_low_confidence(1) | benign(0) | TCGA-BR-6452-01 | Stomach | stomach adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
CHD6 | SNV | Missense_Mutation | c.2743N>T | p.Arg915Cys | p.R915C | Q8TD26 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-BR-6452-01 | Stomach | stomach adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
CHD6 | SNV | Missense_Mutation | c.3170N>G | p.Tyr1057Cys | p.Y1057C | Q8TD26 | protein_coding | deleterious(0) | probably_damaging(0.971) | TCGA-BR-7707-01 | Stomach | stomach adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
CHD6 | SNV | Missense_Mutation | rs374043976 | c.1271N>C | p.Lys424Thr | p.K424T | Q8TD26 | protein_coding | deleterious(0.02) | possibly_damaging(0.796) | TCGA-BR-7716-01 | Stomach | stomach adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
CHD6 | SNV | Missense_Mutation | c.1497N>A | p.Phe499Leu | p.F499L | Q8TD26 | protein_coding | tolerated(0.06) | possibly_damaging(0.773) | TCGA-BR-8361-01 | Stomach | stomach adenocarcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD | |
CHD6 | SNV | Missense_Mutation | c.2194C>T | p.Pro732Ser | p.P732S | Q8TD26 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-BR-8487-01 | Stomach | stomach adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
CHD6 | SNV | Missense_Mutation | c.2042G>T | p.Arg681Leu | p.R681L | Q8TD26 | protein_coding | deleterious(0.01) | possibly_damaging(0.894) | TCGA-BR-8591-01 | Stomach | stomach adenocarcinoma | Male | >=65 | III/IV | Unknown | Unknown | SD |
Page: 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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