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Gene: C5orf42 |
Gene summary for C5ORF42 |
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Gene information | Species | Human | Gene symbol | C5orf42 | Gene ID | 65250 |
Gene name | ciliogenesis and planar polarity effector 1 | |
Gene Alias | C5orf42 | |
Cytomap | 5p13.2 | |
Gene Type | protein-coding | GO ID | GO:0006996 | UniProtAcc | Q9H799 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
65250 | C5orf42 | P1T-E | Human | Esophagus | ESCC | 1.07e-08 | 3.86e-01 | 0.0875 |
65250 | C5orf42 | P2T-E | Human | Esophagus | ESCC | 1.23e-20 | 3.46e-01 | 0.1177 |
65250 | C5orf42 | P4T-E | Human | Esophagus | ESCC | 3.57e-05 | 1.74e-01 | 0.1323 |
65250 | C5orf42 | P5T-E | Human | Esophagus | ESCC | 1.96e-05 | 1.11e-01 | 0.1327 |
65250 | C5orf42 | P8T-E | Human | Esophagus | ESCC | 1.80e-26 | 4.12e-01 | 0.0889 |
65250 | C5orf42 | P9T-E | Human | Esophagus | ESCC | 7.32e-04 | 1.60e-01 | 0.1131 |
65250 | C5orf42 | P10T-E | Human | Esophagus | ESCC | 1.25e-26 | 5.20e-01 | 0.116 |
65250 | C5orf42 | P11T-E | Human | Esophagus | ESCC | 1.54e-08 | 4.24e-01 | 0.1426 |
65250 | C5orf42 | P12T-E | Human | Esophagus | ESCC | 5.68e-24 | 4.09e-01 | 0.1122 |
65250 | C5orf42 | P15T-E | Human | Esophagus | ESCC | 5.32e-05 | 1.12e-01 | 0.1149 |
65250 | C5orf42 | P16T-E | Human | Esophagus | ESCC | 2.48e-11 | 2.54e-01 | 0.1153 |
65250 | C5orf42 | P20T-E | Human | Esophagus | ESCC | 4.64e-11 | 2.39e-01 | 0.1124 |
65250 | C5orf42 | P21T-E | Human | Esophagus | ESCC | 1.59e-15 | 2.02e-01 | 0.1617 |
65250 | C5orf42 | P22T-E | Human | Esophagus | ESCC | 4.16e-22 | 3.14e-01 | 0.1236 |
65250 | C5orf42 | P23T-E | Human | Esophagus | ESCC | 4.63e-02 | 1.20e-01 | 0.108 |
65250 | C5orf42 | P24T-E | Human | Esophagus | ESCC | 7.31e-07 | 8.04e-02 | 0.1287 |
65250 | C5orf42 | P26T-E | Human | Esophagus | ESCC | 3.75e-03 | 1.23e-01 | 0.1276 |
65250 | C5orf42 | P27T-E | Human | Esophagus | ESCC | 3.88e-18 | 3.14e-01 | 0.1055 |
65250 | C5orf42 | P28T-E | Human | Esophagus | ESCC | 1.88e-16 | 3.32e-01 | 0.1149 |
65250 | C5orf42 | P30T-E | Human | Esophagus | ESCC | 1.32e-13 | 4.65e-01 | 0.137 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
C5orf42 | SNV | Missense_Mutation | novel | c.4500N>C | p.Met1500Ile | p.M1500I | Q9H799 | protein_coding | tolerated(0.33) | benign(0.003) | TCGA-O2-A5IB-01 | Lung | lung squamous cell carcinoma | Female | >=65 | III/IV | Unknown | Unknown | PD |
C5orf42 | insertion | Frame_Shift_Ins | novel | c.4598_4599insA | p.Asn1533LysfsTer12 | p.N1533Kfs*12 | Q9H799 | protein_coding | TCGA-95-7567-01 | Lung | lung adenocarcinoma | Male | <65 | I/II | Chemotherapy | cisplatin | SD | ||
C5orf42 | deletion | In_Frame_Del | novel | c.5003_5017delNNNNNNNNNNNNNNN | p.Val1668_Glu1672del | p.V1668_E1672del | Q9H799 | protein_coding | TCGA-37-4130-01 | Lung | lung squamous cell carcinoma | Male | <65 | I/II | Unknown | Unknown | SD | ||
C5orf42 | insertion | Frame_Shift_Ins | novel | c.5883_5884insA | p.Ser1962IlefsTer3 | p.S1962Ifs*3 | Q9H799 | protein_coding | TCGA-43-7656-01 | Lung | lung squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | ||
C5orf42 | SNV | Missense_Mutation | novel | c.5701N>C | p.Glu1901Gln | p.E1901Q | Q9H799 | protein_coding | tolerated(1) | benign(0) | TCGA-BB-A5HY-01 | Oral cavity | head & neck squamous cell carcinoma | Male | <65 | I/II | Chemotherapy | cisplatin | PD |
C5orf42 | SNV | Missense_Mutation | novel | c.9355C>T | p.Pro3119Ser | p.P3119S | Q9H799 | protein_coding | deleterious(0.05) | possibly_damaging(0.457) | TCGA-CV-5970-01 | Oral cavity | head & neck squamous cell carcinoma | Male | <65 | I/II | Unknown | Unknown | PD |
C5orf42 | SNV | Missense_Mutation | novel | c.7921N>G | p.Thr2641Ala | p.T2641A | Q9H799 | protein_coding | deleterious(0.03) | benign(0.067) | TCGA-CV-7424-01 | Oral cavity | head & neck squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | PD |
C5orf42 | SNV | Missense_Mutation | c.9574N>T | p.His3192Tyr | p.H3192Y | Q9H799 | protein_coding | deleterious_low_confidence(0.03) | benign(0) | TCGA-CV-7568-01 | Oral cavity | head & neck squamous cell carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
C5orf42 | SNV | Missense_Mutation | novel | c.4060N>C | p.Glu1354Gln | p.E1354Q | Q9H799 | protein_coding | deleterious(0) | probably_damaging(0.998) | TCGA-UF-A7JO-01 | Oral cavity | head & neck squamous cell carcinoma | Female | >=65 | I/II | Unknown | Unknown | PD |
C5orf42 | SNV | Missense_Mutation | novel | c.6431N>T | p.Pro2144Leu | p.P2144L | Q9H799 | protein_coding | tolerated(0.3) | benign(0) | TCGA-XK-AAIW-01 | Prostate | prostate adenocarcinoma | Male | >=65 | 9 | Unknown | Unknown | PD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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