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Gene: BRWD3 |
Gene summary for BRWD3 |
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Gene information | Species | Human | Gene symbol | BRWD3 | Gene ID | 254065 |
Gene name | bromodomain and WD repeat domain containing 3 | |
Gene Alias | BRODL | |
Cytomap | Xq21.1 | |
Gene Type | protein-coding | GO ID | GO:0000902 | UniProtAcc | Q6RI45 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
254065 | BRWD3 | HCC1_Meng | Human | Liver | HCC | 6.07e-22 | 5.89e-02 | 0.0246 |
254065 | BRWD3 | HCC2_Meng | Human | Liver | HCC | 1.00e-18 | 1.90e-01 | 0.0107 |
254065 | BRWD3 | HCC1 | Human | Liver | HCC | 4.06e-04 | 3.30e+00 | 0.5336 |
254065 | BRWD3 | HCC2 | Human | Liver | HCC | 7.55e-14 | 2.97e+00 | 0.5341 |
254065 | BRWD3 | S014 | Human | Liver | HCC | 1.06e-04 | 2.88e-01 | 0.2254 |
254065 | BRWD3 | S027 | Human | Liver | HCC | 2.66e-05 | 6.54e-01 | 0.2446 |
254065 | BRWD3 | S028 | Human | Liver | HCC | 1.84e-06 | 3.93e-01 | 0.2503 |
254065 | BRWD3 | S029 | Human | Liver | HCC | 3.86e-05 | 3.30e-01 | 0.2581 |
254065 | BRWD3 | RNA-P17T-P17T-4 | Human | Lung | IAC | 3.62e-02 | 4.55e-01 | 0.343 |
254065 | BRWD3 | RNA-P17T-P17T-6 | Human | Lung | IAC | 1.65e-05 | 5.46e-01 | 0.3385 |
254065 | BRWD3 | RNA-P17T-P17T-8 | Human | Lung | IAC | 3.32e-04 | 5.56e-01 | 0.3329 |
254065 | BRWD3 | RNA-P25T1-P25T1-4 | Human | Lung | AIS | 3.19e-05 | 4.04e-01 | -0.2119 |
254065 | BRWD3 | RNA-P6T2-P6T2-2 | Human | Lung | IAC | 2.06e-04 | 2.39e-01 | -0.0132 |
254065 | BRWD3 | RNA-P6T2-P6T2-3 | Human | Lung | IAC | 4.91e-08 | 3.26e-01 | -0.013 |
254065 | BRWD3 | RNA-P6T2-P6T2-4 | Human | Lung | IAC | 3.44e-02 | 2.55e-01 | -0.0121 |
254065 | BRWD3 | HTA12-15-2 | Human | Pancreas | PDAC | 2.48e-02 | 2.69e-01 | 0.2315 |
254065 | BRWD3 | HTA12-23-1 | Human | Pancreas | PDAC | 1.47e-02 | 5.41e-01 | 0.3405 |
254065 | BRWD3 | HTA12-26-1 | Human | Pancreas | PDAC | 6.36e-12 | 6.05e-01 | 0.3728 |
254065 | BRWD3 | HTA12-29-1 | Human | Pancreas | PDAC | 2.24e-16 | 3.94e-01 | 0.3722 |
254065 | BRWD3 | male-WTA | Human | Thyroid | PTC | 8.47e-06 | 6.97e-02 | 0.1037 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:002260422 | Liver | HCC | regulation of cell morphogenesis | 188/7958 | 309/18723 | 4.84e-11 | 1.82e-09 | 188 |
GO:000836022 | Liver | HCC | regulation of cell shape | 92/7958 | 154/18723 | 1.15e-05 | 1.31e-04 | 92 |
GO:00226048 | Lung | IAC | regulation of cell morphogenesis | 74/2061 | 309/18723 | 6.31e-11 | 1.70e-08 | 74 |
GO:00083607 | Lung | IAC | regulation of cell shape | 37/2061 | 154/18723 | 3.35e-06 | 1.42e-04 | 37 |
GO:002260413 | Lung | AIS | regulation of cell morphogenesis | 65/1849 | 309/18723 | 2.97e-09 | 5.09e-07 | 65 |
GO:000836013 | Lung | AIS | regulation of cell shape | 32/1849 | 154/18723 | 3.75e-05 | 1.14e-03 | 32 |
GO:0022604112 | Thyroid | PTC | regulation of cell morphogenesis | 165/5968 | 309/18723 | 2.60e-15 | 1.82e-13 | 165 |
GO:0008360111 | Thyroid | PTC | regulation of cell shape | 86/5968 | 154/18723 | 6.22e-10 | 1.95e-08 | 86 |
GO:002260429 | Thyroid | ATC | regulation of cell morphogenesis | 171/6293 | 309/18723 | 2.36e-15 | 1.70e-13 | 171 |
GO:000836026 | Thyroid | ATC | regulation of cell shape | 91/6293 | 154/18723 | 7.33e-11 | 2.31e-09 | 91 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
BRWD3 | SNV | Missense_Mutation | c.2242N>A | p.Glu748Lys | p.E748K | Q6RI45 | protein_coding | tolerated(0.12) | benign(0.018) | TCGA-18-3406-01 | Lung | lung squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | PD | |
BRWD3 | SNV | Missense_Mutation | c.347N>A | p.Leu116Gln | p.L116Q | Q6RI45 | protein_coding | tolerated(0.13) | benign(0.01) | TCGA-18-4083-01 | Lung | lung squamous cell carcinoma | Male | <65 | I/II | Chemotherapy | cisplatin | SD | |
BRWD3 | SNV | Missense_Mutation | c.1746N>A | p.His582Gln | p.H582Q | Q6RI45 | protein_coding | deleterious(0) | probably_damaging(0.993) | TCGA-21-1070-01 | Lung | lung squamous cell carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD | |
BRWD3 | SNV | Missense_Mutation | novel | c.3854N>G | p.Ser1285Cys | p.S1285C | Q6RI45 | protein_coding | deleterious(0.01) | probably_damaging(0.94) | TCGA-22-4594-01 | Lung | lung squamous cell carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
BRWD3 | SNV | Missense_Mutation | c.1939N>G | p.Leu647Val | p.L647V | Q6RI45 | protein_coding | deleterious(0.03) | probably_damaging(0.99) | TCGA-22-5473-01 | Lung | lung squamous cell carcinoma | Male | >=65 | I/II | Chemotherapy | carboplatin | PD | |
BRWD3 | SNV | Missense_Mutation | c.693N>G | p.Asn231Lys | p.N231K | Q6RI45 | protein_coding | deleterious(0) | possibly_damaging(0.904) | TCGA-22-5492-01 | Lung | lung squamous cell carcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD | |
BRWD3 | SNV | Missense_Mutation | c.1720G>A | p.Asp574Asn | p.D574N | Q6RI45 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-33-6738-01 | Lung | lung squamous cell carcinoma | Male | >=65 | III/IV | Chemotherapy | gemcitabine | SD | |
BRWD3 | SNV | Missense_Mutation | c.4364N>T | p.Ser1455Ile | p.S1455I | Q6RI45 | protein_coding | deleterious(0.03) | possibly_damaging(0.854) | TCGA-33-AASL-01 | Lung | lung squamous cell carcinoma | Female | <65 | I/II | Unknown | Unknown | PD | |
BRWD3 | SNV | Missense_Mutation | novel | c.673N>G | p.Ile225Val | p.I225V | Q6RI45 | protein_coding | deleterious(0.04) | possibly_damaging(0.51) | TCGA-34-8454-01 | Lung | lung squamous cell carcinoma | Female | <65 | III/IV | Chemotherapy | cisplatin | SD |
BRWD3 | SNV | Missense_Mutation | c.772G>T | p.Ala258Ser | p.A258S | Q6RI45 | protein_coding | tolerated(0.06) | possibly_damaging(0.718) | TCGA-37-4141-01 | Lung | lung squamous cell carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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