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Gene: ZDBF2 |
Gene summary for ZDBF2 |
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Gene information | Species | Human | Gene symbol | ZDBF2 | Gene ID | 57683 |
Gene name | zinc finger DBF-type containing 2 | |
Gene Alias | Slx9 | |
Cytomap | 2q33.3 | |
Gene Type | protein-coding | GO ID | GO:0003674 | UniProtAcc | N0DVX5 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
57683 | ZDBF2 | LZE4T | Human | Esophagus | ESCC | 6.44e-07 | 2.97e-01 | 0.0811 |
57683 | ZDBF2 | LZE7T | Human | Esophagus | ESCC | 1.89e-08 | 5.99e-01 | 0.0667 |
57683 | ZDBF2 | P2T-E | Human | Esophagus | ESCC | 2.06e-08 | 1.51e-01 | 0.1177 |
57683 | ZDBF2 | P9T-E | Human | Esophagus | ESCC | 3.65e-03 | 8.10e-02 | 0.1131 |
57683 | ZDBF2 | P10T-E | Human | Esophagus | ESCC | 7.90e-03 | 7.02e-02 | 0.116 |
57683 | ZDBF2 | P16T-E | Human | Esophagus | ESCC | 9.35e-10 | 1.40e-01 | 0.1153 |
57683 | ZDBF2 | P22T-E | Human | Esophagus | ESCC | 4.44e-08 | 1.53e-01 | 0.1236 |
57683 | ZDBF2 | P32T-E | Human | Esophagus | ESCC | 8.84e-05 | 1.03e-01 | 0.1666 |
57683 | ZDBF2 | P37T-E | Human | Esophagus | ESCC | 3.04e-07 | 1.29e-01 | 0.1371 |
57683 | ZDBF2 | P48T-E | Human | Esophagus | ESCC | 3.97e-04 | 1.07e-01 | 0.0959 |
57683 | ZDBF2 | P49T-E | Human | Esophagus | ESCC | 1.22e-03 | 6.53e-01 | 0.1768 |
57683 | ZDBF2 | P56T-E | Human | Esophagus | ESCC | 3.65e-05 | 6.51e-01 | 0.1613 |
57683 | ZDBF2 | P62T-E | Human | Esophagus | ESCC | 2.37e-05 | 9.93e-02 | 0.1302 |
57683 | ZDBF2 | P76T-E | Human | Esophagus | ESCC | 8.40e-04 | 7.63e-02 | 0.1207 |
57683 | ZDBF2 | P79T-E | Human | Esophagus | ESCC | 1.76e-12 | 2.34e-01 | 0.1154 |
57683 | ZDBF2 | P107T-E | Human | Esophagus | ESCC | 1.41e-03 | 1.68e-01 | 0.171 |
57683 | ZDBF2 | P130T-E | Human | Esophagus | ESCC | 9.67e-18 | 3.82e-01 | 0.1676 |
57683 | ZDBF2 | male-WTA | Human | Thyroid | PTC | 9.88e-08 | 6.31e-02 | 0.1037 |
57683 | ZDBF2 | PTC01 | Human | Thyroid | PTC | 1.69e-05 | 3.47e-02 | 0.1899 |
57683 | ZDBF2 | PTC04 | Human | Thyroid | PTC | 1.74e-06 | 1.92e-01 | 0.1927 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
ZDBF2 | SNV | Missense_Mutation | novel | c.6783G>T | p.Lys2261Asn | p.K2261N | Q9HCK1 | protein_coding | tolerated(0.12) | benign(0.005) | TCGA-55-8506-01 | Lung | lung adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
ZDBF2 | SNV | Missense_Mutation | c.5795N>T | p.Arg1932Leu | p.R1932L | Q9HCK1 | protein_coding | tolerated(0.35) | benign(0.131) | TCGA-67-4679-01 | Lung | lung adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
ZDBF2 | SNV | Missense_Mutation | rs374997578 | c.1936N>G | p.Ile646Val | p.I646V | Q9HCK1 | protein_coding | tolerated(0.12) | benign(0.006) | TCGA-78-7536-01 | Lung | lung adenocarcinoma | Male | >=65 | III/IV | Unknown | Unknown | PD |
ZDBF2 | SNV | Missense_Mutation | novel | c.4105N>A | p.Asp1369Asn | p.D1369N | Q9HCK1 | protein_coding | deleterious(0.04) | benign(0.288) | TCGA-78-7539-01 | Lung | lung adenocarcinoma | Female | >=65 | I/II | Chemotherapy | cisplatin | PD |
ZDBF2 | SNV | Missense_Mutation | novel | c.6848N>T | p.Ser2283Leu | p.S2283L | Q9HCK1 | protein_coding | tolerated(0.72) | benign(0) | TCGA-78-8640-01 | Lung | lung adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
ZDBF2 | SNV | Missense_Mutation | novel | c.6722G>T | p.Arg2241Met | p.R2241M | Q9HCK1 | protein_coding | deleterious(0) | possibly_damaging(0.862) | TCGA-86-6851-01 | Lung | lung adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
ZDBF2 | SNV | Missense_Mutation | novel | c.2298T>A | p.His766Gln | p.H766Q | Q9HCK1 | protein_coding | tolerated(0.89) | benign(0) | TCGA-86-7711-01 | Lung | lung adenocarcinoma | Male | >=65 | I/II | Chemotherapy | cisplatin | PD |
ZDBF2 | SNV | Missense_Mutation | c.2188A>C | p.Asn730His | p.N730H | Q9HCK1 | protein_coding | deleterious(0) | possibly_damaging(0.888) | TCGA-86-7955-01 | Lung | lung adenocarcinoma | Male | <65 | I/II | Chemotherapy | etoposide | PD | |
ZDBF2 | SNV | Missense_Mutation | novel | c.6703C>A | p.Arg2235Ser | p.R2235S | Q9HCK1 | protein_coding | tolerated(0.11) | benign(0.018) | TCGA-86-8673-01 | Lung | lung adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | PD |
ZDBF2 | SNV | Missense_Mutation | c.743N>T | p.Ser248Leu | p.S248L | Q9HCK1 | protein_coding | deleterious(0) | probably_damaging(0.992) | TCGA-93-8067-01 | Lung | lung adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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