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Gene: TTC3 |
Gene summary for TTC3 |
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Gene information | Species | Human | Gene symbol | TTC3 | Gene ID | 7267 |
Gene name | tetratricopeptide repeat domain 3 | |
Gene Alias | DCRR1 | |
Cytomap | 21q22.13 | |
Gene Type | protein-coding | GO ID | GO:0000209 | UniProtAcc | P53804 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
7267 | TTC3 | GSM4909281 | Human | Breast | IDC | 3.70e-04 | 3.25e-01 | 0.21 |
7267 | TTC3 | GSM4909285 | Human | Breast | IDC | 7.43e-40 | 7.32e-01 | 0.21 |
7267 | TTC3 | GSM4909286 | Human | Breast | IDC | 8.52e-05 | 2.50e-01 | 0.1081 |
7267 | TTC3 | GSM4909293 | Human | Breast | IDC | 1.55e-13 | 4.57e-01 | 0.1581 |
7267 | TTC3 | GSM4909294 | Human | Breast | IDC | 7.10e-07 | 1.64e-01 | 0.2022 |
7267 | TTC3 | GSM4909296 | Human | Breast | IDC | 1.12e-05 | -2.17e-01 | 0.1524 |
7267 | TTC3 | GSM4909297 | Human | Breast | IDC | 7.37e-10 | -2.51e-01 | 0.1517 |
7267 | TTC3 | GSM4909298 | Human | Breast | IDC | 1.35e-27 | 6.56e-01 | 0.1551 |
7267 | TTC3 | GSM4909308 | Human | Breast | IDC | 2.97e-19 | 5.54e-01 | 0.158 |
7267 | TTC3 | GSM4909311 | Human | Breast | IDC | 5.56e-28 | -8.73e-02 | 0.1534 |
7267 | TTC3 | GSM4909312 | Human | Breast | IDC | 3.41e-12 | 2.24e-01 | 0.1552 |
7267 | TTC3 | GSM4909317 | Human | Breast | IDC | 6.45e-05 | 3.50e-01 | 0.1355 |
7267 | TTC3 | GSM4909319 | Human | Breast | IDC | 3.76e-32 | -5.03e-01 | 0.1563 |
7267 | TTC3 | GSM4909320 | Human | Breast | IDC | 1.43e-05 | -2.53e-01 | 0.1575 |
7267 | TTC3 | GSM4909321 | Human | Breast | IDC | 1.74e-13 | -2.05e-01 | 0.1559 |
7267 | TTC3 | brca1 | Human | Breast | Precancer | 4.22e-05 | -3.25e-01 | -0.0338 |
7267 | TTC3 | brca10 | Human | Breast | Precancer | 6.61e-09 | -4.40e-01 | -0.0029 |
7267 | TTC3 | M5 | Human | Breast | IDC | 2.13e-05 | 6.13e-01 | 0.1598 |
7267 | TTC3 | NCCBC14 | Human | Breast | DCIS | 4.76e-12 | 3.60e-02 | 0.2021 |
7267 | TTC3 | NCCBC2 | Human | Breast | DCIS | 1.91e-03 | -3.95e-02 | 0.1554 |
Page: 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:00512359 | Cervix | CC | maintenance of location | 78/2311 | 327/18723 | 5.18e-09 | 4.92e-07 | 78 |
GO:00108834 | Cervix | CC | regulation of lipid storage | 15/2311 | 57/18723 | 3.13e-03 | 2.05e-02 | 15 |
GO:0000209 | Colorectum | AD | protein polyubiquitination | 78/3918 | 236/18723 | 8.71e-06 | 2.06e-04 | 78 |
GO:0006066 | Colorectum | AD | alcohol metabolic process | 106/3918 | 353/18723 | 3.02e-05 | 5.57e-04 | 106 |
GO:0070936 | Colorectum | AD | protein K48-linked ubiquitination | 27/3918 | 65/18723 | 1.31e-04 | 1.88e-03 | 27 |
GO:0062012 | Colorectum | AD | regulation of small molecule metabolic process | 93/3918 | 334/18723 | 1.46e-03 | 1.24e-02 | 93 |
GO:0010876 | Colorectum | AD | lipid localization | 120/3918 | 448/18723 | 1.59e-03 | 1.33e-02 | 120 |
GO:0006869 | Colorectum | AD | lipid transport | 108/3918 | 398/18723 | 1.67e-03 | 1.39e-02 | 108 |
GO:0008202 | Colorectum | AD | steroid metabolic process | 85/3918 | 319/18723 | 8.07e-03 | 4.75e-02 | 85 |
GO:00002091 | Colorectum | SER | protein polyubiquitination | 58/2897 | 236/18723 | 1.69e-04 | 3.18e-03 | 58 |
GO:00002092 | Colorectum | MSS | protein polyubiquitination | 72/3467 | 236/18723 | 5.19e-06 | 1.42e-04 | 72 |
GO:00709361 | Colorectum | MSS | protein K48-linked ubiquitination | 27/3467 | 65/18723 | 1.40e-05 | 3.18e-04 | 27 |
GO:00060662 | Colorectum | MSS | alcohol metabolic process | 92/3467 | 353/18723 | 2.57e-04 | 3.46e-03 | 92 |
GO:00620121 | Colorectum | MSS | regulation of small molecule metabolic process | 83/3467 | 334/18723 | 2.25e-03 | 1.85e-02 | 83 |
GO:00108761 | Colorectum | MSS | lipid localization | 104/3467 | 448/18723 | 6.76e-03 | 4.38e-02 | 104 |
GO:00709362 | Colorectum | FAP | protein K48-linked ubiquitination | 24/2622 | 65/18723 | 3.42e-06 | 1.23e-04 | 24 |
GO:00002093 | Colorectum | FAP | protein polyubiquitination | 59/2622 | 236/18723 | 4.53e-06 | 1.52e-04 | 59 |
GO:00620122 | Colorectum | FAP | regulation of small molecule metabolic process | 74/2622 | 334/18723 | 3.15e-05 | 7.13e-04 | 74 |
GO:00068691 | Colorectum | FAP | lipid transport | 81/2622 | 398/18723 | 2.84e-04 | 3.76e-03 | 81 |
GO:00108762 | Colorectum | FAP | lipid localization | 85/2622 | 448/18723 | 1.92e-03 | 1.63e-02 | 85 |
Page: 1 2 3 4 5 6 7 8 9 10 11 12 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
TTC3 | deletion | Frame_Shift_Del | rs756650873 | c.2334delA | p.Glu779LysfsTer5 | p.E779Kfs*5 | P53804 | protein_coding | TCGA-BR-4368-01 | Stomach | stomach adenocarcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD | ||
TTC3 | deletion | Frame_Shift_Del | rs756650873 | c.2327delN | p.Glu779LysfsTer5 | p.E779Kfs*5 | P53804 | protein_coding | TCGA-BR-6802-01 | Stomach | stomach adenocarcinoma | Male | >=65 | III/IV | Ancillary | leucovorin | CR | ||
TTC3 | deletion | Frame_Shift_Del | rs756650873 | c.2327delN | p.Glu779LysfsTer5 | p.E779Kfs*5 | P53804 | protein_coding | TCGA-BR-6852-01 | Stomach | stomach adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD | ||
TTC3 | deletion | Frame_Shift_Del | rs756650873 | c.2327delN | p.Glu779LysfsTer5 | p.E779Kfs*5 | P53804 | protein_coding | TCGA-BR-8363-01 | Stomach | stomach adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | ||
TTC3 | deletion | Frame_Shift_Del | rs756650873 | c.2327delN | p.Glu779LysfsTer5 | p.E779Kfs*5 | P53804 | protein_coding | TCGA-BR-8487-01 | Stomach | stomach adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD | ||
TTC3 | deletion | Frame_Shift_Del | rs756650873 | c.2327delN | p.Glu779LysfsTer5 | p.E779Kfs*5 | P53804 | protein_coding | TCGA-CD-A4MJ-01 | Stomach | stomach adenocarcinoma | Male | <65 | I/II | Chemotherapy | cisplatin | CR | ||
TTC3 | deletion | Frame_Shift_Del | rs756650873 | c.2327delN | p.Glu779LysfsTer5 | p.E779Kfs*5 | P53804 | protein_coding | TCGA-CG-4306-01 | Stomach | stomach adenocarcinoma | Male | >=65 | III/IV | Unknown | Unknown | SD | ||
TTC3 | insertion | Frame_Shift_Ins | rs752525442 | c.1761_1762insA | p.Asn590LysfsTer11 | p.N590Kfs*11 | P53804 | protein_coding | TCGA-CG-4460-01 | Stomach | stomach adenocarcinoma | Female | >=65 | III/IV | Chemotherapy | capecitabine | PD | ||
TTC3 | insertion | Frame_Shift_Ins | novel | c.3537_3538insA | p.Arg1182LysfsTer7 | p.R1182Kfs*7 | P53804 | protein_coding | TCGA-CG-4460-01 | Stomach | stomach adenocarcinoma | Female | >=65 | III/IV | Chemotherapy | capecitabine | PD | ||
TTC3 | deletion | Frame_Shift_Del | rs756650873 | c.2327delN | p.Glu779LysfsTer5 | p.E779Kfs*5 | P53804 | protein_coding | TCGA-CG-5721-01 | Stomach | stomach adenocarcinoma | Male | <65 | III/IV | Unknown | Unknown | SD |
Page: 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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