![]() |
|||||
|
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() |
Gene: TET1 |
Gene summary for TET1 |
![]() |
Gene information | Species | Human | Gene symbol | TET1 | Gene ID | 80312 |
Gene name | tet methylcytosine dioxygenase 1 | |
Gene Alias | CXXC6 | |
Cytomap | 10q21.3 | |
Gene Type | protein-coding | GO ID | GO:0001701 | UniProtAcc | Q8NFU7 |
Top |
Malignant transformation analysis |
![]() |
![]() |
Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
80312 | TET1 | PTC05 | Human | Thyroid | PTC | 1.26e-11 | 3.96e-01 | 0.2065 |
80312 | TET1 | PTC07 | Human | Thyroid | PTC | 1.21e-04 | 1.02e-01 | 0.2044 |
80312 | TET1 | ATC12 | Human | Thyroid | ATC | 4.25e-14 | 2.86e-01 | 0.34 |
80312 | TET1 | ATC13 | Human | Thyroid | ATC | 7.21e-44 | 6.86e-01 | 0.34 |
80312 | TET1 | ATC4 | Human | Thyroid | ATC | 7.37e-16 | 3.82e-01 | 0.34 |
80312 | TET1 | ATC5 | Human | Thyroid | ATC | 2.11e-46 | 7.42e-01 | 0.34 |
Page: 1 |
![]() |
Tissue | Expression Dynamics | Abbreviation |
Thyroid | ![]() | ATC: Anaplastic thyroid cancer |
HT: Hashimoto's thyroiditis | ||
PTC: Papillary thyroid cancer |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
Top |
Malignant transformation related pathway analysis |
![]() |
![]() |
Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
![]() |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:001657010 | Thyroid | PTC | histone modification | 235/5968 | 463/18723 | 1.17e-17 | 1.15e-15 | 235 |
GO:0046700111 | Thyroid | PTC | heterocycle catabolic process | 221/5968 | 445/18723 | 2.43e-15 | 1.72e-13 | 221 |
GO:0044270111 | Thyroid | PTC | cellular nitrogen compound catabolic process | 223/5968 | 451/18723 | 3.34e-15 | 2.31e-13 | 223 |
GO:0019439111 | Thyroid | PTC | aromatic compound catabolic process | 225/5968 | 467/18723 | 8.51e-14 | 4.71e-12 | 225 |
GO:1901361111 | Thyroid | PTC | organic cyclic compound catabolic process | 231/5968 | 495/18723 | 2.55e-12 | 1.12e-10 | 231 |
GO:0001701111 | Thyroid | PTC | in utero embryonic development | 175/5968 | 367/18723 | 1.40e-10 | 4.73e-09 | 175 |
GO:003105610 | Thyroid | PTC | regulation of histone modification | 83/5968 | 152/18723 | 5.19e-09 | 1.34e-07 | 83 |
GO:000632520 | Thyroid | PTC | chromatin organization | 183/5968 | 409/18723 | 2.55e-08 | 5.70e-07 | 183 |
GO:00310585 | Thyroid | PTC | positive regulation of histone modification | 53/5968 | 92/18723 | 3.03e-07 | 5.13e-06 | 53 |
GO:00400297 | Thyroid | PTC | regulation of gene expression, epigenetic | 57/5968 | 105/18723 | 1.60e-06 | 2.25e-05 | 57 |
GO:00310626 | Thyroid | PTC | positive regulation of histone methylation | 26/5968 | 41/18723 | 3.23e-05 | 3.07e-04 | 26 |
GO:001657110 | Thyroid | PTC | histone methylation | 67/5968 | 141/18723 | 7.31e-05 | 6.31e-04 | 67 |
GO:000647910 | Thyroid | PTC | protein methylation | 82/5968 | 181/18723 | 1.01e-04 | 8.21e-04 | 82 |
GO:000821310 | Thyroid | PTC | protein alkylation | 82/5968 | 181/18723 | 1.01e-04 | 8.21e-04 | 82 |
GO:00310606 | Thyroid | PTC | regulation of histone methylation | 37/5968 | 69/18723 | 1.46e-04 | 1.13e-03 | 37 |
GO:009872710 | Thyroid | PTC | maintenance of cell number | 63/5968 | 134/18723 | 1.73e-04 | 1.32e-03 | 63 |
GO:00198279 | Thyroid | PTC | stem cell population maintenance | 61/5968 | 131/18723 | 3.01e-04 | 2.12e-03 | 61 |
GO:00322594 | Thyroid | PTC | methylation | 146/5968 | 364/18723 | 4.99e-04 | 3.26e-03 | 146 |
GO:000182513 | Thyroid | PTC | blastocyst formation | 22/5968 | 38/18723 | 8.19e-04 | 5.07e-03 | 22 |
GO:00434145 | Thyroid | PTC | macromolecule methylation | 127/5968 | 316/18723 | 1.02e-03 | 6.07e-03 | 127 |
Page: 1 2 3 |
![]() |
Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
Page: 1 |
Top |
Cell-cell communication analysis |
![]() |
Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
Page: 1 |
Top |
Single-cell gene regulatory network inference analysis |
![]() |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
Page: 1 |
Top |
Somatic mutation of malignant transformation related genes |
![]() |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
TET1 | insertion | Frame_Shift_Ins | novel | c.57_58insA | p.Lys23GlufsTer37 | p.K23Efs*37 | Q8NFU7 | protein_coding | TCGA-XK-AAIW-01 | Prostate | prostate adenocarcinoma | Male | >=65 | 9 | Unknown | Unknown | PD | ||
TET1 | SNV | Missense_Mutation | rs765929366 | c.5798N>T | p.Pro1933Leu | p.P1933L | Q8NFU7 | protein_coding | deleterious(0.01) | benign(0.065) | TCGA-BR-4257-01 | Stomach | stomach adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
TET1 | SNV | Missense_Mutation | rs540373976 | c.5804N>T | p.Thr1935Met | p.T1935M | Q8NFU7 | protein_coding | tolerated(0.17) | possibly_damaging(0.688) | TCGA-BR-4292-01 | Stomach | stomach adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
TET1 | SNV | Missense_Mutation | rs575341146 | c.3866C>T | p.Thr1289Met | p.T1289M | Q8NFU7 | protein_coding | tolerated(0.1) | benign(0.229) | TCGA-BR-4361-01 | Stomach | stomach adenocarcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD |
TET1 | SNV | Missense_Mutation | c.2018N>T | p.Asp673Val | p.D673V | Q8NFU7 | protein_coding | deleterious(0) | benign(0.296) | TCGA-BR-6452-01 | Stomach | stomach adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
TET1 | SNV | Missense_Mutation | c.5387N>T | p.Ser1796Leu | p.S1796L | Q8NFU7 | protein_coding | tolerated(0.08) | benign(0.003) | TCGA-BR-8680-01 | Stomach | stomach adenocarcinoma | Male | <65 | III/IV | Chemotherapy | oxaliplatin | CR | |
TET1 | SNV | Missense_Mutation | c.6113N>A | p.Arg2038His | p.R2038H | Q8NFU7 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-BR-8680-01 | Stomach | stomach adenocarcinoma | Male | <65 | III/IV | Chemotherapy | oxaliplatin | CR | |
TET1 | SNV | Missense_Mutation | c.5578N>C | p.Ala1860Pro | p.A1860P | Q8NFU7 | protein_coding | tolerated(0.14) | benign(0.001) | TCGA-D7-8572-01 | Stomach | stomach adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD | |
TET1 | SNV | Missense_Mutation | novel | c.1749N>T | p.Leu583Phe | p.L583F | Q8NFU7 | protein_coding | deleterious(0.01) | probably_damaging(0.985) | TCGA-D7-A6EZ-01 | Stomach | stomach adenocarcinoma | Male | >=65 | III/IV | Unknown | Unknown | PD |
TET1 | SNV | Missense_Mutation | rs576727317 | c.5555N>T | p.Pro1852Leu | p.P1852L | Q8NFU7 | protein_coding | tolerated(0.48) | benign(0.04) | TCGA-HU-8604-01 | Stomach | stomach adenocarcinoma | Female | >=65 | I/II | Chemotherapy | doxifluridine | SD |
Page: 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 |
Top |
Related drugs of malignant transformation related genes |
![]() |
(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
Page: 1 |