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Gene: SPTBN1 |
Gene summary for SPTBN1 |
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Gene information | Species | Human | Gene symbol | SPTBN1 | Gene ID | 6711 |
Gene name | spectrin beta, non-erythrocytic 1 | |
Gene Alias | DDISBA | |
Cytomap | 2p16.2 | |
Gene Type | protein-coding | GO ID | GO:0000278 | UniProtAcc | B2ZZ89 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
6711 | SPTBN1 | HTA11_3410_2000001011 | Human | Colorectum | AD | 2.17e-05 | -3.88e-01 | 0.0155 |
6711 | SPTBN1 | HTA11_2487_2000001011 | Human | Colorectum | SER | 4.58e-04 | 5.93e-01 | -0.1808 |
6711 | SPTBN1 | HTA11_1938_2000001011 | Human | Colorectum | AD | 1.47e-09 | 6.52e-01 | -0.0811 |
6711 | SPTBN1 | HTA11_78_2000001011 | Human | Colorectum | AD | 3.89e-02 | 4.68e-01 | -0.1088 |
6711 | SPTBN1 | HTA11_347_2000001011 | Human | Colorectum | AD | 3.87e-15 | 7.59e-01 | -0.1954 |
6711 | SPTBN1 | HTA11_411_2000001011 | Human | Colorectum | SER | 2.02e-07 | 1.33e+00 | -0.2602 |
6711 | SPTBN1 | HTA11_1391_2000001011 | Human | Colorectum | AD | 1.03e-02 | 5.14e-01 | -0.059 |
6711 | SPTBN1 | HTA11_99999970781_79442 | Human | Colorectum | MSS | 3.40e-03 | 4.39e-01 | 0.294 |
6711 | SPTBN1 | A002-C-010 | Human | Colorectum | FAP | 9.37e-05 | -1.59e-01 | 0.242 |
6711 | SPTBN1 | A001-C-207 | Human | Colorectum | FAP | 2.58e-02 | -1.41e-01 | 0.1278 |
6711 | SPTBN1 | A015-C-203 | Human | Colorectum | FAP | 3.37e-33 | -3.84e-01 | -0.1294 |
6711 | SPTBN1 | A015-C-204 | Human | Colorectum | FAP | 6.13e-09 | -3.06e-01 | -0.0228 |
6711 | SPTBN1 | A014-C-040 | Human | Colorectum | FAP | 2.15e-03 | -3.21e-01 | -0.1184 |
6711 | SPTBN1 | A002-C-201 | Human | Colorectum | FAP | 1.61e-11 | -2.22e-01 | 0.0324 |
6711 | SPTBN1 | A002-C-203 | Human | Colorectum | FAP | 5.89e-03 | -1.66e-01 | 0.2786 |
6711 | SPTBN1 | A001-C-119 | Human | Colorectum | FAP | 1.10e-06 | -1.05e-01 | -0.1557 |
6711 | SPTBN1 | A001-C-108 | Human | Colorectum | FAP | 5.31e-20 | -6.14e-02 | -0.0272 |
6711 | SPTBN1 | A002-C-205 | Human | Colorectum | FAP | 8.24e-23 | -2.21e-01 | -0.1236 |
6711 | SPTBN1 | A001-C-104 | Human | Colorectum | FAP | 2.81e-04 | 1.13e-01 | 0.0184 |
6711 | SPTBN1 | A015-C-005 | Human | Colorectum | FAP | 3.44e-03 | -1.78e-01 | -0.0336 |
Page: 1 2 3 4 5 6 7 8 9 10 11 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:0072659 | Colorectum | AD | protein localization to plasma membrane | 122/3918 | 284/18723 | 2.86e-17 | 1.49e-14 | 122 |
GO:0007015 | Colorectum | AD | actin filament organization | 167/3918 | 442/18723 | 1.65e-16 | 7.94e-14 | 167 |
GO:1990778 | Colorectum | AD | protein localization to cell periphery | 129/3918 | 333/18723 | 5.51e-14 | 1.15e-11 | 129 |
GO:0032535 | Colorectum | AD | regulation of cellular component size | 142/3918 | 383/18723 | 1.74e-13 | 3.41e-11 | 142 |
GO:1903829 | Colorectum | AD | positive regulation of cellular protein localization | 110/3918 | 276/18723 | 4.58e-13 | 8.44e-11 | 110 |
GO:1902903 | Colorectum | AD | regulation of supramolecular fiber organization | 139/3918 | 383/18723 | 2.01e-12 | 3.19e-10 | 139 |
GO:0032970 | Colorectum | AD | regulation of actin filament-based process | 142/3918 | 397/18723 | 4.05e-12 | 5.90e-10 | 142 |
GO:0110053 | Colorectum | AD | regulation of actin filament organization | 108/3918 | 278/18723 | 5.02e-12 | 6.98e-10 | 108 |
GO:0008154 | Colorectum | AD | actin polymerization or depolymerization | 90/3918 | 218/18723 | 6.14e-12 | 8.23e-10 | 90 |
GO:0032271 | Colorectum | AD | regulation of protein polymerization | 94/3918 | 233/18723 | 1.01e-11 | 1.29e-09 | 94 |
GO:0030041 | Colorectum | AD | actin filament polymerization | 81/3918 | 191/18723 | 1.35e-11 | 1.69e-09 | 81 |
GO:0051258 | Colorectum | AD | protein polymerization | 112/3918 | 297/18723 | 1.85e-11 | 2.27e-09 | 112 |
GO:0043254 | Colorectum | AD | regulation of protein-containing complex assembly | 148/3918 | 428/18723 | 2.64e-11 | 3.18e-09 | 148 |
GO:0008064 | Colorectum | AD | regulation of actin polymerization or depolymerization | 79/3918 | 188/18723 | 4.17e-11 | 4.74e-09 | 79 |
GO:0030833 | Colorectum | AD | regulation of actin filament polymerization | 74/3918 | 172/18723 | 4.50e-11 | 5.03e-09 | 74 |
GO:0030832 | Colorectum | AD | regulation of actin filament length | 79/3918 | 189/18723 | 5.71e-11 | 6.27e-09 | 79 |
GO:0090150 | Colorectum | AD | establishment of protein localization to membrane | 100/3918 | 260/18723 | 6.01e-11 | 6.33e-09 | 100 |
GO:0032956 | Colorectum | AD | regulation of actin cytoskeleton organization | 127/3918 | 358/18723 | 1.03e-10 | 1.04e-08 | 127 |
GO:0048193 | Colorectum | AD | Golgi vesicle transport | 109/3918 | 296/18723 | 1.80e-10 | 1.68e-08 | 109 |
GO:1905475 | Colorectum | AD | regulation of protein localization to membrane | 73/3918 | 175/18723 | 3.37e-10 | 2.93e-08 | 73 |
Page: 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
SPTBN1 | SNV | Missense_Mutation | c.5946N>G | p.His1982Gln | p.H1982Q | Q01082 | protein_coding | deleterious(0) | possibly_damaging(0.607) | TCGA-J9-A52D-01 | Prostate | prostate adenocarcinoma | Male | >=65 | 9 | Unknown | Unknown | SD | |
SPTBN1 | SNV | Missense_Mutation | novel | c.794N>T | p.Ser265Phe | p.S265F | Q01082 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-XK-AAIW-01 | Prostate | prostate adenocarcinoma | Male | >=65 | 9 | Unknown | Unknown | PD |
SPTBN1 | SNV | Missense_Mutation | rs1804471 | c.2323N>A | p.Asp775Asn | p.D775N | Q01082 | protein_coding | deleterious(0) | probably_damaging(0.998) | TCGA-XK-AAIW-01 | Prostate | prostate adenocarcinoma | Male | >=65 | 9 | Unknown | Unknown | PD |
SPTBN1 | SNV | Missense_Mutation | novel | c.2986N>T | p.Arg996Cys | p.R996C | Q01082 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-XK-AAIW-01 | Prostate | prostate adenocarcinoma | Male | >=65 | 9 | Unknown | Unknown | PD |
SPTBN1 | SNV | Missense_Mutation | rs779986830 | c.5263G>A | p.Val1755Met | p.V1755M | Q01082 | protein_coding | deleterious(0.02) | probably_damaging(0.999) | TCGA-BR-4370-01 | Stomach | stomach adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
SPTBN1 | SNV | Missense_Mutation | c.2998G>A | p.Gly1000Ser | p.G1000S | Q01082 | protein_coding | tolerated(0.07) | possibly_damaging(0.881) | TCGA-BR-7851-01 | Stomach | stomach adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
SPTBN1 | SNV | Missense_Mutation | rs750537630 | c.5221N>T | p.Arg1741Trp | p.R1741W | Q01082 | protein_coding | deleterious(0) | probably_damaging(0.996) | TCGA-BR-8078-01 | Stomach | stomach adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
SPTBN1 | SNV | Missense_Mutation | c.1203N>C | p.Lys401Asn | p.K401N | Q01082 | protein_coding | deleterious(0) | probably_damaging(0.968) | TCGA-BR-8286-01 | Stomach | stomach adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD | |
SPTBN1 | SNV | Missense_Mutation | c.2066N>A | p.Gly689Asp | p.G689D | Q01082 | protein_coding | deleterious(0.04) | benign(0.364) | TCGA-BR-8363-01 | Stomach | stomach adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
SPTBN1 | SNV | Missense_Mutation | c.1393G>A | p.Glu465Lys | p.E465K | Q01082 | protein_coding | deleterious(0) | probably_damaging(0.975) | TCGA-BR-8487-01 | Stomach | stomach adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
Page: 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
6711 | SPTBN1 | NA | ABT-413 |
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