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Gene: RANBP2 |
Gene summary for RANBP2 |
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Gene information | Species | Human | Gene symbol | RANBP2 | Gene ID | 5903 |
Gene name | RAN binding protein 2 | |
Gene Alias | ADANE | |
Cytomap | 2q13 | |
Gene Type | protein-coding | GO ID | GO:0000413 | UniProtAcc | P49792 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
5903 | RANBP2 | LZE4T | Human | Esophagus | ESCC | 3.73e-17 | 5.99e-01 | 0.0811 |
5903 | RANBP2 | LZE7T | Human | Esophagus | ESCC | 1.54e-10 | 8.92e-01 | 0.0667 |
5903 | RANBP2 | LZE20T | Human | Esophagus | ESCC | 2.24e-09 | 1.72e-01 | 0.0662 |
5903 | RANBP2 | LZE24T | Human | Esophagus | ESCC | 3.68e-14 | 4.31e-01 | 0.0596 |
5903 | RANBP2 | LZE21T | Human | Esophagus | ESCC | 5.11e-06 | 1.26e-01 | 0.0655 |
5903 | RANBP2 | P1T-E | Human | Esophagus | ESCC | 1.41e-11 | 3.67e-01 | 0.0875 |
5903 | RANBP2 | P2T-E | Human | Esophagus | ESCC | 1.90e-33 | 5.12e-01 | 0.1177 |
5903 | RANBP2 | P4T-E | Human | Esophagus | ESCC | 7.81e-12 | 4.11e-01 | 0.1323 |
5903 | RANBP2 | P5T-E | Human | Esophagus | ESCC | 3.10e-20 | 2.64e-01 | 0.1327 |
5903 | RANBP2 | P8T-E | Human | Esophagus | ESCC | 2.69e-22 | 3.96e-01 | 0.0889 |
5903 | RANBP2 | P9T-E | Human | Esophagus | ESCC | 6.25e-13 | 3.39e-01 | 0.1131 |
5903 | RANBP2 | P10T-E | Human | Esophagus | ESCC | 1.09e-43 | 7.94e-01 | 0.116 |
5903 | RANBP2 | P11T-E | Human | Esophagus | ESCC | 3.88e-12 | 6.18e-01 | 0.1426 |
5903 | RANBP2 | P12T-E | Human | Esophagus | ESCC | 3.65e-24 | 4.76e-01 | 0.1122 |
5903 | RANBP2 | P15T-E | Human | Esophagus | ESCC | 1.56e-23 | 6.92e-01 | 0.1149 |
5903 | RANBP2 | P16T-E | Human | Esophagus | ESCC | 8.95e-22 | 4.87e-01 | 0.1153 |
5903 | RANBP2 | P20T-E | Human | Esophagus | ESCC | 4.25e-15 | 2.65e-01 | 0.1124 |
5903 | RANBP2 | P21T-E | Human | Esophagus | ESCC | 1.16e-32 | 7.03e-01 | 0.1617 |
5903 | RANBP2 | P22T-E | Human | Esophagus | ESCC | 4.24e-24 | 2.30e-01 | 0.1236 |
5903 | RANBP2 | P23T-E | Human | Esophagus | ESCC | 3.00e-20 | 4.29e-01 | 0.108 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:0072594110 | Esophagus | ESCC | establishment of protein localization to organelle | 311/8552 | 422/18723 | 3.02e-32 | 2.13e-29 | 311 |
GO:0006913110 | Esophagus | ESCC | nucleocytoplasmic transport | 230/8552 | 301/18723 | 6.04e-28 | 2.02e-25 | 230 |
GO:0051169110 | Esophagus | ESCC | nuclear transport | 230/8552 | 301/18723 | 6.04e-28 | 2.02e-25 | 230 |
GO:0006403110 | Esophagus | ESCC | RNA localization | 166/8552 | 201/18723 | 1.95e-27 | 6.18e-25 | 166 |
GO:003450418 | Esophagus | ESCC | protein localization to nucleus | 211/8552 | 290/18723 | 4.06e-21 | 6.60e-19 | 211 |
GO:0006457110 | Esophagus | ESCC | protein folding | 163/8552 | 212/18723 | 1.13e-20 | 1.74e-18 | 163 |
GO:005123617 | Esophagus | ESCC | establishment of RNA localization | 134/8552 | 166/18723 | 1.23e-20 | 1.81e-18 | 134 |
GO:005102815 | Esophagus | ESCC | mRNA transport | 110/8552 | 130/18723 | 2.76e-20 | 3.80e-18 | 110 |
GO:001820514 | Esophagus | ESCC | peptidyl-lysine modification | 259/8552 | 376/18723 | 3.90e-20 | 5.26e-18 | 259 |
GO:005065717 | Esophagus | ESCC | nucleic acid transport | 131/8552 | 163/18723 | 6.94e-20 | 8.46e-18 | 131 |
GO:005065817 | Esophagus | ESCC | RNA transport | 131/8552 | 163/18723 | 6.94e-20 | 8.46e-18 | 131 |
GO:001593117 | Esophagus | ESCC | nucleobase-containing compound transport | 162/8552 | 222/18723 | 9.87e-17 | 7.93e-15 | 162 |
GO:001703818 | Esophagus | ESCC | protein import | 149/8552 | 206/18723 | 5.90e-15 | 3.31e-13 | 149 |
GO:005117014 | Esophagus | ESCC | import into nucleus | 111/8552 | 159/18723 | 5.69e-10 | 1.44e-08 | 111 |
GO:000660613 | Esophagus | ESCC | protein import into nucleus | 108/8552 | 155/18723 | 1.16e-09 | 2.77e-08 | 108 |
GO:00059969 | Esophagus | ESCC | monosaccharide metabolic process | 159/8552 | 257/18723 | 1.11e-07 | 1.81e-06 | 159 |
GO:001820816 | Esophagus | ESCC | peptidyl-proline modification | 46/8552 | 58/18723 | 1.59e-07 | 2.51e-06 | 46 |
GO:00193189 | Esophagus | ESCC | hexose metabolic process | 147/8552 | 237/18723 | 2.63e-07 | 3.94e-06 | 147 |
GO:001692512 | Esophagus | ESCC | protein sumoylation | 41/8552 | 53/18723 | 2.49e-06 | 2.86e-05 | 41 |
GO:00618428 | Esophagus | ESCC | microtubule organizing center localization | 28/8552 | 33/18723 | 3.80e-06 | 4.12e-05 | 28 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa05014210 | Esophagus | ESCC | Amyotrophic lateral sclerosis | 266/4205 | 364/8465 | 1.31e-20 | 2.20e-18 | 1.13e-18 | 266 |
hsa0301321 | Esophagus | ESCC | Nucleocytoplasmic transport | 89/4205 | 108/8465 | 1.20e-12 | 2.37e-11 | 1.21e-11 | 89 |
hsa032509 | Esophagus | ESCC | Viral life cycle - HIV-1 | 54/4205 | 63/8465 | 2.01e-09 | 2.17e-08 | 1.11e-08 | 54 |
hsa0501438 | Esophagus | ESCC | Amyotrophic lateral sclerosis | 266/4205 | 364/8465 | 1.31e-20 | 2.20e-18 | 1.13e-18 | 266 |
hsa0301331 | Esophagus | ESCC | Nucleocytoplasmic transport | 89/4205 | 108/8465 | 1.20e-12 | 2.37e-11 | 1.21e-11 | 89 |
hsa0325014 | Esophagus | ESCC | Viral life cycle - HIV-1 | 54/4205 | 63/8465 | 2.01e-09 | 2.17e-08 | 1.11e-08 | 54 |
hsa0501422 | Liver | HCC | Amyotrophic lateral sclerosis | 252/4020 | 364/8465 | 8.85e-18 | 7.41e-16 | 4.12e-16 | 252 |
hsa03013 | Liver | HCC | Nucleocytoplasmic transport | 81/4020 | 108/8465 | 4.28e-09 | 6.83e-08 | 3.80e-08 | 81 |
hsa032502 | Liver | HCC | Viral life cycle - HIV-1 | 46/4020 | 63/8465 | 3.25e-05 | 1.88e-04 | 1.04e-04 | 46 |
hsa0501432 | Liver | HCC | Amyotrophic lateral sclerosis | 252/4020 | 364/8465 | 8.85e-18 | 7.41e-16 | 4.12e-16 | 252 |
hsa030131 | Liver | HCC | Nucleocytoplasmic transport | 81/4020 | 108/8465 | 4.28e-09 | 6.83e-08 | 3.80e-08 | 81 |
hsa0325011 | Liver | HCC | Viral life cycle - HIV-1 | 46/4020 | 63/8465 | 3.25e-05 | 1.88e-04 | 1.04e-04 | 46 |
hsa0501426 | Prostate | BPH | Amyotrophic lateral sclerosis | 151/1718 | 364/8465 | 3.37e-21 | 1.01e-19 | 6.25e-20 | 151 |
hsa032504 | Prostate | BPH | Viral life cycle - HIV-1 | 24/1718 | 63/8465 | 8.32e-04 | 3.98e-03 | 2.46e-03 | 24 |
hsa05014111 | Prostate | BPH | Amyotrophic lateral sclerosis | 151/1718 | 364/8465 | 3.37e-21 | 1.01e-19 | 6.25e-20 | 151 |
hsa0325012 | Prostate | BPH | Viral life cycle - HIV-1 | 24/1718 | 63/8465 | 8.32e-04 | 3.98e-03 | 2.46e-03 | 24 |
hsa0501427 | Prostate | Tumor | Amyotrophic lateral sclerosis | 155/1791 | 364/8465 | 3.41e-21 | 1.13e-19 | 6.99e-20 | 155 |
hsa0325021 | Prostate | Tumor | Viral life cycle - HIV-1 | 25/1791 | 63/8465 | 6.13e-04 | 3.07e-03 | 1.91e-03 | 25 |
hsa0501436 | Prostate | Tumor | Amyotrophic lateral sclerosis | 155/1791 | 364/8465 | 3.41e-21 | 1.13e-19 | 6.99e-20 | 155 |
hsa032503 | Prostate | Tumor | Viral life cycle - HIV-1 | 25/1791 | 63/8465 | 6.13e-04 | 3.07e-03 | 1.91e-03 | 25 |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
RANBP2 | SNV | Missense_Mutation | c.7612A>T | p.Ser2538Cys | p.S2538C | P49792 | protein_coding | deleterious(0) | possibly_damaging(0.72) | TCGA-78-7166-01 | Lung | lung adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
RANBP2 | SNV | Missense_Mutation | c.5776N>T | p.Asp1926Tyr | p.D1926Y | P49792 | protein_coding | deleterious(0.05) | possibly_damaging(0.781) | TCGA-78-7539-01 | Lung | lung adenocarcinoma | Female | >=65 | I/II | Chemotherapy | cisplatin | PD | |
RANBP2 | SNV | Missense_Mutation | novel | c.6083N>C | p.Gly2028Ala | p.G2028A | P49792 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-78-8640-01 | Lung | lung adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
RANBP2 | SNV | Missense_Mutation | novel | c.86N>C | p.Gly29Ala | p.G29A | P49792 | protein_coding | deleterious(0) | probably_damaging(0.998) | TCGA-78-8662-01 | Lung | lung adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | PD |
RANBP2 | SNV | Missense_Mutation | c.8924N>C | p.Arg2975Thr | p.R2975T | P49792 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-86-8073-01 | Lung | lung adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD | |
RANBP2 | SNV | Missense_Mutation | novel | c.7324N>A | p.Ala2442Thr | p.A2442T | P49792 | protein_coding | deleterious(0.01) | probably_damaging(0.977) | TCGA-86-8674-01 | Lung | lung adenocarcinoma | Male | <65 | I/II | Chemotherapy | vinblastine | PD |
RANBP2 | SNV | Missense_Mutation | c.4306A>G | p.Ile1436Val | p.I1436V | P49792 | protein_coding | tolerated(0.77) | benign(0.014) | TCGA-91-6829-01 | Lung | lung adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
RANBP2 | SNV | Missense_Mutation | novel | c.245G>A | p.Cys82Tyr | p.C82Y | P49792 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-97-7941-01 | Lung | lung adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
RANBP2 | SNV | Missense_Mutation | novel | c.1231G>T | p.Val411Leu | p.V411L | P49792 | protein_coding | deleterious(0.03) | benign(0) | TCGA-J2-A4AD-01 | Lung | lung adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | PD |
RANBP2 | SNV | Missense_Mutation | c.9015N>T | p.Trp3005Cys | p.W3005C | P49792 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-L9-A7SV-01 | Lung | lung adenocarcinoma | Male | >=65 | I/II | Chemotherapy | cisplatin | CR |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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