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Gene: PTPRZ1 |
Gene summary for PTPRZ1 |
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Gene information | Species | Human | Gene symbol | PTPRZ1 | Gene ID | 5803 |
Gene name | protein tyrosine phosphatase receptor type Z1 | |
Gene Alias | HPTPZ | |
Cytomap | 7q31.32 | |
Gene Type | protein-coding | GO ID | GO:0000902 | UniProtAcc | B4DFE7 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
5803 | PTPRZ1 | LZE4T | Human | Esophagus | ESCC | 3.82e-02 | 5.66e-02 | 0.0811 |
5803 | PTPRZ1 | LZE5T | Human | Esophagus | ESCC | 3.69e-04 | 3.02e-01 | 0.0514 |
5803 | PTPRZ1 | LZE8T | Human | Esophagus | ESCC | 6.94e-03 | 1.09e-02 | 0.067 |
5803 | PTPRZ1 | LZE21T | Human | Esophagus | ESCC | 4.36e-04 | 5.33e-01 | 0.0655 |
5803 | PTPRZ1 | P1T-E | Human | Esophagus | ESCC | 8.74e-05 | 2.50e-01 | 0.0875 |
5803 | PTPRZ1 | P2T-E | Human | Esophagus | ESCC | 6.95e-05 | -2.19e-01 | 0.1177 |
5803 | PTPRZ1 | P4T-E | Human | Esophagus | ESCC | 1.51e-16 | 2.23e-01 | 0.1323 |
5803 | PTPRZ1 | P5T-E | Human | Esophagus | ESCC | 1.64e-07 | -1.25e-01 | 0.1327 |
5803 | PTPRZ1 | P8T-E | Human | Esophagus | ESCC | 3.05e-16 | 3.84e-01 | 0.0889 |
5803 | PTPRZ1 | P9T-E | Human | Esophagus | ESCC | 4.41e-08 | 1.35e-01 | 0.1131 |
5803 | PTPRZ1 | P10T-E | Human | Esophagus | ESCC | 1.79e-08 | 2.81e-01 | 0.116 |
5803 | PTPRZ1 | P11T-E | Human | Esophagus | ESCC | 2.22e-03 | 6.68e-01 | 0.1426 |
5803 | PTPRZ1 | P12T-E | Human | Esophagus | ESCC | 1.06e-72 | 1.78e+00 | 0.1122 |
5803 | PTPRZ1 | P15T-E | Human | Esophagus | ESCC | 2.69e-43 | 1.30e+00 | 0.1149 |
5803 | PTPRZ1 | P16T-E | Human | Esophagus | ESCC | 1.01e-13 | 2.94e-01 | 0.1153 |
5803 | PTPRZ1 | P19T-E | Human | Esophagus | ESCC | 6.73e-04 | 4.85e-01 | 0.1662 |
5803 | PTPRZ1 | P20T-E | Human | Esophagus | ESCC | 2.87e-03 | 1.11e-01 | 0.1124 |
5803 | PTPRZ1 | P21T-E | Human | Esophagus | ESCC | 3.00e-25 | 8.53e-01 | 0.1617 |
5803 | PTPRZ1 | P22T-E | Human | Esophagus | ESCC | 3.21e-15 | -1.66e-01 | 0.1236 |
5803 | PTPRZ1 | P23T-E | Human | Esophagus | ESCC | 3.21e-05 | -1.06e-01 | 0.108 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:001631110 | Esophagus | ESCC | dephosphorylation | 251/8552 | 417/18723 | 1.26e-09 | 2.99e-08 | 251 |
GO:000647018 | Esophagus | ESCC | protein dephosphorylation | 177/8552 | 281/18723 | 3.13e-09 | 6.72e-08 | 177 |
GO:0070997111 | Esophagus | ESCC | neuron death | 216/8552 | 361/18723 | 3.49e-08 | 6.45e-07 | 216 |
GO:0051402110 | Esophagus | ESCC | neuron apoptotic process | 148/8552 | 246/18723 | 3.08e-06 | 3.47e-05 | 148 |
GO:1901214111 | Esophagus | ESCC | regulation of neuron death | 186/8552 | 319/18723 | 3.35e-06 | 3.73e-05 | 186 |
GO:001072010 | Esophagus | ESCC | positive regulation of cell development | 172/8552 | 298/18723 | 1.74e-05 | 1.55e-04 | 172 |
GO:00425524 | Esophagus | ESCC | myelination | 85/8552 | 134/18723 | 2.51e-05 | 2.13e-04 | 85 |
GO:00072724 | Esophagus | ESCC | ensheathment of neurons | 86/8552 | 136/18723 | 2.68e-05 | 2.24e-04 | 86 |
GO:00083664 | Esophagus | ESCC | axon ensheathment | 86/8552 | 136/18723 | 2.68e-05 | 2.24e-04 | 86 |
GO:00420636 | Esophagus | ESCC | gliogenesis | 172/8552 | 301/18723 | 3.75e-05 | 3.04e-04 | 172 |
GO:005076710 | Esophagus | ESCC | regulation of neurogenesis | 203/8552 | 364/18723 | 6.10e-05 | 4.68e-04 | 203 |
GO:00507697 | Esophagus | ESCC | positive regulation of neurogenesis | 131/8552 | 225/18723 | 9.71e-05 | 6.90e-04 | 131 |
GO:006156415 | Esophagus | ESCC | axon development | 251/8552 | 467/18723 | 2.41e-04 | 1.49e-03 | 251 |
GO:00100016 | Esophagus | ESCC | glial cell differentiation | 129/8552 | 225/18723 | 2.73e-04 | 1.65e-03 | 129 |
GO:004352317 | Esophagus | ESCC | regulation of neuron apoptotic process | 122/8552 | 212/18723 | 3.21e-04 | 1.90e-03 | 122 |
GO:00519606 | Esophagus | ESCC | regulation of nervous system development | 237/8552 | 443/18723 | 5.02e-04 | 2.78e-03 | 237 |
GO:00519625 | Esophagus | ESCC | positive regulation of nervous system development | 149/8552 | 272/18723 | 1.50e-03 | 7.06e-03 | 149 |
GO:000740915 | Esophagus | ESCC | axonogenesis | 219/8552 | 418/18723 | 3.14e-03 | 1.31e-02 | 219 |
GO:190121516 | Esophagus | ESCC | negative regulation of neuron death | 115/8552 | 208/18723 | 3.24e-03 | 1.34e-02 | 115 |
GO:0031641 | Esophagus | ESCC | regulation of myelination | 31/8552 | 47/18723 | 4.01e-03 | 1.62e-02 | 31 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa0512018 | Esophagus | ESCC | Epithelial cell signaling in Helicobacter pylori infection | 52/4205 | 70/8465 | 2.17e-05 | 1.07e-04 | 5.47e-05 | 52 |
hsa0512019 | Esophagus | ESCC | Epithelial cell signaling in Helicobacter pylori infection | 52/4205 | 70/8465 | 2.17e-05 | 1.07e-04 | 5.47e-05 | 52 |
hsa0512010 | Oral cavity | OSCC | Epithelial cell signaling in Helicobacter pylori infection | 49/3704 | 70/8465 | 7.57e-06 | 3.59e-05 | 1.83e-05 | 49 |
hsa0512017 | Oral cavity | OSCC | Epithelial cell signaling in Helicobacter pylori infection | 49/3704 | 70/8465 | 7.57e-06 | 3.59e-05 | 1.83e-05 | 49 |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
MDK | PTPRZ1 | MDK_PTPRZ1 | MK | Cervix | CC |
PTN | PTPRZ1 | PTN_PTPRZ1 | PTN | Cervix | CC |
MDK | PTPRZ1 | MDK_PTPRZ1 | MK | CRC | ADJ |
MDK | PTPRZ1 | MDK_PTPRZ1 | MK | Esophagus | ESCC |
PTN | PTPRZ1 | PTN_PTPRZ1 | PTN | Esophagus | ESCC |
MDK | PTPRZ1 | MDK_PTPRZ1 | MK | GC | GC |
PTN | PTPRZ1 | PTN_PTPRZ1 | PTN | GC | GC |
MDK | PTPRZ1 | MDK_PTPRZ1 | MK | HNSCC | OSCC |
PTN | PTPRZ1 | PTN_PTPRZ1 | PTN | HNSCC | OSCC |
MDK | PTPRZ1 | MDK_PTPRZ1 | MK | HNSCC | Precancer |
PTN | PTPRZ1 | PTN_PTPRZ1 | PTN | HNSCC | Precancer |
PTN | PTPRZ1 | PTN_PTPRZ1 | PTN | Prostate | BPH |
MDK | PTPRZ1 | MDK_PTPRZ1 | MK | Prostate | BPH |
MDK | PTPRZ1 | MDK_PTPRZ1 | MK | Prostate | Tumor |
PTN | PTPRZ1 | PTN_PTPRZ1 | PTN | Prostate | Tumor |
MDK | PTPRZ1 | MDK_PTPRZ1 | MK | Skin | ADJ |
PTN | PTPRZ1 | PTN_PTPRZ1 | PTN | Skin | ADJ |
PTN | PTPRZ1 | PTN_PTPRZ1 | PTN | Skin | AK |
MDK | PTPRZ1 | MDK_PTPRZ1 | MK | Skin | AK |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
PTPRZ1 | SNV | Missense_Mutation | c.6653N>A | p.Pro2218His | p.P2218H | P23471 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-50-6590-01 | Lung | lung adenocarcinoma | Female | >=65 | I/II | Chemotherapy | paclitaxel | CR | |
PTPRZ1 | SNV | Missense_Mutation | c.3217N>T | p.Asn1073Tyr | p.N1073Y | P23471 | protein_coding | deleterious_low_confidence(0) | benign(0.123) | TCGA-53-7813-01 | Lung | lung adenocarcinoma | Female | <65 | III/IV | Chemotherapy | cisplatin | SD | |
PTPRZ1 | SNV | Missense_Mutation | c.5222C>G | p.Thr1741Arg | p.T1741R | P23471 | protein_coding | deleterious(0.01) | probably_damaging(0.991) | TCGA-55-5899-01 | Lung | lung adenocarcinoma | Male | <65 | I/II | Chemotherapy | carboplatin | CR | |
PTPRZ1 | SNV | Missense_Mutation | c.3703N>G | p.Met1235Val | p.M1235V | P23471 | protein_coding | tolerated_low_confidence(0.38) | benign(0.001) | TCGA-55-7726-01 | Lung | lung adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
PTPRZ1 | SNV | Missense_Mutation | novel | c.1806N>A | p.Asn602Lys | p.N602K | P23471 | protein_coding | tolerated_low_confidence(0.06) | benign(0.084) | TCGA-55-7907-01 | Lung | lung adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | PD |
PTPRZ1 | SNV | Missense_Mutation | rs775565817 | c.3029N>A | p.Thr1010Lys | p.T1010K | P23471 | protein_coding | tolerated_low_confidence(0.09) | benign(0.327) | TCGA-55-7907-01 | Lung | lung adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | PD |
PTPRZ1 | SNV | Missense_Mutation | rs148162051 | c.2802G>T | p.Glu934Asp | p.E934D | P23471 | protein_coding | tolerated_low_confidence(0.16) | benign(0.054) | TCGA-55-7913-01 | Lung | lung adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | PD |
PTPRZ1 | SNV | Missense_Mutation | c.6262N>A | p.Gln2088Lys | p.Q2088K | P23471 | protein_coding | tolerated(0.1) | possibly_damaging(0.869) | TCGA-55-7994-01 | Lung | lung adenocarcinoma | Male | >=65 | I/II | Chemotherapy | carboplatin | CR | |
PTPRZ1 | SNV | Missense_Mutation | c.716N>A | p.Pro239His | p.P239H | P23471 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-55-7995-01 | Lung | lung adenocarcinoma | Female | >=65 | I/II | Chemotherapy | carboplatin | CR | |
PTPRZ1 | SNV | Missense_Mutation | c.6228N>A | p.Asp2076Glu | p.D2076E | P23471 | protein_coding | deleterious(0) | probably_damaging(0.99) | TCGA-55-7995-01 | Lung | lung adenocarcinoma | Female | >=65 | I/II | Chemotherapy | carboplatin | CR |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
5803 | PTPRZ1 | PROTEIN PHOSPHATASE, DRUGGABLE GENOME | RETINOIC ACID | 10809755 | ||
5803 | PTPRZ1 | PROTEIN PHOSPHATASE, DRUGGABLE GENOME | PMA | 10809755 | ||
5803 | PTPRZ1 | PROTEIN PHOSPHATASE, DRUGGABLE GENOME | VITAMIN D | 10809755 |
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