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Gene: MYH9 |
Gene summary for MYH9 |
Gene summary. |
Gene information | Species | Human | Gene symbol | MYH9 | Gene ID | 4627 |
Gene name | myosin heavy chain 9 | |
Gene Alias | BDPLT6 | |
Cytomap | 22q12.3 | |
Gene Type | protein-coding | GO ID | GO:0000003 | UniProtAcc | A0A024R1N1 |
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Malignant transformation analysis |
Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells |
Malignant transformation involving gene list. |
Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
4627 | MYH9 | GSM4909281 | Human | Breast | IDC | 1.58e-18 | 5.40e-01 | 0.21 |
4627 | MYH9 | GSM4909285 | Human | Breast | IDC | 3.92e-10 | -4.37e-01 | 0.21 |
4627 | MYH9 | GSM4909286 | Human | Breast | IDC | 2.55e-02 | -3.26e-01 | 0.1081 |
4627 | MYH9 | GSM4909294 | Human | Breast | IDC | 1.38e-05 | -3.24e-01 | 0.2022 |
4627 | MYH9 | GSM4909296 | Human | Breast | IDC | 7.96e-11 | -3.53e-01 | 0.1524 |
4627 | MYH9 | GSM4909297 | Human | Breast | IDC | 8.22e-18 | -4.03e-01 | 0.1517 |
4627 | MYH9 | GSM4909298 | Human | Breast | IDC | 4.99e-02 | -2.75e-01 | 0.1551 |
4627 | MYH9 | GSM4909301 | Human | Breast | IDC | 4.50e-06 | -3.60e-01 | 0.1577 |
4627 | MYH9 | GSM4909306 | Human | Breast | IDC | 5.31e-08 | -3.77e-01 | 0.1564 |
4627 | MYH9 | GSM4909308 | Human | Breast | IDC | 4.54e-04 | -2.95e-01 | 0.158 |
4627 | MYH9 | GSM4909311 | Human | Breast | IDC | 8.92e-32 | -3.19e-01 | 0.1534 |
4627 | MYH9 | GSM4909312 | Human | Breast | IDC | 2.30e-14 | -3.54e-01 | 0.1552 |
4627 | MYH9 | GSM4909313 | Human | Breast | IDC | 3.94e-03 | -2.42e-01 | 0.0391 |
4627 | MYH9 | GSM4909319 | Human | Breast | IDC | 7.67e-33 | -5.41e-01 | 0.1563 |
4627 | MYH9 | GSM4909320 | Human | Breast | IDC | 9.34e-10 | -4.70e-01 | 0.1575 |
4627 | MYH9 | GSM4909321 | Human | Breast | IDC | 1.40e-29 | -5.25e-01 | 0.1559 |
4627 | MYH9 | brca1 | Human | Breast | Precancer | 3.22e-03 | 2.39e-01 | -0.0338 |
4627 | MYH9 | brca3 | Human | Breast | Precancer | 8.78e-14 | 4.94e-01 | -0.0263 |
4627 | MYH9 | brca10 | Human | Breast | Precancer | 7.49e-03 | 3.42e-01 | -0.0029 |
4627 | MYH9 | NCCBC14 | Human | Breast | DCIS | 6.39e-14 | -2.06e-02 | 0.2021 |
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Transcriptomic changes along malignancy continuum. |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
Find out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer |
Figure of enriched GO biological processes. |
Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | |
Colorectum | SER | |
Colorectum | MSS | |
Colorectum | MSI-H | |
Colorectum | FAP |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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Enriched GO biological processes. |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:00458629 | Breast | Precancer | positive regulation of proteolysis | 51/1080 | 372/18723 | 7.77e-09 | 5.70e-07 | 51 |
GO:00509006 | Breast | Precancer | leukocyte migration | 47/1080 | 369/18723 | 2.82e-07 | 1.39e-05 | 47 |
GO:00341099 | Breast | Precancer | homotypic cell-cell adhesion | 18/1080 | 90/18723 | 3.15e-06 | 1.03e-04 | 18 |
GO:00300999 | Breast | Precancer | myeloid cell differentiation | 45/1080 | 381/18723 | 4.00e-06 | 1.25e-04 | 45 |
GO:00420609 | Breast | Precancer | wound healing | 48/1080 | 422/18723 | 5.48e-06 | 1.63e-04 | 48 |
GO:00421107 | Breast | Precancer | T cell activation | 52/1080 | 487/18723 | 1.37e-05 | 3.42e-04 | 52 |
GO:00106319 | Breast | Precancer | epithelial cell migration | 40/1080 | 357/18723 | 4.57e-05 | 9.71e-04 | 40 |
GO:00901329 | Breast | Precancer | epithelium migration | 40/1080 | 360/18723 | 5.51e-05 | 1.14e-03 | 40 |
GO:00025737 | Breast | Precancer | myeloid leukocyte differentiation | 27/1080 | 208/18723 | 6.72e-05 | 1.35e-03 | 27 |
GO:00435426 | Breast | Precancer | endothelial cell migration | 33/1080 | 279/18723 | 7.28e-05 | 1.44e-03 | 33 |
GO:00901309 | Breast | Precancer | tissue migration | 40/1080 | 365/18723 | 7.48e-05 | 1.47e-03 | 40 |
GO:00329709 | Breast | Precancer | regulation of actin filament-based process | 42/1080 | 397/18723 | 1.11e-04 | 2.01e-03 | 42 |
GO:00302248 | Breast | Precancer | monocyte differentiation | 9/1080 | 36/18723 | 1.56e-04 | 2.66e-03 | 9 |
GO:00508789 | Breast | Precancer | regulation of body fluid levels | 40/1080 | 379/18723 | 1.68e-04 | 2.77e-03 | 40 |
GO:00016678 | Breast | Precancer | ameboidal-type cell migration | 47/1080 | 475/18723 | 2.19e-04 | 3.35e-03 | 47 |
GO:19031313 | Breast | Precancer | mononuclear cell differentiation | 43/1080 | 426/18723 | 2.61e-04 | 3.84e-03 | 43 |
GO:00705278 | Breast | Precancer | platelet aggregation | 12/1080 | 67/18723 | 4.02e-04 | 5.43e-03 | 12 |
GO:00075995 | Breast | Precancer | hemostasis | 24/1080 | 222/18723 | 2.31e-03 | 2.15e-02 | 24 |
GO:00017017 | Breast | Precancer | in utero embryonic development | 35/1080 | 367/18723 | 2.47e-03 | 2.27e-02 | 35 |
GO:00075965 | Breast | Precancer | blood coagulation | 23/1080 | 217/18723 | 3.61e-03 | 2.98e-02 | 23 |
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Enriched KEGG pathways. |
Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa0513018 | Breast | Precancer | Pathogenic Escherichia coli infection | 38/684 | 197/8465 | 3.12e-07 | 5.81e-06 | 4.45e-06 | 38 |
hsa0453018 | Breast | Precancer | Tight junction | 31/684 | 169/8465 | 1.13e-05 | 1.26e-04 | 9.64e-05 | 31 |
hsa0513019 | Breast | Precancer | Pathogenic Escherichia coli infection | 38/684 | 197/8465 | 3.12e-07 | 5.81e-06 | 4.45e-06 | 38 |
hsa0453019 | Breast | Precancer | Tight junction | 31/684 | 169/8465 | 1.13e-05 | 1.26e-04 | 9.64e-05 | 31 |
hsa0453024 | Breast | IDC | Tight junction | 38/867 | 169/8465 | 2.07e-06 | 3.20e-05 | 2.39e-05 | 38 |
hsa0513024 | Breast | IDC | Pathogenic Escherichia coli infection | 42/867 | 197/8465 | 2.66e-06 | 3.92e-05 | 2.94e-05 | 42 |
hsa0481014 | Breast | IDC | Regulation of actin cytoskeleton | 36/867 | 229/8465 | 5.79e-03 | 3.13e-02 | 2.34e-02 | 36 |
hsa0453034 | Breast | IDC | Tight junction | 38/867 | 169/8465 | 2.07e-06 | 3.20e-05 | 2.39e-05 | 38 |
hsa0513034 | Breast | IDC | Pathogenic Escherichia coli infection | 42/867 | 197/8465 | 2.66e-06 | 3.92e-05 | 2.94e-05 | 42 |
hsa0481015 | Breast | IDC | Regulation of actin cytoskeleton | 36/867 | 229/8465 | 5.79e-03 | 3.13e-02 | 2.34e-02 | 36 |
hsa0513043 | Breast | DCIS | Pathogenic Escherichia coli infection | 42/846 | 197/8465 | 1.40e-06 | 2.15e-05 | 1.59e-05 | 42 |
hsa0453044 | Breast | DCIS | Tight junction | 37/846 | 169/8465 | 3.07e-06 | 4.20e-05 | 3.09e-05 | 37 |
hsa0481023 | Breast | DCIS | Regulation of actin cytoskeleton | 35/846 | 229/8465 | 6.89e-03 | 3.37e-02 | 2.48e-02 | 35 |
hsa0513053 | Breast | DCIS | Pathogenic Escherichia coli infection | 42/846 | 197/8465 | 1.40e-06 | 2.15e-05 | 1.59e-05 | 42 |
hsa0453054 | Breast | DCIS | Tight junction | 37/846 | 169/8465 | 3.07e-06 | 4.20e-05 | 3.09e-05 | 37 |
hsa0481033 | Breast | DCIS | Regulation of actin cytoskeleton | 35/846 | 229/8465 | 6.89e-03 | 3.37e-02 | 2.48e-02 | 35 |
hsa0513020 | Cervix | CC | Pathogenic Escherichia coli infection | 63/1267 | 197/8465 | 9.28e-10 | 2.00e-08 | 1.19e-08 | 63 |
hsa0481016 | Cervix | CC | Regulation of actin cytoskeleton | 64/1267 | 229/8465 | 2.24e-07 | 2.59e-06 | 1.53e-06 | 64 |
hsa0453020 | Cervix | CC | Tight junction | 49/1267 | 169/8465 | 1.87e-06 | 1.78e-05 | 1.05e-05 | 49 |
hsa05130110 | Cervix | CC | Pathogenic Escherichia coli infection | 63/1267 | 197/8465 | 9.28e-10 | 2.00e-08 | 1.19e-08 | 63 |
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Cell-cell communication analysis |
Identification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states |
Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
Find out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states |
TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
Annotation of somatic variants for genes involved in malignant transformation |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
MYH9 | SNV | Missense_Mutation | rs756528783 | c.3799N>A | p.Val1267Met | p.V1267M | P35579 | protein_coding | tolerated(0.1) | benign(0.109) | TCGA-F1-6874-01 | Stomach | stomach adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
MYH9 | SNV | Missense_Mutation | rs781388651 | c.5807G>A | p.Arg1936Gln | p.R1936Q | P35579 | protein_coding | tolerated(0.05) | benign(0.251) | TCGA-HU-A4G8-01 | Stomach | stomach adenocarcinoma | Female | >=65 | I/II | Chemotherapy | 5-fluorouracil | SD |
MYH9 | SNV | Missense_Mutation | c.1683N>T | p.Gln561His | p.Q561H | P35579 | protein_coding | tolerated(0.12) | benign(0.017) | TCGA-HU-A4H0-01 | Stomach | stomach adenocarcinoma | Male | >=65 | III/IV | Unknown | Unknown | SD | |
MYH9 | SNV | Missense_Mutation | c.1462N>C | p.Glu488Gln | p.E488Q | P35579 | protein_coding | deleterious(0.01) | possibly_damaging(0.476) | TCGA-IN-A6RL-01 | Stomach | stomach adenocarcinoma | Male | >=65 | III/IV | Unknown | Unknown | PD | |
MYH9 | SNV | Missense_Mutation | novel | c.548N>G | p.Asn183Ser | p.N183S | P35579 | protein_coding | deleterious(0.01) | benign(0.071) | TCGA-VQ-A8DV-01 | Stomach | stomach adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | PD |
MYH9 | SNV | Missense_Mutation | rs569649580 | c.4078G>A | p.Ala1360Thr | p.A1360T | P35579 | protein_coding | tolerated(0.56) | benign(0.003) | TCGA-VQ-A8P2-01 | Stomach | stomach adenocarcinoma | Male | >=65 | III/IV | Unspecific | Complete Response | |
MYH9 | SNV | Missense_Mutation | rs149169068 | c.4753A>C | p.Lys1585Gln | p.K1585Q | P35579 | protein_coding | tolerated(0.08) | benign(0.411) | TCGA-VQ-A94T-01 | Stomach | stomach adenocarcinoma | Male | >=65 | III/IV | Unknown | Unknown | PD |
MYH9 | deletion | Frame_Shift_Del | c.3682delN | p.Glu1228SerfsTer6 | p.E1228Sfs*6 | P35579 | protein_coding | TCGA-BR-4292-01 | Stomach | stomach adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |||
MYH9 | deletion | Frame_Shift_Del | c.2127delC | p.Asn710ThrfsTer15 | p.N710Tfs*15 | P35579 | protein_coding | TCGA-CD-8536-01 | Stomach | stomach adenocarcinoma | Male | >=65 | I/II | Chemotherapy | epirubicin | CR | |||
MYH9 | insertion | Nonsense_Mutation | novel | c.5557_5558insGATG | p.Asp1853GlyfsTer2 | p.D1853Gfs*2 | P35579 | protein_coding | TCGA-D7-A6EV-01 | Stomach | stomach adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
Identification of chemicals and drugs interact with genes involved in malignant transfromation |
(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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