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Gene: GOLGB1 |
Gene summary for GOLGB1 |
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Gene information | Species | Human | Gene symbol | GOLGB1 | Gene ID | 2804 |
Gene name | golgin B1 | |
Gene Alias | GCP | |
Cytomap | 3q13.33 | |
Gene Type | protein-coding | GO ID | GO:0006139 | UniProtAcc | Q14789 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
2804 | GOLGB1 | GSM4909293 | Human | Breast | IDC | 2.19e-11 | 4.12e-01 | 0.1581 |
2804 | GOLGB1 | GSM4909296 | Human | Breast | IDC | 1.06e-08 | -2.96e-01 | 0.1524 |
2804 | GOLGB1 | GSM4909297 | Human | Breast | IDC | 7.43e-10 | -2.64e-01 | 0.1517 |
2804 | GOLGB1 | GSM4909311 | Human | Breast | IDC | 1.54e-24 | -2.24e-01 | 0.1534 |
2804 | GOLGB1 | GSM4909312 | Human | Breast | IDC | 2.88e-08 | -2.84e-01 | 0.1552 |
2804 | GOLGB1 | GSM4909317 | Human | Breast | IDC | 6.56e-16 | 5.68e-01 | 0.1355 |
2804 | GOLGB1 | GSM4909319 | Human | Breast | IDC | 1.12e-28 | -3.06e-01 | 0.1563 |
2804 | GOLGB1 | GSM4909321 | Human | Breast | IDC | 2.26e-14 | -2.66e-01 | 0.1559 |
2804 | GOLGB1 | M2 | Human | Breast | IDC | 1.67e-03 | 1.98e-01 | 0.21 |
2804 | GOLGB1 | NCCBC14 | Human | Breast | DCIS | 2.52e-11 | 2.21e-02 | 0.2021 |
2804 | GOLGB1 | NCCBC2 | Human | Breast | DCIS | 4.07e-02 | 1.23e-01 | 0.1554 |
2804 | GOLGB1 | NCCBC3 | Human | Breast | DCIS | 1.63e-04 | 2.73e-01 | 0.1198 |
2804 | GOLGB1 | NCCBC5 | Human | Breast | DCIS | 3.24e-08 | -1.92e-01 | 0.2046 |
2804 | GOLGB1 | P1 | Human | Breast | IDC | 2.94e-11 | 3.44e-02 | 0.1527 |
2804 | GOLGB1 | P2 | Human | Breast | IDC | 2.55e-04 | 2.66e-01 | 0.21 |
2804 | GOLGB1 | DCIS2 | Human | Breast | DCIS | 1.05e-62 | 7.40e-01 | 0.0085 |
2804 | GOLGB1 | CA_HPV_1 | Human | Cervix | CC | 3.23e-06 | -2.30e-01 | 0.0264 |
2804 | GOLGB1 | CA_HPV_3 | Human | Cervix | CC | 2.24e-02 | 8.66e-02 | 0.0414 |
2804 | GOLGB1 | HSIL_HPV_1 | Human | Cervix | HSIL_HPV | 3.68e-02 | -2.90e-01 | 0.0116 |
2804 | GOLGB1 | CCI_1 | Human | Cervix | CC | 1.99e-02 | 5.47e-01 | 0.528 |
Page: 1 2 3 4 5 6 7 8 9 10 11 12 13 14 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:00070304 | Cervix | CC | Golgi organization | 32/2311 | 157/18723 | 2.78e-03 | 1.87e-02 | 32 |
GO:0071539 | Colorectum | AD | protein localization to centrosome | 16/3918 | 33/18723 | 3.86e-04 | 4.41e-03 | 16 |
GO:1905508 | Colorectum | AD | protein localization to microtubule organizing center | 16/3918 | 35/18723 | 8.76e-04 | 8.51e-03 | 16 |
GO:00715391 | Colorectum | MSS | protein localization to centrosome | 16/3467 | 33/18723 | 8.66e-05 | 1.40e-03 | 16 |
GO:19055081 | Colorectum | MSS | protein localization to microtubule organizing center | 16/3467 | 35/18723 | 2.07e-04 | 2.89e-03 | 16 |
GO:0044380 | Colorectum | MSS | protein localization to cytoskeleton | 19/3467 | 58/18723 | 6.69e-03 | 4.38e-02 | 19 |
GO:0072698 | Colorectum | MSS | protein localization to microtubule cytoskeleton | 18/3467 | 54/18723 | 6.70e-03 | 4.38e-02 | 18 |
GO:00715392 | Colorectum | FAP | protein localization to centrosome | 14/2622 | 33/18723 | 6.39e-05 | 1.23e-03 | 14 |
GO:19055082 | Colorectum | FAP | protein localization to microtubule organizing center | 14/2622 | 35/18723 | 1.38e-04 | 2.18e-03 | 14 |
GO:00726981 | Colorectum | FAP | protein localization to microtubule cytoskeleton | 16/2622 | 54/18723 | 2.26e-03 | 1.84e-02 | 16 |
GO:00443801 | Colorectum | FAP | protein localization to cytoskeleton | 16/2622 | 58/18723 | 4.97e-03 | 3.32e-02 | 16 |
GO:00715393 | Colorectum | CRC | protein localization to centrosome | 11/2078 | 33/18723 | 5.80e-04 | 7.89e-03 | 11 |
GO:19055083 | Colorectum | CRC | protein localization to microtubule organizing center | 11/2078 | 35/18723 | 1.02e-03 | 1.20e-02 | 11 |
GO:00726982 | Colorectum | CRC | protein localization to microtubule cytoskeleton | 13/2078 | 54/18723 | 5.25e-03 | 3.98e-02 | 13 |
GO:00070305 | Endometrium | AEH | Golgi organization | 32/2100 | 157/18723 | 5.73e-04 | 5.69e-03 | 32 |
GO:000703012 | Endometrium | EEC | Golgi organization | 32/2168 | 157/18723 | 9.87e-04 | 8.76e-03 | 32 |
GO:00726985 | Esophagus | ESCC | protein localization to microtubule cytoskeleton | 43/8552 | 54/18723 | 3.28e-07 | 4.61e-06 | 43 |
GO:00443804 | Esophagus | ESCC | protein localization to cytoskeleton | 45/8552 | 58/18723 | 6.89e-07 | 8.99e-06 | 45 |
GO:00070308 | Esophagus | ESCC | Golgi organization | 101/8552 | 157/18723 | 1.78e-06 | 2.10e-05 | 101 |
GO:19055086 | Esophagus | ESCC | protein localization to microtubule organizing center | 28/8552 | 35/18723 | 3.40e-05 | 2.78e-04 | 28 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
GOLGB1 | SNV | Missense_Mutation | rs762516224 | c.157N>T | p.Arg53Cys | p.R53C | Q14789 | protein_coding | deleterious(0) | probably_damaging(0.998) | TCGA-55-8506-01 | Lung | lung adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
GOLGB1 | SNV | Missense_Mutation | c.7034N>T | p.Gly2345Val | p.G2345V | Q14789 | protein_coding | tolerated(0.23) | benign(0.059) | TCGA-62-A46R-01 | Lung | lung adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
GOLGB1 | SNV | Missense_Mutation | rs754110137 | c.6343G>A | p.Glu2115Lys | p.E2115K | Q14789 | protein_coding | deleterious(0.01) | possibly_damaging(0.523) | TCGA-64-1679-01 | Lung | lung adenocarcinoma | Female | <65 | III/IV | Chemotherapy | cisplatin | SD |
GOLGB1 | SNV | Missense_Mutation | c.2219N>G | p.Asn740Ser | p.N740S | Q14789 | protein_coding | tolerated(1) | benign(0) | TCGA-67-3771-01 | Lung | lung adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
GOLGB1 | SNV | Missense_Mutation | c.5104N>A | p.Asp1702Asn | p.D1702N | Q14789 | protein_coding | deleterious(0) | possibly_damaging(0.642) | TCGA-86-8585-01 | Lung | lung adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD | |
GOLGB1 | SNV | Missense_Mutation | c.9655N>C | p.Thr3219Pro | p.T3219P | Q14789 | protein_coding | tolerated(0.37) | benign(0.001) | TCGA-93-7347-01 | Lung | lung adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
GOLGB1 | SNV | Missense_Mutation | novel | c.4747N>T | p.Gly1583Cys | p.G1583C | Q14789 | protein_coding | deleterious(0.01) | probably_damaging(0.984) | TCGA-99-7458-01 | Lung | lung adenocarcinoma | Female | >=65 | III/IV | Targeted Molecular therapy | tarceva | SD |
GOLGB1 | SNV | Missense_Mutation | rs537556767 | c.5021N>C | p.Gln1674Pro | p.Q1674P | Q14789 | protein_coding | deleterious(0) | possibly_damaging(0.744) | TCGA-MP-A4SV-01 | Lung | lung adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
GOLGB1 | SNV | Missense_Mutation | c.5244N>T | p.Gln1748His | p.Q1748H | Q14789 | protein_coding | deleterious(0) | benign(0.179) | TCGA-MP-A4TD-01 | Lung | lung adenocarcinoma | Male | >=65 | III/IV | Chemotherapy | cisplatin | PD | |
GOLGB1 | SNV | Missense_Mutation | rs758640097 | c.1016N>T | p.Ser339Phe | p.S339F | Q14789 | protein_coding | deleterious(0.02) | probably_damaging(0.998) | TCGA-NJ-A4YF-01 | Lung | lung adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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