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Gene: DMBT1 |
Gene summary for DMBT1 |
Gene summary. |
Gene information | Species | Human | Gene symbol | DMBT1 | Gene ID | 1755 |
Gene name | deleted in malignant brain tumors 1 | |
Gene Alias | GP340 | |
Cytomap | 10q26.13 | |
Gene Type | protein-coding | GO ID | GO:0002237 | UniProtAcc | Q9UGM3 |
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Malignant transformation analysis |
Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells |
Malignant transformation involving gene list. |
Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
1755 | DMBT1 | HTA11_78_2000001011 | Human | Colorectum | AD | 3.36e-02 | -3.00e-01 | -0.1088 |
1755 | DMBT1 | HTA11_347_2000001011 | Human | Colorectum | AD | 1.32e-05 | -4.99e-02 | -0.1954 |
1755 | DMBT1 | HTA11_1391_2000001011 | Human | Colorectum | AD | 3.34e-20 | 2.56e+00 | -0.059 |
1755 | DMBT1 | HTA11_866_3004761011 | Human | Colorectum | AD | 5.01e-05 | 8.03e-01 | 0.096 |
1755 | DMBT1 | HTA11_7696_3000711011 | Human | Colorectum | AD | 1.94e-06 | -3.27e-01 | 0.0674 |
1755 | DMBT1 | HTA11_99999965104_69814 | Human | Colorectum | MSS | 1.70e-03 | 8.66e-01 | 0.281 |
1755 | DMBT1 | HTA11_99999971662_82457 | Human | Colorectum | MSS | 6.51e-13 | -4.04e-01 | 0.3859 |
1755 | DMBT1 | HTA11_99999974143_84620 | Human | Colorectum | MSS | 6.58e-17 | -4.18e-01 | 0.3005 |
1755 | DMBT1 | F007 | Human | Colorectum | FAP | 2.60e-03 | -4.03e-01 | 0.1176 |
1755 | DMBT1 | A002-C-010 | Human | Colorectum | FAP | 4.40e-05 | -2.20e-01 | 0.242 |
1755 | DMBT1 | A001-C-207 | Human | Colorectum | FAP | 1.78e-08 | -4.22e-01 | 0.1278 |
1755 | DMBT1 | A015-C-203 | Human | Colorectum | FAP | 7.63e-19 | -4.22e-01 | -0.1294 |
1755 | DMBT1 | A015-C-204 | Human | Colorectum | FAP | 1.18e-08 | -4.22e-01 | -0.0228 |
1755 | DMBT1 | A001-C-119 | Human | Colorectum | FAP | 8.75e-07 | -4.22e-01 | -0.1557 |
1755 | DMBT1 | A001-C-108 | Human | Colorectum | FAP | 3.65e-16 | -4.16e-01 | -0.0272 |
1755 | DMBT1 | A002-C-021 | Human | Colorectum | FAP | 2.54e-05 | -3.26e-01 | 0.1171 |
1755 | DMBT1 | A002-C-205 | Human | Colorectum | FAP | 4.12e-12 | -4.22e-01 | -0.1236 |
1755 | DMBT1 | A014-C-108 | Human | Colorectum | FAP | 3.34e-08 | -4.22e-01 | -0.124 |
1755 | DMBT1 | A001-C-104 | Human | Colorectum | FAP | 1.75e-18 | -4.22e-01 | 0.0184 |
1755 | DMBT1 | A015-C-005 | Human | Colorectum | FAP | 3.46e-07 | -4.05e-01 | -0.0336 |
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Transcriptomic changes along malignancy continuum. |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
Find out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer |
Figure of enriched GO biological processes. |
Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | |
Colorectum | SER | |
Colorectum | MSS | |
Colorectum | MSI-H | |
Colorectum | FAP |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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Enriched GO biological processes. |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:000223710 | Endometrium | AEH | response to molecule of bacterial origin | 65/2100 | 363/18723 | 9.00e-05 | 1.30e-03 | 65 |
GO:00096159 | Endometrium | AEH | response to virus | 63/2100 | 367/18723 | 3.81e-04 | 4.10e-03 | 63 |
GO:000223714 | Endometrium | EEC | response to molecule of bacterial origin | 68/2168 | 363/18723 | 3.96e-05 | 6.64e-04 | 68 |
GO:000961513 | Endometrium | EEC | response to virus | 66/2168 | 367/18723 | 1.78e-04 | 2.20e-03 | 66 |
GO:00096156 | Lung | IAC | response to virus | 61/2061 | 367/18723 | 6.75e-04 | 9.12e-03 | 61 |
GO:00022377 | Lung | IAC | response to molecule of bacterial origin | 56/2061 | 363/18723 | 5.78e-03 | 4.21e-02 | 56 |
GO:0019730 | Stomach | GC | antimicrobial humoral response | 25/1159 | 122/18723 | 9.62e-08 | 6.08e-06 | 25 |
GO:0006959 | Stomach | GC | humoral immune response | 42/1159 | 317/18723 | 2.59e-06 | 1.10e-04 | 42 |
GO:0002237 | Stomach | GC | response to molecule of bacterial origin | 45/1159 | 363/18723 | 6.89e-06 | 2.57e-04 | 45 |
GO:0019731 | Stomach | GC | antibacterial humoral response | 13/1159 | 60/18723 | 6.18e-05 | 1.40e-03 | 13 |
GO:0042742 | Stomach | GC | defense response to bacterium | 37/1159 | 350/18723 | 1.05e-03 | 1.23e-02 | 37 |
GO:00096154 | Stomach | GC | response to virus | 37/1159 | 367/18723 | 2.41e-03 | 2.30e-02 | 37 |
GO:00197301 | Stomach | CAG with IM | antimicrobial humoral response | 23/1050 | 122/18723 | 2.62e-07 | 1.61e-05 | 23 |
GO:00069591 | Stomach | CAG with IM | humoral immune response | 39/1050 | 317/18723 | 3.43e-06 | 1.36e-04 | 39 |
GO:00022371 | Stomach | CAG with IM | response to molecule of bacterial origin | 39/1050 | 363/18723 | 7.73e-05 | 1.82e-03 | 39 |
GO:00197311 | Stomach | CAG with IM | antibacterial humoral response | 12/1050 | 60/18723 | 1.04e-04 | 2.28e-03 | 12 |
GO:00096151 | Stomach | CAG with IM | response to virus | 36/1050 | 367/18723 | 8.12e-04 | 1.08e-02 | 36 |
GO:00427421 | Stomach | CAG with IM | defense response to bacterium | 34/1050 | 350/18723 | 1.32e-03 | 1.56e-02 | 34 |
GO:00197302 | Stomach | CSG | antimicrobial humoral response | 23/1034 | 122/18723 | 1.99e-07 | 1.30e-05 | 23 |
GO:00069592 | Stomach | CSG | humoral immune response | 40/1034 | 317/18723 | 9.26e-07 | 4.76e-05 | 40 |
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Enriched KEGG pathways. |
Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa04970 | Colorectum | FAP | Salivary secretion | 24/1404 | 93/8465 | 1.52e-02 | 4.99e-02 | 3.03e-02 | 24 |
hsa049701 | Colorectum | FAP | Salivary secretion | 24/1404 | 93/8465 | 1.52e-02 | 4.99e-02 | 3.03e-02 | 24 |
hsa049702 | Colorectum | CRC | Salivary secretion | 22/1091 | 93/8465 | 3.03e-03 | 1.91e-02 | 1.29e-02 | 22 |
hsa049703 | Colorectum | CRC | Salivary secretion | 22/1091 | 93/8465 | 3.03e-03 | 1.91e-02 | 1.29e-02 | 22 |
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Cell-cell communication analysis |
Identification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states |
Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
Find out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states |
TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
Annotation of somatic variants for genes involved in malignant transformation |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
DMBT1 | SNV | Missense_Mutation | novel | c.6502N>T | p.Pro2168Ser | p.P2168S | Q9UGM3 | protein_coding | tolerated(1) | benign(0.003) | TCGA-CV-A468-01 | Oral cavity | head & neck squamous cell carcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
DMBT1 | SNV | Missense_Mutation | c.5783G>T | p.Gly1928Val | p.G1928V | Q9UGM3 | protein_coding | deleterious(0) | possibly_damaging(0.826) | TCGA-D6-8568-01 | Oral cavity | head & neck squamous cell carcinoma | Male | <65 | I/II | Unknown | Unknown | SD | |
DMBT1 | insertion | Frame_Shift_Ins | novel | c.3657_3658insCCAGT | p.Ile1220ProfsTer34 | p.I1220Pfs*34 | Q9UGM3 | protein_coding | TCGA-H7-8502-01 | Oral cavity | head & neck squamous cell carcinoma | Male | <65 | I/II | Chemotherapy | unknown | SD | ||
DMBT1 | SNV | Missense_Mutation | rs773492969 | c.3055G>A | p.Asp1019Asn | p.D1019N | Q9UGM3 | protein_coding | deleterious(0.04) | probably_damaging(1) | TCGA-EJ-5532-01 | Prostate | prostate adenocarcinoma | Male | <65 | 7 | Unknown | Unknown | SD |
DMBT1 | SNV | Missense_Mutation | c.6090N>A | p.Asn2030Lys | p.N2030K | Q9UGM3 | protein_coding | deleterious(0.01) | benign(0.372) | TCGA-HC-7231-01 | Prostate | prostate adenocarcinoma | Male | >=65 | 7 | Unknown | Unknown | SD | |
DMBT1 | SNV | Missense_Mutation | c.3238N>T | p.His1080Tyr | p.H1080Y | Q9UGM3 | protein_coding | deleterious(0) | benign(0.04) | TCGA-V1-A9ZG-01 | Prostate | prostate adenocarcinoma | Male | <65 | 9 | Unknown | Unknown | SD | |
DMBT1 | SNV | Missense_Mutation | novel | c.5093N>A | p.Gly1698Asp | p.G1698D | Q9UGM3 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-XK-AAIW-01 | Prostate | prostate adenocarcinoma | Male | >=65 | 9 | Unknown | Unknown | PD |
DMBT1 | SNV | Missense_Mutation | novel | c.7028N>A | p.Arg2343Gln | p.R2343Q | Q9UGM3 | protein_coding | tolerated(0.06) | benign(0.025) | TCGA-XK-AAIW-01 | Prostate | prostate adenocarcinoma | Male | >=65 | 9 | Unknown | Unknown | PD |
DMBT1 | SNV | Missense_Mutation | c.1730N>A | p.Gly577Asp | p.G577D | Q9UGM3 | protein_coding | deleterious(0.03) | benign(0.149) | TCGA-BR-4256-01 | Stomach | stomach adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
DMBT1 | SNV | Missense_Mutation | c.1730N>A | p.Gly577Asp | p.G577D | Q9UGM3 | protein_coding | deleterious(0.03) | benign(0.149) | TCGA-BR-6452-01 | Stomach | stomach adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
Identification of chemicals and drugs interact with genes involved in malignant transfromation |
(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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