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Gene: TRPM6 |
Gene summary for TRPM6 |
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Gene information | Species | Human | Gene symbol | TRPM6 | Gene ID | 140803 |
Gene name | transient receptor potential cation channel subfamily M member 6 | |
Gene Alias | CHAK2 | |
Cytomap | 9q21.13 | |
Gene Type | protein-coding | GO ID | GO:0006464 | UniProtAcc | Q9BX84 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
140803 | TRPM6 | HTA11_347_2000001011 | Human | Colorectum | AD | 3.43e-42 | 1.46e+00 | -0.1954 |
140803 | TRPM6 | HTA11_2112_2000001011 | Human | Colorectum | SER | 6.66e-04 | 5.70e-01 | -0.2196 |
140803 | TRPM6 | HTA11_3361_2000001011 | Human | Colorectum | AD | 3.95e-05 | 4.87e-01 | -0.1207 |
140803 | TRPM6 | HTA11_696_2000001011 | Human | Colorectum | AD | 6.43e-10 | 5.47e-01 | -0.1464 |
140803 | TRPM6 | HTA11_2992_2000001011 | Human | Colorectum | SER | 3.39e-02 | 6.46e-01 | -0.1706 |
140803 | TRPM6 | HTA11_5212_2000001011 | Human | Colorectum | AD | 2.90e-08 | 1.11e+00 | -0.2061 |
140803 | TRPM6 | A008-E-015 | Human | Colorectum | FAP | 1.04e-06 | 3.10e-01 | 0.0177 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:0009636 | Colorectum | AD | response to toxic substance | 88/3918 | 262/18723 | 1.12e-06 | 3.72e-05 | 88 |
GO:00096361 | Colorectum | SER | response to toxic substance | 71/2897 | 262/18723 | 8.63e-07 | 4.07e-05 | 71 |
GO:00096363 | Colorectum | FAP | response to toxic substance | 53/2622 | 262/18723 | 3.35e-03 | 2.46e-02 | 53 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
TRPM6 | SNV | Missense_Mutation | c.388N>A | p.Glu130Lys | p.E130K | Q9BX84 | protein_coding | deleterious(0) | probably_damaging(0.945) | TCGA-46-3769-01 | Lung | lung squamous cell carcinoma | Male | <65 | III/IV | Chemotherapy | cisplatin | SD | |
TRPM6 | SNV | Missense_Mutation | novel | c.856N>C | p.Val286Leu | p.V286L | Q9BX84 | protein_coding | deleterious(0) | possibly_damaging(0.526) | TCGA-58-8390-01 | Lung | lung squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
TRPM6 | SNV | Missense_Mutation | novel | c.4414T>A | p.Trp1472Arg | p.W1472R | Q9BX84 | protein_coding | tolerated_low_confidence(0.3) | benign(0.003) | TCGA-60-2697-01 | Lung | lung squamous cell carcinoma | Male | <65 | I/II | Chemotherapy | cytoxan | PD |
TRPM6 | SNV | Missense_Mutation | c.4476N>C | p.Lys1492Asn | p.K1492N | Q9BX84 | protein_coding | tolerated_low_confidence(0.47) | benign(0) | TCGA-66-2759-01 | Lung | lung squamous cell carcinoma | Male | >=65 | III/IV | Chemotherapy | carboplatin | CR | |
TRPM6 | SNV | Missense_Mutation | c.1972N>T | p.Val658Leu | p.V658L | Q9BX84 | protein_coding | tolerated(0.14) | benign(0.013) | TCGA-85-6560-01 | Lung | lung squamous cell carcinoma | Male | <65 | I/II | Chemotherapy | cisplatin | SD | |
TRPM6 | SNV | Missense_Mutation | c.793C>T | p.Leu265Phe | p.L265F | Q9BX84 | protein_coding | deleterious(0.02) | probably_damaging(0.955) | TCGA-85-6561-01 | Lung | lung squamous cell carcinoma | Male | >=65 | I/II | Chemotherapy | cisplatin | SD | |
TRPM6 | SNV | Missense_Mutation | novel | c.2170N>G | p.Cys724Gly | p.C724G | Q9BX84 | protein_coding | deleterious(0.01) | possibly_damaging(0.87) | TCGA-85-8287-01 | Lung | lung squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
TRPM6 | SNV | Missense_Mutation | c.769G>A | p.Gly257Ser | p.G257S | Q9BX84 | protein_coding | deleterious(0.02) | probably_damaging(0.946) | TCGA-90-A59Q-01 | Lung | lung squamous cell carcinoma | Female | <65 | I/II | Chemotherapy | cisplatin | PD | |
TRPM6 | SNV | Missense_Mutation | rs375797671 | c.3700N>A | p.Asp1234Asn | p.D1234N | Q9BX84 | protein_coding | tolerated(0.18) | benign(0.367) | TCGA-LA-A446-01 | Lung | lung squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
TRPM6 | SNV | Missense_Mutation | rs370195494 | c.3508G>A | p.Glu1170Lys | p.E1170K | Q9BX84 | protein_coding | tolerated(0.1) | benign(0.04) | TCGA-MF-A522-01 | Lung | lung squamous cell carcinoma | Male | <65 | I/II | Chemotherapy | cisplatin | PD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
140803 | TRPM6 | ION CHANNEL, DRUGGABLE GENOME, ENZYME, TRANSPORTER, KINASE, SERINE THREONINE KINASE | blocker | 135652746 | ||
140803 | TRPM6 | ION CHANNEL, DRUGGABLE GENOME, ENZYME, TRANSPORTER, KINASE, SERINE THREONINE KINASE | blocker,activator | 135652741 | ||
140803 | TRPM6 | ION CHANNEL, DRUGGABLE GENOME, ENZYME, TRANSPORTER, KINASE, SERINE THREONINE KINASE | activator | 135652738 | ||
140803 | TRPM6 | ION CHANNEL, DRUGGABLE GENOME, ENZYME, TRANSPORTER, KINASE, SERINE THREONINE KINASE | activator | 135649695 | ||
140803 | TRPM6 | ION CHANNEL, DRUGGABLE GENOME, ENZYME, TRANSPORTER, KINASE, SERINE THREONINE KINASE | blocker | 135652731 |
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