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Gene: SPTAN1 |
Gene summary for SPTAN1 |
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Gene information | Species | Human | Gene symbol | SPTAN1 | Gene ID | 6709 |
Gene name | spectrin alpha, non-erythrocytic 1 | |
Gene Alias | DEE5 | |
Cytomap | 9q34.11 | |
Gene Type | protein-coding | GO ID | GO:0006996 | UniProtAcc | Q13813 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
6709 | SPTAN1 | CA_HPV_1 | Human | Cervix | CC | 4.22e-05 | -1.40e-01 | 0.0264 |
6709 | SPTAN1 | CCI_2 | Human | Cervix | CC | 4.40e-04 | 7.75e-01 | 0.5249 |
6709 | SPTAN1 | CCI_3 | Human | Cervix | CC | 1.35e-06 | 6.75e-01 | 0.516 |
6709 | SPTAN1 | L1 | Human | Cervix | CC | 4.94e-03 | -3.62e-02 | 0.0802 |
6709 | SPTAN1 | HTA11_3410_2000001011 | Human | Colorectum | AD | 2.77e-11 | 4.41e-01 | 0.0155 |
6709 | SPTAN1 | HTA11_2487_2000001011 | Human | Colorectum | SER | 5.74e-16 | 7.66e-01 | -0.1808 |
6709 | SPTAN1 | HTA11_1938_2000001011 | Human | Colorectum | AD | 8.21e-20 | 8.56e-01 | -0.0811 |
6709 | SPTAN1 | HTA11_78_2000001011 | Human | Colorectum | AD | 4.10e-07 | 5.12e-01 | -0.1088 |
6709 | SPTAN1 | HTA11_347_2000001011 | Human | Colorectum | AD | 1.26e-36 | 9.94e-01 | -0.1954 |
6709 | SPTAN1 | HTA11_411_2000001011 | Human | Colorectum | SER | 1.75e-09 | 1.22e+00 | -0.2602 |
6709 | SPTAN1 | HTA11_3361_2000001011 | Human | Colorectum | AD | 2.39e-02 | 4.64e-01 | -0.1207 |
6709 | SPTAN1 | HTA11_83_2000001011 | Human | Colorectum | SER | 2.52e-02 | 3.53e-01 | -0.1526 |
6709 | SPTAN1 | HTA11_696_2000001011 | Human | Colorectum | AD | 1.11e-14 | 7.28e-01 | -0.1464 |
6709 | SPTAN1 | HTA11_866_2000001011 | Human | Colorectum | AD | 6.96e-07 | 5.08e-01 | -0.1001 |
6709 | SPTAN1 | HTA11_1391_2000001011 | Human | Colorectum | AD | 7.76e-14 | 7.30e-01 | -0.059 |
6709 | SPTAN1 | HTA11_5212_2000001011 | Human | Colorectum | AD | 2.71e-04 | 5.76e-01 | -0.2061 |
6709 | SPTAN1 | HTA11_546_2000001011 | Human | Colorectum | AD | 1.05e-03 | 4.43e-01 | -0.0842 |
6709 | SPTAN1 | HTA11_7862_2000001011 | Human | Colorectum | AD | 3.81e-03 | 4.53e-01 | -0.0179 |
6709 | SPTAN1 | HTA11_866_3004761011 | Human | Colorectum | AD | 1.31e-18 | 8.22e-01 | 0.096 |
6709 | SPTAN1 | HTA11_4255_2000001011 | Human | Colorectum | SER | 1.25e-02 | 5.46e-01 | 0.0446 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:000701510 | Cervix | CC | actin filament organization | 109/2311 | 442/18723 | 4.92e-13 | 2.45e-10 | 109 |
GO:003297010 | Cervix | CC | regulation of actin filament-based process | 96/2311 | 397/18723 | 4.00e-11 | 8.54e-09 | 96 |
GO:190290310 | Cervix | CC | regulation of supramolecular fiber organization | 92/2311 | 383/18723 | 1.49e-10 | 2.48e-08 | 92 |
GO:003295610 | Cervix | CC | regulation of actin cytoskeleton organization | 86/2311 | 358/18723 | 5.90e-10 | 7.51e-08 | 86 |
GO:004325410 | Cervix | CC | regulation of protein-containing complex assembly | 96/2311 | 428/18723 | 2.91e-09 | 3.05e-07 | 96 |
GO:011005310 | Cervix | CC | regulation of actin filament organization | 67/2311 | 278/18723 | 4.01e-08 | 2.54e-06 | 67 |
GO:005125810 | Cervix | CC | protein polymerization | 70/2311 | 297/18723 | 5.20e-08 | 3.11e-06 | 70 |
GO:003227110 | Cervix | CC | regulation of protein polymerization | 57/2311 | 233/18723 | 2.37e-07 | 1.03e-05 | 57 |
GO:00081549 | Cervix | CC | actin polymerization or depolymerization | 51/2311 | 218/18723 | 4.05e-06 | 1.05e-04 | 51 |
GO:00300419 | Cervix | CC | actin filament polymerization | 45/2311 | 191/18723 | 1.20e-05 | 2.54e-04 | 45 |
GO:00325359 | Cervix | CC | regulation of cellular component size | 76/2311 | 383/18723 | 1.66e-05 | 3.21e-04 | 76 |
GO:19029048 | Cervix | CC | negative regulation of supramolecular fiber organization | 40/2311 | 167/18723 | 2.39e-05 | 4.17e-04 | 40 |
GO:00313339 | Cervix | CC | negative regulation of protein-containing complex assembly | 35/2311 | 141/18723 | 3.41e-05 | 5.55e-04 | 35 |
GO:00308339 | Cervix | CC | regulation of actin filament polymerization | 40/2311 | 172/18723 | 4.90e-05 | 7.40e-04 | 40 |
GO:002241110 | Cervix | CC | cellular component disassembly | 83/2311 | 443/18723 | 6.04e-05 | 8.68e-04 | 83 |
GO:00106399 | Cervix | CC | negative regulation of organelle organization | 68/2311 | 348/18723 | 7.40e-05 | 1.03e-03 | 68 |
GO:00080649 | Cervix | CC | regulation of actin polymerization or depolymerization | 42/2311 | 188/18723 | 8.60e-05 | 1.15e-03 | 42 |
GO:00308328 | Cervix | CC | regulation of actin filament length | 42/2311 | 189/18723 | 9.76e-05 | 1.27e-03 | 42 |
GO:00514948 | Cervix | CC | negative regulation of cytoskeleton organization | 37/2311 | 163/18723 | 1.57e-04 | 1.88e-03 | 37 |
GO:00322728 | Cervix | CC | negative regulation of protein polymerization | 20/2311 | 80/18723 | 1.40e-03 | 1.10e-02 | 20 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa042109 | Cervix | CC | Apoptosis | 36/1267 | 136/8465 | 3.21e-04 | 1.68e-03 | 9.91e-04 | 36 |
hsa0421014 | Cervix | CC | Apoptosis | 36/1267 | 136/8465 | 3.21e-04 | 1.68e-03 | 9.91e-04 | 36 |
hsa04210 | Colorectum | MSS | Apoptosis | 44/1875 | 136/8465 | 3.66e-03 | 1.66e-02 | 1.01e-02 | 44 |
hsa042101 | Colorectum | MSS | Apoptosis | 44/1875 | 136/8465 | 3.66e-03 | 1.66e-02 | 1.01e-02 | 44 |
hsa0421027 | Esophagus | ESCC | Apoptosis | 102/4205 | 136/8465 | 1.05e-09 | 1.21e-08 | 6.21e-09 | 102 |
hsa0421037 | Esophagus | ESCC | Apoptosis | 102/4205 | 136/8465 | 1.05e-09 | 1.21e-08 | 6.21e-09 | 102 |
hsa042106 | Liver | Cirrhotic | Apoptosis | 58/2530 | 136/8465 | 9.84e-04 | 5.55e-03 | 3.42e-03 | 58 |
hsa0421011 | Liver | Cirrhotic | Apoptosis | 58/2530 | 136/8465 | 9.84e-04 | 5.55e-03 | 3.42e-03 | 58 |
hsa042102 | Liver | HCC | Apoptosis | 83/4020 | 136/8465 | 9.51e-04 | 3.58e-03 | 1.99e-03 | 83 |
hsa042103 | Liver | HCC | Apoptosis | 83/4020 | 136/8465 | 9.51e-04 | 3.58e-03 | 1.99e-03 | 83 |
hsa042107 | Lung | IAC | Apoptosis | 30/1053 | 136/8465 | 1.11e-03 | 7.82e-03 | 5.19e-03 | 30 |
hsa0421012 | Lung | IAC | Apoptosis | 30/1053 | 136/8465 | 1.11e-03 | 7.82e-03 | 5.19e-03 | 30 |
hsa0421018 | Oral cavity | OSCC | Apoptosis | 101/3704 | 136/8465 | 3.34e-13 | 7.00e-12 | 3.56e-12 | 101 |
hsa0421019 | Oral cavity | OSCC | Apoptosis | 101/3704 | 136/8465 | 3.34e-13 | 7.00e-12 | 3.56e-12 | 101 |
hsa0421026 | Oral cavity | LP | Apoptosis | 65/2418 | 136/8465 | 1.33e-06 | 1.48e-05 | 9.53e-06 | 65 |
hsa0421036 | Oral cavity | LP | Apoptosis | 65/2418 | 136/8465 | 1.33e-06 | 1.48e-05 | 9.53e-06 | 65 |
hsa0421043 | Oral cavity | EOLP | Apoptosis | 40/1218 | 136/8465 | 4.20e-06 | 2.91e-05 | 1.72e-05 | 40 |
hsa0421053 | Oral cavity | EOLP | Apoptosis | 40/1218 | 136/8465 | 4.20e-06 | 2.91e-05 | 1.72e-05 | 40 |
hsa0421016 | Prostate | BPH | Apoptosis | 46/1718 | 136/8465 | 1.41e-04 | 8.31e-04 | 5.14e-04 | 46 |
hsa0421017 | Prostate | BPH | Apoptosis | 46/1718 | 136/8465 | 1.41e-04 | 8.31e-04 | 5.14e-04 | 46 |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
SPTAN1 | SNV | Missense_Mutation | rs777267488 | c.5455G>C | p.Ala1819Pro | p.A1819P | Q13813 | protein_coding | deleterious(0.05) | benign(0) | TCGA-D7-A6EZ-01 | Stomach | stomach adenocarcinoma | Male | >=65 | III/IV | Unknown | Unknown | PD |
SPTAN1 | SNV | Missense_Mutation | rs200834733 | c.6497N>A | p.Arg2166His | p.R2166H | Q13813 | protein_coding | deleterious(0.02) | benign(0.07) | TCGA-HU-A4G8-01 | Stomach | stomach adenocarcinoma | Female | >=65 | I/II | Chemotherapy | 5-fluorouracil | SD |
SPTAN1 | SNV | Missense_Mutation | c.2929N>A | p.Asp977Asn | p.D977N | Q13813 | protein_coding | deleterious(0.01) | probably_damaging(0.982) | TCGA-HU-A4GN-01 | Stomach | stomach adenocarcinoma | Male | <65 | I/II | Chemotherapy | mitomycin | PD | |
SPTAN1 | SNV | Missense_Mutation | c.3176N>T | p.Ala1059Val | p.A1059V | Q13813 | protein_coding | tolerated(0.65) | benign(0.001) | TCGA-HU-A4GQ-01 | Stomach | stomach adenocarcinoma | Male | >=65 | III/IV | Unknown | Unknown | SD | |
SPTAN1 | SNV | Missense_Mutation | c.222C>G | p.Asp74Glu | p.D74E | Q13813 | protein_coding | tolerated(0.17) | benign(0.425) | TCGA-IN-8663-01 | Stomach | stomach adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
SPTAN1 | SNV | Missense_Mutation | novel | c.7222N>A | p.Val2408Ile | p.V2408I | Q13813 | protein_coding | tolerated(0.77) | possibly_damaging(0.899) | TCGA-VQ-A8E3-01 | Stomach | stomach adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | PD |
SPTAN1 | SNV | Missense_Mutation | c.6886N>A | p.Ala2296Thr | p.A2296T | Q13813 | protein_coding | deleterious(0) | probably_damaging(0.982) | TCGA-VQ-A8PP-01 | Stomach | stomach adenocarcinoma | Male | >=65 | III/IV | Chemotherapy | fluorouracil | PD | |
SPTAN1 | SNV | Missense_Mutation | novel | c.6500N>C | p.Val2167Ala | p.V2167A | Q13813 | protein_coding | deleterious(0.01) | probably_damaging(0.932) | TCGA-VQ-A8PX-01 | Stomach | stomach adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
SPTAN1 | insertion | Frame_Shift_Ins | novel | c.760dupG | p.Ala254GlyfsTer8 | p.A254Gfs*8 | Q13813 | protein_coding | TCGA-CG-4306-01 | Stomach | stomach adenocarcinoma | Male | >=65 | III/IV | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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