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Gene: SDK2 |
Gene summary for SDK2 |
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Gene information | Species | Human | Gene symbol | SDK2 | Gene ID | 54549 |
Gene name | sidekick cell adhesion molecule 2 | |
Gene Alias | SDK2 | |
Cytomap | 17q25.1 | |
Gene Type | protein-coding | GO ID | GO:0001654 | UniProtAcc | Q58EX2 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
54549 | SDK2 | C30 | Human | Oral cavity | OSCC | 3.92e-39 | 1.26e+00 | 0.3055 |
54549 | SDK2 | C38 | Human | Oral cavity | OSCC | 1.36e-05 | 6.81e-01 | 0.172 |
54549 | SDK2 | C51 | Human | Oral cavity | OSCC | 1.66e-17 | 6.35e-01 | 0.2674 |
54549 | SDK2 | C06 | Human | Oral cavity | OSCC | 1.70e-02 | 5.25e-01 | 0.2699 |
54549 | SDK2 | C08 | Human | Oral cavity | OSCC | 4.92e-05 | 1.60e-01 | 0.1919 |
54549 | SDK2 | C09 | Human | Oral cavity | OSCC | 1.75e-10 | 4.36e-01 | 0.1431 |
54549 | SDK2 | EOLP-1 | Human | Oral cavity | EOLP | 2.93e-08 | 2.32e-01 | -0.0202 |
54549 | SDK2 | SYSMH3 | Human | Oral cavity | OSCC | 8.14e-22 | 3.79e-01 | 0.2442 |
54549 | SDK2 | SYSMH5 | Human | Oral cavity | OSCC | 3.58e-03 | 1.53e-01 | 0.0647 |
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Tissue | Expression Dynamics | Abbreviation |
Oral Cavity | ![]() | EOLP: Erosive Oral lichen planus |
LP: leukoplakia | ||
NEOLP: Non-erosive oral lichen planus | ||
OSCC: Oral squamous cell carcinoma |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:003432916 | Oral cavity | OSCC | cell junction assembly | 190/7305 | 420/18723 | 4.99e-03 | 1.96e-02 | 190 |
GO:003432917 | Oral cavity | EOLP | cell junction assembly | 76/2218 | 420/18723 | 1.02e-04 | 1.17e-03 | 76 |
GO:00016542 | Oral cavity | EOLP | eye development | 62/2218 | 371/18723 | 3.18e-03 | 1.85e-02 | 62 |
GO:01500632 | Oral cavity | EOLP | visual system development | 62/2218 | 375/18723 | 4.07e-03 | 2.24e-02 | 62 |
GO:00488802 | Oral cavity | EOLP | sensory system development | 62/2218 | 381/18723 | 5.82e-03 | 2.94e-02 | 62 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
SDK2 | SNV | Missense_Mutation | novel | c.6491N>A | p.Pro2164His | p.P2164H | Q58EX2 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-G9-6377-01 | Prostate | prostate adenocarcinoma | Male | <65 | 7 | Unknown | Unknown | SD |
SDK2 | SNV | Missense_Mutation | rs377237314 | c.4319N>A | p.Arg1440His | p.R1440H | Q58EX2 | protein_coding | deleterious(0.01) | possibly_damaging(0.903) | TCGA-XK-AAIW-01 | Prostate | prostate adenocarcinoma | Male | >=65 | 9 | Unknown | Unknown | PD |
SDK2 | SNV | Missense_Mutation | novel | c.4199N>T | p.Pro1400Leu | p.P1400L | Q58EX2 | protein_coding | deleterious(0) | probably_damaging(0.997) | TCGA-XK-AAIW-01 | Prostate | prostate adenocarcinoma | Male | >=65 | 9 | Unknown | Unknown | PD |
SDK2 | SNV | Missense_Mutation | c.3214N>T | p.Arg1072Cys | p.R1072C | Q58EX2 | protein_coding | deleterious(0.02) | probably_damaging(0.947) | TCGA-XK-AAIW-01 | Prostate | prostate adenocarcinoma | Male | >=65 | 9 | Unknown | Unknown | PD | |
SDK2 | SNV | Missense_Mutation | novel | c.3564N>C | p.Gln1188His | p.Q1188H | Q58EX2 | protein_coding | tolerated(0.08) | benign(0.003) | TCGA-XQ-A8TA-01 | Prostate | prostate adenocarcinoma | Male | <65 | 10 | Unknown | Unknown | PD |
SDK2 | SNV | Missense_Mutation | rs200915505 | c.1663N>T | p.His555Tyr | p.H555Y | Q58EX2 | protein_coding | tolerated(1) | benign(0.317) | TCGA-B7-A5TI-01 | Stomach | stomach adenocarcinoma | Male | <65 | III/IV | Chemotherapy | eloxatin | CR |
SDK2 | SNV | Missense_Mutation | novel | c.3323N>T | p.Ala1108Val | p.A1108V | Q58EX2 | protein_coding | deleterious(0.04) | benign(0.141) | TCGA-BR-4363-01 | Stomach | stomach adenocarcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
SDK2 | SNV | Missense_Mutation | rs775786137 | c.1490N>A | p.Arg497His | p.R497H | Q58EX2 | protein_coding | tolerated(0.37) | possibly_damaging(0.735) | TCGA-BR-6566-01 | Stomach | stomach adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
SDK2 | SNV | Missense_Mutation | rs374738523 | c.4625G>A | p.Arg1542Gln | p.R1542Q | Q58EX2 | protein_coding | tolerated(0.08) | benign(0.243) | TCGA-BR-7707-01 | Stomach | stomach adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
SDK2 | SNV | Missense_Mutation | rs373850295 | c.5861N>A | p.Arg1954Gln | p.R1954Q | Q58EX2 | protein_coding | tolerated(0.05) | benign(0.383) | TCGA-BR-8382-01 | Stomach | stomach adenocarcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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