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Gene: NCOR1 |
Gene summary for NCOR1 |
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Gene information | Species | Human | Gene symbol | NCOR1 | Gene ID | 9611 |
Gene name | nuclear receptor corepressor 1 | |
Gene Alias | N-CoR | |
Cytomap | 17p12-p11.2 | |
Gene Type | protein-coding | GO ID | GO:0000122 | UniProtAcc | O75376 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
9611 | NCOR1 | HTA11_3410_2000001011 | Human | Colorectum | AD | 4.83e-37 | -7.84e-01 | 0.0155 |
9611 | NCOR1 | HTA11_2951_2000001011 | Human | Colorectum | AD | 5.96e-04 | -6.65e-01 | 0.0216 |
9611 | NCOR1 | HTA11_347_2000001011 | Human | Colorectum | AD | 2.28e-18 | 7.34e-01 | -0.1954 |
9611 | NCOR1 | HTA11_3361_2000001011 | Human | Colorectum | AD | 1.21e-06 | -4.66e-01 | -0.1207 |
9611 | NCOR1 | HTA11_866_3004761011 | Human | Colorectum | AD | 1.92e-03 | -3.75e-01 | 0.096 |
9611 | NCOR1 | HTA11_4255_2000001011 | Human | Colorectum | SER | 1.11e-03 | -5.03e-01 | 0.0446 |
9611 | NCOR1 | HTA11_8622_2000001021 | Human | Colorectum | SER | 1.25e-03 | -6.07e-01 | 0.0528 |
9611 | NCOR1 | HTA11_10711_2000001011 | Human | Colorectum | AD | 1.45e-02 | -3.95e-01 | 0.0338 |
9611 | NCOR1 | HTA11_7469_2000001011 | Human | Colorectum | AD | 5.59e-05 | -2.61e-01 | -0.0124 |
9611 | NCOR1 | HTA11_11156_2000001011 | Human | Colorectum | AD | 3.08e-03 | -7.05e-01 | 0.0397 |
9611 | NCOR1 | HTA11_6818_2000001021 | Human | Colorectum | AD | 9.62e-08 | -6.13e-01 | 0.0588 |
9611 | NCOR1 | HTA11_99999970781_79442 | Human | Colorectum | MSS | 6.40e-13 | -4.93e-01 | 0.294 |
9611 | NCOR1 | HTA11_99999965062_69753 | Human | Colorectum | MSI-H | 1.39e-04 | 5.48e-01 | 0.3487 |
9611 | NCOR1 | HTA11_99999971662_82457 | Human | Colorectum | MSS | 7.03e-13 | -5.96e-01 | 0.3859 |
9611 | NCOR1 | HTA11_99999973899_84307 | Human | Colorectum | MSS | 6.05e-21 | -9.78e-01 | 0.2585 |
9611 | NCOR1 | HTA11_99999974143_84620 | Human | Colorectum | MSS | 1.15e-30 | -7.25e-01 | 0.3005 |
9611 | NCOR1 | F007 | Human | Colorectum | FAP | 1.08e-03 | -1.11e-01 | 0.1176 |
9611 | NCOR1 | A001-C-207 | Human | Colorectum | FAP | 3.22e-07 | -2.28e-01 | 0.1278 |
9611 | NCOR1 | A015-C-203 | Human | Colorectum | FAP | 1.32e-36 | -2.79e-01 | -0.1294 |
9611 | NCOR1 | A015-C-204 | Human | Colorectum | FAP | 2.75e-06 | -1.53e-01 | -0.0228 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:0046034 | Colorectum | AD | ATP metabolic process | 142/3918 | 277/18723 | 2.64e-29 | 8.26e-26 | 142 |
GO:0006091 | Colorectum | AD | generation of precursor metabolites and energy | 209/3918 | 490/18723 | 3.17e-28 | 6.61e-25 | 209 |
GO:0009150 | Colorectum | AD | purine ribonucleotide metabolic process | 142/3918 | 368/18723 | 4.29e-15 | 1.17e-12 | 142 |
GO:0006163 | Colorectum | AD | purine nucleotide metabolic process | 149/3918 | 396/18723 | 1.08e-14 | 2.80e-12 | 149 |
GO:0072521 | Colorectum | AD | purine-containing compound metabolic process | 153/3918 | 416/18723 | 4.34e-14 | 1.01e-11 | 153 |
GO:0009259 | Colorectum | AD | ribonucleotide metabolic process | 144/3918 | 385/18723 | 5.25e-14 | 1.13e-11 | 144 |
GO:0009895 | Colorectum | AD | negative regulation of catabolic process | 124/3918 | 320/18723 | 1.66e-13 | 3.35e-11 | 124 |
GO:0019693 | Colorectum | AD | ribose phosphate metabolic process | 145/3918 | 396/18723 | 3.01e-13 | 5.71e-11 | 145 |
GO:0009117 | Colorectum | AD | nucleotide metabolic process | 168/3918 | 489/18723 | 2.20e-12 | 3.36e-10 | 168 |
GO:0006753 | Colorectum | AD | nucleoside phosphate metabolic process | 169/3918 | 497/18723 | 4.99e-12 | 6.98e-10 | 169 |
GO:0009135 | Colorectum | AD | purine nucleoside diphosphate metabolic process | 47/3918 | 103/18723 | 1.61e-08 | 9.22e-07 | 47 |
GO:0009179 | Colorectum | AD | purine ribonucleoside diphosphate metabolic process | 47/3918 | 103/18723 | 1.61e-08 | 9.22e-07 | 47 |
GO:0006090 | Colorectum | AD | pyruvate metabolic process | 47/3918 | 106/18723 | 4.85e-08 | 2.55e-06 | 47 |
GO:0009185 | Colorectum | AD | ribonucleoside diphosphate metabolic process | 47/3918 | 106/18723 | 4.85e-08 | 2.55e-06 | 47 |
GO:0046031 | Colorectum | AD | ADP metabolic process | 41/3918 | 90/18723 | 1.37e-07 | 6.42e-06 | 41 |
GO:0006096 | Colorectum | AD | glycolytic process | 38/3918 | 81/18723 | 1.52e-07 | 6.78e-06 | 38 |
GO:0006757 | Colorectum | AD | ATP generation from ADP | 38/3918 | 82/18723 | 2.26e-07 | 9.37e-06 | 38 |
GO:0071383 | Colorectum | AD | cellular response to steroid hormone stimulus | 73/3918 | 204/18723 | 6.31e-07 | 2.24e-05 | 73 |
GO:0009132 | Colorectum | AD | nucleoside diphosphate metabolic process | 49/3918 | 124/18723 | 1.75e-06 | 5.31e-05 | 49 |
GO:0046939 | Colorectum | AD | nucleotide phosphorylation | 42/3918 | 101/18723 | 1.99e-06 | 5.92e-05 | 42 |
Page: 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 69 70 71 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa04919 | Colorectum | AD | Thyroid hormone signaling pathway | 51/2092 | 121/8465 | 1.71e-05 | 1.73e-04 | 1.10e-04 | 51 |
hsa049191 | Colorectum | AD | Thyroid hormone signaling pathway | 51/2092 | 121/8465 | 1.71e-05 | 1.73e-04 | 1.10e-04 | 51 |
hsa049192 | Colorectum | SER | Thyroid hormone signaling pathway | 40/1580 | 121/8465 | 1.02e-04 | 1.06e-03 | 7.67e-04 | 40 |
hsa04350 | Colorectum | SER | TGF-beta signaling pathway | 31/1580 | 108/8465 | 7.00e-03 | 3.77e-02 | 2.74e-02 | 31 |
hsa049193 | Colorectum | SER | Thyroid hormone signaling pathway | 40/1580 | 121/8465 | 1.02e-04 | 1.06e-03 | 7.67e-04 | 40 |
hsa043501 | Colorectum | SER | TGF-beta signaling pathway | 31/1580 | 108/8465 | 7.00e-03 | 3.77e-02 | 2.74e-02 | 31 |
hsa049194 | Colorectum | MSS | Thyroid hormone signaling pathway | 46/1875 | 121/8465 | 5.04e-05 | 4.97e-04 | 3.05e-04 | 46 |
hsa049195 | Colorectum | MSS | Thyroid hormone signaling pathway | 46/1875 | 121/8465 | 5.04e-05 | 4.97e-04 | 3.05e-04 | 46 |
hsa049196 | Colorectum | MSI-H | Thyroid hormone signaling pathway | 21/797 | 121/8465 | 4.18e-03 | 4.10e-02 | 3.44e-02 | 21 |
hsa049197 | Colorectum | MSI-H | Thyroid hormone signaling pathway | 21/797 | 121/8465 | 4.18e-03 | 4.10e-02 | 3.44e-02 | 21 |
hsa049198 | Colorectum | FAP | Thyroid hormone signaling pathway | 41/1404 | 121/8465 | 2.28e-06 | 4.28e-05 | 2.60e-05 | 41 |
hsa05202 | Colorectum | FAP | Transcriptional misregulation in cancer | 45/1404 | 193/8465 | 9.19e-03 | 3.33e-02 | 2.03e-02 | 45 |
hsa049199 | Colorectum | FAP | Thyroid hormone signaling pathway | 41/1404 | 121/8465 | 2.28e-06 | 4.28e-05 | 2.60e-05 | 41 |
hsa052021 | Colorectum | FAP | Transcriptional misregulation in cancer | 45/1404 | 193/8465 | 9.19e-03 | 3.33e-02 | 2.03e-02 | 45 |
hsa0491910 | Colorectum | CRC | Thyroid hormone signaling pathway | 35/1091 | 121/8465 | 2.05e-06 | 6.85e-05 | 4.64e-05 | 35 |
hsa0491911 | Colorectum | CRC | Thyroid hormone signaling pathway | 35/1091 | 121/8465 | 2.05e-06 | 6.85e-05 | 4.64e-05 | 35 |
hsa0491928 | Esophagus | ESCC | Thyroid hormone signaling pathway | 78/4205 | 121/8465 | 6.79e-04 | 2.23e-03 | 1.14e-03 | 78 |
hsa043507 | Esophagus | ESCC | TGF-beta signaling pathway | 69/4205 | 108/8465 | 1.92e-03 | 5.54e-03 | 2.84e-03 | 69 |
hsa052028 | Esophagus | ESCC | Transcriptional misregulation in cancer | 116/4205 | 193/8465 | 2.08e-03 | 5.95e-03 | 3.05e-03 | 116 |
hsa015227 | Esophagus | ESCC | Endocrine resistance | 63/4205 | 98/8465 | 2.38e-03 | 6.58e-03 | 3.37e-03 | 63 |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
NCOR1 | STM | Liver | Cirrhotic | SLC2A9,MARCH6,THOC1, etc. | 3.10e-01 | ![]() |
NCOR1 | STM | Liver | HCC | SLC2A9,MARCH6,THOC1, etc. | 1.89e-01 | ![]() |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
NCOR1 | SNV | Missense_Mutation | novel | c.6751N>T | p.Gly2251Cys | p.G2251C | O75376 | protein_coding | tolerated(0.11) | benign(0.425) | TCGA-QK-A6VB-01 | Oral cavity | head & neck squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | PD |
NCOR1 | insertion | In_Frame_Ins | novel | c.6177_6178insCCCTGG | p.Ile2059_Thr2060insProTrp | p.I2059_T2060insPW | O75376 | protein_coding | TCGA-CV-A45U-01 | Oral cavity | head & neck squamous cell carcinoma | Male | <65 | I/II | Unknown | Unknown | PD | ||
NCOR1 | SNV | Missense_Mutation | rs543425229 | c.5581A>G | p.Ser1861Gly | p.S1861G | O75376 | protein_coding | tolerated(0.12) | benign(0.039) | TCGA-HC-8261-01 | Prostate | prostate adenocarcinoma | Male | <65 | 7 | Unknown | Unknown | SD |
NCOR1 | deletion | Frame_Shift_Del | novel | c.1995_1996delNN | p.Phe665LeufsTer3 | p.F665Lfs*3 | O75376 | protein_coding | TCGA-EJ-5521-01 | Prostate | prostate adenocarcinoma | Male | <65 | 7 | Unknown | Unknown | SD | ||
NCOR1 | deletion | Frame_Shift_Del | c.5497delN | p.Gln1833ArgfsTer17 | p.Q1833Rfs*17 | O75376 | protein_coding | TCGA-EJ-7782-01 | Prostate | prostate adenocarcinoma | Male | >=65 | 8 | Unknown | Unknown | SD | |||
NCOR1 | insertion | Frame_Shift_Ins | novel | c.4968_4969insC | p.Asn1657GlnfsTer57 | p.N1657Qfs*57 | O75376 | protein_coding | TCGA-HC-7744-01 | Prostate | prostate adenocarcinoma | Male | <65 | 7 | Unknown | Unknown | SD | ||
NCOR1 | SNV | Missense_Mutation | c.7192C>T | p.Pro2398Ser | p.P2398S | O75376 | protein_coding | tolerated(0.05) | probably_damaging(0.996) | TCGA-BR-4368-01 | Stomach | stomach adenocarcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD | |
NCOR1 | SNV | Missense_Mutation | c.1903N>A | p.Val635Ile | p.V635I | O75376 | protein_coding | tolerated(0.12) | benign(0.345) | TCGA-BR-6452-01 | Stomach | stomach adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
NCOR1 | SNV | Missense_Mutation | rs759534850 | c.5159N>A | p.Arg1720Gln | p.R1720Q | O75376 | protein_coding | tolerated(0.06) | probably_damaging(0.921) | TCGA-BR-8361-01 | Stomach | stomach adenocarcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD |
NCOR1 | SNV | Missense_Mutation | c.1768N>G | p.Thr590Ala | p.T590A | O75376 | protein_coding | tolerated(1) | benign(0.12) | TCGA-BR-8487-01 | Stomach | stomach adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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