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Gene: NCKAP5 |
Gene summary for NCKAP5 |
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Gene information | Species | Human | Gene symbol | NCKAP5 | Gene ID | 344148 |
Gene name | NCK associated protein 5 | |
Gene Alias | ERIH1 | |
Cytomap | 2q21.2 | |
Gene Type | protein-coding | GO ID | GO:0000226 | UniProtAcc | O14513 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
344148 | NCKAP5 | HTA11_2487_2000001011 | Human | Colorectum | SER | 1.46e-06 | 6.15e-01 | -0.1808 |
344148 | NCKAP5 | HTA11_1938_2000001011 | Human | Colorectum | AD | 2.45e-13 | 9.66e-01 | -0.0811 |
344148 | NCKAP5 | HTA11_78_2000001011 | Human | Colorectum | AD | 3.03e-07 | 6.59e-01 | -0.1088 |
344148 | NCKAP5 | HTA11_347_2000001011 | Human | Colorectum | AD | 6.44e-13 | 6.56e-01 | -0.1954 |
344148 | NCKAP5 | HTA11_3361_2000001011 | Human | Colorectum | AD | 4.20e-05 | 4.56e-01 | -0.1207 |
344148 | NCKAP5 | HTA11_83_2000001011 | Human | Colorectum | SER | 1.30e-07 | 7.09e-01 | -0.1526 |
344148 | NCKAP5 | HTA11_696_2000001011 | Human | Colorectum | AD | 3.11e-08 | 4.35e-01 | -0.1464 |
344148 | NCKAP5 | HTA11_866_2000001011 | Human | Colorectum | AD | 9.85e-07 | 3.49e-01 | -0.1001 |
344148 | NCKAP5 | HTA11_7663_2000001011 | Human | Colorectum | SER | 2.36e-06 | 9.60e-01 | 0.0131 |
344148 | NCKAP5 | HTA11_7696_3000711011 | Human | Colorectum | AD | 3.08e-07 | 4.35e-01 | 0.0674 |
344148 | NCKAP5 | HTA11_6818_2000001021 | Human | Colorectum | AD | 3.48e-18 | 1.14e+00 | 0.0588 |
344148 | NCKAP5 | HTA11_99999970781_79442 | Human | Colorectum | MSS | 4.17e-06 | 4.43e-01 | 0.294 |
344148 | NCKAP5 | HTA11_99999965062_69753 | Human | Colorectum | MSI-H | 1.12e-04 | 1.21e+00 | 0.3487 |
344148 | NCKAP5 | HTA11_99999974143_84620 | Human | Colorectum | MSS | 1.19e-40 | 1.20e+00 | 0.3005 |
344148 | NCKAP5 | A015-C-203 | Human | Colorectum | FAP | 3.22e-08 | 2.44e-01 | -0.1294 |
344148 | NCKAP5 | A002-C-201 | Human | Colorectum | FAP | 5.88e-04 | -1.59e-01 | 0.0324 |
344148 | NCKAP5 | A001-C-119 | Human | Colorectum | FAP | 2.02e-11 | 6.56e-01 | -0.1557 |
344148 | NCKAP5 | A001-C-108 | Human | Colorectum | FAP | 4.41e-03 | 2.54e-02 | -0.0272 |
344148 | NCKAP5 | A002-C-205 | Human | Colorectum | FAP | 1.43e-05 | 9.06e-02 | -0.1236 |
344148 | NCKAP5 | A015-C-006 | Human | Colorectum | FAP | 1.84e-03 | 1.09e-01 | -0.0994 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:0022411 | Colorectum | AD | cellular component disassembly | 147/3918 | 443/18723 | 8.53e-10 | 6.76e-08 | 147 |
GO:0032984 | Colorectum | AD | protein-containing complex disassembly | 81/3918 | 224/18723 | 9.41e-08 | 4.65e-06 | 81 |
GO:0043624 | Colorectum | AD | cellular protein complex disassembly | 45/3918 | 136/18723 | 6.24e-04 | 6.48e-03 | 45 |
GO:0051261 | Colorectum | AD | protein depolymerization | 39/3918 | 114/18723 | 6.74e-04 | 6.91e-03 | 39 |
GO:00224111 | Colorectum | SER | cellular component disassembly | 114/2897 | 443/18723 | 1.17e-08 | 9.59e-07 | 114 |
GO:00329841 | Colorectum | SER | protein-containing complex disassembly | 61/2897 | 224/18723 | 4.17e-06 | 1.60e-04 | 61 |
GO:00436241 | Colorectum | SER | cellular protein complex disassembly | 37/2897 | 136/18723 | 3.08e-04 | 5.00e-03 | 37 |
GO:00512611 | Colorectum | SER | protein depolymerization | 31/2897 | 114/18723 | 9.18e-04 | 1.11e-02 | 31 |
GO:00224112 | Colorectum | MSS | cellular component disassembly | 130/3467 | 443/18723 | 1.44e-08 | 8.46e-07 | 130 |
GO:00329842 | Colorectum | MSS | protein-containing complex disassembly | 69/3467 | 224/18723 | 5.61e-06 | 1.50e-04 | 69 |
GO:00329843 | Colorectum | MSI-H | protein-containing complex disassembly | 28/1319 | 224/18723 | 2.24e-03 | 3.01e-02 | 28 |
GO:00224113 | Colorectum | MSI-H | cellular component disassembly | 47/1319 | 443/18723 | 3.26e-03 | 3.99e-02 | 47 |
GO:00224114 | Colorectum | FAP | cellular component disassembly | 97/2622 | 443/18723 | 3.44e-06 | 1.23e-04 | 97 |
GO:00329844 | Colorectum | FAP | protein-containing complex disassembly | 54/2622 | 224/18723 | 3.37e-05 | 7.48e-04 | 54 |
GO:00512612 | Colorectum | FAP | protein depolymerization | 26/2622 | 114/18723 | 7.36e-03 | 4.40e-02 | 26 |
GO:00329845 | Colorectum | CRC | protein-containing complex disassembly | 46/2078 | 224/18723 | 2.61e-05 | 7.18e-04 | 46 |
GO:00224115 | Colorectum | CRC | cellular component disassembly | 75/2078 | 443/18723 | 1.26e-04 | 2.42e-03 | 75 |
GO:00512613 | Colorectum | CRC | protein depolymerization | 22/2078 | 114/18723 | 6.73e-03 | 4.77e-02 | 22 |
GO:0022411111 | Esophagus | ESCC | cellular component disassembly | 305/8552 | 443/18723 | 1.94e-23 | 4.57e-21 | 305 |
GO:003298416 | Esophagus | ESCC | protein-containing complex disassembly | 151/8552 | 224/18723 | 3.45e-11 | 1.15e-09 | 151 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
NCKAP5 | SNV | Missense_Mutation | novel | c.2393A>G | p.Gln798Arg | p.Q798R | O14513 | protein_coding | tolerated(0.48) | benign(0.083) | TCGA-99-7458-01 | Lung | lung adenocarcinoma | Female | >=65 | III/IV | Targeted Molecular therapy | tarceva | SD |
NCKAP5 | SNV | Missense_Mutation | novel | c.2725N>A | p.Pro909Thr | p.P909T | O14513 | protein_coding | tolerated(0.06) | possibly_damaging(0.656) | TCGA-L9-A444-01 | Lung | lung adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
NCKAP5 | SNV | Missense_Mutation | novel | c.2060N>T | p.Gly687Val | p.G687V | O14513 | protein_coding | deleterious(0) | probably_damaging(0.995) | TCGA-L9-A444-01 | Lung | lung adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
NCKAP5 | SNV | Missense_Mutation | c.5183N>T | p.Pro1728Leu | p.P1728L | O14513 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-MP-A4TC-01 | Lung | lung adenocarcinoma | Male | >=65 | III/IV | Chemotherapy | cisplatin | CR | |
NCKAP5 | SNV | Missense_Mutation | rs777479794 | c.251G>A | p.Arg84His | p.R84H | O14513 | protein_coding | deleterious(0) | probably_damaging(0.973) | TCGA-18-4086-01 | Lung | lung squamous cell carcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
NCKAP5 | SNV | Missense_Mutation | c.2014G>A | p.Asp672Asn | p.D672N | O14513 | protein_coding | deleterious(0) | possibly_damaging(0.781) | TCGA-18-5592-01 | Lung | lung squamous cell carcinoma | Male | <65 | I/II | Unknown | Unknown | SD | |
NCKAP5 | SNV | Missense_Mutation | c.4070G>T | p.Ser1357Ile | p.S1357I | O14513 | protein_coding | deleterious(0.01) | possibly_damaging(0.837) | TCGA-21-5787-01 | Lung | lung squamous cell carcinoma | Male | >=65 | III/IV | Unknown | Unknown | PD | |
NCKAP5 | SNV | Missense_Mutation | c.5360N>C | p.Ile1787Thr | p.I1787T | O14513 | protein_coding | deleterious(0.02) | benign(0.408) | TCGA-22-4613-01 | Lung | lung squamous cell carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
NCKAP5 | SNV | Missense_Mutation | c.5089G>T | p.Asp1697Tyr | p.D1697Y | O14513 | protein_coding | deleterious(0) | probably_damaging(0.979) | TCGA-22-5478-01 | Lung | lung squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
NCKAP5 | SNV | Missense_Mutation | c.3547N>T | p.Val1183Leu | p.V1183L | O14513 | protein_coding | deleterious(0) | possibly_damaging(0.802) | TCGA-33-4566-01 | Lung | lung squamous cell carcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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