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Gene: HIVEP3 |
Gene summary for HIVEP3 |
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Gene information | Species | Human | Gene symbol | HIVEP3 | Gene ID | 59269 |
Gene name | HIVEP zinc finger 3 | |
Gene Alias | KBP-1 | |
Cytomap | 1p34.2 | |
Gene Type | protein-coding | GO ID | GO:0006139 | UniProtAcc | Q5T1R4 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
59269 | HIVEP3 | CCI_1 | Human | Cervix | CC | 2.53e-05 | 6.84e-01 | 0.528 |
59269 | HIVEP3 | CCI_3 | Human | Cervix | CC | 2.02e-14 | 8.87e-01 | 0.516 |
59269 | HIVEP3 | CCII_1 | Human | Cervix | CC | 1.13e-02 | 2.04e-01 | 0.3249 |
59269 | HIVEP3 | LZE8T | Human | Esophagus | ESCC | 3.59e-04 | 2.32e-01 | 0.067 |
59269 | HIVEP3 | P1T-E | Human | Esophagus | ESCC | 1.20e-04 | 3.39e-01 | 0.0875 |
59269 | HIVEP3 | P2T-E | Human | Esophagus | ESCC | 3.05e-07 | 1.06e-01 | 0.1177 |
59269 | HIVEP3 | P8T-E | Human | Esophagus | ESCC | 4.15e-03 | 1.40e-01 | 0.0889 |
59269 | HIVEP3 | P10T-E | Human | Esophagus | ESCC | 9.62e-06 | 3.45e-02 | 0.116 |
59269 | HIVEP3 | P12T-E | Human | Esophagus | ESCC | 3.00e-06 | 7.81e-02 | 0.1122 |
59269 | HIVEP3 | P15T-E | Human | Esophagus | ESCC | 1.00e-02 | 1.09e-01 | 0.1149 |
59269 | HIVEP3 | P16T-E | Human | Esophagus | ESCC | 4.93e-12 | 4.27e-01 | 0.1153 |
59269 | HIVEP3 | P20T-E | Human | Esophagus | ESCC | 2.26e-04 | 1.89e-01 | 0.1124 |
59269 | HIVEP3 | P21T-E | Human | Esophagus | ESCC | 3.73e-07 | 2.18e-01 | 0.1617 |
59269 | HIVEP3 | P23T-E | Human | Esophagus | ESCC | 2.10e-08 | 1.13e-01 | 0.108 |
59269 | HIVEP3 | P26T-E | Human | Esophagus | ESCC | 2.85e-10 | 6.09e-02 | 0.1276 |
59269 | HIVEP3 | P27T-E | Human | Esophagus | ESCC | 1.70e-15 | 8.90e-02 | 0.1055 |
59269 | HIVEP3 | P30T-E | Human | Esophagus | ESCC | 1.50e-04 | 1.32e-01 | 0.137 |
59269 | HIVEP3 | P31T-E | Human | Esophagus | ESCC | 3.32e-03 | 1.97e-01 | 0.1251 |
59269 | HIVEP3 | P32T-E | Human | Esophagus | ESCC | 1.53e-11 | 1.67e-01 | 0.1666 |
59269 | HIVEP3 | P36T-E | Human | Esophagus | ESCC | 1.10e-05 | 1.74e-01 | 0.1187 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:00605375 | Cervix | CC | muscle tissue development | 76/2311 | 403/18723 | 9.76e-05 | 1.27e-03 | 76 |
GO:00147064 | Cervix | CC | striated muscle tissue development | 72/2311 | 384/18723 | 1.76e-04 | 2.07e-03 | 72 |
GO:00075173 | Cervix | CC | muscle organ development | 58/2311 | 327/18723 | 2.73e-03 | 1.85e-02 | 58 |
GO:00075192 | Cervix | CC | skeletal muscle tissue development | 30/2311 | 155/18723 | 7.97e-03 | 4.18e-02 | 30 |
GO:006053716 | Esophagus | ESCC | muscle tissue development | 211/8552 | 403/18723 | 3.84e-03 | 1.56e-02 | 211 |
GO:001470615 | Esophagus | ESCC | striated muscle tissue development | 197/8552 | 384/18723 | 1.46e-02 | 4.74e-02 | 197 |
GO:00605373 | Lung | IAC | muscle tissue development | 61/2061 | 403/18723 | 6.24e-03 | 4.48e-02 | 61 |
GO:00605371 | Lung | AIS | muscle tissue development | 58/1849 | 403/18723 | 2.22e-03 | 2.37e-02 | 58 |
GO:0060538 | Lung | AAH | skeletal muscle organ development | 14/613 | 166/18723 | 1.15e-03 | 3.33e-02 | 14 |
GO:0007517 | Lung | AAH | muscle organ development | 22/613 | 327/18723 | 1.20e-03 | 3.33e-02 | 22 |
GO:0007519 | Lung | AAH | skeletal muscle tissue development | 13/613 | 155/18723 | 1.79e-03 | 4.22e-02 | 13 |
GO:00605372 | Lung | AAH | muscle tissue development | 25/613 | 403/18723 | 1.79e-03 | 4.22e-02 | 25 |
GO:00605378 | Oral cavity | OSCC | muscle tissue development | 185/7305 | 403/18723 | 2.60e-03 | 1.14e-02 | 185 |
GO:00147067 | Oral cavity | OSCC | striated muscle tissue development | 174/7305 | 384/18723 | 6.45e-03 | 2.40e-02 | 174 |
GO:006053715 | Oral cavity | EOLP | muscle tissue development | 77/2218 | 403/18723 | 1.37e-05 | 2.31e-04 | 77 |
GO:001470614 | Oral cavity | EOLP | striated muscle tissue development | 72/2218 | 384/18723 | 4.87e-05 | 6.43e-04 | 72 |
GO:00605384 | Oral cavity | EOLP | skeletal muscle organ development | 35/2218 | 166/18723 | 4.65e-04 | 4.08e-03 | 35 |
GO:00075195 | Oral cavity | EOLP | skeletal muscle tissue development | 32/2218 | 155/18723 | 1.15e-03 | 8.37e-03 | 32 |
GO:00075176 | Oral cavity | EOLP | muscle organ development | 57/2218 | 327/18723 | 1.76e-03 | 1.15e-02 | 57 |
GO:006053723 | Oral cavity | NEOLP | muscle tissue development | 75/2005 | 403/18723 | 1.22e-06 | 3.15e-05 | 75 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
HIVEP3 | SNV | Missense_Mutation | novel | c.1969A>G | p.Asn657Asp | p.N657D | Q5T1R4 | protein_coding | tolerated(0.36) | possibly_damaging(0.874) | TCGA-VQ-A8PC-01 | Stomach | stomach adenocarcinoma | Male | >=65 | III/IV | Unknown | Unknown | PD |
HIVEP3 | SNV | Missense_Mutation | novel | c.802N>G | p.Ile268Val | p.I268V | Q5T1R4 | protein_coding | tolerated(0.2) | benign(0.053) | TCGA-VQ-A8PP-01 | Stomach | stomach adenocarcinoma | Male | >=65 | III/IV | Chemotherapy | fluorouracil | PD |
HIVEP3 | SNV | Missense_Mutation | novel | c.2753G>A | p.Gly918Glu | p.G918E | Q5T1R4 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-VQ-A91D-01 | Stomach | stomach adenocarcinoma | Male | >=65 | III/IV | Chemotherapy | fluorouracil | PD |
HIVEP3 | insertion | Frame_Shift_Ins | novel | c.4345_4346insA | p.Arg1449LysfsTer12 | p.R1449Kfs*12 | Q5T1R4 | protein_coding | TCGA-BR-8487-01 | Stomach | stomach adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD | ||
HIVEP3 | insertion | Frame_Shift_Ins | novel | c.5279dupG | p.Ile1761AsnfsTer18 | p.I1761Nfs*18 | Q5T1R4 | protein_coding | TCGA-CD-5800-01 | Stomach | stomach adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD | ||
HIVEP3 | SNV | Missense_Mutation | rs141921424 | c.5996N>A | p.Pro1999Gln | p.P1999Q | Q5T1R4 | protein_coding | deleterious(0) | benign(0.039) | TCGA-DJ-A2QB-01 | Thyroid | thyroid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
HIVEP3 | SNV | Missense_Mutation | novel | c.5836C>A | p.Pro1946Thr | p.P1946T | Q5T1R4 | protein_coding | tolerated(0.31) | benign(0.058) | TCGA-FY-A3BL-01 | Thyroid | thyroid carcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
HIVEP3 | SNV | Missense_Mutation | novel | c.919N>G | p.Leu307Val | p.L307V | Q5T1R4 | protein_coding | tolerated(0.08) | possibly_damaging(0.874) | TCGA-FY-A4B0-01 | Thyroid | thyroid carcinoma | Male | >=65 | I/II | Hormone Therapy | synthroid | SD |
HIVEP3 | SNV | Missense_Mutation | novel | c.208N>C | p.Ser70Pro | p.S70P | Q5T1R4 | protein_coding | tolerated(0.2) | benign(0.003) | TCGA-FY-A4B0-01 | Thyroid | thyroid carcinoma | Male | >=65 | I/II | Hormone Therapy | synthroid | SD |
HIVEP3 | insertion | Frame_Shift_Ins | novel | c.917_918insGTGGG | p.Leu307TrpfsTer46 | p.L307Wfs*46 | Q5T1R4 | protein_coding | TCGA-FY-A4B0-01 | Thyroid | thyroid carcinoma | Male | >=65 | I/II | Hormone Therapy | synthroid | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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