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Gene: CHD7 |
Gene summary for CHD7 |
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Gene information | Species | Human | Gene symbol | CHD7 | Gene ID | 55636 |
Gene name | chromodomain helicase DNA binding protein 7 | |
Gene Alias | CRG | |
Cytomap | 8q12.2 | |
Gene Type | protein-coding | GO ID | GO:0000003 | UniProtAcc | Q9P2D1 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
55636 | CHD7 | CCI_1 | Human | Cervix | CC | 8.23e-03 | 5.69e-01 | 0.528 |
55636 | CHD7 | CCI_2 | Human | Cervix | CC | 8.73e-03 | 7.12e-01 | 0.5249 |
55636 | CHD7 | CCI_3 | Human | Cervix | CC | 5.80e-06 | 5.65e-01 | 0.516 |
55636 | CHD7 | HTA11_3410_2000001011 | Human | Colorectum | AD | 7.20e-29 | -7.03e-01 | 0.0155 |
55636 | CHD7 | HTA11_2487_2000001011 | Human | Colorectum | SER | 2.04e-12 | -6.76e-01 | -0.1808 |
55636 | CHD7 | HTA11_2951_2000001011 | Human | Colorectum | AD | 3.50e-02 | -6.16e-01 | 0.0216 |
55636 | CHD7 | HTA11_2112_2000001011 | Human | Colorectum | SER | 9.97e-04 | -7.56e-01 | -0.2196 |
55636 | CHD7 | HTA11_3361_2000001011 | Human | Colorectum | AD | 1.11e-06 | -6.13e-01 | -0.1207 |
55636 | CHD7 | HTA11_696_2000001011 | Human | Colorectum | AD | 1.22e-03 | -2.97e-01 | -0.1464 |
55636 | CHD7 | HTA11_866_2000001011 | Human | Colorectum | AD | 2.14e-04 | -3.45e-01 | -0.1001 |
55636 | CHD7 | HTA11_2992_2000001011 | Human | Colorectum | SER | 1.49e-05 | -6.98e-01 | -0.1706 |
55636 | CHD7 | HTA11_5212_2000001011 | Human | Colorectum | AD | 1.24e-03 | -6.69e-01 | -0.2061 |
55636 | CHD7 | HTA11_9341_2000001011 | Human | Colorectum | SER | 3.95e-03 | -8.56e-01 | -0.00410000000000005 |
55636 | CHD7 | HTA11_7862_2000001011 | Human | Colorectum | AD | 9.85e-09 | -7.97e-01 | -0.0179 |
55636 | CHD7 | HTA11_866_3004761011 | Human | Colorectum | AD | 6.63e-03 | -3.26e-01 | 0.096 |
55636 | CHD7 | HTA11_4255_2000001011 | Human | Colorectum | SER | 2.01e-02 | -6.69e-01 | 0.0446 |
55636 | CHD7 | HTA11_8622_2000001021 | Human | Colorectum | SER | 2.10e-04 | -6.47e-01 | 0.0528 |
55636 | CHD7 | HTA11_6801_2000001011 | Human | Colorectum | SER | 8.77e-03 | -7.02e-01 | 0.0171 |
55636 | CHD7 | HTA11_10711_2000001011 | Human | Colorectum | AD | 7.83e-06 | -4.65e-01 | 0.0338 |
55636 | CHD7 | HTA11_7696_3000711011 | Human | Colorectum | AD | 4.12e-04 | -3.41e-01 | 0.0674 |
Page: 1 2 3 4 5 6 7 8 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:00421108 | Cervix | CC | T cell activation | 107/2311 | 487/18723 | 1.24e-09 | 1.46e-07 | 107 |
GO:00512359 | Cervix | CC | maintenance of location | 78/2311 | 327/18723 | 5.18e-09 | 4.92e-07 | 78 |
GO:005165110 | Cervix | CC | maintenance of location in cell | 55/2311 | 214/18723 | 6.63e-08 | 3.85e-06 | 55 |
GO:00614588 | Cervix | CC | reproductive system development | 87/2311 | 427/18723 | 1.37e-06 | 4.55e-05 | 87 |
GO:00486088 | Cervix | CC | reproductive structure development | 86/2311 | 424/18723 | 1.90e-06 | 5.97e-05 | 86 |
GO:002261310 | Cervix | CC | ribonucleoprotein complex biogenesis | 88/2311 | 463/18723 | 2.11e-05 | 3.82e-04 | 88 |
GO:004225410 | Cervix | CC | ribosome biogenesis | 62/2311 | 299/18723 | 2.48e-05 | 4.27e-04 | 62 |
GO:00063257 | Cervix | CC | chromatin organization | 78/2311 | 409/18723 | 5.40e-05 | 8.02e-04 | 78 |
GO:00017018 | Cervix | CC | in utero embryonic development | 71/2311 | 367/18723 | 7.21e-05 | 1.00e-03 | 71 |
GO:00605375 | Cervix | CC | muscle tissue development | 76/2311 | 403/18723 | 9.76e-05 | 1.27e-03 | 76 |
GO:00459277 | Cervix | CC | positive regulation of growth | 53/2311 | 259/18723 | 1.33e-04 | 1.64e-03 | 53 |
GO:00147064 | Cervix | CC | striated muscle tissue development | 72/2311 | 384/18723 | 1.76e-04 | 2.07e-03 | 72 |
GO:00302173 | Cervix | CC | T cell differentiation | 51/2311 | 257/18723 | 3.81e-04 | 3.89e-03 | 51 |
GO:19031314 | Cervix | CC | mononuclear cell differentiation | 76/2311 | 426/18723 | 5.66e-04 | 5.42e-03 | 76 |
GO:00486386 | Cervix | CC | regulation of developmental growth | 61/2311 | 330/18723 | 7.69e-04 | 6.85e-03 | 61 |
GO:00519603 | Cervix | CC | regulation of nervous system development | 77/2311 | 443/18723 | 1.13e-03 | 9.30e-03 | 77 |
GO:00507676 | Cervix | CC | regulation of neurogenesis | 65/2311 | 364/18723 | 1.33e-03 | 1.05e-02 | 65 |
GO:00487365 | Cervix | CC | appendage development | 35/2311 | 172/18723 | 1.88e-03 | 1.39e-02 | 35 |
GO:00601735 | Cervix | CC | limb development | 35/2311 | 172/18723 | 1.88e-03 | 1.39e-02 | 35 |
GO:00323923 | Cervix | CC | DNA geometric change | 21/2311 | 90/18723 | 2.71e-03 | 1.85e-02 | 21 |
Page: 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
CHD7 | SNV | Missense_Mutation | c.5842N>A | p.Val1948Met | p.V1948M | Q9P2D1 | protein_coding | tolerated(0.57) | possibly_damaging(0.652) | TCGA-G3-A5SM-01 | Liver | liver hepatocellular carcinoma | Male | <65 | I/II | Unknown | Unknown | PD | |
CHD7 | SNV | Missense_Mutation | c.316N>T | p.His106Tyr | p.H106Y | Q9P2D1 | protein_coding | deleterious_low_confidence(0) | benign(0.346) | TCGA-KR-A7K2-01 | Liver | liver hepatocellular carcinoma | Male | <65 | I/II | Unknown | Unknown | SD | |
CHD7 | SNV | Missense_Mutation | novel | c.7310N>T | p.Gly2437Val | p.G2437V | Q9P2D1 | protein_coding | deleterious(0.04) | probably_damaging(0.923) | TCGA-05-4420-01 | Lung | lung adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
CHD7 | SNV | Missense_Mutation | c.8623N>T | p.Gly2875Cys | p.G2875C | Q9P2D1 | protein_coding | deleterious(0.03) | possibly_damaging(0.536) | TCGA-35-5375-01 | Lung | lung adenocarcinoma | Male | <65 | III/IV | Unknown | Unknown | SD | |
CHD7 | SNV | Missense_Mutation | c.1292N>G | p.Pro431Arg | p.P431R | Q9P2D1 | protein_coding | deleterious_low_confidence(0.01) | benign(0.35) | TCGA-44-2665-01 | Lung | lung adenocarcinoma | Female | <65 | I/II | Targeted Molecular therapy | bevacizumab | SD | |
CHD7 | SNV | Missense_Mutation | c.3014N>G | p.Thr1005Arg | p.T1005R | Q9P2D1 | protein_coding | deleterious(0) | probably_damaging(0.968) | TCGA-44-6144-01 | Lung | lung adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | PD | |
CHD7 | SNV | Missense_Mutation | c.4732N>A | p.Asp1578Asn | p.D1578N | Q9P2D1 | protein_coding | deleterious(0.02) | possibly_damaging(0.694) | TCGA-49-6745-01 | Lung | lung adenocarcinoma | Male | >=65 | III/IV | Chemotherapy | unknown | SD | |
CHD7 | SNV | Missense_Mutation | rs745778752 | c.1072N>T | p.Gly358Cys | p.G358C | Q9P2D1 | protein_coding | deleterious_low_confidence(0) | benign(0.241) | TCGA-53-7624-01 | Lung | lung adenocarcinoma | Female | <65 | III/IV | Chemotherapy | cisplatin | PD |
CHD7 | SNV | Missense_Mutation | c.698G>T | p.Gly233Val | p.G233V | Q9P2D1 | protein_coding | tolerated_low_confidence(0.36) | benign(0.127) | TCGA-53-7626-01 | Lung | lung adenocarcinoma | Female | >=65 | I/II | Unspecific | Cisplatin | PD | |
CHD7 | SNV | Missense_Mutation | c.437N>T | p.Gly146Val | p.G146V | Q9P2D1 | protein_coding | deleterious_low_confidence(0) | benign(0.006) | TCGA-55-5899-01 | Lung | lung adenocarcinoma | Male | <65 | I/II | Chemotherapy | carboplatin | CR |
Page: 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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