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Gene: ANKHD1 |
Gene summary for ANKHD1 |
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Gene information | Species | Human | Gene symbol | ANKHD1 | Gene ID | 54882 |
Gene name | ankyrin repeat and KH domain containing 1 | |
Gene Alias | MASK | |
Cytomap | 5q31.3 | |
Gene Type | protein-coding | GO ID | GO:0002376 | UniProtAcc | Q8IWZ3 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
54882 | ANKHD1 | HTA11_3410_2000001011 | Human | Colorectum | AD | 7.99e-40 | 6.47e-01 | 0.0155 |
54882 | ANKHD1 | HTA11_2487_2000001011 | Human | Colorectum | SER | 1.97e-41 | 9.33e-01 | -0.1808 |
54882 | ANKHD1 | HTA11_2951_2000001011 | Human | Colorectum | AD | 9.20e-14 | 6.52e-01 | 0.0216 |
54882 | ANKHD1 | HTA11_1938_2000001011 | Human | Colorectum | AD | 3.65e-52 | 1.20e+00 | -0.0811 |
54882 | ANKHD1 | HTA11_78_2000001011 | Human | Colorectum | AD | 2.34e-67 | 1.45e+00 | -0.1088 |
54882 | ANKHD1 | HTA11_347_2000001011 | Human | Colorectum | AD | 1.29e-110 | 1.75e+00 | -0.1954 |
54882 | ANKHD1 | HTA11_411_2000001011 | Human | Colorectum | SER | 9.56e-24 | 1.29e+00 | -0.2602 |
54882 | ANKHD1 | HTA11_2112_2000001011 | Human | Colorectum | SER | 1.45e-19 | 8.18e-01 | -0.2196 |
54882 | ANKHD1 | HTA11_3361_2000001011 | Human | Colorectum | AD | 5.46e-22 | 6.47e-01 | -0.1207 |
54882 | ANKHD1 | HTA11_83_2000001011 | Human | Colorectum | SER | 5.94e-40 | 1.04e+00 | -0.1526 |
54882 | ANKHD1 | HTA11_696_2000001011 | Human | Colorectum | AD | 9.72e-65 | 1.08e+00 | -0.1464 |
54882 | ANKHD1 | HTA11_866_2000001011 | Human | Colorectum | AD | 2.19e-76 | 1.14e+00 | -0.1001 |
54882 | ANKHD1 | HTA11_1391_2000001011 | Human | Colorectum | AD | 4.62e-41 | 9.64e-01 | -0.059 |
54882 | ANKHD1 | HTA11_2992_2000001011 | Human | Colorectum | SER | 1.27e-18 | 9.86e-01 | -0.1706 |
54882 | ANKHD1 | HTA11_5212_2000001011 | Human | Colorectum | AD | 2.61e-16 | 7.32e-01 | -0.2061 |
54882 | ANKHD1 | HTA11_5216_2000001011 | Human | Colorectum | SER | 6.82e-15 | 6.74e-01 | -0.1462 |
54882 | ANKHD1 | HTA11_546_2000001011 | Human | Colorectum | AD | 8.94e-38 | 1.14e+00 | -0.0842 |
54882 | ANKHD1 | HTA11_9341_2000001011 | Human | Colorectum | SER | 4.42e-10 | 8.53e-01 | -0.00410000000000005 |
54882 | ANKHD1 | HTA11_7862_2000001011 | Human | Colorectum | AD | 1.30e-28 | 9.24e-01 | -0.0179 |
54882 | ANKHD1 | HTA11_866_3004761011 | Human | Colorectum | AD | 4.72e-44 | 8.78e-01 | 0.096 |
Page: 1 2 3 4 5 6 7 8 9 10 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
Page: 1 |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
Page: 1 |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
Page: 1 |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
ANKHD1 | insertion | Frame_Shift_Ins | novel | c.2387_2388insGC | p.Ile796MetfsTer12 | p.I796Mfs*12 | Q8IWZ3 | protein_coding | TCGA-FY-A4B0-01 | Thyroid | thyroid carcinoma | Male | >=65 | I/II | Hormone Therapy | synthroid | SD | ||
ANKHD1 | insertion | Nonsense_Mutation | novel | c.4687_4688insTATTCACTAAGAAATA | p.Glu1563ValfsTer6 | p.E1563Vfs*6 | Q8IWZ3 | protein_coding | TCGA-FY-A4B0-01 | Thyroid | thyroid carcinoma | Male | >=65 | I/II | Hormone Therapy | synthroid | SD | ||
ANKHD1 | insertion | Nonsense_Mutation | novel | c.5600_5601insGAGAAGTTAGCATGAA | p.Ile1867MetfsTer4 | p.I1867Mfs*4 | Q8IWZ3 | protein_coding | TCGA-FY-A4B0-01 | Thyroid | thyroid carcinoma | Male | >=65 | I/II | Hormone Therapy | synthroid | SD |
Page: 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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