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Gene: TEP1 |
Gene summary for TEP1 |
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Gene information | Species | Human | Gene symbol | TEP1 | Gene ID | 7011 |
Gene name | telomerase associated protein 1 | |
Gene Alias | TLP1 | |
Cytomap | 14q11.2 | |
Gene Type | protein-coding | GO ID | GO:0000722 | UniProtAcc | G3V5X7 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
7011 | TEP1 | HCC1_Meng | Human | Liver | HCC | 5.51e-12 | 9.91e-03 | 0.0246 |
7011 | TEP1 | HCC2_Meng | Human | Liver | HCC | 3.49e-14 | 1.19e-01 | 0.0107 |
7011 | TEP1 | HCC1 | Human | Liver | HCC | 6.07e-13 | 1.25e+00 | 0.5336 |
7011 | TEP1 | HCC2 | Human | Liver | HCC | 2.99e-28 | 2.33e+00 | 0.5341 |
7011 | TEP1 | HCC5 | Human | Liver | HCC | 1.18e-16 | 9.99e-01 | 0.4932 |
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Tissue | Expression Dynamics | Abbreviation |
Liver | ![]() | HCC: Hepatocellular carcinoma |
NAFLD: Non-alcoholic fatty liver disease |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:000072311 | Liver | HCC | telomere maintenance | 85/7958 | 131/18723 | 1.86e-07 | 3.40e-06 | 85 |
GO:000627811 | Liver | HCC | RNA-dependent DNA biosynthetic process | 50/7958 | 75/18723 | 2.02e-05 | 2.17e-04 | 50 |
GO:00718975 | Liver | HCC | DNA biosynthetic process | 99/7958 | 180/18723 | 4.66e-04 | 3.08e-03 | 99 |
GO:00322001 | Liver | HCC | telomere organization | 86/7958 | 159/18723 | 2.06e-03 | 1.04e-02 | 86 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
TEP1 | SNV | Missense_Mutation | c.6033N>A | p.Phe2011Leu | p.F2011L | Q99973 | protein_coding | tolerated(0.2) | benign(0.001) | TCGA-D7-A4YT-01 | Stomach | stomach adenocarcinoma | Male | <65 | III/IV | Unknown | Unknown | SD | |
TEP1 | SNV | Missense_Mutation | rs773475088 | c.5252N>A | p.Arg1751Gln | p.R1751Q | Q99973 | protein_coding | deleterious(0.01) | possibly_damaging(0.863) | TCGA-D7-A6EY-01 | Stomach | stomach adenocarcinoma | Female | >=65 | III/IV | Unknown | Unknown | PD |
TEP1 | SNV | Missense_Mutation | c.2690N>A | p.Arg897His | p.R897H | Q99973 | protein_coding | tolerated(0.09) | benign(0.007) | TCGA-FP-A4BE-01 | Stomach | stomach adenocarcinoma | Male | <65 | I/II | Chemotherapy | 5-fluorouracil | CR | |
TEP1 | SNV | Missense_Mutation | c.1796N>A | p.Thr599Asn | p.T599N | Q99973 | protein_coding | tolerated(0.5) | benign(0.043) | TCGA-HF-7136-01 | Stomach | stomach adenocarcinoma | Male | Unknown | III/IV | Unspecific | Cepecitabine | SD | |
TEP1 | SNV | Missense_Mutation | rs779605418 | c.3440G>A | p.Arg1147His | p.R1147H | Q99973 | protein_coding | tolerated(0.08) | benign(0.005) | TCGA-HU-8244-01 | Stomach | stomach adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
TEP1 | SNV | Missense_Mutation | rs771792941 | c.4736N>A | p.Arg1579Gln | p.R1579Q | Q99973 | protein_coding | tolerated(0.5) | benign(0.001) | TCGA-VQ-A8P2-01 | Stomach | stomach adenocarcinoma | Male | >=65 | III/IV | Unspecific | Complete Response | |
TEP1 | SNV | Missense_Mutation | novel | c.2006N>G | p.His669Arg | p.H669R | Q99973 | protein_coding | deleterious(0.01) | possibly_damaging(0.745) | TCGA-VQ-A8P2-01 | Stomach | stomach adenocarcinoma | Male | >=65 | III/IV | Unspecific | Complete Response | |
TEP1 | SNV | Missense_Mutation | novel | c.6986N>T | p.Ser2329Leu | p.S2329L | Q99973 | protein_coding | deleterious(0.02) | possibly_damaging(0.859) | TCGA-VQ-A91K-01 | Stomach | stomach adenocarcinoma | Male | >=65 | III/IV | Chemotherapy | fluorouracil | CR |
TEP1 | deletion | Frame_Shift_Del | novel | c.3504delG | p.Gln1169SerfsTer28 | p.Q1169Sfs*28 | Q99973 | protein_coding | TCGA-HU-A4G9-01 | Stomach | stomach adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | ||
TEP1 | deletion | Frame_Shift_Del | novel | c.5887delN | p.Ala1963LeufsTer16 | p.A1963Lfs*16 | Q99973 | protein_coding | TCGA-SW-A7EA-01 | Stomach | stomach adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
7011 | TEP1 | NA | V934/V935 |
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