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Gene: SIPA1L1 |
Gene summary for SIPA1L1 |
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Gene information | Species | Human | Gene symbol | SIPA1L1 | Gene ID | 26037 |
Gene name | signal induced proliferation associated 1 like 1 | |
Gene Alias | E6TP1 | |
Cytomap | 14q24.2 | |
Gene Type | protein-coding | GO ID | GO:0000902 | UniProtAcc | O43166 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
26037 | SIPA1L1 | CCI_1 | Human | Cervix | CC | 4.61e-11 | 1.32e+00 | 0.528 |
26037 | SIPA1L1 | CCI_2 | Human | Cervix | CC | 1.07e-09 | 1.30e+00 | 0.5249 |
26037 | SIPA1L1 | CCI_3 | Human | Cervix | CC | 4.25e-15 | 1.14e+00 | 0.516 |
26037 | SIPA1L1 | HTA11_3410_2000001011 | Human | Colorectum | AD | 5.41e-19 | -5.41e-01 | 0.0155 |
26037 | SIPA1L1 | HTA11_2951_2000001011 | Human | Colorectum | AD | 5.76e-03 | -7.52e-01 | 0.0216 |
26037 | SIPA1L1 | HTA11_347_2000001011 | Human | Colorectum | AD | 1.67e-06 | 4.93e-01 | -0.1954 |
26037 | SIPA1L1 | HTA11_5216_2000001011 | Human | Colorectum | SER | 1.26e-05 | -4.97e-01 | -0.1462 |
26037 | SIPA1L1 | HTA11_11156_2000001011 | Human | Colorectum | AD | 5.40e-04 | -9.24e-01 | 0.0397 |
26037 | SIPA1L1 | HTA11_99999965062_69753 | Human | Colorectum | MSI-H | 2.95e-07 | 9.19e-01 | 0.3487 |
26037 | SIPA1L1 | HTA11_99999971662_82457 | Human | Colorectum | MSS | 1.31e-18 | -6.61e-01 | 0.3859 |
26037 | SIPA1L1 | HTA11_99999974143_84620 | Human | Colorectum | MSS | 6.13e-25 | -7.23e-01 | 0.3005 |
26037 | SIPA1L1 | F007 | Human | Colorectum | FAP | 1.44e-02 | -1.27e-01 | 0.1176 |
26037 | SIPA1L1 | A001-C-207 | Human | Colorectum | FAP | 5.09e-05 | -4.33e-01 | 0.1278 |
26037 | SIPA1L1 | A015-C-203 | Human | Colorectum | FAP | 1.51e-32 | -5.32e-01 | -0.1294 |
26037 | SIPA1L1 | A015-C-204 | Human | Colorectum | FAP | 4.20e-04 | -2.77e-01 | -0.0228 |
26037 | SIPA1L1 | A014-C-040 | Human | Colorectum | FAP | 2.87e-04 | -3.79e-01 | -0.1184 |
26037 | SIPA1L1 | A002-C-201 | Human | Colorectum | FAP | 2.52e-16 | -4.07e-01 | 0.0324 |
26037 | SIPA1L1 | A001-C-119 | Human | Colorectum | FAP | 1.12e-07 | -4.22e-01 | -0.1557 |
26037 | SIPA1L1 | A001-C-108 | Human | Colorectum | FAP | 1.23e-21 | -4.92e-01 | -0.0272 |
26037 | SIPA1L1 | A002-C-205 | Human | Colorectum | FAP | 2.85e-31 | -5.93e-01 | -0.1236 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:00510566 | Cervix | CC | regulation of small GTPase mediated signal transduction | 75/2311 | 302/18723 | 1.54e-09 | 1.74e-07 | 75 |
GO:00430877 | Cervix | CC | regulation of GTPase activity | 79/2311 | 348/18723 | 4.21e-08 | 2.60e-06 | 79 |
GO:00163587 | Cervix | CC | dendrite development | 58/2311 | 243/18723 | 4.52e-07 | 1.76e-05 | 58 |
GO:00315328 | Cervix | CC | actin cytoskeleton reorganization | 31/2311 | 107/18723 | 3.34e-06 | 8.99e-05 | 31 |
GO:00109757 | Cervix | CC | regulation of neuron projection development | 88/2311 | 445/18723 | 4.26e-06 | 1.09e-04 | 88 |
GO:00609965 | Cervix | CC | dendritic spine development | 28/2311 | 99/18723 | 1.61e-05 | 3.15e-04 | 28 |
GO:00615647 | Cervix | CC | axon development | 89/2311 | 467/18723 | 1.71e-05 | 3.27e-04 | 89 |
GO:00435476 | Cervix | CC | positive regulation of GTPase activity | 53/2311 | 255/18723 | 8.72e-05 | 1.16e-03 | 53 |
GO:00074097 | Cervix | CC | axonogenesis | 78/2311 | 418/18723 | 1.14e-04 | 1.43e-03 | 78 |
GO:00507705 | Cervix | CC | regulation of axonogenesis | 34/2311 | 154/18723 | 4.87e-04 | 4.76e-03 | 34 |
GO:00480131 | Cervix | CC | ephrin receptor signaling pathway | 14/2311 | 51/18723 | 2.78e-03 | 1.87e-02 | 14 |
GO:00488135 | Cervix | CC | dendrite morphogenesis | 30/2311 | 146/18723 | 3.27e-03 | 2.13e-02 | 30 |
GO:01060277 | Cervix | CC | neuron projection organization | 21/2311 | 93/18723 | 4.10e-03 | 2.54e-02 | 21 |
GO:00507733 | Cervix | CC | regulation of dendrite development | 22/2311 | 103/18723 | 6.75e-03 | 3.71e-02 | 22 |
GO:00610014 | Cervix | CC | regulation of dendritic spine morphogenesis | 12/2311 | 47/18723 | 1.01e-02 | 4.91e-02 | 12 |
GO:0043087 | Colorectum | AD | regulation of GTPase activity | 110/3918 | 348/18723 | 1.64e-06 | 5.03e-05 | 110 |
GO:0051056 | Colorectum | AD | regulation of small GTPase mediated signal transduction | 94/3918 | 302/18723 | 1.81e-05 | 3.76e-04 | 94 |
GO:0031532 | Colorectum | AD | actin cytoskeleton reorganization | 41/3918 | 107/18723 | 2.81e-05 | 5.28e-04 | 41 |
GO:0010975 | Colorectum | AD | regulation of neuron projection development | 129/3918 | 445/18723 | 2.88e-05 | 5.37e-04 | 129 |
GO:0007409 | Colorectum | AD | axonogenesis | 122/3918 | 418/18723 | 3.36e-05 | 6.15e-04 | 122 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa0401512 | Cervix | CC | Rap1 signaling pathway | 56/1267 | 210/8465 | 6.23e-06 | 5.61e-05 | 3.32e-05 | 56 |
hsa0401513 | Cervix | CC | Rap1 signaling pathway | 56/1267 | 210/8465 | 6.23e-06 | 5.61e-05 | 3.32e-05 | 56 |
hsa04015 | Colorectum | AD | Rap1 signaling pathway | 71/2092 | 210/8465 | 1.72e-03 | 9.68e-03 | 6.18e-03 | 71 |
hsa040151 | Colorectum | AD | Rap1 signaling pathway | 71/2092 | 210/8465 | 1.72e-03 | 9.68e-03 | 6.18e-03 | 71 |
hsa040152 | Colorectum | SER | Rap1 signaling pathway | 54/1580 | 210/8465 | 6.55e-03 | 3.68e-02 | 2.67e-02 | 54 |
hsa040153 | Colorectum | SER | Rap1 signaling pathway | 54/1580 | 210/8465 | 6.55e-03 | 3.68e-02 | 2.67e-02 | 54 |
hsa040154 | Colorectum | MSS | Rap1 signaling pathway | 66/1875 | 210/8465 | 1.03e-03 | 5.94e-03 | 3.64e-03 | 66 |
hsa040155 | Colorectum | MSS | Rap1 signaling pathway | 66/1875 | 210/8465 | 1.03e-03 | 5.94e-03 | 3.64e-03 | 66 |
hsa040156 | Colorectum | FAP | Rap1 signaling pathway | 53/1404 | 210/8465 | 7.93e-04 | 5.14e-03 | 3.13e-03 | 53 |
hsa040157 | Colorectum | FAP | Rap1 signaling pathway | 53/1404 | 210/8465 | 7.93e-04 | 5.14e-03 | 3.13e-03 | 53 |
hsa040158 | Colorectum | CRC | Rap1 signaling pathway | 48/1091 | 210/8465 | 4.00e-05 | 8.70e-04 | 5.90e-04 | 48 |
hsa040159 | Colorectum | CRC | Rap1 signaling pathway | 48/1091 | 210/8465 | 4.00e-05 | 8.70e-04 | 5.90e-04 | 48 |
hsa0401514 | Endometrium | AEH | Rap1 signaling pathway | 49/1197 | 210/8465 | 2.03e-04 | 1.78e-03 | 1.30e-03 | 49 |
hsa0401515 | Endometrium | AEH | Rap1 signaling pathway | 49/1197 | 210/8465 | 2.03e-04 | 1.78e-03 | 1.30e-03 | 49 |
hsa0401522 | Endometrium | EEC | Rap1 signaling pathway | 49/1237 | 210/8465 | 4.45e-04 | 3.47e-03 | 2.59e-03 | 49 |
hsa0401532 | Endometrium | EEC | Rap1 signaling pathway | 49/1237 | 210/8465 | 4.45e-04 | 3.47e-03 | 2.59e-03 | 49 |
hsa0401510 | Lung | IAC | Rap1 signaling pathway | 41/1053 | 210/8465 | 2.01e-03 | 1.07e-02 | 7.10e-03 | 41 |
hsa0401511 | Lung | IAC | Rap1 signaling pathway | 41/1053 | 210/8465 | 2.01e-03 | 1.07e-02 | 7.10e-03 | 41 |
hsa0401521 | Lung | AIS | Rap1 signaling pathway | 41/961 | 210/8465 | 3.23e-04 | 3.38e-03 | 2.16e-03 | 41 |
hsa0401531 | Lung | AIS | Rap1 signaling pathway | 41/961 | 210/8465 | 3.23e-04 | 3.38e-03 | 2.16e-03 | 41 |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
SIPA1L1 | SNV | Missense_Mutation | rs542018760 | c.502C>T | p.Arg168Cys | p.R168C | O43166 | protein_coding | deleterious(0.03) | probably_damaging(0.99) | TCGA-BR-6801-01 | Stomach | stomach adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
SIPA1L1 | SNV | Missense_Mutation | c.109C>T | p.Arg37Trp | p.R37W | O43166 | protein_coding | deleterious(0) | probably_damaging(0.99) | TCGA-BR-6802-01 | Stomach | stomach adenocarcinoma | Male | >=65 | III/IV | Ancillary | leucovorin | CR | |
SIPA1L1 | SNV | Missense_Mutation | rs113469231 | c.3325G>A | p.Ala1109Thr | p.A1109T | O43166 | protein_coding | tolerated(0.17) | benign(0.006) | TCGA-BR-7707-01 | Stomach | stomach adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
SIPA1L1 | SNV | Missense_Mutation | c.2554G>A | p.Glu852Lys | p.E852K | O43166 | protein_coding | deleterious(0.01) | probably_damaging(0.972) | TCGA-BR-8361-01 | Stomach | stomach adenocarcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD | |
SIPA1L1 | SNV | Missense_Mutation | rs753010914 | c.4505N>T | p.Thr1502Met | p.T1502M | O43166 | protein_coding | deleterious(0.03) | possibly_damaging(0.614) | TCGA-BR-8487-01 | Stomach | stomach adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
SIPA1L1 | SNV | Missense_Mutation | c.1982N>G | p.Leu661Arg | p.L661R | O43166 | protein_coding | deleterious(0) | probably_damaging(0.998) | TCGA-BR-8589-01 | Stomach | stomach adenocarcinoma | Male | <65 | III/IV | Unknown | Unknown | SD | |
SIPA1L1 | SNV | Missense_Mutation | c.2906N>C | p.Asn969Thr | p.N969T | O43166 | protein_coding | deleterious(0.01) | probably_damaging(0.971) | TCGA-BR-8589-01 | Stomach | stomach adenocarcinoma | Male | <65 | III/IV | Unknown | Unknown | SD | |
SIPA1L1 | SNV | Missense_Mutation | c.554T>A | p.Val185Glu | p.V185E | O43166 | protein_coding | tolerated(0.25) | benign(0.038) | TCGA-BR-A4PE-01 | Stomach | stomach adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
SIPA1L1 | SNV | Missense_Mutation | rs146483394 | c.113N>A | p.Arg38His | p.R38H | O43166 | protein_coding | tolerated(0.21) | probably_damaging(0.987) | TCGA-BR-A4QI-01 | Stomach | stomach adenocarcinoma | Female | >=65 | I/II | Chemotherapy | 5-fluorouracil | PD |
SIPA1L1 | SNV | Missense_Mutation | c.1325N>T | p.Cys442Phe | p.C442F | O43166 | protein_coding | tolerated(0.62) | benign(0.015) | TCGA-CD-A486-01 | Stomach | stomach adenocarcinoma | Male | >=65 | I/II | Chemotherapy | taxol | PD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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