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Gene: MIA3 |
Gene summary for MIA3 |
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Gene information | Species | Human | Gene symbol | MIA3 | Gene ID | 375056 |
Gene name | MIA SH3 domain ER export factor 3 | |
Gene Alias | ARNT | |
Cytomap | 1q41 | |
Gene Type | protein-coding | GO ID | GO:0001525 | UniProtAcc | Q5JRA6 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
375056 | MIA3 | LZE2T | Human | Esophagus | ESCC | 5.15e-10 | 6.99e-01 | 0.082 |
375056 | MIA3 | LZE4T | Human | Esophagus | ESCC | 5.61e-15 | 4.75e-01 | 0.0811 |
375056 | MIA3 | LZE5T | Human | Esophagus | ESCC | 3.25e-05 | 5.34e-01 | 0.0514 |
375056 | MIA3 | LZE7T | Human | Esophagus | ESCC | 7.83e-12 | 6.69e-01 | 0.0667 |
375056 | MIA3 | LZE20T | Human | Esophagus | ESCC | 7.03e-08 | 2.04e-01 | 0.0662 |
375056 | MIA3 | LZE22D1 | Human | Esophagus | HGIN | 6.09e-03 | 8.30e-02 | 0.0595 |
375056 | MIA3 | LZE22T | Human | Esophagus | ESCC | 1.58e-05 | 5.56e-01 | 0.068 |
375056 | MIA3 | LZE24T | Human | Esophagus | ESCC | 1.06e-21 | 6.70e-01 | 0.0596 |
375056 | MIA3 | LZE6T | Human | Esophagus | ESCC | 4.92e-03 | 2.37e-01 | 0.0845 |
375056 | MIA3 | P1T-E | Human | Esophagus | ESCC | 2.91e-20 | 7.80e-01 | 0.0875 |
375056 | MIA3 | P2T-E | Human | Esophagus | ESCC | 1.37e-44 | 8.44e-01 | 0.1177 |
375056 | MIA3 | P4T-E | Human | Esophagus | ESCC | 1.47e-11 | 3.95e-01 | 0.1323 |
375056 | MIA3 | P5T-E | Human | Esophagus | ESCC | 2.35e-20 | 3.02e-01 | 0.1327 |
375056 | MIA3 | P8T-E | Human | Esophagus | ESCC | 1.32e-23 | 4.53e-01 | 0.0889 |
375056 | MIA3 | P9T-E | Human | Esophagus | ESCC | 6.11e-15 | 3.93e-01 | 0.1131 |
375056 | MIA3 | P10T-E | Human | Esophagus | ESCC | 1.90e-30 | 5.58e-01 | 0.116 |
375056 | MIA3 | P11T-E | Human | Esophagus | ESCC | 4.21e-19 | 6.70e-01 | 0.1426 |
375056 | MIA3 | P12T-E | Human | Esophagus | ESCC | 1.13e-18 | 3.74e-01 | 0.1122 |
375056 | MIA3 | P15T-E | Human | Esophagus | ESCC | 1.79e-23 | 5.28e-01 | 0.1149 |
375056 | MIA3 | P16T-E | Human | Esophagus | ESCC | 3.00e-24 | 5.53e-01 | 0.1153 |
Page: 1 2 3 4 5 6 7 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:004819317 | Esophagus | HGIN | Golgi vesicle transport | 83/2587 | 296/18723 | 8.59e-11 | 8.89e-09 | 83 |
GO:00068889 | Esophagus | HGIN | endoplasmic reticulum to Golgi vesicle-mediated transport | 40/2587 | 130/18723 | 4.67e-07 | 2.07e-05 | 40 |
GO:000690020 | Esophagus | HGIN | vesicle budding from membrane | 23/2587 | 61/18723 | 2.85e-06 | 9.93e-05 | 23 |
GO:007097210 | Esophagus | HGIN | protein localization to endoplasmic reticulum | 26/2587 | 74/18723 | 3.09e-06 | 1.05e-04 | 26 |
GO:00160509 | Esophagus | HGIN | vesicle organization | 65/2587 | 300/18723 | 1.24e-04 | 2.54e-03 | 65 |
GO:00901146 | Esophagus | HGIN | COPII-coated vesicle budding | 11/2587 | 29/18723 | 1.08e-03 | 1.32e-02 | 11 |
GO:00070295 | Esophagus | HGIN | endoplasmic reticulum organization | 22/2587 | 87/18723 | 3.07e-03 | 2.90e-02 | 22 |
GO:004819318 | Esophagus | ESCC | Golgi vesicle transport | 231/8552 | 296/18723 | 1.82e-30 | 9.63e-28 | 231 |
GO:001605014 | Esophagus | ESCC | vesicle organization | 211/8552 | 300/18723 | 2.85e-18 | 2.87e-16 | 211 |
GO:000688815 | Esophagus | ESCC | endoplasmic reticulum to Golgi vesicle-mediated transport | 102/8552 | 130/18723 | 1.73e-14 | 9.22e-13 | 102 |
GO:0006900111 | Esophagus | ESCC | vesicle budding from membrane | 54/8552 | 61/18723 | 2.66e-12 | 1.07e-10 | 54 |
GO:000702914 | Esophagus | ESCC | endoplasmic reticulum organization | 65/8552 | 87/18723 | 3.28e-08 | 6.08e-07 | 65 |
GO:009011414 | Esophagus | ESCC | COPII-coated vesicle budding | 27/8552 | 29/18723 | 8.09e-08 | 1.39e-06 | 27 |
GO:004206027 | Esophagus | ESCC | wound healing | 243/8552 | 422/18723 | 4.62e-07 | 6.25e-06 | 243 |
GO:007097218 | Esophagus | ESCC | protein localization to endoplasmic reticulum | 52/8552 | 74/18723 | 1.58e-05 | 1.42e-04 | 52 |
GO:00901104 | Esophagus | ESCC | COPII-coated vesicle cargo loading | 14/8552 | 15/18723 | 1.47e-04 | 9.85e-04 | 14 |
GO:002240720 | Esophagus | ESCC | regulation of cell-cell adhesion | 239/8552 | 448/18723 | 5.88e-04 | 3.19e-03 | 239 |
GO:000268316 | Esophagus | ESCC | negative regulation of immune system process | 231/8552 | 434/18723 | 8.48e-04 | 4.36e-03 | 231 |
GO:000166720 | Esophagus | ESCC | ameboidal-type cell migration | 250/8552 | 475/18723 | 1.22e-03 | 5.97e-03 | 250 |
GO:000930617 | Esophagus | ESCC | protein secretion | 190/8552 | 359/18723 | 3.22e-03 | 1.34e-02 | 190 |
Page: 1 2 3 4 5 6 7 8 9 10 11 12 13 14 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
MIA3 | insertion | Frame_Shift_Ins | novel | c.5568_5569insA | p.Gly1857ArgfsTer29 | p.G1857Rfs*29 | Q5JRA6 | protein_coding | TCGA-FY-A4B0-01 | Thyroid | thyroid carcinoma | Male | >=65 | I/II | Hormone Therapy | synthroid | SD | ||
MIA3 | insertion | Frame_Shift_Ins | novel | c.5570_5571insAACGTATTTAAAT | p.Arg1859TyrfsTer31 | p.R1859Yfs*31 | Q5JRA6 | protein_coding | TCGA-FY-A4B0-01 | Thyroid | thyroid carcinoma | Male | >=65 | I/II | Hormone Therapy | synthroid | SD |
Page: 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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