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Gene: TIAM1 |
Gene summary for TIAM1 |
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Gene information | Species | Human | Gene symbol | TIAM1 | Gene ID | 7074 |
Gene name | TIAM Rac1 associated GEF 1 | |
Gene Alias | TIAM-1 | |
Cytomap | 21q22.11 | |
Gene Type | protein-coding | GO ID | GO:0000165 | UniProtAcc | Q13009 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
7074 | TIAM1 | CCI_1 | Human | Cervix | CC | 6.22e-17 | 1.56e+00 | 0.528 |
7074 | TIAM1 | CCI_2 | Human | Cervix | CC | 1.25e-05 | 9.57e-01 | 0.5249 |
7074 | TIAM1 | CCI_3 | Human | Cervix | CC | 2.01e-07 | 7.55e-01 | 0.516 |
7074 | TIAM1 | AEH-subject2 | Human | Endometrium | AEH | 2.67e-03 | 1.57e-01 | -0.2525 |
7074 | TIAM1 | AEH-subject4 | Human | Endometrium | AEH | 7.66e-11 | 4.04e-01 | -0.2657 |
7074 | TIAM1 | AEH-subject5 | Human | Endometrium | AEH | 3.46e-33 | 7.75e-01 | -0.2953 |
7074 | TIAM1 | EEC-subject2 | Human | Endometrium | EEC | 1.59e-10 | 3.41e-01 | -0.2607 |
7074 | TIAM1 | P2T-E | Human | Esophagus | ESCC | 1.20e-14 | 6.68e-02 | 0.1177 |
7074 | TIAM1 | P4T-E | Human | Esophagus | ESCC | 4.06e-04 | 1.12e-01 | 0.1323 |
7074 | TIAM1 | P5T-E | Human | Esophagus | ESCC | 3.41e-07 | 1.05e-02 | 0.1327 |
7074 | TIAM1 | P8T-E | Human | Esophagus | ESCC | 7.87e-05 | -2.35e-02 | 0.0889 |
7074 | TIAM1 | P9T-E | Human | Esophagus | ESCC | 3.79e-04 | 7.92e-02 | 0.1131 |
7074 | TIAM1 | P10T-E | Human | Esophagus | ESCC | 1.07e-49 | 8.69e-01 | 0.116 |
7074 | TIAM1 | P11T-E | Human | Esophagus | ESCC | 5.58e-03 | 9.96e-02 | 0.1426 |
7074 | TIAM1 | P12T-E | Human | Esophagus | ESCC | 3.03e-05 | 6.09e-02 | 0.1122 |
7074 | TIAM1 | P15T-E | Human | Esophagus | ESCC | 8.37e-03 | 1.77e-02 | 0.1149 |
7074 | TIAM1 | P16T-E | Human | Esophagus | ESCC | 5.86e-04 | 2.00e-02 | 0.1153 |
7074 | TIAM1 | P21T-E | Human | Esophagus | ESCC | 3.49e-03 | -7.68e-02 | 0.1617 |
7074 | TIAM1 | P22T-E | Human | Esophagus | ESCC | 3.39e-08 | -4.21e-02 | 0.1236 |
7074 | TIAM1 | P23T-E | Human | Esophagus | ESCC | 2.06e-05 | 1.88e-01 | 0.108 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:00315898 | Cervix | CC | cell-substrate adhesion | 96/2311 | 363/18723 | 1.48e-13 | 8.85e-11 | 96 |
GO:002260410 | Cervix | CC | regulation of cell morphogenesis | 84/2311 | 309/18723 | 1.00e-12 | 4.29e-10 | 84 |
GO:00510566 | Cervix | CC | regulation of small GTPase mediated signal transduction | 75/2311 | 302/18723 | 1.54e-09 | 1.74e-07 | 75 |
GO:00160557 | Cervix | CC | Wnt signaling pathway | 98/2311 | 444/18723 | 4.82e-09 | 4.65e-07 | 98 |
GO:00321035 | Cervix | CC | positive regulation of response to external stimulus | 95/2311 | 427/18723 | 5.44e-09 | 5.03e-07 | 95 |
GO:01987387 | Cervix | CC | cell-cell signaling by wnt | 98/2311 | 446/18723 | 6.16e-09 | 5.58e-07 | 98 |
GO:003367410 | Cervix | CC | positive regulation of kinase activity | 101/2311 | 467/18723 | 8.66e-09 | 7.22e-07 | 101 |
GO:00072656 | Cervix | CC | Ras protein signal transduction | 79/2311 | 337/18723 | 9.49e-09 | 7.77e-07 | 79 |
GO:00071608 | Cervix | CC | cell-matrix adhesion | 60/2311 | 233/18723 | 1.58e-08 | 1.23e-06 | 60 |
GO:00603267 | Cervix | CC | cell chemotaxis | 73/2311 | 310/18723 | 2.82e-08 | 1.96e-06 | 73 |
GO:00301117 | Cervix | CC | regulation of Wnt signaling pathway | 76/2311 | 328/18723 | 3.05e-08 | 2.08e-06 | 76 |
GO:00430877 | Cervix | CC | regulation of GTPase activity | 79/2311 | 348/18723 | 4.21e-08 | 2.60e-06 | 79 |
GO:00458608 | Cervix | CC | positive regulation of protein kinase activity | 85/2311 | 386/18723 | 5.61e-08 | 3.29e-06 | 85 |
GO:005109810 | Cervix | CC | regulation of binding | 80/2311 | 363/18723 | 1.32e-07 | 6.42e-06 | 80 |
GO:00107699 | Cervix | CC | regulation of cell morphogenesis involved in differentiation | 31/2311 | 96/18723 | 2.43e-07 | 1.05e-05 | 31 |
GO:00163587 | Cervix | CC | dendrite development | 58/2311 | 243/18723 | 4.52e-07 | 1.76e-05 | 58 |
GO:00719007 | Cervix | CC | regulation of protein serine/threonine kinase activity | 75/2311 | 359/18723 | 2.76e-06 | 8.02e-05 | 75 |
GO:00109757 | Cervix | CC | regulation of neuron projection development | 88/2311 | 445/18723 | 4.26e-06 | 1.09e-04 | 88 |
GO:00107206 | Cervix | CC | positive regulation of cell development | 64/2311 | 298/18723 | 5.69e-06 | 1.41e-04 | 64 |
GO:00509203 | Cervix | CC | regulation of chemotaxis | 51/2311 | 223/18723 | 8.03e-06 | 1.86e-04 | 51 |
Page: 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa0520516 | Cervix | CC | Proteoglycans in cancer | 60/1267 | 205/8465 | 9.13e-08 | 1.18e-06 | 7.00e-07 | 60 |
hsa0481016 | Cervix | CC | Regulation of actin cytoskeleton | 64/1267 | 229/8465 | 2.24e-07 | 2.59e-06 | 1.53e-06 | 64 |
hsa0453020 | Cervix | CC | Tight junction | 49/1267 | 169/8465 | 1.87e-06 | 1.78e-05 | 1.05e-05 | 49 |
hsa0401512 | Cervix | CC | Rap1 signaling pathway | 56/1267 | 210/8465 | 6.23e-06 | 5.61e-05 | 3.32e-05 | 56 |
hsa040142 | Cervix | CC | Ras signaling pathway | 51/1267 | 236/8465 | 3.55e-03 | 1.34e-02 | 7.91e-03 | 51 |
hsa04062 | Cervix | CC | Chemokine signaling pathway | 43/1267 | 192/8465 | 3.60e-03 | 1.34e-02 | 7.91e-03 | 43 |
hsa0520517 | Cervix | CC | Proteoglycans in cancer | 60/1267 | 205/8465 | 9.13e-08 | 1.18e-06 | 7.00e-07 | 60 |
hsa0481017 | Cervix | CC | Regulation of actin cytoskeleton | 64/1267 | 229/8465 | 2.24e-07 | 2.59e-06 | 1.53e-06 | 64 |
hsa04530110 | Cervix | CC | Tight junction | 49/1267 | 169/8465 | 1.87e-06 | 1.78e-05 | 1.05e-05 | 49 |
hsa0401513 | Cervix | CC | Rap1 signaling pathway | 56/1267 | 210/8465 | 6.23e-06 | 5.61e-05 | 3.32e-05 | 56 |
hsa0401411 | Cervix | CC | Ras signaling pathway | 51/1267 | 236/8465 | 3.55e-03 | 1.34e-02 | 7.91e-03 | 51 |
hsa040621 | Cervix | CC | Chemokine signaling pathway | 43/1267 | 192/8465 | 3.60e-03 | 1.34e-02 | 7.91e-03 | 43 |
hsa0453026 | Endometrium | AEH | Tight junction | 54/1197 | 169/8465 | 1.99e-09 | 3.80e-08 | 2.78e-08 | 54 |
hsa0520518 | Endometrium | AEH | Proteoglycans in cancer | 53/1197 | 205/8465 | 5.43e-06 | 6.53e-05 | 4.78e-05 | 53 |
hsa0401514 | Endometrium | AEH | Rap1 signaling pathway | 49/1197 | 210/8465 | 2.03e-04 | 1.78e-03 | 1.30e-03 | 49 |
hsa0481018 | Endometrium | AEH | Regulation of actin cytoskeleton | 50/1197 | 229/8465 | 9.08e-04 | 5.78e-03 | 4.23e-03 | 50 |
hsa04530112 | Endometrium | AEH | Tight junction | 54/1197 | 169/8465 | 1.99e-09 | 3.80e-08 | 2.78e-08 | 54 |
hsa0520519 | Endometrium | AEH | Proteoglycans in cancer | 53/1197 | 205/8465 | 5.43e-06 | 6.53e-05 | 4.78e-05 | 53 |
hsa0401515 | Endometrium | AEH | Rap1 signaling pathway | 49/1197 | 210/8465 | 2.03e-04 | 1.78e-03 | 1.30e-03 | 49 |
hsa0481019 | Endometrium | AEH | Regulation of actin cytoskeleton | 50/1197 | 229/8465 | 9.08e-04 | 5.78e-03 | 4.23e-03 | 50 |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
TIAM1 | SNV | Missense_Mutation | novel | c.1304G>A | p.Arg435His | p.R435H | Q13009 | protein_coding | deleterious(0) | probably_damaging(0.997) | TCGA-98-A53I-01 | Lung | lung squamous cell carcinoma | Male | <65 | I/II | Chemotherapy | navelbine | SD |
TIAM1 | SNV | Missense_Mutation | c.2753C>T | p.Pro918Leu | p.P918L | Q13009 | protein_coding | tolerated(0.13) | benign(0.003) | TCGA-NC-A5HG-01 | Lung | lung squamous cell carcinoma | Male | <65 | III/IV | Chemotherapy | cisplatin | CR | |
TIAM1 | SNV | Missense_Mutation | rs146528832 | c.1511N>T | p.Ala504Val | p.A504V | Q13009 | protein_coding | deleterious(0) | benign(0.171) | TCGA-BA-A6DD-01 | Oral cavity | head & neck squamous cell carcinoma | Male | <65 | I/II | Chemotherapy | cisplatin | PD |
TIAM1 | SNV | Missense_Mutation | novel | c.65G>A | p.Gly22Glu | p.G22E | Q13009 | protein_coding | deleterious_low_confidence(0.02) | benign(0.073) | TCGA-BB-A5HZ-01 | Oral cavity | head & neck squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | PD |
TIAM1 | SNV | Missense_Mutation | novel | c.3933N>C | p.Lys1311Asn | p.K1311N | Q13009 | protein_coding | deleterious(0) | possibly_damaging(0.804) | TCGA-CN-4723-01 | Oral cavity | head & neck squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
TIAM1 | SNV | Missense_Mutation | novel | c.19N>G | p.Gln7Glu | p.Q7E | Q13009 | protein_coding | deleterious_low_confidence(0) | benign(0.282) | TCGA-CN-5369-01 | Oral cavity | head & neck squamous cell carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
TIAM1 | SNV | Missense_Mutation | novel | c.1190N>G | p.Asn397Ser | p.N397S | Q13009 | protein_coding | tolerated(0.15) | benign(0.001) | TCGA-CN-6992-01 | Oral cavity | head & neck squamous cell carcinoma | Male | <65 | I/II | Chemotherapy | cisplatin | SD |
TIAM1 | SNV | Missense_Mutation | novel | c.3539C>T | p.Ser1180Phe | p.S1180F | Q13009 | protein_coding | deleterious(0.01) | possibly_damaging(0.501) | TCGA-CR-6472-01 | Oral cavity | head & neck squamous cell carcinoma | Male | <65 | I/II | Chemotherapy | paclitaxel | SD |
TIAM1 | SNV | Missense_Mutation | rs760689982 | c.2713N>A | p.Ala905Thr | p.A905T | Q13009 | protein_coding | tolerated(0.63) | benign(0) | TCGA-CV-6935-01 | Oral cavity | head & neck squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | PD |
TIAM1 | SNV | Missense_Mutation | rs781362985 | c.1958N>A | p.Arg653His | p.R653H | Q13009 | protein_coding | deleterious(0) | possibly_damaging(0.834) | TCGA-F7-A624-01 | Oral cavity | head & neck squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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