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Gene: NCAM2 |
Gene summary for NCAM2 |
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Gene information | Species | Human | Gene symbol | NCAM2 | Gene ID | 4685 |
Gene name | neural cell adhesion molecule 2 | |
Gene Alias | NCAM21 | |
Cytomap | 21q21.1 | |
Gene Type | protein-coding | GO ID | GO:0003008 | UniProtAcc | O15394 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
4685 | NCAM2 | RNA-P18T-P18T-2 | Human | Lung | IAC | 5.73e-08 | 1.43e+00 | 0.1129 |
4685 | NCAM2 | RNA-P18T-P18T-6 | Human | Lung | IAC | 1.73e-02 | 8.59e-01 | 0.0856 |
4685 | NCAM2 | RNA-P18T-P18T-8 | Human | Lung | IAC | 7.36e-03 | 8.75e-01 | 0.1151 |
4685 | NCAM2 | RNA-P3T-P3T-1 | Human | Lung | IAC | 8.87e-03 | 3.77e-01 | 0.1829 |
4685 | NCAM2 | RNA-P3T-P3T-4 | Human | Lung | IAC | 1.67e-02 | 3.62e-01 | 0.1859 |
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Tissue | Expression Dynamics | Abbreviation |
Lung | ![]() | AAH: Atypical adenomatous hyperplasia |
AIS: Adenocarcinoma in situ | ||
IAC: Invasive lung adenocarcinoma | ||
MIA: Minimally invasive adenocarcinoma |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:00615646 | Lung | IAC | axon development | 78/2061 | 467/18723 | 1.12e-04 | 2.15e-03 | 78 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa045146 | Lung | IAC | Cell adhesion molecules | 30/1053 | 157/8465 | 1.03e-02 | 3.83e-02 | 2.54e-02 | 30 |
hsa0451411 | Lung | IAC | Cell adhesion molecules | 30/1053 | 157/8465 | 1.03e-02 | 3.83e-02 | 2.54e-02 | 30 |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
NCAM1 | NCAM2 | NCAM1_NCAM2 | NCAM | CRC | ADJ |
NCAM1 | NCAM2 | NCAM1_NCAM2 | NCAM | CRC | FAP |
NCAM1 | NCAM2 | NCAM1_NCAM2 | NCAM | Esophagus | ESCC |
NCAM2 | L1CAM | NCAM2_L1CAM | NCAM | Esophagus | ESCC |
NCAM1 | NCAM2 | NCAM1_NCAM2 | NCAM | GC | ADJ |
NCAM1 | NCAM2 | NCAM1_NCAM2 | NCAM | GC | GC |
NCAM1 | NCAM2 | NCAM1_NCAM2 | NCAM | Liver | Healthy |
NCAM1 | NCAM2 | NCAM1_NCAM2 | NCAM | Lung | MIAC |
NCAM1 | NCAM2 | NCAM1_NCAM2 | NCAM | Skin | SCCIS |
NCAM2 | L1CAM | NCAM2_L1CAM | NCAM | Skin | SCCIS |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
NCAM2 | SNV | Missense_Mutation | c.2273N>T | p.Ala758Val | p.A758V | O15394 | protein_coding | deleterious(0) | benign(0.197) | TCGA-F1-6874-01 | Stomach | stomach adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
NCAM2 | SNV | Missense_Mutation | rs763784898 | c.721G>A | p.Ala241Thr | p.A241T | O15394 | protein_coding | tolerated(1) | benign(0) | TCGA-HU-8602-01 | Stomach | stomach adenocarcinoma | Female | <65 | I/II | Chemotherapy | xeloda | CR |
NCAM2 | SNV | Missense_Mutation | c.2411N>T | p.Pro804Leu | p.P804L | O15394 | protein_coding | tolerated(0.14) | benign(0.028) | TCGA-HU-A4H4-01 | Stomach | stomach adenocarcinoma | Female | <65 | I/II | Chemotherapy | ts-1 | CR | |
NCAM2 | SNV | Missense_Mutation | novel | c.1043A>G | p.Lys348Arg | p.K348R | O15394 | protein_coding | deleterious(0) | possibly_damaging(0.868) | TCGA-IN-A7NT-01 | Stomach | stomach adenocarcinoma | Female | >=65 | I/II | Chemotherapy | leucovorin | SD |
NCAM2 | SNV | Missense_Mutation | novel | c.842N>A | p.Cys281Tyr | p.C281Y | O15394 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-MX-A5UJ-01 | Stomach | stomach adenocarcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD |
NCAM2 | SNV | Missense_Mutation | c.226T>A | p.Ser76Thr | p.S76T | O15394 | protein_coding | deleterious(0) | probably_damaging(0.995) | TCGA-SW-A7EB-01 | Stomach | stomach adenocarcinoma | Male | <65 | III/IV | Chemotherapy | fluorouracil | SD | |
NCAM2 | SNV | Missense_Mutation | novel | c.212A>T | p.Lys71Met | p.K71M | O15394 | protein_coding | deleterious(0.02) | possibly_damaging(0.853) | TCGA-VQ-A8PH-01 | Stomach | stomach adenocarcinoma | Male | <65 | III/IV | Unknown | Unknown | PD |
NCAM2 | insertion | Nonsense_Mutation | novel | c.334_335insTAAAAATATTTGTTTGA | p.Tyr112LeufsTer6 | p.Y112Lfs*6 | O15394 | protein_coding | TCGA-DJ-A3VL-01 | Thyroid | thyroid carcinoma | Male | <65 | I/II | Unknown | Unknown | PD | ||
NCAM2 | insertion | Frame_Shift_Ins | novel | c.1157_1158insGGTGACCAAACATATAACATTA | p.Ile386MetfsTer18 | p.I386Mfs*18 | O15394 | protein_coding | TCGA-EL-A3ZG-01 | Thyroid | thyroid carcinoma | Male | <65 | I/II | Unknown | Unknown | SD | ||
NCAM2 | insertion | Frame_Shift_Ins | novel | c.295_296insTGGAAAAT | p.Lys99MetfsTer12 | p.K99Mfs*12 | O15394 | protein_coding | TCGA-EL-A3ZM-01 | Thyroid | thyroid carcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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