![]() |
|||||
|
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() |
Gene: MUC3A |
Gene summary for MUC3A |
![]() |
Gene information | Species | Human | Gene symbol | MUC3A | Gene ID | 4584 |
Gene name | mucin 3A, cell surface associated | |
Gene Alias | MUC-3A | |
Cytomap | 7q22.1 | |
Gene Type | protein-coding | GO ID | GO:0005575 | UniProtAcc | Q02505 |
Top |
Malignant transformation analysis |
![]() |
![]() |
Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
4584 | MUC3A | HTA11_2487_2000001011 | Human | Colorectum | SER | 6.49e-27 | 1.05e+00 | -0.1808 |
4584 | MUC3A | HTA11_1938_2000001011 | Human | Colorectum | AD | 1.07e-02 | 3.51e-01 | -0.0811 |
4584 | MUC3A | HTA11_347_2000001011 | Human | Colorectum | AD | 1.80e-37 | 9.77e-01 | -0.1954 |
4584 | MUC3A | HTA11_411_2000001011 | Human | Colorectum | SER | 1.22e-14 | 1.51e+00 | -0.2602 |
4584 | MUC3A | HTA11_2112_2000001011 | Human | Colorectum | SER | 4.54e-11 | 1.11e+00 | -0.2196 |
4584 | MUC3A | HTA11_3361_2000001011 | Human | Colorectum | AD | 1.97e-13 | 5.99e-01 | -0.1207 |
4584 | MUC3A | HTA11_83_2000001011 | Human | Colorectum | SER | 1.21e-03 | 5.10e-01 | -0.1526 |
4584 | MUC3A | HTA11_696_2000001011 | Human | Colorectum | AD | 9.71e-55 | 1.46e+00 | -0.1464 |
4584 | MUC3A | HTA11_866_2000001011 | Human | Colorectum | AD | 5.43e-17 | 6.43e-01 | -0.1001 |
4584 | MUC3A | HTA11_1391_2000001011 | Human | Colorectum | AD | 1.69e-21 | 8.30e-01 | -0.059 |
4584 | MUC3A | HTA11_2992_2000001011 | Human | Colorectum | SER | 9.18e-13 | 1.20e+00 | -0.1706 |
4584 | MUC3A | HTA11_5212_2000001011 | Human | Colorectum | AD | 4.45e-04 | 4.69e-01 | -0.2061 |
4584 | MUC3A | HTA11_546_2000001011 | Human | Colorectum | AD | 2.90e-09 | 6.74e-01 | -0.0842 |
4584 | MUC3A | HTA11_7862_2000001011 | Human | Colorectum | AD | 8.19e-04 | 4.74e-01 | -0.0179 |
4584 | MUC3A | HTA11_866_3004761011 | Human | Colorectum | AD | 7.58e-10 | 4.95e-01 | 0.096 |
4584 | MUC3A | HTA11_9408_2000001011 | Human | Colorectum | AD | 9.75e-12 | 1.12e+00 | 0.0451 |
4584 | MUC3A | HTA11_8622_2000001021 | Human | Colorectum | SER | 3.42e-06 | 7.06e-01 | 0.0528 |
4584 | MUC3A | HTA11_7663_2000001011 | Human | Colorectum | SER | 1.48e-04 | 8.80e-01 | 0.0131 |
4584 | MUC3A | HTA11_10623_2000001011 | Human | Colorectum | AD | 2.33e-07 | 6.82e-01 | -0.0177 |
4584 | MUC3A | HTA11_6801_2000001011 | Human | Colorectum | SER | 1.71e-04 | 7.38e-01 | 0.0171 |
Page: 1 2 3 |
![]() |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
Top |
Malignant transformation related pathway analysis |
![]() |
![]() |
Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
![]() |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
Page: 1 |
![]() |
Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
Page: 1 |
Top |
Cell-cell communication analysis |
![]() |
Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
Page: 1 |
Top |
Single-cell gene regulatory network inference analysis |
![]() |
TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
Page: 1 |
Top |
Somatic mutation of malignant transformation related genes |
![]() |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
MUC3A | SNV | Missense_Mutation | novel | c.9675N>T | p.Arg3225Ser | p.R3225S | Q02505 | protein_coding | deleterious_low_confidence(0.03) | possibly_damaging(0.661) | TCGA-D7-A4YV-01 | Stomach | stomach adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
MUC3A | SNV | Missense_Mutation | novel | c.7634N>G | p.Ser2545Cys | p.S2545C | Q02505 | protein_coding | deleterious_low_confidence(0.02) | unknown(0) | TCGA-D7-A74A-01 | Stomach | stomach adenocarcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
MUC3A | SNV | Missense_Mutation | novel | c.7628N>G | p.Thr2543Ser | p.T2543S | Q02505 | protein_coding | tolerated_low_confidence(0.05) | unknown(0) | TCGA-F1-6875-01 | Stomach | stomach adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
MUC3A | SNV | Missense_Mutation | rs762561742 | c.9011N>G | p.Tyr3004Cys | p.Y3004C | Q02505 | protein_coding | deleterious_low_confidence(0) | probably_damaging(0.957) | TCGA-F1-6875-01 | Stomach | stomach adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
MUC3A | SNV | Missense_Mutation | novel | c.6271N>G | p.Leu2091Val | p.L2091V | Q02505 | protein_coding | tolerated_low_confidence(0.58) | unknown(0) | TCGA-FP-8631-01 | Stomach | stomach adenocarcinoma | Male | >=65 | III/IV | Unknown | Unknown | SD |
MUC3A | SNV | Missense_Mutation | rs759534118 | c.8921G>A | p.Gly2974Glu | p.G2974E | Q02505 | protein_coding | deleterious_low_confidence(0.04) | probably_damaging(0.996) | TCGA-HU-A4G6-01 | Stomach | stomach adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
MUC3A | SNV | Missense_Mutation | novel | c.7705A>G | p.Ser2569Gly | p.S2569G | Q02505 | protein_coding | deleterious_low_confidence(0) | benign(0.129) | TCGA-HU-A4GH-01 | Stomach | stomach adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
MUC3A | SNV | Missense_Mutation | novel | c.6374N>G | p.Pro2125Arg | p.P2125R | Q02505 | protein_coding | deleterious_low_confidence(0) | unknown(0) | TCGA-R5-A805-01 | Stomach | stomach adenocarcinoma | Male | >=65 | III/IV | Unknown | Unknown | PD |
MUC3A | SNV | Missense_Mutation | novel | c.6590N>G | p.Thr2197Ser | p.T2197S | Q02505 | protein_coding | deleterious_low_confidence(0) | unknown(0) | TCGA-RD-A8N6-01 | Stomach | stomach adenocarcinoma | Female | >=65 | III/IV | Unknown | Unknown | PD |
MUC3A | SNV | Missense_Mutation | novel | c.8410N>C | p.Thr2804Pro | p.T2804P | Q02505 | protein_coding | deleterious_low_confidence(0.05) | benign(0) | TCGA-VQ-A8P2-01 | Stomach | stomach adenocarcinoma | Male | >=65 | III/IV | Unspecific | Complete Response |
Page: 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 |
Top |
Related drugs of malignant transformation related genes |
![]() |
(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
Page: 1 |