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Gene: DSP |
Gene summary for DSP |
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Gene information | Species | Human | Gene symbol | DSP | Gene ID | 1832 |
Gene name | desmoplakin | |
Gene Alias | DCWHKTA | |
Cytomap | 6p24.3 | |
Gene Type | protein-coding | GO ID | GO:0001508 | UniProtAcc | B4DKX6 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
1832 | DSP | GSM4909282 | Human | Breast | IDC | 8.91e-04 | 3.32e-01 | -0.0288 |
1832 | DSP | GSM4909285 | Human | Breast | IDC | 4.85e-23 | 6.21e-01 | 0.21 |
1832 | DSP | GSM4909286 | Human | Breast | IDC | 1.56e-11 | 4.37e-01 | 0.1081 |
1832 | DSP | GSM4909293 | Human | Breast | IDC | 3.85e-47 | 8.59e-01 | 0.1581 |
1832 | DSP | GSM4909296 | Human | Breast | IDC | 2.09e-10 | -5.99e-02 | 0.1524 |
1832 | DSP | GSM4909297 | Human | Breast | IDC | 4.09e-14 | 5.84e-02 | 0.1517 |
1832 | DSP | GSM4909298 | Human | Breast | IDC | 2.03e-28 | 7.22e-01 | 0.1551 |
1832 | DSP | GSM4909303 | Human | Breast | IDC | 4.14e-02 | 3.78e-01 | 0.0438 |
1832 | DSP | GSM4909304 | Human | Breast | IDC | 5.66e-06 | 3.83e-01 | 0.1636 |
1832 | DSP | GSM4909306 | Human | Breast | IDC | 2.62e-05 | 4.26e-01 | 0.1564 |
1832 | DSP | GSM4909307 | Human | Breast | IDC | 1.00e-11 | 5.19e-01 | 0.1569 |
1832 | DSP | GSM4909308 | Human | Breast | IDC | 1.03e-41 | 7.82e-01 | 0.158 |
1832 | DSP | GSM4909309 | Human | Breast | IDC | 2.35e-02 | 1.91e-01 | 0.0483 |
1832 | DSP | GSM4909311 | Human | Breast | IDC | 7.71e-30 | -6.88e-02 | 0.1534 |
1832 | DSP | GSM4909312 | Human | Breast | IDC | 1.71e-04 | -5.47e-02 | 0.1552 |
1832 | DSP | GSM4909313 | Human | Breast | IDC | 4.61e-04 | 1.27e-01 | 0.0391 |
1832 | DSP | GSM4909315 | Human | Breast | IDC | 5.37e-10 | 3.70e-01 | 0.21 |
1832 | DSP | GSM4909317 | Human | Breast | IDC | 9.31e-09 | 4.40e-01 | 0.1355 |
1832 | DSP | GSM4909319 | Human | Breast | IDC | 1.84e-33 | -5.20e-01 | 0.1563 |
1832 | DSP | GSM4909320 | Human | Breast | IDC | 1.75e-04 | -3.53e-01 | 0.1575 |
Page: 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:00341099 | Breast | Precancer | homotypic cell-cell adhesion | 18/1080 | 90/18723 | 3.15e-06 | 1.03e-04 | 18 |
GO:00420609 | Breast | Precancer | wound healing | 48/1080 | 422/18723 | 5.48e-06 | 1.63e-04 | 48 |
GO:00329709 | Breast | Precancer | regulation of actin filament-based process | 42/1080 | 397/18723 | 1.11e-04 | 2.01e-03 | 42 |
GO:0045104 | Breast | Precancer | intermediate filament cytoskeleton organization | 11/1080 | 51/18723 | 1.26e-04 | 2.22e-03 | 11 |
GO:0045103 | Breast | Precancer | intermediate filament-based process | 11/1080 | 52/18723 | 1.52e-04 | 2.60e-03 | 11 |
GO:00085445 | Breast | Precancer | epidermis development | 35/1080 | 324/18723 | 2.71e-04 | 3.96e-03 | 35 |
GO:00099136 | Breast | Precancer | epidermal cell differentiation | 23/1080 | 202/18723 | 1.43e-03 | 1.50e-02 | 23 |
GO:00302163 | Breast | Precancer | keratinocyte differentiation | 17/1080 | 139/18723 | 2.71e-03 | 2.39e-02 | 17 |
GO:00605374 | Breast | Precancer | muscle tissue development | 37/1080 | 403/18723 | 3.60e-03 | 2.98e-02 | 37 |
GO:00147063 | Breast | Precancer | striated muscle tissue development | 35/1080 | 384/18723 | 5.10e-03 | 3.83e-02 | 35 |
GO:00860654 | Breast | Precancer | cell communication involved in cardiac conduction | 9/1080 | 58/18723 | 5.67e-03 | 4.08e-02 | 9 |
GO:003297014 | Breast | IDC | regulation of actin filament-based process | 56/1434 | 397/18723 | 6.37e-06 | 1.99e-04 | 56 |
GO:003410913 | Breast | IDC | homotypic cell-cell adhesion | 20/1434 | 90/18723 | 1.20e-05 | 3.17e-04 | 20 |
GO:004206014 | Breast | IDC | wound healing | 55/1434 | 422/18723 | 7.27e-05 | 1.45e-03 | 55 |
GO:008606511 | Breast | IDC | cell communication involved in cardiac conduction | 13/1434 | 58/18723 | 3.59e-04 | 5.18e-03 | 13 |
GO:006053711 | Breast | IDC | muscle tissue development | 50/1434 | 403/18723 | 4.91e-04 | 6.45e-03 | 50 |
GO:000854412 | Breast | IDC | epidermis development | 41/1434 | 324/18723 | 1.03e-03 | 1.14e-02 | 41 |
GO:00451041 | Breast | IDC | intermediate filament cytoskeleton organization | 11/1434 | 51/18723 | 1.40e-03 | 1.44e-02 | 11 |
GO:000991312 | Breast | IDC | epidermal cell differentiation | 28/1434 | 202/18723 | 1.62e-03 | 1.60e-02 | 28 |
GO:00451031 | Breast | IDC | intermediate filament-based process | 11/1434 | 52/18723 | 1.66e-03 | 1.63e-02 | 11 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa054127 | Cervix | HSIL_HPV | Arrhythmogenic right ventricular cardiomyopathy | 10/459 | 77/8465 | 8.34e-03 | 4.70e-02 | 3.80e-02 | 10 |
hsa0541212 | Cervix | HSIL_HPV | Arrhythmogenic right ventricular cardiomyopathy | 10/459 | 77/8465 | 8.34e-03 | 4.70e-02 | 3.80e-02 | 10 |
hsa05412 | Colorectum | FAP | Arrhythmogenic right ventricular cardiomyopathy | 23/1404 | 77/8465 | 2.58e-03 | 1.19e-02 | 7.23e-03 | 23 |
hsa054121 | Colorectum | FAP | Arrhythmogenic right ventricular cardiomyopathy | 23/1404 | 77/8465 | 2.58e-03 | 1.19e-02 | 7.23e-03 | 23 |
hsa054122 | Colorectum | CRC | Arrhythmogenic right ventricular cardiomyopathy | 18/1091 | 77/8465 | 7.90e-03 | 3.77e-02 | 2.55e-02 | 18 |
hsa054123 | Colorectum | CRC | Arrhythmogenic right ventricular cardiomyopathy | 18/1091 | 77/8465 | 7.90e-03 | 3.77e-02 | 2.55e-02 | 18 |
hsa054126 | Lung | IAC | Arrhythmogenic right ventricular cardiomyopathy | 22/1053 | 77/8465 | 1.15e-04 | 1.49e-03 | 9.88e-04 | 22 |
hsa0541211 | Lung | IAC | Arrhythmogenic right ventricular cardiomyopathy | 22/1053 | 77/8465 | 1.15e-04 | 1.49e-03 | 9.88e-04 | 22 |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
DSP | SNV | Missense_Mutation | rs753652255 | c.4805N>A | p.Arg1602Lys | p.R1602K | P15924 | protein_coding | tolerated(0.4) | benign(0.344) | TCGA-44-A47B-01 | Lung | lung adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
DSP | SNV | Missense_Mutation | c.5583N>T | p.Gln1861His | p.Q1861H | P15924 | protein_coding | tolerated(0.12) | benign(0.005) | TCGA-55-A490-01 | Lung | lung adenocarcinoma | Male | >=65 | I/II | Chemotherapy | carboplatin | SD | |
DSP | SNV | Missense_Mutation | novel | c.6038G>T | p.Arg2013Leu | p.R2013L | P15924 | protein_coding | tolerated(0.23) | benign(0.097) | TCGA-62-8399-01 | Lung | lung adenocarcinoma | Male | <65 | III/IV | Unknown | Unknown | SD |
DSP | SNV | Missense_Mutation | c.3115G>C | p.Glu1039Gln | p.E1039Q | P15924 | protein_coding | deleterious(0.01) | probably_damaging(0.922) | TCGA-62-A46O-01 | Lung | lung adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | PD | |
DSP | SNV | Missense_Mutation | novel | c.1538N>A | p.Pro513His | p.P513H | P15924 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-78-7145-01 | Lung | lung adenocarcinoma | Female | <65 | III/IV | Chemotherapy | cisplatin | PD |
DSP | SNV | Missense_Mutation | c.4693N>C | p.Glu1565Gln | p.E1565Q | P15924 | protein_coding | tolerated(0.15) | benign(0.283) | TCGA-78-7150-01 | Lung | lung adenocarcinoma | Male | <65 | I/II | Chemotherapy | carboplatin | PD | |
DSP | SNV | Missense_Mutation | rs778162217 | c.6097G>A | p.Glu2033Lys | p.E2033K | P15924 | protein_coding | deleterious(0.01) | benign(0.237) | TCGA-78-7155-01 | Lung | lung adenocarcinoma | Male | >=65 | I/II | Chemotherapy | carboplatin | PD |
DSP | SNV | Missense_Mutation | c.898G>T | p.Asp300Tyr | p.D300Y | P15924 | protein_coding | deleterious(0) | probably_damaging(0.993) | TCGA-86-8073-01 | Lung | lung adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD | |
DSP | SNV | Missense_Mutation | c.2534A>C | p.Gln845Pro | p.Q845P | P15924 | protein_coding | tolerated(0.27) | benign(0.139) | TCGA-86-8073-01 | Lung | lung adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD | |
DSP | SNV | Missense_Mutation | c.7089C>A | p.His2363Gln | p.H2363Q | P15924 | protein_coding | deleterious(0.01) | possibly_damaging(0.469) | TCGA-86-8073-01 | Lung | lung adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
1832 | DSP | NA | ENALAPRIL | ENALAPRIL | 10839195 |
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