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Gene: TRIO |
Gene summary for TRIO |
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Gene information | Species | Human | Gene symbol | TRIO | Gene ID | 7204 |
Gene name | trio Rho guanine nucleotide exchange factor | |
Gene Alias | ARHGEF23 | |
Cytomap | 5p15.2 | |
Gene Type | protein-coding | GO ID | GO:0000902 | UniProtAcc | O75962 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
7204 | TRIO | CCI_1 | Human | Cervix | CC | 5.17e-17 | 1.46e+00 | 0.528 |
7204 | TRIO | CCI_2 | Human | Cervix | CC | 5.32e-14 | 1.68e+00 | 0.5249 |
7204 | TRIO | CCI_3 | Human | Cervix | CC | 1.84e-20 | 1.43e+00 | 0.516 |
7204 | TRIO | CCII_1 | Human | Cervix | CC | 7.42e-05 | 4.93e-01 | 0.3249 |
7204 | TRIO | HTA11_3410_2000001011 | Human | Colorectum | AD | 7.88e-11 | -3.83e-01 | 0.0155 |
7204 | TRIO | HTA11_2487_2000001011 | Human | Colorectum | SER | 3.20e-05 | -4.34e-01 | -0.1808 |
7204 | TRIO | HTA11_347_2000001011 | Human | Colorectum | AD | 6.55e-08 | 5.41e-01 | -0.1954 |
7204 | TRIO | HTA11_7663_2000001011 | Human | Colorectum | SER | 7.90e-04 | 6.52e-01 | 0.0131 |
7204 | TRIO | HTA11_6801_2000001011 | Human | Colorectum | SER | 4.21e-03 | 2.43e-01 | 0.0171 |
7204 | TRIO | HTA11_6818_2000001021 | Human | Colorectum | AD | 9.96e-05 | 5.12e-01 | 0.0588 |
7204 | TRIO | HTA11_99999965104_69814 | Human | Colorectum | MSS | 7.47e-06 | 5.18e-01 | 0.281 |
7204 | TRIO | HTA11_99999971662_82457 | Human | Colorectum | MSS | 4.51e-06 | 6.49e-01 | 0.3859 |
7204 | TRIO | HTA11_99999974143_84620 | Human | Colorectum | MSS | 1.83e-04 | -3.28e-01 | 0.3005 |
7204 | TRIO | A015-C-203 | Human | Colorectum | FAP | 3.69e-30 | -5.52e-01 | -0.1294 |
7204 | TRIO | A015-C-204 | Human | Colorectum | FAP | 4.60e-03 | -2.52e-01 | -0.0228 |
7204 | TRIO | A014-C-040 | Human | Colorectum | FAP | 4.85e-02 | -1.67e-01 | -0.1184 |
7204 | TRIO | A002-C-201 | Human | Colorectum | FAP | 7.52e-16 | -4.33e-01 | 0.0324 |
7204 | TRIO | A001-C-119 | Human | Colorectum | FAP | 4.33e-09 | -4.61e-01 | -0.1557 |
7204 | TRIO | A001-C-108 | Human | Colorectum | FAP | 1.38e-11 | -3.11e-01 | -0.0272 |
7204 | TRIO | A002-C-205 | Human | Colorectum | FAP | 3.95e-30 | -5.90e-01 | -0.1236 |
Page: 1 2 3 4 5 6 7 8 9 10 11 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:00510566 | Cervix | CC | regulation of small GTPase mediated signal transduction | 75/2311 | 302/18723 | 1.54e-09 | 1.74e-07 | 75 |
GO:00454445 | Cervix | CC | fat cell differentiation | 53/2311 | 229/18723 | 3.72e-06 | 9.75e-05 | 53 |
GO:00615647 | Cervix | CC | axon development | 89/2311 | 467/18723 | 1.71e-05 | 3.27e-04 | 89 |
GO:00074097 | Cervix | CC | axonogenesis | 78/2311 | 418/18723 | 1.14e-04 | 1.43e-03 | 78 |
GO:0045598 | Cervix | CC | regulation of fat cell differentiation | 31/2311 | 139/18723 | 7.06e-04 | 6.41e-03 | 31 |
GO:0007015 | Colorectum | AD | actin filament organization | 167/3918 | 442/18723 | 1.65e-16 | 7.94e-14 | 167 |
GO:0032535 | Colorectum | AD | regulation of cellular component size | 142/3918 | 383/18723 | 1.74e-13 | 3.41e-11 | 142 |
GO:1902903 | Colorectum | AD | regulation of supramolecular fiber organization | 139/3918 | 383/18723 | 2.01e-12 | 3.19e-10 | 139 |
GO:0032970 | Colorectum | AD | regulation of actin filament-based process | 142/3918 | 397/18723 | 4.05e-12 | 5.90e-10 | 142 |
GO:0110053 | Colorectum | AD | regulation of actin filament organization | 108/3918 | 278/18723 | 5.02e-12 | 6.98e-10 | 108 |
GO:0008154 | Colorectum | AD | actin polymerization or depolymerization | 90/3918 | 218/18723 | 6.14e-12 | 8.23e-10 | 90 |
GO:0032271 | Colorectum | AD | regulation of protein polymerization | 94/3918 | 233/18723 | 1.01e-11 | 1.29e-09 | 94 |
GO:0030041 | Colorectum | AD | actin filament polymerization | 81/3918 | 191/18723 | 1.35e-11 | 1.69e-09 | 81 |
GO:0051258 | Colorectum | AD | protein polymerization | 112/3918 | 297/18723 | 1.85e-11 | 2.27e-09 | 112 |
GO:0043254 | Colorectum | AD | regulation of protein-containing complex assembly | 148/3918 | 428/18723 | 2.64e-11 | 3.18e-09 | 148 |
GO:0002064 | Colorectum | AD | epithelial cell development | 89/3918 | 220/18723 | 2.98e-11 | 3.52e-09 | 89 |
GO:0008064 | Colorectum | AD | regulation of actin polymerization or depolymerization | 79/3918 | 188/18723 | 4.17e-11 | 4.74e-09 | 79 |
GO:0030833 | Colorectum | AD | regulation of actin filament polymerization | 74/3918 | 172/18723 | 4.50e-11 | 5.03e-09 | 74 |
GO:0030832 | Colorectum | AD | regulation of actin filament length | 79/3918 | 189/18723 | 5.71e-11 | 6.27e-09 | 79 |
GO:0032956 | Colorectum | AD | regulation of actin cytoskeleton organization | 127/3918 | 358/18723 | 1.03e-10 | 1.04e-08 | 127 |
Page: 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
TRIO | SNV | Missense_Mutation | c.6075N>C | p.Trp2025Cys | p.W2025C | O75962 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-64-5778-01 | Lung | lung adenocarcinoma | Male | <65 | I/II | Targeted Molecular therapy | tarceva | PD | |
TRIO | SNV | Missense_Mutation | c.2433N>C | p.Gln811His | p.Q811H | O75962 | protein_coding | tolerated(0.17) | benign(0.359) | TCGA-67-3771-01 | Lung | lung adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
TRIO | SNV | Missense_Mutation | c.2120A>T | p.Gln707Leu | p.Q707L | O75962 | protein_coding | deleterious(0) | possibly_damaging(0.901) | TCGA-69-7979-01 | Lung | lung adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
TRIO | SNV | Missense_Mutation | c.1854G>T | p.Gln618His | p.Q618H | O75962 | protein_coding | deleterious(0) | probably_damaging(0.995) | TCGA-73-4659-01 | Lung | lung adenocarcinoma | Male | >=65 | III/IV | Chemotherapy | alimta | PD | |
TRIO | SNV | Missense_Mutation | c.1053N>T | p.Lys351Asn | p.K351N | O75962 | protein_coding | deleterious(0) | probably_damaging(0.997) | TCGA-78-7147-01 | Lung | lung adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | PD | |
TRIO | SNV | Missense_Mutation | c.4967N>T | p.Gly1656Val | p.G1656V | O75962 | protein_coding | deleterious(0) | probably_damaging(0.998) | TCGA-86-8073-01 | Lung | lung adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD | |
TRIO | SNV | Missense_Mutation | c.8084N>A | p.Thr2695Lys | p.T2695K | O75962 | protein_coding | deleterious(0) | probably_damaging(0.99) | TCGA-86-8279-01 | Lung | lung adenocarcinoma | Male | <65 | I/II | Chemotherapy | etoposide | CR | |
TRIO | SNV | Missense_Mutation | c.6024N>C | p.Met2008Ile | p.M2008I | O75962 | protein_coding | tolerated(0.21) | benign(0.071) | TCGA-93-8067-01 | Lung | lung adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
TRIO | SNV | Missense_Mutation | novel | c.3367N>T | p.Val1123Leu | p.V1123L | O75962 | protein_coding | deleterious(0.01) | probably_damaging(0.97) | TCGA-97-7546-01 | Lung | lung adenocarcinoma | Female | >=65 | I/II | Targeted Molecular therapy | tarceva | SD |
TRIO | SNV | Missense_Mutation | c.1789G>T | p.Gly597Trp | p.G597W | O75962 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-L9-A7SV-01 | Lung | lung adenocarcinoma | Male | >=65 | I/II | Chemotherapy | cisplatin | CR |
Page: 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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