GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:0016049110 | Esophagus | ESCC | cell growth | 289/8552 | 482/18723 | 1.29e-10 | 3.77e-09 | 289 |
GO:000155819 | Esophagus | ESCC | regulation of cell growth | 248/8552 | 414/18723 | 2.97e-09 | 6.45e-08 | 248 |
GO:000206420 | Esophagus | ESCC | epithelial cell development | 136/8552 | 220/18723 | 9.50e-07 | 1.21e-05 | 136 |
GO:003367420 | Esophagus | ESCC | positive regulation of kinase activity | 260/8552 | 467/18723 | 7.26e-06 | 7.22e-05 | 260 |
GO:00319294 | Esophagus | ESCC | TOR signaling | 79/8552 | 126/18723 | 8.57e-05 | 6.21e-04 | 79 |
GO:00182124 | Esophagus | ESCC | peptidyl-tyrosine modification | 202/8552 | 378/18723 | 1.34e-03 | 6.39e-03 | 202 |
GO:00320061 | Esophagus | ESCC | regulation of TOR signaling | 63/8552 | 104/18723 | 1.55e-03 | 7.29e-03 | 63 |
GO:00181084 | Esophagus | ESCC | peptidyl-tyrosine phosphorylation | 200/8552 | 375/18723 | 1.60e-03 | 7.45e-03 | 200 |
GO:0002066 | Esophagus | ESCC | columnar/cuboidal epithelial cell development | 29/8552 | 44/18723 | 5.41e-03 | 2.02e-02 | 29 |
GO:00610417 | Liver | NAFLD | regulation of wound healing | 39/1882 | 134/18723 | 5.52e-10 | 1.28e-07 | 39 |
GO:00420607 | Liver | NAFLD | wound healing | 84/1882 | 422/18723 | 6.56e-10 | 1.37e-07 | 84 |
GO:0042730 | Liver | NAFLD | fibrinolysis | 15/1882 | 25/18723 | 1.26e-09 | 2.30e-07 | 15 |
GO:0030195 | Liver | NAFLD | negative regulation of blood coagulation | 21/1882 | 49/18723 | 2.42e-09 | 4.05e-07 | 21 |
GO:1900047 | Liver | NAFLD | negative regulation of hemostasis | 21/1882 | 50/18723 | 3.78e-09 | 5.40e-07 | 21 |
GO:0030193 | Liver | NAFLD | regulation of blood coagulation | 24/1882 | 66/18723 | 9.30e-09 | 1.26e-06 | 24 |
GO:0050819 | Liver | NAFLD | negative regulation of coagulation | 21/1882 | 53/18723 | 1.33e-08 | 1.69e-06 | 21 |
GO:1900046 | Liver | NAFLD | regulation of hemostasis | 24/1882 | 68/18723 | 1.84e-08 | 2.09e-06 | 24 |
GO:0061045 | Liver | NAFLD | negative regulation of wound healing | 26/1882 | 78/18723 | 1.86e-08 | 2.09e-06 | 26 |
GO:19030347 | Liver | NAFLD | regulation of response to wounding | 41/1882 | 167/18723 | 4.70e-08 | 4.58e-06 | 41 |
GO:0050818 | Liver | NAFLD | regulation of coagulation | 24/1882 | 71/18723 | 4.80e-08 | 4.60e-06 | 24 |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
ROS1 | SNV | Missense_Mutation | rs140178288 | c.1397N>A | p.Arg466Gln | p.R466Q | P08922 | protein_coding | deleterious(0) | benign(0.246) | TCGA-EY-A1GD-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
ROS1 | SNV | Missense_Mutation | novel | c.1136A>G | p.Gln379Arg | p.Q379R | P08922 | protein_coding | tolerated(0.12) | benign(0.08) | TCGA-EY-A1GI-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
ROS1 | SNV | Missense_Mutation | novel | c.5782N>A | p.Leu1928Ile | p.L1928I | P08922 | protein_coding | deleterious(0.03) | benign(0.125) | TCGA-EY-A548-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
ROS1 | SNV | Missense_Mutation | novel | c.5786C>T | p.Pro1929Leu | p.P1929L | P08922 | protein_coding | deleterious(0) | benign(0.382) | TCGA-FI-A2D0-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
ROS1 | SNV | Missense_Mutation | novel | c.2432G>T | p.Ser811Ile | p.S811I | P08922 | protein_coding | deleterious(0.01) | probably_damaging(0.963) | TCGA-FI-A2D0-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
ROS1 | SNV | Missense_Mutation | novel | c.227G>A | p.Cys76Tyr | p.C76Y | P08922 | protein_coding | deleterious(0) | probably_damaging(0.977) | TCGA-FI-A2D0-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
ROS1 | SNV | Missense_Mutation | rs771164515 | c.6940G>T | p.Asp2314Tyr | p.D2314Y | P08922 | protein_coding | deleterious_low_confidence(0) | possibly_damaging(0.552) | TCGA-FI-A2D5-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | carboplatinum | PD |
ROS1 | SNV | Missense_Mutation | novel | c.6346N>G | p.Arg2116Gly | p.R2116G | P08922 | protein_coding | deleterious(0) | probably_damaging(0.993) | TCGA-FI-A2F4-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
ROS1 | SNV | Missense_Mutation | rs771802350 | c.294N>G | p.Asn98Lys | p.N98K | P08922 | protein_coding | tolerated(0.31) | benign(0.027) | TCGA-FI-A3PX-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
ROS1 | insertion | Nonsense_Mutation | novel | c.5118_5119insTAGTATCTCAAATATAGT | p.Cys1706_Ser1707insTer | p.C1706_S1707ins* | P08922 | protein_coding | | | TCGA-A5-A0R8-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | PD |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
6098 | ROS1 | TYROSINE KINASE, CLINICALLY ACTIONABLE, DRUG RESISTANCE, ENZYME, DRUGGABLE GENOME, KINASE, TRANSCRIPTION FACTOR | | Imidazo[1,2-b]pyridazine derivative 2 | | |
6098 | ROS1 | TYROSINE KINASE, CLINICALLY ACTIONABLE, DRUG RESISTANCE, ENZYME, DRUGGABLE GENOME, KINASE, TRANSCRIPTION FACTOR | | ENTRECTINIB | ENTRECTINIB | 28183697 |
6098 | ROS1 | TYROSINE KINASE, CLINICALLY ACTIONABLE, DRUG RESISTANCE, ENZYME, DRUGGABLE GENOME, KINASE, TRANSCRIPTION FACTOR | inhibitor | HESPERADIN | HESPERADIN | 19035792 |
6098 | ROS1 | TYROSINE KINASE, CLINICALLY ACTIONABLE, DRUG RESISTANCE, ENZYME, DRUGGABLE GENOME, KINASE, TRANSCRIPTION FACTOR | | CRIZOTINIB | CRIZOTINIB | 23724914,25733882,25351743,25688157,26372962 |
6098 | ROS1 | TYROSINE KINASE, CLINICALLY ACTIONABLE, DRUG RESISTANCE, ENZYME, DRUGGABLE GENOME, KINASE, TRANSCRIPTION FACTOR | | AZD3463 | | 26372962 |
6098 | ROS1 | TYROSINE KINASE, CLINICALLY ACTIONABLE, DRUG RESISTANCE, ENZYME, DRUGGABLE GENOME, KINASE, TRANSCRIPTION FACTOR | | TPX-0005 | | |
6098 | ROS1 | TYROSINE KINASE, CLINICALLY ACTIONABLE, DRUG RESISTANCE, ENZYME, DRUGGABLE GENOME, KINASE, TRANSCRIPTION FACTOR | inhibitor | CRIZOTINIB | CRIZOTINIB | |
6098 | ROS1 | TYROSINE KINASE, CLINICALLY ACTIONABLE, DRUG RESISTANCE, ENZYME, DRUGGABLE GENOME, KINASE, TRANSCRIPTION FACTOR | | DS6051b | | |
6098 | ROS1 | TYROSINE KINASE, CLINICALLY ACTIONABLE, DRUG RESISTANCE, ENZYME, DRUGGABLE GENOME, KINASE, TRANSCRIPTION FACTOR | | CYC-116 | CYC-116 | |
6098 | ROS1 | TYROSINE KINASE, CLINICALLY ACTIONABLE, DRUG RESISTANCE, ENZYME, DRUGGABLE GENOME, KINASE, TRANSCRIPTION FACTOR | | CRIZOTINIB | CRIZOTINIB | 29596029,23724914,25264305,24875859,25922291,22215748,25688157,26372962,25667280,30980071,29333528 |