GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:190290318 | Prostate | BPH | regulation of supramolecular fiber organization | 133/3107 | 383/18723 | 2.40e-18 | 8.73e-16 | 133 |
GO:190290518 | Prostate | BPH | positive regulation of supramolecular fiber organization | 84/3107 | 209/18723 | 3.00e-16 | 5.63e-14 | 84 |
GO:004325418 | Prostate | BPH | regulation of protein-containing complex assembly | 133/3107 | 428/18723 | 5.40e-14 | 6.08e-12 | 133 |
GO:005149516 | Prostate | BPH | positive regulation of cytoskeleton organization | 83/3107 | 226/18723 | 1.83e-13 | 1.86e-11 | 83 |
GO:003133418 | Prostate | BPH | positive regulation of protein-containing complex assembly | 84/3107 | 237/18723 | 1.24e-12 | 1.04e-10 | 84 |
GO:003227317 | Prostate | BPH | positive regulation of protein polymerization | 57/3107 | 138/18723 | 4.64e-12 | 3.68e-10 | 57 |
GO:005125818 | Prostate | BPH | protein polymerization | 96/3107 | 297/18723 | 1.52e-11 | 1.10e-09 | 96 |
GO:003227118 | Prostate | BPH | regulation of protein polymerization | 80/3107 | 233/18723 | 2.67e-11 | 1.78e-09 | 80 |
GO:002241117 | Prostate | BPH | cellular component disassembly | 121/3107 | 443/18723 | 6.34e-09 | 2.25e-07 | 121 |
GO:190290410 | Prostate | BPH | negative regulation of supramolecular fiber organization | 55/3107 | 167/18723 | 1.60e-07 | 3.63e-06 | 55 |
GO:00705076 | Prostate | BPH | regulation of microtubule cytoskeleton organization | 48/3107 | 148/18723 | 1.57e-06 | 2.67e-05 | 48 |
GO:00329849 | Prostate | BPH | protein-containing complex disassembly | 65/3107 | 224/18723 | 2.19e-06 | 3.60e-05 | 65 |
GO:00512715 | Prostate | BPH | negative regulation of cellular component movement | 94/3107 | 367/18723 | 6.18e-06 | 9.00e-05 | 94 |
GO:005149410 | Prostate | BPH | negative regulation of cytoskeleton organization | 49/3107 | 163/18723 | 1.32e-05 | 1.74e-04 | 49 |
GO:20001465 | Prostate | BPH | negative regulation of cell motility | 91/3107 | 359/18723 | 1.34e-05 | 1.76e-04 | 91 |
GO:00311166 | Prostate | BPH | positive regulation of microtubule polymerization | 16/3107 | 33/18723 | 2.15e-05 | 2.60e-04 | 16 |
GO:00400135 | Prostate | BPH | negative regulation of locomotion | 96/3107 | 391/18723 | 3.11e-05 | 3.54e-04 | 96 |
GO:001063916 | Prostate | BPH | negative regulation of organelle organization | 87/3107 | 348/18723 | 3.56e-05 | 3.90e-04 | 87 |
GO:00303365 | Prostate | BPH | negative regulation of cell migration | 86/3107 | 344/18723 | 3.93e-05 | 4.25e-04 | 86 |
GO:00328862 | Prostate | BPH | regulation of microtubule-based process | 64/3107 | 240/18723 | 4.93e-05 | 5.11e-04 | 64 |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
NAV3 | SNV | Missense_Mutation | | c.3298N>A | p.Ala1100Thr | p.A1100T | Q8IVL0 | protein_coding | deleterious(0.03) | benign(0.101) | TCGA-EO-A22T-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
NAV3 | SNV | Missense_Mutation | rs746603031 | c.1382N>A | p.Ser461Tyr | p.S461Y | Q8IVL0 | protein_coding | deleterious(0) | possibly_damaging(0.896) | TCGA-EO-A22U-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
NAV3 | SNV | Missense_Mutation | rs772277113 | c.2249N>A | p.Arg750Gln | p.R750Q | Q8IVL0 | protein_coding | deleterious(0) | probably_damaging(0.978) | TCGA-EO-A22U-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
NAV3 | SNV | Missense_Mutation | novel | c.2876N>A | p.Gly959Asp | p.G959D | Q8IVL0 | protein_coding | deleterious(0.04) | benign(0.033) | TCGA-EO-A22U-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
NAV3 | SNV | Missense_Mutation | novel | c.4214N>A | p.Ser1405Asn | p.S1405N | Q8IVL0 | protein_coding | deleterious(0) | probably_damaging(0.993) | TCGA-EO-A22U-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
NAV3 | SNV | Missense_Mutation | novel | c.4337N>A | p.Ser1446Tyr | p.S1446Y | Q8IVL0 | protein_coding | deleterious(0) | probably_damaging(0.998) | TCGA-EO-A22U-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
NAV3 | SNV | Missense_Mutation | | c.6466N>G | p.Met2156Val | p.M2156V | Q8IVL0 | protein_coding | deleterious(0) | probably_damaging(0.989) | TCGA-EO-A22U-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
NAV3 | SNV | Missense_Mutation | novel | c.10N>A | p.Leu4Ile | p.L4I | Q8IVL0 | protein_coding | tolerated_low_confidence(1) | benign(0.048) | TCGA-EO-A22X-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unspecific | Carboplatin | Complete Response |
NAV3 | SNV | Missense_Mutation | rs200565461 | c.2806N>A | p.Glu936Lys | p.E936K | Q8IVL0 | protein_coding | tolerated(0.16) | benign(0.038) | TCGA-EO-A22X-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unspecific | Carboplatin | Complete Response |
NAV3 | SNV | Missense_Mutation | novel | c.6424N>A | p.Leu2142Ile | p.L2142I | Q8IVL0 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-EO-A3AY-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | PD |