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Gene: DOPEY1 |
Gene summary for DOPEY1 |
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Gene information | Species | Human | Gene symbol | DOPEY1 | Gene ID | 23033 |
Gene name | DOP1 leucine zipper like protein A | |
Gene Alias | DOP1 | |
Cytomap | 6q14.1 | |
Gene Type | protein-coding | GO ID | GO:0006810 | UniProtAcc | Q5TA12 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
23033 | DOPEY1 | HTA11_3410_2000001011 | Human | Colorectum | AD | 2.27e-41 | -8.93e-01 | 0.0155 |
23033 | DOPEY1 | HTA11_2487_2000001011 | Human | Colorectum | SER | 1.62e-25 | -8.93e-01 | -0.1808 |
23033 | DOPEY1 | HTA11_2951_2000001011 | Human | Colorectum | AD | 1.04e-06 | -8.93e-01 | 0.0216 |
23033 | DOPEY1 | HTA11_1938_2000001011 | Human | Colorectum | AD | 7.46e-20 | -8.93e-01 | -0.0811 |
23033 | DOPEY1 | HTA11_78_2000001011 | Human | Colorectum | AD | 1.20e-29 | -8.93e-01 | -0.1088 |
23033 | DOPEY1 | HTA11_347_2000001011 | Human | Colorectum | AD | 3.39e-44 | -8.93e-01 | -0.1954 |
23033 | DOPEY1 | HTA11_411_2000001011 | Human | Colorectum | SER | 3.24e-04 | -8.93e-01 | -0.2602 |
23033 | DOPEY1 | HTA11_2112_2000001011 | Human | Colorectum | SER | 8.13e-06 | -8.93e-01 | -0.2196 |
23033 | DOPEY1 | HTA11_3361_2000001011 | Human | Colorectum | AD | 1.50e-20 | -8.93e-01 | -0.1207 |
23033 | DOPEY1 | HTA11_83_2000001011 | Human | Colorectum | SER | 8.50e-17 | -8.93e-01 | -0.1526 |
23033 | DOPEY1 | HTA11_696_2000001011 | Human | Colorectum | AD | 1.20e-62 | -8.93e-01 | -0.1464 |
23033 | DOPEY1 | HTA11_866_2000001011 | Human | Colorectum | AD | 1.40e-59 | -8.93e-01 | -0.1001 |
23033 | DOPEY1 | HTA11_1391_2000001011 | Human | Colorectum | AD | 4.72e-34 | -8.93e-01 | -0.059 |
23033 | DOPEY1 | HTA11_2992_2000001011 | Human | Colorectum | SER | 1.88e-08 | -8.93e-01 | -0.1706 |
23033 | DOPEY1 | HTA11_5212_2000001011 | Human | Colorectum | AD | 1.01e-09 | -8.93e-01 | -0.2061 |
23033 | DOPEY1 | HTA11_5216_2000001011 | Human | Colorectum | SER | 1.04e-06 | -8.93e-01 | -0.1462 |
23033 | DOPEY1 | HTA11_546_2000001011 | Human | Colorectum | AD | 9.96e-15 | -8.93e-01 | -0.0842 |
23033 | DOPEY1 | HTA11_9341_2000001011 | Human | Colorectum | SER | 3.24e-04 | -8.93e-01 | -0.00410000000000005 |
23033 | DOPEY1 | HTA11_7862_2000001011 | Human | Colorectum | AD | 3.51e-12 | -8.93e-01 | -0.0179 |
23033 | DOPEY1 | HTA11_866_3004761011 | Human | Colorectum | AD | 7.39e-37 | -8.93e-01 | 0.096 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
Page: 1 |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
DOPEY1 | SNV | Missense_Mutation | novel | c.6636N>A | p.Phe2212Leu | p.F2212L | protein_coding | deleterious(0) | probably_damaging(0.967) | TCGA-77-A5G6-01 | Lung | lung squamous cell carcinoma | Male | >=65 | III/IV | Unknown | Unknown | PD | |
DOPEY1 | SNV | Missense_Mutation | novel | c.4496N>G | p.Ala1499Gly | p.A1499G | protein_coding | tolerated(0.37) | benign(0.176) | TCGA-NC-A5HN-01 | Lung | lung squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
DOPEY1 | SNV | Missense_Mutation | novel | c.4407N>G | p.Asp1469Glu | p.D1469E | protein_coding | tolerated(0.05) | probably_damaging(0.999) | TCGA-C9-A47Z-01 | Oral cavity | head & neck squamous cell carcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD | |
DOPEY1 | SNV | Missense_Mutation | novel | c.466G>A | p.Glu156Lys | p.E156K | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-CN-6013-01 | Oral cavity | head & neck squamous cell carcinoma | Male | <65 | I/II | Chemotherapy | cisplatin | PD | |
DOPEY1 | SNV | Missense_Mutation | c.3010N>T | p.Arg1004Cys | p.R1004C | protein_coding | tolerated(0.26) | possibly_damaging(0.553) | TCGA-CQ-5324-01 | Oral cavity | head & neck squamous cell carcinoma | Male | <65 | III/IV | Unknown | Unknown | SD | ||
DOPEY1 | SNV | Missense_Mutation | novel | c.3346N>A | p.Glu1116Lys | p.E1116K | protein_coding | tolerated_low_confidence(0.2) | benign(0.381) | TCGA-CQ-A4CB-01 | Oral cavity | head & neck squamous cell carcinoma | Male | <65 | III/IV | Unknown | Unknown | SD | |
DOPEY1 | SNV | Missense_Mutation | c.1037G>A | p.Arg346His | p.R346H | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-CR-6472-01 | Oral cavity | head & neck squamous cell carcinoma | Male | <65 | I/II | Chemotherapy | paclitaxel | SD | ||
DOPEY1 | SNV | Missense_Mutation | novel | c.233N>C | p.Gly78Ala | p.G78A | protein_coding | deleterious(0) | possibly_damaging(0.753) | TCGA-CR-7386-01 | Oral cavity | head & neck squamous cell carcinoma | Male | >=65 | I/II | Chemotherapy | paclitaxel | PD | |
DOPEY1 | SNV | Missense_Mutation | novel | c.5130G>A | p.Met1710Ile | p.M1710I | protein_coding | deleterious(0.03) | benign(0.036) | TCGA-CV-6933-01 | Oral cavity | head & neck squamous cell carcinoma | Male | <65 | III/IV | Unknown | Unknown | SD | |
DOPEY1 | SNV | Missense_Mutation | novel | c.1675G>A | p.Glu559Lys | p.E559K | protein_coding | tolerated(0.3) | benign(0.236) | TCGA-CV-6937-01 | Oral cavity | head & neck squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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