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Gene: ADAMTS18 |
Gene summary for ADAMTS18 |
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Gene information | Species | Human | Gene symbol | ADAMTS18 | Gene ID | 170692 |
Gene name | ADAM metallopeptidase with thrombospondin type 1 motif 18 | |
Gene Alias | ADAMTS21 | |
Cytomap | 16q23.1 | |
Gene Type | protein-coding | GO ID | GO:0001654 | UniProtAcc | Q2VYF7 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
170692 | ADAMTS18 | S014 | Human | Liver | HCC | 4.12e-18 | 5.96e-01 | 0.2254 |
170692 | ADAMTS18 | S015 | Human | Liver | HCC | 2.68e-22 | 9.39e-01 | 0.2375 |
170692 | ADAMTS18 | S016 | Human | Liver | HCC | 6.12e-28 | 8.13e-01 | 0.2243 |
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Tissue | Expression Dynamics | Abbreviation |
Liver | ![]() | HCC: Hepatocellular carcinoma |
NAFLD: Non-alcoholic fatty liver disease |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:00301932 | Liver | HCC | regulation of blood coagulation | 46/7958 | 66/18723 | 7.12e-06 | 8.47e-05 | 46 |
GO:19000462 | Liver | HCC | regulation of hemostasis | 46/7958 | 68/18723 | 2.43e-05 | 2.56e-04 | 46 |
GO:00508182 | Liver | HCC | regulation of coagulation | 47/7958 | 71/18723 | 4.68e-05 | 4.50e-04 | 47 |
GO:004206022 | Liver | HCC | wound healing | 219/7958 | 422/18723 | 5.34e-05 | 5.04e-04 | 219 |
GO:006104122 | Liver | HCC | regulation of wound healing | 78/7958 | 134/18723 | 1.73e-04 | 1.36e-03 | 78 |
GO:190303421 | Liver | HCC | regulation of response to wounding | 94/7958 | 167/18723 | 2.19e-04 | 1.66e-03 | 94 |
GO:00075962 | Liver | HCC | blood coagulation | 118/7958 | 217/18723 | 2.63e-04 | 1.94e-03 | 118 |
GO:003410912 | Liver | HCC | homotypic cell-cell adhesion | 55/7958 | 90/18723 | 2.81e-04 | 2.02e-03 | 55 |
GO:00301952 | Liver | HCC | negative regulation of blood coagulation | 33/7958 | 49/18723 | 3.86e-04 | 2.62e-03 | 33 |
GO:00075992 | Liver | HCC | hemostasis | 119/7958 | 222/18723 | 5.25e-04 | 3.41e-03 | 119 |
GO:19000472 | Liver | HCC | negative regulation of hemostasis | 33/7958 | 50/18723 | 6.74e-04 | 4.15e-03 | 33 |
GO:00508172 | Liver | HCC | coagulation | 118/7958 | 222/18723 | 8.41e-04 | 5.03e-03 | 118 |
GO:005087822 | Liver | HCC | regulation of body fluid levels | 191/7958 | 379/18723 | 1.06e-03 | 6.11e-03 | 191 |
GO:00508192 | Liver | HCC | negative regulation of coagulation | 34/7958 | 53/18723 | 1.20e-03 | 6.68e-03 | 34 |
GO:007052712 | Liver | HCC | platelet aggregation | 40/7958 | 67/18723 | 3.35e-03 | 1.53e-02 | 40 |
GO:00341102 | Liver | HCC | regulation of homotypic cell-cell adhesion | 22/7958 | 33/18723 | 4.38e-03 | 1.90e-02 | 22 |
GO:0034111 | Liver | HCC | negative regulation of homotypic cell-cell adhesion | 11/7958 | 14/18723 | 6.81e-03 | 2.73e-02 | 11 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
ADAMTS18 | SNV | Missense_Mutation | rs758362638 | c.269N>T | p.Ala90Val | p.A90V | Q8TE60 | protein_coding | tolerated(0.29) | benign(0.041) | TCGA-RD-A8MW-01 | Stomach | stomach adenocarcinoma | Male | >=65 | III/IV | Chemotherapy | 5-fluorouracil | PD |
ADAMTS18 | SNV | Missense_Mutation | novel | c.3013N>G | p.Lys1005Glu | p.K1005E | Q8TE60 | protein_coding | deleterious(0.04) | benign(0.439) | TCGA-VQ-A8PK-01 | Stomach | stomach adenocarcinoma | Male | <65 | III/IV | Unknown | Unknown | PD |
ADAMTS18 | SNV | Missense_Mutation | novel | c.3068N>T | p.Ala1023Val | p.A1023V | Q8TE60 | protein_coding | tolerated(0.13) | benign(0.091) | TCGA-VQ-A91E-01 | Stomach | stomach adenocarcinoma | Female | >=65 | III/IV | Chemotherapy | fluorouracil | CR |
ADAMTS18 | SNV | Missense_Mutation | novel | c.3035N>T | p.Arg1012Met | p.R1012M | Q8TE60 | protein_coding | deleterious(0.04) | possibly_damaging(0.595) | TCGA-VQ-A924-01 | Stomach | stomach adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | PD |
ADAMTS18 | deletion | Frame_Shift_Del | rs772504358 | c.2085delN | p.Phe695LeufsTer7 | p.F695Lfs*7 | Q8TE60 | protein_coding | TCGA-BR-4280-01 | Stomach | stomach adenocarcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD | ||
ADAMTS18 | deletion | Frame_Shift_Del | rs772504358 | c.2085delN | p.Phe695LeufsTer7 | p.F695Lfs*7 | Q8TE60 | protein_coding | TCGA-BR-4292-01 | Stomach | stomach adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | ||
ADAMTS18 | deletion | Frame_Shift_Del | rs772504358 | c.2085delN | p.Phe695LeufsTer7 | p.F695Lfs*7 | Q8TE60 | protein_coding | TCGA-BR-4361-01 | Stomach | stomach adenocarcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD | ||
ADAMTS18 | deletion | Frame_Shift_Del | rs772504358 | c.2085delN | p.Phe695LeufsTer7 | p.F695Lfs*7 | Q8TE60 | protein_coding | TCGA-BR-4362-01 | Stomach | stomach adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | ||
ADAMTS18 | insertion | Frame_Shift_Ins | novel | c.2952dupA | p.Ala985SerfsTer31 | p.A985Sfs*31 | Q8TE60 | protein_coding | TCGA-BR-8372-01 | Stomach | stomach adenocarcinoma | Male | <65 | III/IV | Chemotherapy | etoposide | CR | ||
ADAMTS18 | deletion | Frame_Shift_Del | rs772504358 | c.2085delT | p.Phe695LeufsTer7 | p.F695Lfs*7 | Q8TE60 | protein_coding | TCGA-BR-8372-01 | Stomach | stomach adenocarcinoma | Male | <65 | III/IV | Chemotherapy | etoposide | CR |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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