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Gene: TRANK1 |
Gene summary for TRANK1 |
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Gene information | Species | Human | Gene symbol | TRANK1 | Gene ID | 9881 |
Gene name | tetratricopeptide repeat and ankyrin repeat containing 1 | |
Gene Alias | LBA1 | |
Cytomap | 3p22.2 | |
Gene Type | protein-coding | GO ID | NA | UniProtAcc | O15050 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
9881 | TRANK1 | HTA11_2487_2000001011 | Human | Colorectum | SER | 1.45e-10 | 6.93e-01 | -0.1808 |
9881 | TRANK1 | HTA11_347_2000001011 | Human | Colorectum | AD | 6.70e-10 | 5.83e-01 | -0.1954 |
9881 | TRANK1 | HTA11_411_2000001011 | Human | Colorectum | SER | 3.75e-06 | 1.57e+00 | -0.2602 |
9881 | TRANK1 | HTA11_2112_2000001011 | Human | Colorectum | SER | 2.16e-05 | 1.25e+00 | -0.2196 |
9881 | TRANK1 | HTA11_696_2000001011 | Human | Colorectum | AD | 1.82e-04 | 3.63e-01 | -0.1464 |
9881 | TRANK1 | HTA11_866_2000001011 | Human | Colorectum | AD | 4.79e-02 | 2.60e-01 | -0.1001 |
9881 | TRANK1 | HCC2 | Human | Liver | HCC | 3.43e-15 | 3.79e+00 | 0.5341 |
9881 | TRANK1 | S028 | Human | Liver | HCC | 4.03e-02 | 2.32e-01 | 0.2503 |
9881 | TRANK1 | S029 | Human | Liver | HCC | 5.46e-11 | 5.71e-01 | 0.2581 |
9881 | TRANK1 | 048752_1579-all-cells | Human | Prostate | BPH | 2.69e-16 | 3.14e-01 | 0.1008 |
9881 | TRANK1 | 052097_1595-all-cells | Human | Prostate | BPH | 7.05e-03 | 1.29e-01 | 0.0972 |
9881 | TRANK1 | 052099_1652-all-cells | Human | Prostate | BPH | 3.33e-06 | 1.80e-01 | 0.1038 |
9881 | TRANK1 | GSM5353221_PA_PB2A_Pool_1_3_S25_L001 | Human | Prostate | Tumor | 9.07e-11 | 5.04e-01 | 0.1633 |
9881 | TRANK1 | GSM5353222_PA_PB2B_Pool_1_3_S52_L002 | Human | Prostate | Tumor | 1.97e-09 | 3.88e-01 | 0.1608 |
9881 | TRANK1 | GSM5353223_PA_PB2B_Pool_2_S26_L001 | Human | Prostate | Tumor | 5.02e-03 | 2.67e-01 | 0.1604 |
9881 | TRANK1 | GSM5353224_PA_PR5186_Pool_1_2_3_S27_L001 | Human | Prostate | Tumor | 5.21e-05 | 3.21e-01 | 0.1621 |
9881 | TRANK1 | GSM5353228_PA_PR5199-640K_Pool_1_3_S108_L004 | Human | Prostate | Tumor | 3.15e-04 | 8.95e-01 | 0.1537 |
9881 | TRANK1 | GSM5353237_PA_PR5251_T2_S8_L001 | Human | Prostate | Tumor | 1.37e-02 | 4.49e-01 | 0.1622 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
TRANK1 | SNV | Missense_Mutation | rs375370078 | c.6508N>T | p.Arg2170Trp | p.R2170W | O15050 | protein_coding | deleterious(0.02) | possibly_damaging(0.759) | TCGA-ED-A66Y-01 | Liver | liver hepatocellular carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
TRANK1 | SNV | Missense_Mutation | novel | c.6380A>T | p.His2127Leu | p.H2127L | O15050 | protein_coding | deleterious(0.02) | probably_damaging(0.996) | TCGA-MI-A75C-01 | Liver | liver hepatocellular carcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
TRANK1 | SNV | Missense_Mutation | c.3779N>T | p.Glu1260Val | p.E1260V | O15050 | protein_coding | deleterious(0.01) | probably_damaging(0.939) | TCGA-UB-A7MB-01 | Liver | liver hepatocellular carcinoma | Male | <65 | I/II | Targeted Molecular therapy | sorafenib | PD | |
TRANK1 | SNV | Missense_Mutation | c.2085N>T | p.Leu695Phe | p.L695F | O15050 | protein_coding | deleterious(0) | possibly_damaging(0.896) | TCGA-05-4403-01 | Lung | lung adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
TRANK1 | SNV | Missense_Mutation | novel | c.8477N>A | p.Gly2826Asp | p.G2826D | O15050 | protein_coding | deleterious(0.03) | possibly_damaging(0.654) | TCGA-35-3615-01 | Lung | lung adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
TRANK1 | SNV | Missense_Mutation | rs765419817 | c.8203N>A | p.Gly2735Ser | p.G2735S | O15050 | protein_coding | tolerated_low_confidence(0.89) | benign(0) | TCGA-44-2656-01 | Lung | lung adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | PD |
TRANK1 | SNV | Missense_Mutation | c.3154N>C | p.Val1052Leu | p.V1052L | O15050 | protein_coding | tolerated(0.23) | benign(0.007) | TCGA-44-7669-01 | Lung | lung adenocarcinoma | Male | <65 | I/II | Chemotherapy | alimta | PD | |
TRANK1 | SNV | Missense_Mutation | c.2095G>T | p.Val699Phe | p.V699F | O15050 | protein_coding | tolerated(0.07) | benign(0.178) | TCGA-44-8117-01 | Lung | lung adenocarcinoma | Female | <65 | I/II | Chemotherapy | cisplatin | CR | |
TRANK1 | SNV | Missense_Mutation | c.7444N>G | p.Leu2482Val | p.L2482V | O15050 | protein_coding | deleterious(0.01) | probably_damaging(0.991) | TCGA-55-7570-01 | Lung | lung adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD | |
TRANK1 | SNV | Missense_Mutation | c.2803A>G | p.Lys935Glu | p.K935E | O15050 | protein_coding | tolerated(0.25) | benign(0.036) | TCGA-64-1679-01 | Lung | lung adenocarcinoma | Female | <65 | III/IV | Chemotherapy | cisplatin | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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