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Gene: THBS2 |
Gene summary for THBS2 |
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Gene information | Species | Human | Gene symbol | THBS2 | Gene ID | 7058 |
Gene name | thrombospondin 2 | |
Gene Alias | TSP2 | |
Cytomap | 6q27 | |
Gene Type | protein-coding | GO ID | GO:0001525 | UniProtAcc | P35442 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
7058 | THBS2 | LZE7T | Human | Esophagus | ESCC | 2.46e-12 | 6.48e-02 | 0.0667 |
7058 | THBS2 | P2T-E | Human | Esophagus | ESCC | 1.54e-03 | -1.91e-01 | 0.1177 |
7058 | THBS2 | P8T-E | Human | Esophagus | ESCC | 2.71e-02 | -1.80e-01 | 0.0889 |
7058 | THBS2 | P11T-E | Human | Esophagus | ESCC | 1.49e-02 | 9.12e-01 | 0.1426 |
7058 | THBS2 | P12T-E | Human | Esophagus | ESCC | 3.77e-05 | -2.05e-01 | 0.1122 |
7058 | THBS2 | P20T-E | Human | Esophagus | ESCC | 2.77e-02 | 2.08e-01 | 0.1124 |
7058 | THBS2 | P26T-E | Human | Esophagus | ESCC | 5.88e-05 | -1.82e-01 | 0.1276 |
7058 | THBS2 | P37T-E | Human | Esophagus | ESCC | 2.65e-44 | 1.60e+00 | 0.1371 |
7058 | THBS2 | P48T-E | Human | Esophagus | ESCC | 1.12e-04 | -1.98e-01 | 0.0959 |
7058 | THBS2 | P76T-E | Human | Esophagus | ESCC | 1.20e-04 | 4.94e-01 | 0.1207 |
7058 | THBS2 | P107T-E | Human | Esophagus | ESCC | 2.64e-02 | -1.99e-01 | 0.171 |
7058 | THBS2 | P127T-E | Human | Esophagus | ESCC | 1.76e-02 | -1.62e-01 | 0.0826 |
7058 | THBS2 | C04 | Human | Oral cavity | OSCC | 1.54e-15 | 8.04e-01 | 0.2633 |
7058 | THBS2 | C21 | Human | Oral cavity | OSCC | 1.88e-25 | 8.53e-01 | 0.2678 |
7058 | THBS2 | C51 | Human | Oral cavity | OSCC | 5.58e-41 | 1.88e+00 | 0.2674 |
7058 | THBS2 | C07 | Human | Oral cavity | OSCC | 5.72e-03 | 1.06e+00 | 0.2491 |
7058 | THBS2 | LP15 | Human | Oral cavity | LP | 8.27e-07 | 1.73e+00 | 0.2174 |
7058 | THBS2 | NEOLP-1 | Human | Oral cavity | NEOLP | 1.07e-13 | 5.66e-01 | -0.0194 |
7058 | THBS2 | SYSMH2 | Human | Oral cavity | OSCC | 2.26e-11 | 4.18e-01 | 0.2326 |
7058 | THBS2 | SYSMH3 | Human | Oral cavity | OSCC | 5.70e-25 | 9.46e-01 | 0.2442 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:003432918 | Esophagus | ESCC | cell junction assembly | 227/8552 | 420/18723 | 3.06e-04 | 1.83e-03 | 227 |
GO:00519606 | Esophagus | ESCC | regulation of nervous system development | 237/8552 | 443/18723 | 5.02e-04 | 2.78e-03 | 237 |
GO:00519625 | Esophagus | ESCC | positive regulation of nervous system development | 149/8552 | 272/18723 | 1.50e-03 | 7.06e-03 | 149 |
GO:190188810 | Esophagus | ESCC | regulation of cell junction assembly | 109/8552 | 204/18723 | 1.53e-02 | 4.96e-02 | 109 |
GO:00519624 | Oral cavity | OSCC | positive regulation of nervous system development | 135/7305 | 272/18723 | 2.20e-04 | 1.44e-03 | 135 |
GO:00519605 | Oral cavity | OSCC | regulation of nervous system development | 205/7305 | 443/18723 | 9.80e-04 | 5.11e-03 | 205 |
GO:003432916 | Oral cavity | OSCC | cell junction assembly | 190/7305 | 420/18723 | 4.99e-03 | 1.96e-02 | 190 |
GO:003432923 | Oral cavity | NEOLP | cell junction assembly | 88/2005 | 420/18723 | 4.18e-10 | 3.44e-08 | 88 |
GO:190188814 | Oral cavity | NEOLP | regulation of cell junction assembly | 47/2005 | 204/18723 | 2.82e-07 | 8.96e-06 | 47 |
GO:190134213 | Oral cavity | NEOLP | regulation of vasculature development | 59/2005 | 348/18723 | 2.42e-04 | 2.52e-03 | 59 |
GO:00457655 | Oral cavity | NEOLP | regulation of angiogenesis | 58/2005 | 342/18723 | 2.70e-04 | 2.72e-03 | 58 |
GO:005196212 | Oral cavity | NEOLP | positive regulation of nervous system development | 47/2005 | 272/18723 | 6.49e-04 | 5.47e-03 | 47 |
GO:005196012 | Oral cavity | NEOLP | regulation of nervous system development | 68/2005 | 443/18723 | 1.46e-03 | 1.03e-02 | 68 |
GO:003432919 | Skin | AK | cell junction assembly | 86/1910 | 420/18723 | 1.95e-10 | 2.68e-08 | 86 |
GO:190188815 | Skin | AK | regulation of cell junction assembly | 43/1910 | 204/18723 | 2.99e-06 | 7.93e-05 | 43 |
GO:00508088 | Skin | AK | synapse organization | 71/1910 | 426/18723 | 2.21e-05 | 4.07e-04 | 71 |
GO:00519607 | Skin | AK | regulation of nervous system development | 72/1910 | 443/18723 | 4.53e-05 | 7.11e-04 | 72 |
GO:00519626 | Skin | AK | positive regulation of nervous system development | 49/1910 | 272/18723 | 5.65e-05 | 8.50e-04 | 49 |
GO:00508031 | Skin | AK | regulation of synapse structure or activity | 38/1910 | 218/18723 | 7.06e-04 | 6.01e-03 | 38 |
GO:00508073 | Skin | AK | regulation of synapse organization | 37/1910 | 211/18723 | 7.35e-04 | 6.20e-03 | 37 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa0516510 | Esophagus | ESCC | Human papillomavirus infection | 215/4205 | 331/8465 | 7.86e-09 | 7.12e-08 | 3.65e-08 | 215 |
hsa0414530 | Esophagus | ESCC | Phagosome | 100/4205 | 152/8465 | 3.81e-05 | 1.72e-04 | 8.82e-05 | 100 |
hsa0451020 | Esophagus | ESCC | Focal adhesion | 127/4205 | 203/8465 | 1.25e-04 | 4.99e-04 | 2.56e-04 | 127 |
hsa041517 | Esophagus | ESCC | PI3K-Akt signaling pathway | 197/4205 | 354/8465 | 1.24e-02 | 2.83e-02 | 1.45e-02 | 197 |
hsa0516515 | Esophagus | ESCC | Human papillomavirus infection | 215/4205 | 331/8465 | 7.86e-09 | 7.12e-08 | 3.65e-08 | 215 |
hsa04145114 | Esophagus | ESCC | Phagosome | 100/4205 | 152/8465 | 3.81e-05 | 1.72e-04 | 8.82e-05 | 100 |
hsa04510111 | Esophagus | ESCC | Focal adhesion | 127/4205 | 203/8465 | 1.25e-04 | 4.99e-04 | 2.56e-04 | 127 |
hsa0415114 | Esophagus | ESCC | PI3K-Akt signaling pathway | 197/4205 | 354/8465 | 1.24e-02 | 2.83e-02 | 1.45e-02 | 197 |
hsa051659 | Oral cavity | OSCC | Human papillomavirus infection | 200/3704 | 331/8465 | 3.83e-10 | 4.93e-09 | 2.51e-09 | 200 |
hsa0451019 | Oral cavity | OSCC | Focal adhesion | 128/3704 | 203/8465 | 1.71e-08 | 1.63e-07 | 8.31e-08 | 128 |
hsa0414528 | Oral cavity | OSCC | Phagosome | 88/3704 | 152/8465 | 2.83e-04 | 9.13e-04 | 4.65e-04 | 88 |
hsa041516 | Oral cavity | OSCC | PI3K-Akt signaling pathway | 185/3704 | 354/8465 | 6.26e-04 | 1.86e-03 | 9.49e-04 | 185 |
hsa0516514 | Oral cavity | OSCC | Human papillomavirus infection | 200/3704 | 331/8465 | 3.83e-10 | 4.93e-09 | 2.51e-09 | 200 |
hsa04510110 | Oral cavity | OSCC | Focal adhesion | 128/3704 | 203/8465 | 1.71e-08 | 1.63e-07 | 8.31e-08 | 128 |
hsa04145113 | Oral cavity | OSCC | Phagosome | 88/3704 | 152/8465 | 2.83e-04 | 9.13e-04 | 4.65e-04 | 88 |
hsa0415113 | Oral cavity | OSCC | PI3K-Akt signaling pathway | 185/3704 | 354/8465 | 6.26e-04 | 1.86e-03 | 9.49e-04 | 185 |
hsa0414529 | Oral cavity | LP | Phagosome | 73/2418 | 152/8465 | 2.37e-07 | 3.29e-06 | 2.12e-06 | 73 |
hsa0516523 | Oral cavity | LP | Human papillomavirus infection | 121/2418 | 331/8465 | 8.00e-04 | 3.86e-03 | 2.49e-03 | 121 |
hsa0414536 | Oral cavity | LP | Phagosome | 73/2418 | 152/8465 | 2.37e-07 | 3.29e-06 | 2.12e-06 | 73 |
hsa0516533 | Oral cavity | LP | Human papillomavirus infection | 121/2418 | 331/8465 | 8.00e-04 | 3.86e-03 | 2.49e-03 | 121 |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
THBS2 | SDC4 | THBS2_SDC4 | THBS | Breast | ADJ |
THBS2 | CD47 | THBS2_CD47 | THBS | Breast | ADJ |
THBS2 | SDC1 | THBS2_SDC1 | THBS | Breast | DCIS |
THBS2 | SDC4 | THBS2_SDC4 | THBS | Breast | DCIS |
THBS2 | CD36 | THBS2_CD36 | THBS | Breast | DCIS |
THBS2 | CD47 | THBS2_CD47 | THBS | Breast | DCIS |
THBS2 | SDC1 | THBS2_SDC1 | THBS | Breast | Healthy |
THBS2 | SDC4 | THBS2_SDC4 | THBS | Breast | Healthy |
THBS2 | CD36 | THBS2_CD36 | THBS | Breast | Healthy |
THBS2 | CD47 | THBS2_CD47 | THBS | Breast | Healthy |
THBS2 | SDC1 | THBS2_SDC1 | THBS | Breast | IDC |
THBS2 | SDC4 | THBS2_SDC4 | THBS | Breast | IDC |
THBS2 | CD36 | THBS2_CD36 | THBS | Breast | IDC |
THBS2 | CD47 | THBS2_CD47 | THBS | Breast | IDC |
THBS2 | SDC4 | THBS2_SDC4 | THBS | Breast | Precancer |
THBS2 | CD36 | THBS2_CD36 | THBS | Breast | Precancer |
THBS2 | CD47 | THBS2_CD47 | THBS | Breast | Precancer |
THBS2 | ITGA3_ITGB1 | THBS2_ITGA3_ITGB1 | THBS | Cervix | ADJ |
THBS2 | SDC1 | THBS2_SDC1 | THBS | Cervix | ADJ |
THBS2 | SDC4 | THBS2_SDC4 | THBS | Cervix | ADJ |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
THBS2 | SNV | Missense_Mutation | rs766329088 | c.368N>T | p.Thr123Met | p.T123M | P35442 | protein_coding | deleterious(0) | probably_damaging(0.961) | TCGA-BR-4201-01 | Stomach | stomach adenocarcinoma | Female | >=65 | I/II | Chemotherapy | cisplatin | SD |
THBS2 | SNV | Missense_Mutation | rs184952882 | c.2713G>A | p.Val905Ile | p.V905I | P35442 | protein_coding | tolerated(1) | benign(0.003) | TCGA-BR-6452-01 | Stomach | stomach adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
THBS2 | SNV | Missense_Mutation | rs566007634 | c.2783G>A | p.Arg928Gln | p.R928Q | P35442 | protein_coding | tolerated(0.13) | probably_damaging(0.997) | TCGA-BR-A452-01 | Stomach | stomach adenocarcinoma | Male | <65 | III/IV | Unknown | Unknown | SD |
THBS2 | SNV | Missense_Mutation | c.2891T>A | p.Met964Lys | p.M964K | P35442 | protein_coding | deleterious(0.01) | possibly_damaging(0.686) | TCGA-BR-A4PD-01 | Stomach | stomach adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
THBS2 | SNV | Missense_Mutation | rs201813061 | c.2242G>A | p.Gly748Ser | p.G748S | P35442 | protein_coding | deleterious(0.05) | benign(0.425) | TCGA-CG-4306-01 | Stomach | stomach adenocarcinoma | Male | >=65 | III/IV | Unknown | Unknown | SD |
THBS2 | SNV | Missense_Mutation | c.3364N>C | p.Tyr1122His | p.Y1122H | P35442 | protein_coding | tolerated(0.05) | possibly_damaging(0.867) | TCGA-CG-5721-01 | Stomach | stomach adenocarcinoma | Male | <65 | III/IV | Unknown | Unknown | SD | |
THBS2 | SNV | Missense_Mutation | c.280N>A | p.Gly94Ser | p.G94S | P35442 | protein_coding | tolerated(0.06) | benign(0.022) | TCGA-CG-5721-01 | Stomach | stomach adenocarcinoma | Male | <65 | III/IV | Unknown | Unknown | SD | |
THBS2 | SNV | Missense_Mutation | c.463C>A | p.Gln155Lys | p.Q155K | P35442 | protein_coding | tolerated(0.29) | benign(0.298) | TCGA-D7-A4YX-01 | Stomach | stomach adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD | |
THBS2 | SNV | Missense_Mutation | c.1064N>A | p.Cys355Tyr | p.C355Y | P35442 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-D7-A4YY-01 | Stomach | stomach adenocarcinoma | Male | <65 | III/IV | Chemotherapy | 5-fluorouracil | SD | |
THBS2 | SNV | Missense_Mutation | rs369355659 | c.296N>T | p.Thr99Met | p.T99M | P35442 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-HJ-7597-01 | Stomach | stomach adenocarcinoma | Female | >=65 | I/II | Chemotherapy | fluorouracil | CR |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
7058 | THBS2 | DRUGGABLE GENOME | BEVACIZUMAB | BEVACIZUMAB | 16365183 | |
7058 | THBS2 | DRUGGABLE GENOME | ADRENOCORTICOTROPIC HORMONE | 8698834 |
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