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Gene: PCNX1 |
Gene summary for PCNX1 |
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Gene information | Species | Human | Gene symbol | PCNX1 | Gene ID | 22990 |
Gene name | pecanex 1 | |
Gene Alias | PCNX | |
Cytomap | 14q24.2 | |
Gene Type | protein-coding | GO ID | GO:0005575 | UniProtAcc | Q96RV3 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
22990 | PCNX1 | CCI_2 | Human | Cervix | CC | 9.56e-03 | 5.89e-01 | 0.5249 |
22990 | PCNX1 | CCI_3 | Human | Cervix | CC | 2.90e-03 | 5.63e-01 | 0.516 |
22990 | PCNX1 | Tumor | Human | Cervix | CC | 4.20e-08 | -1.96e-01 | 0.1241 |
22990 | PCNX1 | L1 | Human | Cervix | CC | 2.03e-02 | -1.67e-01 | 0.0802 |
22990 | PCNX1 | AEH-subject1 | Human | Endometrium | AEH | 3.02e-19 | 3.92e-01 | -0.3059 |
22990 | PCNX1 | AEH-subject2 | Human | Endometrium | AEH | 2.67e-12 | 2.72e-01 | -0.2525 |
22990 | PCNX1 | AEH-subject3 | Human | Endometrium | AEH | 3.99e-06 | 1.91e-01 | -0.2576 |
22990 | PCNX1 | AEH-subject4 | Human | Endometrium | AEH | 1.74e-24 | 5.58e-01 | -0.2657 |
22990 | PCNX1 | AEH-subject5 | Human | Endometrium | AEH | 2.44e-20 | 4.09e-01 | -0.2953 |
22990 | PCNX1 | EEC-subject1 | Human | Endometrium | EEC | 1.31e-19 | 3.81e-01 | -0.2682 |
22990 | PCNX1 | EEC-subject2 | Human | Endometrium | EEC | 8.15e-11 | 3.18e-01 | -0.2607 |
22990 | PCNX1 | EEC-subject3 | Human | Endometrium | EEC | 1.89e-07 | 2.58e-01 | -0.2525 |
22990 | PCNX1 | EEC-subject4 | Human | Endometrium | EEC | 1.14e-15 | 3.50e-01 | -0.2571 |
22990 | PCNX1 | EEC-subject5 | Human | Endometrium | EEC | 5.07e-16 | 3.55e-01 | -0.249 |
22990 | PCNX1 | GSM5276935 | Human | Endometrium | EEC | 3.71e-04 | 1.02e-01 | -0.123 |
22990 | PCNX1 | GSM5276937 | Human | Endometrium | EEC | 5.05e-07 | 1.54e-01 | -0.0897 |
22990 | PCNX1 | GSM6177621_NYU_UCEC2_lib1_lib1 | Human | Endometrium | EEC | 7.85e-04 | 1.82e-01 | -0.1934 |
22990 | PCNX1 | GSM6177623_NYU_UCEC3_Vis | Human | Endometrium | EEC | 1.88e-08 | 2.42e-01 | -0.1269 |
22990 | PCNX1 | NAFLD1 | Human | Liver | NAFLD | 1.05e-09 | 8.12e-01 | -0.04 |
22990 | PCNX1 | S41 | Human | Liver | Cirrhotic | 8.05e-04 | 5.26e-01 | -0.0343 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
Page: 1 |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
PCNX1 | SNV | Missense_Mutation | c.3482N>A | p.Leu1161His | p.L1161H | Q96RV3 | protein_coding | deleterious(0.03) | probably_damaging(0.997) | TCGA-BR-4357-01 | Stomach | stomach adenocarcinoma | Male | <65 | III/IV | Unknown | Unknown | SD | |
PCNX1 | SNV | Missense_Mutation | c.434N>T | p.Arg145Ile | p.R145I | Q96RV3 | protein_coding | deleterious(0.04) | probably_damaging(0.986) | TCGA-BR-6452-01 | Stomach | stomach adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
PCNX1 | SNV | Missense_Mutation | c.1720N>C | p.Ser574Pro | p.S574P | Q96RV3 | protein_coding | tolerated_low_confidence(0.18) | benign(0.099) | TCGA-BR-6452-01 | Stomach | stomach adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
PCNX1 | SNV | Missense_Mutation | c.854N>A | p.Arg285Gln | p.R285Q | Q96RV3 | protein_coding | tolerated_low_confidence(0.14) | probably_damaging(0.978) | TCGA-BR-6852-01 | Stomach | stomach adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
PCNX1 | SNV | Missense_Mutation | rs755555770 | c.6824N>A | p.Arg2275Gln | p.R2275Q | Q96RV3 | protein_coding | deleterious_low_confidence(0) | probably_damaging(0.978) | TCGA-BR-7851-01 | Stomach | stomach adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
PCNX1 | SNV | Missense_Mutation | c.5471C>T | p.Ala1824Val | p.A1824V | Q96RV3 | protein_coding | deleterious(0) | probably_damaging(0.997) | TCGA-BR-8368-01 | Stomach | stomach adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
PCNX1 | SNV | Missense_Mutation | c.5828N>G | p.Lys1943Arg | p.K1943R | Q96RV3 | protein_coding | tolerated(0.78) | benign(0.192) | TCGA-BR-8487-01 | Stomach | stomach adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
PCNX1 | SNV | Missense_Mutation | c.2114A>G | p.Asn705Ser | p.N705S | Q96RV3 | protein_coding | tolerated(0.86) | benign(0) | TCGA-BR-8591-01 | Stomach | stomach adenocarcinoma | Male | >=65 | III/IV | Unknown | Unknown | SD | |
PCNX1 | SNV | Missense_Mutation | c.5957A>G | p.Asp1986Gly | p.D1986G | Q96RV3 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-BR-8591-01 | Stomach | stomach adenocarcinoma | Male | >=65 | III/IV | Unknown | Unknown | SD | |
PCNX1 | SNV | Missense_Mutation | c.647A>G | p.Asp216Gly | p.D216G | Q96RV3 | protein_coding | tolerated(0.14) | probably_damaging(0.989) | TCGA-BR-8680-01 | Stomach | stomach adenocarcinoma | Male | <65 | III/IV | Chemotherapy | oxaliplatin | CR |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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