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Gene: MAP2 |
Gene summary for MAP2 |
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Gene information | Species | Human | Gene symbol | MAP2 | Gene ID | 4133 |
Gene name | microtubule associated protein 2 | |
Gene Alias | MAP-2 | |
Cytomap | 2q34 | |
Gene Type | protein-coding | GO ID | GO:0000226 | UniProtAcc | P11137 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
4133 | MAP2 | LZE4T | Human | Esophagus | ESCC | 7.93e-16 | 5.39e-01 | 0.0811 |
4133 | MAP2 | LZE7T | Human | Esophagus | ESCC | 1.27e-09 | 6.53e-01 | 0.0667 |
4133 | MAP2 | P5T-E | Human | Esophagus | ESCC | 8.79e-05 | 6.41e-02 | 0.1327 |
4133 | MAP2 | P9T-E | Human | Esophagus | ESCC | 1.96e-08 | 2.07e-01 | 0.1131 |
4133 | MAP2 | P11T-E | Human | Esophagus | ESCC | 3.36e-02 | 1.76e-01 | 0.1426 |
4133 | MAP2 | P12T-E | Human | Esophagus | ESCC | 9.39e-07 | 1.71e-01 | 0.1122 |
4133 | MAP2 | P15T-E | Human | Esophagus | ESCC | 1.77e-13 | 2.75e-01 | 0.1149 |
4133 | MAP2 | P16T-E | Human | Esophagus | ESCC | 1.13e-12 | 4.01e-02 | 0.1153 |
4133 | MAP2 | P28T-E | Human | Esophagus | ESCC | 7.08e-07 | 1.36e-01 | 0.1149 |
4133 | MAP2 | P37T-E | Human | Esophagus | ESCC | 8.26e-10 | 1.77e-01 | 0.1371 |
4133 | MAP2 | P39T-E | Human | Esophagus | ESCC | 9.62e-04 | 4.87e-02 | 0.0894 |
4133 | MAP2 | P49T-E | Human | Esophagus | ESCC | 7.51e-08 | 5.77e-01 | 0.1768 |
4133 | MAP2 | P52T-E | Human | Esophagus | ESCC | 7.12e-05 | 9.14e-02 | 0.1555 |
4133 | MAP2 | P74T-E | Human | Esophagus | ESCC | 2.98e-06 | 1.44e-01 | 0.1479 |
4133 | MAP2 | P76T-E | Human | Esophagus | ESCC | 3.34e-03 | 1.16e-01 | 0.1207 |
4133 | MAP2 | P79T-E | Human | Esophagus | ESCC | 3.29e-03 | 2.52e-01 | 0.1154 |
4133 | MAP2 | P107T-E | Human | Esophagus | ESCC | 1.35e-28 | 5.78e-01 | 0.171 |
4133 | MAP2 | S42 | Human | Liver | HCC | 6.69e-03 | 5.00e-01 | -0.0103 |
4133 | MAP2 | HCC1_Meng | Human | Liver | HCC | 4.42e-34 | -7.14e-02 | 0.0246 |
4133 | MAP2 | HCC1 | Human | Liver | HCC | 1.49e-02 | 3.15e+00 | 0.5336 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:200123310 | Cervix | CC | regulation of apoptotic signaling pathway | 96/2311 | 356/18723 | 4.08e-14 | 3.05e-11 | 96 |
GO:005254710 | Cervix | CC | regulation of peptidase activity | 112/2311 | 461/18723 | 6.70e-13 | 3.08e-10 | 112 |
GO:005254810 | Cervix | CC | regulation of endopeptidase activity | 103/2311 | 432/18723 | 1.89e-11 | 5.14e-09 | 103 |
GO:009013210 | Cervix | CC | epithelium migration | 90/2311 | 360/18723 | 2.45e-11 | 6.11e-09 | 90 |
GO:00016679 | Cervix | CC | ameboidal-type cell migration | 110/2311 | 475/18723 | 2.66e-11 | 6.36e-09 | 110 |
GO:001063110 | Cervix | CC | epithelial cell migration | 89/2311 | 357/18723 | 3.72e-11 | 8.54e-09 | 89 |
GO:00085446 | Cervix | CC | epidermis development | 83/2311 | 324/18723 | 3.91e-11 | 8.54e-09 | 83 |
GO:009013010 | Cervix | CC | tissue migration | 90/2311 | 365/18723 | 5.42e-11 | 1.05e-08 | 90 |
GO:00435884 | Cervix | CC | skin development | 71/2311 | 263/18723 | 8.04e-11 | 1.46e-08 | 71 |
GO:002240710 | Cervix | CC | regulation of cell-cell adhesion | 103/2311 | 448/18723 | 1.78e-10 | 2.87e-08 | 103 |
GO:007149610 | Cervix | CC | cellular response to external stimulus | 78/2311 | 320/18723 | 1.82e-09 | 1.98e-07 | 78 |
GO:00506737 | Cervix | CC | epithelial cell proliferation | 98/2311 | 437/18723 | 2.01e-09 | 2.15e-07 | 98 |
GO:001063210 | Cervix | CC | regulation of epithelial cell migration | 72/2311 | 292/18723 | 4.52e-09 | 4.43e-07 | 72 |
GO:003367410 | Cervix | CC | positive regulation of kinase activity | 101/2311 | 467/18723 | 8.66e-09 | 7.22e-07 | 101 |
GO:200011610 | Cervix | CC | regulation of cysteine-type endopeptidase activity | 61/2311 | 235/18723 | 8.69e-09 | 7.22e-07 | 61 |
GO:00302164 | Cervix | CC | keratinocyte differentiation | 42/2311 | 139/18723 | 1.74e-08 | 1.28e-06 | 42 |
GO:00071626 | Cervix | CC | negative regulation of cell adhesion | 72/2311 | 303/18723 | 2.36e-08 | 1.70e-06 | 72 |
GO:004328110 | Cervix | CC | regulation of cysteine-type endopeptidase activity involved in apoptotic process | 55/2311 | 209/18723 | 2.77e-08 | 1.95e-06 | 55 |
GO:004586110 | Cervix | CC | negative regulation of proteolysis | 80/2311 | 351/18723 | 2.88e-08 | 1.98e-06 | 80 |
GO:00099137 | Cervix | CC | epidermal cell differentiation | 53/2311 | 202/18723 | 5.48e-08 | 3.25e-06 | 53 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
MAP2 | SNV | Missense_Mutation | c.1727N>G | p.Ser576Cys | p.S576C | P11137 | protein_coding | deleterious(0) | probably_damaging(0.996) | TCGA-44-A47A-01 | Lung | lung adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | PD | |
MAP2 | SNV | Missense_Mutation | c.4480N>T | p.Thr1494Ser | p.T1494S | P11137 | protein_coding | deleterious(0.03) | possibly_damaging(0.581) | TCGA-49-AAR9-01 | Lung | lung adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | PD | |
MAP2 | SNV | Missense_Mutation | rs759447374 | c.4402N>T | p.Ala1468Ser | p.A1468S | P11137 | protein_coding | deleterious(0.02) | possibly_damaging(0.455) | TCGA-49-AARO-01 | Lung | lung adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | PD |
MAP2 | SNV | Missense_Mutation | c.1137N>T | p.Met379Ile | p.M379I | P11137 | protein_coding | tolerated_low_confidence(0.12) | benign(0) | TCGA-50-5930-01 | Lung | lung adenocarcinoma | Male | <65 | III/IV | Chemotherapy | taxotere | PD | |
MAP2 | SNV | Missense_Mutation | c.1138N>T | p.Ala380Ser | p.A380S | P11137 | protein_coding | deleterious_low_confidence(0.03) | benign(0.253) | TCGA-50-5930-01 | Lung | lung adenocarcinoma | Male | <65 | III/IV | Chemotherapy | taxotere | PD | |
MAP2 | SNV | Missense_Mutation | c.3726G>C | p.Gln1242His | p.Q1242H | P11137 | protein_coding | deleterious_low_confidence(0.05) | benign(0.273) | TCGA-50-7109-01 | Lung | lung adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | PD | |
MAP2 | SNV | Missense_Mutation | c.3124N>T | p.Val1042Phe | p.V1042F | P11137 | protein_coding | deleterious_low_confidence(0) | possibly_damaging(0.478) | TCGA-55-6969-01 | Lung | lung adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD | |
MAP2 | SNV | Missense_Mutation | c.4048N>T | p.Ala1350Ser | p.A1350S | P11137 | protein_coding | deleterious(0) | probably_damaging(0.989) | TCGA-55-6971-01 | Lung | lung adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
MAP2 | SNV | Missense_Mutation | c.2798A>G | p.Lys933Arg | p.K933R | P11137 | protein_coding | tolerated_low_confidence(0.11) | benign(0.011) | TCGA-55-6985-01 | Lung | lung adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
MAP2 | SNV | Missense_Mutation | novel | c.3208C>A | p.Leu1070Ile | p.L1070I | P11137 | protein_coding | tolerated_low_confidence(0.33) | benign(0.055) | TCGA-55-7913-01 | Lung | lung adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | PD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
4133 | MAP2 | NA | MELATONIN | MELATONIN | 8829136 | |
4133 | MAP2 | NA | COLCHICINE | COLCHICINE | 7511033 |
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