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Gene: HIVEP1 |
Gene summary for HIVEP1 |
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Gene information | Species | Human | Gene symbol | HIVEP1 | Gene ID | 3096 |
Gene name | HIVEP zinc finger 1 | |
Gene Alias | CIRIP | |
Cytomap | 6p24.1 | |
Gene Type | protein-coding | GO ID | GO:0000122 | UniProtAcc | P15822 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
3096 | HIVEP1 | CCI_1 | Human | Cervix | CC | 7.47e-03 | 7.06e-01 | 0.528 |
3096 | HIVEP1 | CCI_2 | Human | Cervix | CC | 1.53e-15 | 1.74e+00 | 0.5249 |
3096 | HIVEP1 | CCI_3 | Human | Cervix | CC | 2.01e-08 | 7.90e-01 | 0.516 |
3096 | HIVEP1 | HTA11_3410_2000001011 | Human | Colorectum | AD | 1.76e-10 | -5.26e-01 | 0.0155 |
3096 | HIVEP1 | HTA11_3361_2000001011 | Human | Colorectum | AD | 1.17e-04 | -5.65e-01 | -0.1207 |
3096 | HIVEP1 | HTA11_696_2000001011 | Human | Colorectum | AD | 2.43e-11 | -4.77e-01 | -0.1464 |
3096 | HIVEP1 | HTA11_866_2000001011 | Human | Colorectum | AD | 4.96e-04 | -3.35e-01 | -0.1001 |
3096 | HIVEP1 | HTA11_866_3004761011 | Human | Colorectum | AD | 1.63e-07 | -4.90e-01 | 0.096 |
3096 | HIVEP1 | HTA11_10711_2000001011 | Human | Colorectum | AD | 1.07e-05 | -5.84e-01 | 0.0338 |
3096 | HIVEP1 | HTA11_7696_3000711011 | Human | Colorectum | AD | 1.91e-16 | -5.13e-01 | 0.0674 |
3096 | HIVEP1 | HTA11_6818_2000001021 | Human | Colorectum | AD | 3.76e-02 | -4.57e-01 | 0.0588 |
3096 | HIVEP1 | HTA11_99999970781_79442 | Human | Colorectum | MSS | 6.49e-07 | -3.46e-01 | 0.294 |
3096 | HIVEP1 | HTA11_99999971662_82457 | Human | Colorectum | MSS | 2.91e-14 | -4.74e-01 | 0.3859 |
3096 | HIVEP1 | HTA11_99999974143_84620 | Human | Colorectum | MSS | 1.21e-19 | -6.10e-01 | 0.3005 |
3096 | HIVEP1 | A015-C-203 | Human | Colorectum | FAP | 9.98e-28 | -2.87e-01 | -0.1294 |
3096 | HIVEP1 | A015-C-204 | Human | Colorectum | FAP | 2.46e-02 | -4.64e-02 | -0.0228 |
3096 | HIVEP1 | A002-C-201 | Human | Colorectum | FAP | 8.71e-08 | -2.17e-01 | 0.0324 |
3096 | HIVEP1 | A002-C-203 | Human | Colorectum | FAP | 4.88e-02 | -6.82e-02 | 0.2786 |
3096 | HIVEP1 | A001-C-108 | Human | Colorectum | FAP | 2.29e-17 | -5.47e-02 | -0.0272 |
3096 | HIVEP1 | A002-C-205 | Human | Colorectum | FAP | 4.40e-14 | -1.51e-01 | -0.1236 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:00071786 | Cervix | CC | transmembrane receptor protein serine/threonine kinase signaling pathway | 67/2311 | 355/18723 | 2.39e-04 | 2.67e-03 | 67 |
GO:0007178 | Colorectum | AD | transmembrane receptor protein serine/threonine kinase signaling pathway | 99/3918 | 355/18723 | 9.92e-04 | 9.28e-03 | 99 |
GO:00071781 | Colorectum | MSS | transmembrane receptor protein serine/threonine kinase signaling pathway | 86/3467 | 355/18723 | 4.04e-03 | 2.95e-02 | 86 |
GO:00071782 | Colorectum | FAP | transmembrane receptor protein serine/threonine kinase signaling pathway | 81/2622 | 355/18723 | 4.28e-06 | 1.46e-04 | 81 |
GO:0071772 | Colorectum | FAP | response to BMP | 37/2622 | 165/18723 | 2.20e-03 | 1.80e-02 | 37 |
GO:0071773 | Colorectum | FAP | cellular response to BMP stimulus | 37/2622 | 165/18723 | 2.20e-03 | 1.80e-02 | 37 |
GO:0030509 | Colorectum | FAP | BMP signaling pathway | 34/2622 | 152/18723 | 3.38e-03 | 2.47e-02 | 34 |
GO:00071783 | Colorectum | CRC | transmembrane receptor protein serine/threonine kinase signaling pathway | 66/2078 | 355/18723 | 1.74e-05 | 5.28e-04 | 66 |
GO:00305091 | Colorectum | CRC | BMP signaling pathway | 31/2078 | 152/18723 | 5.73e-04 | 7.89e-03 | 31 |
GO:00717721 | Colorectum | CRC | response to BMP | 32/2078 | 165/18723 | 1.16e-03 | 1.33e-02 | 32 |
GO:00717731 | Colorectum | CRC | cellular response to BMP stimulus | 32/2078 | 165/18723 | 1.16e-03 | 1.33e-02 | 32 |
GO:00071787 | Endometrium | AEH | transmembrane receptor protein serine/threonine kinase signaling pathway | 67/2100 | 355/18723 | 1.28e-05 | 2.80e-04 | 67 |
GO:00305092 | Endometrium | AEH | BMP signaling pathway | 32/2100 | 152/18723 | 3.15e-04 | 3.54e-03 | 32 |
GO:00717722 | Endometrium | AEH | response to BMP | 32/2100 | 165/18723 | 1.38e-03 | 1.16e-02 | 32 |
GO:00717732 | Endometrium | AEH | cellular response to BMP stimulus | 32/2100 | 165/18723 | 1.38e-03 | 1.16e-02 | 32 |
GO:000717814 | Endometrium | EEC | transmembrane receptor protein serine/threonine kinase signaling pathway | 68/2168 | 355/18723 | 1.90e-05 | 3.50e-04 | 68 |
GO:003050911 | Endometrium | EEC | BMP signaling pathway | 32/2168 | 152/18723 | 5.52e-04 | 5.52e-03 | 32 |
GO:007177211 | Endometrium | EEC | response to BMP | 33/2168 | 165/18723 | 1.16e-03 | 9.90e-03 | 33 |
GO:007177311 | Endometrium | EEC | cellular response to BMP stimulus | 33/2168 | 165/18723 | 1.16e-03 | 9.90e-03 | 33 |
GO:000717810 | Esophagus | ESCC | transmembrane receptor protein serine/threonine kinase signaling pathway | 195/8552 | 355/18723 | 2.58e-04 | 1.58e-03 | 195 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
HIVEP1 | SNV | Missense_Mutation | c.7213C>T | p.His2405Tyr | p.H2405Y | P15822 | protein_coding | deleterious(0.01) | possibly_damaging(0.761) | TCGA-78-7536-01 | Lung | lung adenocarcinoma | Male | >=65 | III/IV | Unknown | Unknown | PD | |
HIVEP1 | SNV | Missense_Mutation | novel | c.5419C>T | p.Pro1807Ser | p.P1807S | P15822 | protein_coding | deleterious(0.02) | probably_damaging(1) | TCGA-86-A4JF-01 | Lung | lung adenocarcinoma | Male | <65 | I/II | Chemotherapy | unknown | PD |
HIVEP1 | SNV | Missense_Mutation | novel | c.3500N>T | p.Arg1167Ile | p.R1167I | P15822 | protein_coding | tolerated(0.11) | probably_damaging(0.956) | TCGA-91-6830-01 | Lung | lung adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | PD |
HIVEP1 | SNV | Missense_Mutation | c.4271N>C | p.Arg1424Thr | p.R1424T | P15822 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-91-6830-01 | Lung | lung adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | PD | |
HIVEP1 | SNV | Missense_Mutation | c.4046C>T | p.Ala1349Val | p.A1349V | P15822 | protein_coding | tolerated(0.32) | possibly_damaging(0.611) | TCGA-L9-A8F4-01 | Lung | lung adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
HIVEP1 | SNV | Missense_Mutation | rs773414935 | c.8077C>G | p.Leu2693Val | p.L2693V | P15822 | protein_coding | tolerated(0.55) | possibly_damaging(0.474) | TCGA-18-3407-01 | Lung | lung squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
HIVEP1 | SNV | Missense_Mutation | rs779150057 | c.7666N>T | p.Pro2556Ser | p.P2556S | P15822 | protein_coding | deleterious(0.01) | benign(0.329) | TCGA-18-3409-01 | Lung | lung squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | PD |
HIVEP1 | SNV | Missense_Mutation | c.7667N>T | p.Pro2556Leu | p.P2556L | P15822 | protein_coding | deleterious(0) | probably_damaging(0.925) | TCGA-18-3409-01 | Lung | lung squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | PD | |
HIVEP1 | SNV | Missense_Mutation | c.2173N>A | p.Gly725Arg | p.G725R | P15822 | protein_coding | tolerated(0.15) | benign(0.059) | TCGA-18-4721-01 | Lung | lung squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
HIVEP1 | SNV | Missense_Mutation | c.6511N>C | p.Glu2171Gln | p.E2171Q | P15822 | protein_coding | deleterious(0.02) | probably_damaging(0.92) | TCGA-22-1011-01 | Lung | lung squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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