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Gene: DPP10 |
Gene summary for DPP10 |
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Gene information | Species | Human | Gene symbol | DPP10 | Gene ID | 57628 |
Gene name | dipeptidyl peptidase like 10 | |
Gene Alias | DPL2 | |
Cytomap | 2q14.1 | |
Gene Type | protein-coding | GO ID | GO:0006508 | UniProtAcc | B4DKB5 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
57628 | DPP10 | HTA11_3410_2000001011 | Human | Colorectum | AD | 7.86e-58 | -1.24e+00 | 0.0155 |
57628 | DPP10 | HTA11_2487_2000001011 | Human | Colorectum | SER | 1.82e-21 | -9.88e-01 | -0.1808 |
57628 | DPP10 | HTA11_2951_2000001011 | Human | Colorectum | AD | 6.49e-05 | -8.38e-01 | 0.0216 |
57628 | DPP10 | HTA11_1938_2000001011 | Human | Colorectum | AD | 1.83e-18 | -1.05e+00 | -0.0811 |
57628 | DPP10 | HTA11_78_2000001011 | Human | Colorectum | AD | 2.47e-19 | -8.92e-01 | -0.1088 |
57628 | DPP10 | HTA11_411_2000001011 | Human | Colorectum | SER | 2.91e-02 | -1.95e-01 | -0.2602 |
57628 | DPP10 | HTA11_2112_2000001011 | Human | Colorectum | SER | 1.07e-03 | -9.04e-01 | -0.2196 |
57628 | DPP10 | HTA11_3361_2000001011 | Human | Colorectum | AD | 2.48e-23 | -9.98e-01 | -0.1207 |
57628 | DPP10 | HTA11_83_2000001011 | Human | Colorectum | SER | 2.35e-09 | -7.12e-01 | -0.1526 |
57628 | DPP10 | HTA11_696_2000001011 | Human | Colorectum | AD | 3.22e-22 | -7.95e-01 | -0.1464 |
57628 | DPP10 | HTA11_866_2000001011 | Human | Colorectum | AD | 1.23e-30 | -9.27e-01 | -0.1001 |
57628 | DPP10 | HTA11_1391_2000001011 | Human | Colorectum | AD | 5.77e-32 | -1.02e+00 | -0.059 |
57628 | DPP10 | HTA11_5212_2000001011 | Human | Colorectum | AD | 1.32e-09 | -9.46e-01 | -0.2061 |
57628 | DPP10 | HTA11_5216_2000001011 | Human | Colorectum | SER | 1.11e-08 | -7.43e-01 | -0.1462 |
57628 | DPP10 | HTA11_546_2000001011 | Human | Colorectum | AD | 1.44e-09 | -8.73e-01 | -0.0842 |
57628 | DPP10 | HTA11_866_3004761011 | Human | Colorectum | AD | 6.09e-52 | -1.24e+00 | 0.096 |
57628 | DPP10 | HTA11_9408_2000001011 | Human | Colorectum | AD | 3.78e-07 | -1.21e+00 | 0.0451 |
57628 | DPP10 | HTA11_8622_2000001021 | Human | Colorectum | SER | 6.14e-13 | -1.14e+00 | 0.0528 |
57628 | DPP10 | HTA11_10711_2000001011 | Human | Colorectum | AD | 9.57e-16 | -7.91e-01 | 0.0338 |
57628 | DPP10 | HTA11_7696_3000711011 | Human | Colorectum | AD | 3.85e-24 | -7.32e-01 | 0.0674 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:0072659 | Colorectum | AD | protein localization to plasma membrane | 122/3918 | 284/18723 | 2.86e-17 | 1.49e-14 | 122 |
GO:1990778 | Colorectum | AD | protein localization to cell periphery | 129/3918 | 333/18723 | 5.51e-14 | 1.15e-11 | 129 |
GO:1903829 | Colorectum | AD | positive regulation of cellular protein localization | 110/3918 | 276/18723 | 4.58e-13 | 8.44e-11 | 110 |
GO:1905475 | Colorectum | AD | regulation of protein localization to membrane | 73/3918 | 175/18723 | 3.37e-10 | 2.93e-08 | 73 |
GO:1903076 | Colorectum | AD | regulation of protein localization to plasma membrane | 48/3918 | 104/18723 | 7.17e-09 | 4.36e-07 | 48 |
GO:1904375 | Colorectum | AD | regulation of protein localization to cell periphery | 54/3918 | 125/18723 | 1.52e-08 | 9.00e-07 | 54 |
GO:1905477 | Colorectum | AD | positive regulation of protein localization to membrane | 46/3918 | 106/18723 | 1.47e-07 | 6.64e-06 | 46 |
GO:1903078 | Colorectum | AD | positive regulation of protein localization to plasma membrane | 28/3918 | 62/18723 | 1.57e-05 | 3.34e-04 | 28 |
GO:1904377 | Colorectum | AD | positive regulation of protein localization to cell periphery | 30/3918 | 69/18723 | 1.98e-05 | 4.05e-04 | 30 |
GO:00726591 | Colorectum | SER | protein localization to plasma membrane | 92/2897 | 284/18723 | 6.36e-13 | 1.86e-10 | 92 |
GO:19038291 | Colorectum | SER | positive regulation of cellular protein localization | 86/2897 | 276/18723 | 3.61e-11 | 6.11e-09 | 86 |
GO:19907781 | Colorectum | SER | protein localization to cell periphery | 98/2897 | 333/18723 | 6.09e-11 | 9.57e-09 | 98 |
GO:19030761 | Colorectum | SER | regulation of protein localization to plasma membrane | 36/2897 | 104/18723 | 1.12e-06 | 5.18e-05 | 36 |
GO:19054751 | Colorectum | SER | regulation of protein localization to membrane | 52/2897 | 175/18723 | 1.31e-06 | 6.04e-05 | 52 |
GO:19043751 | Colorectum | SER | regulation of protein localization to cell periphery | 40/2897 | 125/18723 | 2.85e-06 | 1.16e-04 | 40 |
GO:19054771 | Colorectum | SER | positive regulation of protein localization to membrane | 33/2897 | 106/18723 | 3.83e-05 | 9.82e-04 | 33 |
GO:19030781 | Colorectum | SER | positive regulation of protein localization to plasma membrane | 22/2897 | 62/18723 | 8.58e-05 | 1.88e-03 | 22 |
GO:19043771 | Colorectum | SER | positive regulation of protein localization to cell periphery | 23/2897 | 69/18723 | 1.78e-04 | 3.30e-03 | 23 |
GO:00726592 | Colorectum | MSS | protein localization to plasma membrane | 113/3467 | 284/18723 | 3.23e-17 | 1.55e-14 | 113 |
GO:19907782 | Colorectum | MSS | protein localization to cell periphery | 120/3467 | 333/18723 | 2.02e-14 | 5.47e-12 | 120 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
DPP10 | SNV | Missense_Mutation | c.1301C>T | p.Ala434Val | p.A434V | Q8N608 | protein_coding | deleterious(0.02) | benign(0.06) | TCGA-VQ-A8PO-01 | Stomach | stomach adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | PD | |
DPP10 | SNV | Missense_Mutation | novel | c.1659N>T | p.Leu553Phe | p.L553F | Q8N608 | protein_coding | deleterious(0.01) | probably_damaging(0.972) | TCGA-VQ-A91V-01 | Stomach | stomach adenocarcinoma | Male | <65 | III/IV | Chemotherapy | cisplatin | PD |
DPP10 | deletion | Frame_Shift_Del | novel | c.681delT | p.Phe227LeufsTer32 | p.F227Lfs*32 | Q8N608 | protein_coding | TCGA-BR-8297-01 | Stomach | stomach adenocarcinoma | Male | <65 | III/IV | Chemotherapy | etoposide | SD | ||
DPP10 | insertion | Nonsense_Mutation | novel | c.1895_1896insGAAAATCTGGTAG | p.Ile632MetfsTer5 | p.I632Mfs*5 | Q8N608 | protein_coding | TCGA-ET-A40R-01 | Thyroid | thyroid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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