|
|||||
|
 | |
| |
| |
| |
| |
| |
|
Gene: DOPEY1 |
Gene summary for DOPEY1 |
 Gene summary. |
| Gene information | Species | Human | Gene symbol | DOPEY1 | Gene ID | 23033 |
| Gene name | DOP1 leucine zipper like protein A | |
| Gene Alias | DOP1 | |
| Cytomap | 6q14.1 | |
| Gene Type | protein-coding | GO ID | GO:0006810 | UniProtAcc | Q5TA12 |
Top |
Malignant transformation analysis |
| Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells |
| Malignant transformation involving gene list. |
| Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
| 23033 | DOPEY1 | HTA11_3410_2000001011 | Human | Colorectum | AD | 2.27e-41 | -8.93e-01 | 0.0155 |
| 23033 | DOPEY1 | HTA11_2487_2000001011 | Human | Colorectum | SER | 1.62e-25 | -8.93e-01 | -0.1808 |
| 23033 | DOPEY1 | HTA11_2951_2000001011 | Human | Colorectum | AD | 1.04e-06 | -8.93e-01 | 0.0216 |
| 23033 | DOPEY1 | HTA11_1938_2000001011 | Human | Colorectum | AD | 7.46e-20 | -8.93e-01 | -0.0811 |
| 23033 | DOPEY1 | HTA11_78_2000001011 | Human | Colorectum | AD | 1.20e-29 | -8.93e-01 | -0.1088 |
| 23033 | DOPEY1 | HTA11_347_2000001011 | Human | Colorectum | AD | 3.39e-44 | -8.93e-01 | -0.1954 |
| 23033 | DOPEY1 | HTA11_411_2000001011 | Human | Colorectum | SER | 3.24e-04 | -8.93e-01 | -0.2602 |
| 23033 | DOPEY1 | HTA11_2112_2000001011 | Human | Colorectum | SER | 8.13e-06 | -8.93e-01 | -0.2196 |
| 23033 | DOPEY1 | HTA11_3361_2000001011 | Human | Colorectum | AD | 1.50e-20 | -8.93e-01 | -0.1207 |
| 23033 | DOPEY1 | HTA11_83_2000001011 | Human | Colorectum | SER | 8.50e-17 | -8.93e-01 | -0.1526 |
| 23033 | DOPEY1 | HTA11_696_2000001011 | Human | Colorectum | AD | 1.20e-62 | -8.93e-01 | -0.1464 |
| 23033 | DOPEY1 | HTA11_866_2000001011 | Human | Colorectum | AD | 1.40e-59 | -8.93e-01 | -0.1001 |
| 23033 | DOPEY1 | HTA11_1391_2000001011 | Human | Colorectum | AD | 4.72e-34 | -8.93e-01 | -0.059 |
| 23033 | DOPEY1 | HTA11_2992_2000001011 | Human | Colorectum | SER | 1.88e-08 | -8.93e-01 | -0.1706 |
| 23033 | DOPEY1 | HTA11_5212_2000001011 | Human | Colorectum | AD | 1.01e-09 | -8.93e-01 | -0.2061 |
| 23033 | DOPEY1 | HTA11_5216_2000001011 | Human | Colorectum | SER | 1.04e-06 | -8.93e-01 | -0.1462 |
| 23033 | DOPEY1 | HTA11_546_2000001011 | Human | Colorectum | AD | 9.96e-15 | -8.93e-01 | -0.0842 |
| 23033 | DOPEY1 | HTA11_9341_2000001011 | Human | Colorectum | SER | 3.24e-04 | -8.93e-01 | -0.00410000000000005 |
| 23033 | DOPEY1 | HTA11_7862_2000001011 | Human | Colorectum | AD | 3.51e-12 | -8.93e-01 | -0.0179 |
| 23033 | DOPEY1 | HTA11_866_3004761011 | Human | Colorectum | AD | 7.39e-37 | -8.93e-01 | 0.096 |
| Page: 1 2 3 4 |
| Transcriptomic changes along malignancy continuum. |
| Tissue | Expression Dynamics | Abbreviation |
| Colorectum (GSE201348) |  | FAP: Familial adenomatous polyposis |
| CRC: Colorectal cancer | ||
| Colorectum (HTA11) |  | AD: Adenomas |
| SER: Sessile serrated lesions | ||
| MSI-H: Microsatellite-high colorectal cancer | ||
| MSS: Microsatellite stable colorectal cancer | ||
| Prostate |  | BPH: Benign Prostatic Hyperplasia |
| ∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
Top |
Malignant transformation related pathway analysis |
| Find out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer |
| Figure of enriched GO biological processes. |
| Tissue | Disease Stage | Enriched GO biological Processes |
| Colorectum | AD |  |
| Colorectum | SER |  |
| Colorectum | MSS |  |
| Colorectum | MSI-H |  |
| Colorectum | FAP |  |
| ∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
| Page: 1 2 3 4 5 6 7 8 9 |
| Enriched GO biological processes. |
| GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
| Page: 1 |
| Enriched KEGG pathways. |
| Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
| Page: 1 |
Top |
Cell-cell communication analysis |
| Identification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states |
| Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
| Page: 1 |
Top |
Single-cell gene regulatory network inference analysis |
| Find out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states |
| TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
| ∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
| Page: 1 |
Top |
Somatic mutation of malignant transformation related genes |
| Annotation of somatic variants for genes involved in malignant transformation |
| Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
| DOPEY1 | SNV | Missense_Mutation | novel | c.5222N>G | p.Asp1741Gly | p.D1741G | protein_coding | tolerated(0.05) | probably_damaging(0.999) | TCGA-21-1080-01 | Lung | lung squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
| DOPEY1 | SNV | Missense_Mutation | c.4909C>G | p.Arg1637Gly | p.R1637G | protein_coding | deleterious(0) | probably_damaging(0.997) | TCGA-21-5783-01 | Lung | lung squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | ||
| DOPEY1 | SNV | Missense_Mutation | novel | c.6380N>G | p.Asp2127Gly | p.D2127G | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-33-A5GW-01 | Lung | lung squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
| DOPEY1 | SNV | Missense_Mutation | novel | c.5159N>T | p.Ala1720Val | p.A1720V | protein_coding | deleterious(0) | benign(0.127) | TCGA-56-7731-01 | Lung | lung squamous cell carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
| DOPEY1 | SNV | Missense_Mutation | novel | c.3839N>C | p.Glu1280Ala | p.E1280A | protein_coding | tolerated(0.24) | possibly_damaging(0.693) | TCGA-58-8391-01 | Lung | lung squamous cell carcinoma | Female | <65 | III/IV | Chemotherapy | carboplatin | PD | |
| DOPEY1 | SNV | Missense_Mutation | c.3805N>C | p.Glu1269Gln | p.E1269Q | protein_coding | tolerated_low_confidence(0.09) | possibly_damaging(0.61) | TCGA-60-2698-01 | Lung | lung squamous cell carcinoma | Male | <65 | I/II | Chemotherapy | mithramycin | PD | ||
| DOPEY1 | SNV | Missense_Mutation | novel | c.6213N>G | p.Ser2071Arg | p.S2071R | protein_coding | deleterious(0.01) | probably_damaging(0.999) | TCGA-60-2706-01 | Lung | lung squamous cell carcinoma | Male | <65 | I/II | Unknown | Unknown | SD | |
| DOPEY1 | SNV | Missense_Mutation | c.6858N>C | p.Leu2286Phe | p.L2286F | protein_coding | deleterious(0.01) | benign(0.041) | TCGA-60-2713-01 | Lung | lung squamous cell carcinoma | Male | <65 | I/II | Chemotherapy | gemzar | SD | ||
| DOPEY1 | SNV | Missense_Mutation | c.7226N>A | p.Pro2409Gln | p.P2409Q | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-66-2734-01 | Lung | lung squamous cell carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | ||
| DOPEY1 | SNV | Missense_Mutation | rs749894496 | c.2394N>C | p.Gln798His | p.Q798H | protein_coding | deleterious(0) | benign(0.085) | TCGA-66-2791-01 | Lung | lung squamous cell carcinoma | Male | >=65 | III/IV | Unknown | Unknown | SD |
| Page: 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 |
Top |
Related drugs of malignant transformation related genes |
| Identification of chemicals and drugs interact with genes involved in malignant transfromation |
| (DGIdb 4.0) |
| Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
| Page: 1 |
Copyright 2023-Present -The University of Texas Health Science Center at Houston |