![]() |
|||||
|
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() |
Gene: DOCK5 |
Gene summary for DOCK5 |
![]() |
Gene information | Species | Human | Gene symbol | DOCK5 | Gene ID | 80005 |
Gene name | dedicator of cytokinesis 5 | |
Gene Alias | DOCK5 | |
Cytomap | 8p21.2 | |
Gene Type | protein-coding | GO ID | GO:0000902 | UniProtAcc | B9A015 |
Top |
Malignant transformation analysis |
![]() |
![]() |
Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
80005 | DOCK5 | HTA11_3410_2000001011 | Human | Colorectum | AD | 1.40e-19 | -6.06e-01 | 0.0155 |
80005 | DOCK5 | HTA11_347_2000001011 | Human | Colorectum | AD | 1.15e-12 | 6.09e-01 | -0.1954 |
80005 | DOCK5 | HTA11_411_2000001011 | Human | Colorectum | SER | 1.98e-03 | 7.91e-01 | -0.2602 |
80005 | DOCK5 | HTA11_866_3004761011 | Human | Colorectum | AD | 4.24e-10 | -4.60e-01 | 0.096 |
80005 | DOCK5 | HTA11_8622_2000001021 | Human | Colorectum | SER | 1.60e-03 | -6.47e-01 | 0.0528 |
80005 | DOCK5 | HTA11_99999970781_79442 | Human | Colorectum | MSS | 1.21e-05 | -3.52e-01 | 0.294 |
80005 | DOCK5 | HTA11_99999965104_69814 | Human | Colorectum | MSS | 1.84e-09 | -5.84e-01 | 0.281 |
80005 | DOCK5 | HTA11_99999971662_82457 | Human | Colorectum | MSS | 2.06e-17 | -5.92e-01 | 0.3859 |
80005 | DOCK5 | HTA11_99999973899_84307 | Human | Colorectum | MSS | 3.00e-04 | -5.32e-01 | 0.2585 |
80005 | DOCK5 | HTA11_99999974143_84620 | Human | Colorectum | MSS | 3.79e-22 | -5.61e-01 | 0.3005 |
80005 | DOCK5 | F007 | Human | Colorectum | FAP | 2.38e-03 | -4.21e-01 | 0.1176 |
80005 | DOCK5 | A015-C-203 | Human | Colorectum | FAP | 1.63e-36 | -5.05e-01 | -0.1294 |
80005 | DOCK5 | A015-C-204 | Human | Colorectum | FAP | 6.33e-05 | -3.36e-01 | -0.0228 |
80005 | DOCK5 | A014-C-040 | Human | Colorectum | FAP | 6.25e-07 | -6.59e-01 | -0.1184 |
80005 | DOCK5 | A002-C-201 | Human | Colorectum | FAP | 1.17e-13 | -3.44e-01 | 0.0324 |
80005 | DOCK5 | A002-C-203 | Human | Colorectum | FAP | 1.87e-03 | -1.56e-01 | 0.2786 |
80005 | DOCK5 | A001-C-119 | Human | Colorectum | FAP | 2.89e-11 | -5.00e-01 | -0.1557 |
80005 | DOCK5 | A001-C-108 | Human | Colorectum | FAP | 5.45e-20 | -2.92e-01 | -0.0272 |
80005 | DOCK5 | A002-C-205 | Human | Colorectum | FAP | 2.48e-24 | -4.71e-01 | -0.1236 |
80005 | DOCK5 | A001-C-104 | Human | Colorectum | FAP | 2.57e-02 | -1.72e-01 | 0.0184 |
Page: 1 2 3 4 5 6 7 8 |
![]() |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
Top |
Malignant transformation related pathway analysis |
![]() |
![]() |
Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
![]() |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:0022604 | Colorectum | AD | regulation of cell morphogenesis | 109/3918 | 309/18723 | 3.08e-09 | 2.07e-07 | 109 |
GO:0010811 | Colorectum | AD | positive regulation of cell-substrate adhesion | 53/3918 | 123/18723 | 2.30e-08 | 1.27e-06 | 53 |
GO:0010810 | Colorectum | AD | regulation of cell-substrate adhesion | 81/3918 | 221/18723 | 4.80e-08 | 2.55e-06 | 81 |
GO:0031589 | Colorectum | AD | cell-substrate adhesion | 116/3918 | 363/18723 | 4.68e-07 | 1.76e-05 | 116 |
GO:0001667 | Colorectum | AD | ameboidal-type cell migration | 137/3918 | 475/18723 | 2.17e-05 | 4.33e-04 | 137 |
GO:0034446 | Colorectum | AD | substrate adhesion-dependent cell spreading | 40/3918 | 108/18723 | 8.52e-05 | 1.32e-03 | 40 |
GO:0090132 | Colorectum | AD | epithelium migration | 105/3918 | 360/18723 | 1.18e-04 | 1.73e-03 | 105 |
GO:0010632 | Colorectum | AD | regulation of epithelial cell migration | 88/3918 | 292/18723 | 1.19e-04 | 1.75e-03 | 88 |
GO:0010631 | Colorectum | AD | epithelial cell migration | 104/3918 | 357/18723 | 1.33e-04 | 1.90e-03 | 104 |
GO:0090130 | Colorectum | AD | tissue migration | 105/3918 | 365/18723 | 2.10e-04 | 2.77e-03 | 105 |
GO:1900026 | Colorectum | AD | positive regulation of substrate adhesion-dependent cell spreading | 19/3918 | 41/18723 | 2.37e-04 | 3.03e-03 | 19 |
GO:1900024 | Colorectum | AD | regulation of substrate adhesion-dependent cell spreading | 24/3918 | 57/18723 | 2.38e-04 | 3.03e-03 | 24 |
GO:0045785 | Colorectum | AD | positive regulation of cell adhesion | 122/3918 | 437/18723 | 2.65e-04 | 3.28e-03 | 122 |
GO:0010769 | Colorectum | AD | regulation of cell morphogenesis involved in differentiation | 35/3918 | 96/18723 | 3.26e-04 | 3.85e-03 | 35 |
GO:0010770 | Colorectum | AD | positive regulation of cell morphogenesis involved in differentiation | 30/3918 | 79/18723 | 3.81e-04 | 4.38e-03 | 30 |
GO:0010720 | Colorectum | AD | positive regulation of cell development | 87/3918 | 298/18723 | 4.17e-04 | 4.71e-03 | 87 |
GO:0010634 | Colorectum | AD | positive regulation of epithelial cell migration | 56/3918 | 176/18723 | 4.51e-04 | 5.03e-03 | 56 |
GO:0090257 | Colorectum | AD | regulation of muscle system process | 73/3918 | 252/18723 | 1.46e-03 | 1.24e-02 | 73 |
GO:00226041 | Colorectum | SER | regulation of cell morphogenesis | 89/2897 | 309/18723 | 1.51e-09 | 1.52e-07 | 89 |
GO:00108101 | Colorectum | SER | regulation of cell-substrate adhesion | 64/2897 | 221/18723 | 2.34e-07 | 1.29e-05 | 64 |
Page: 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 |
![]() |
Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
Page: 1 |
Top |
Cell-cell communication analysis |
![]() |
Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
Page: 1 |
Top |
Single-cell gene regulatory network inference analysis |
![]() |
TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
Page: 1 |
Top |
Somatic mutation of malignant transformation related genes |
![]() |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
DOCK5 | SNV | Missense_Mutation | novel | c.4126N>A | p.Leu1376Ile | p.L1376I | Q9H7D0 | protein_coding | tolerated(0.07) | possibly_damaging(0.567) | TCGA-MX-A5UJ-01 | Stomach | stomach adenocarcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD |
DOCK5 | SNV | Missense_Mutation | novel | c.3110N>A | p.Ser1037Asn | p.S1037N | Q9H7D0 | protein_coding | tolerated(1) | benign(0.001) | TCGA-VQ-A8P2-01 | Stomach | stomach adenocarcinoma | Male | >=65 | III/IV | Unspecific | Complete Response | |
DOCK5 | SNV | Missense_Mutation | novel | c.4913N>T | p.Gly1638Val | p.G1638V | Q9H7D0 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-VQ-A8P2-01 | Stomach | stomach adenocarcinoma | Male | >=65 | III/IV | Unspecific | Complete Response | |
DOCK5 | deletion | Frame_Shift_Del | c.4633delN | p.His1545ThrfsTer45 | p.H1545Tfs*45 | Q9H7D0 | protein_coding | TCGA-VQ-A924-01 | Stomach | stomach adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | PD | |||
DOCK5 | SNV | Missense_Mutation | c.3289N>T | p.His1097Tyr | p.H1097Y | Q9H7D0 | protein_coding | tolerated(0.15) | benign(0.024) | TCGA-BJ-A3F0-01 | Thyroid | thyroid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
DOCK5 | insertion | Frame_Shift_Ins | novel | c.1816_1817insTATCA | p.Val607SerfsTer34 | p.V607Sfs*34 | Q9H7D0 | protein_coding | TCGA-EL-A3ZG-01 | Thyroid | thyroid carcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
Page: 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 |
Top |
Related drugs of malignant transformation related genes |
![]() |
(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
Page: 1 |