![]() |
|||||
|
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() |
Gene: CPAMD8 |
Gene summary for CPAMD8 |
![]() |
Gene information | Species | Human | Gene symbol | CPAMD8 | Gene ID | 27151 |
Gene name | C3 and PZP like alpha-2-macroglobulin domain containing 8 | |
Gene Alias | ASGD8 | |
Cytomap | 19p13.11 | |
Gene Type | protein-coding | GO ID | GO:0001654 | UniProtAcc | NA |
Top |
Malignant transformation analysis |
![]() |
![]() |
Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
27151 | CPAMD8 | RNA-P6T1-P6T1-3 | Human | Lung | MIAC | 3.80e-03 | 6.38e-01 | -0.0296 |
27151 | CPAMD8 | RNA-P6T1-P6T1-4 | Human | Lung | MIAC | 2.32e-05 | 7.38e-01 | -0.0263 |
27151 | CPAMD8 | RNA-P6T2-P6T2-1 | Human | Lung | IAC | 1.90e-15 | 5.09e-01 | -0.0166 |
27151 | CPAMD8 | RNA-P6T2-P6T2-2 | Human | Lung | IAC | 4.09e-13 | 4.57e-01 | -0.0132 |
27151 | CPAMD8 | RNA-P6T2-P6T2-3 | Human | Lung | IAC | 1.97e-23 | 6.15e-01 | -0.013 |
27151 | CPAMD8 | RNA-P6T2-P6T2-4 | Human | Lung | IAC | 1.27e-04 | 2.97e-01 | -0.0121 |
Page: 1 |
![]() |
Tissue | Expression Dynamics | Abbreviation |
Lung | ![]() | AAH: Atypical adenomatous hyperplasia |
AIS: Adenocarcinoma in situ | ||
IAC: Invasive lung adenocarcinoma | ||
MIA: Minimally invasive adenocarcinoma |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
Top |
Malignant transformation related pathway analysis |
![]() |
![]() |
Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
![]() |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:00525478 | Lung | IAC | regulation of peptidase activity | 80/2061 | 461/18723 | 2.39e-05 | 6.50e-04 | 80 |
GO:00525488 | Lung | IAC | regulation of endopeptidase activity | 75/2061 | 432/18723 | 4.18e-05 | 1.01e-03 | 75 |
GO:00458618 | Lung | IAC | negative regulation of proteolysis | 58/2061 | 351/18723 | 1.04e-03 | 1.24e-02 | 58 |
GO:00109518 | Lung | IAC | negative regulation of endopeptidase activity | 41/2061 | 252/18723 | 6.84e-03 | 4.75e-02 | 41 |
Page: 1 |
![]() |
Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
Page: 1 |
Top |
Cell-cell communication analysis |
![]() |
Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
Page: 1 |
Top |
Single-cell gene regulatory network inference analysis |
![]() |
TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
Page: 1 |
Top |
Somatic mutation of malignant transformation related genes |
![]() |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
CPAMD8 | SNV | Missense_Mutation | c.1577N>T | p.Pro526Leu | p.P526L | Q8IZJ3 | protein_coding | deleterious(0) | possibly_damaging(0.897) | TCGA-BR-6453-01 | Stomach | stomach adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD | |
CPAMD8 | SNV | Missense_Mutation | c.5057C>T | p.Ser1686Leu | p.S1686L | Q8IZJ3 | protein_coding | tolerated(0.08) | benign(0.207) | TCGA-BR-6457-01 | Stomach | stomach adenocarcinoma | Male | >=65 | I/II | Ancillary | leucovorin | CR | |
CPAMD8 | SNV | Missense_Mutation | rs183563770 | c.1280N>T | p.Thr427Met | p.T427M | Q8IZJ3 | protein_coding | tolerated(0.08) | benign(0.392) | TCGA-BR-6564-01 | Stomach | stomach adenocarcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
CPAMD8 | SNV | Missense_Mutation | c.1858N>A | p.Asp620Asn | p.D620N | Q8IZJ3 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-BR-7717-01 | Stomach | stomach adenocarcinoma | Male | <65 | III/IV | Unknown | Unknown | SD | |
CPAMD8 | SNV | Missense_Mutation | rs374200163 | c.1831N>A | p.Val611Ile | p.V611I | Q8IZJ3 | protein_coding | tolerated(0.09) | benign(0.075) | TCGA-BR-8589-01 | Stomach | stomach adenocarcinoma | Male | <65 | III/IV | Unknown | Unknown | SD |
CPAMD8 | SNV | Missense_Mutation | c.2401N>T | p.His801Tyr | p.H801Y | Q8IZJ3 | protein_coding | deleterious(0.04) | benign(0) | TCGA-BR-8679-01 | Stomach | stomach adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
CPAMD8 | SNV | Missense_Mutation | c.4972C>T | p.Leu1658Phe | p.L1658F | Q8IZJ3 | protein_coding | tolerated(0.09) | benign(0.027) | TCGA-BR-8680-01 | Stomach | stomach adenocarcinoma | Male | <65 | III/IV | Chemotherapy | oxaliplatin | CR | |
CPAMD8 | SNV | Missense_Mutation | c.1559C>A | p.Ser520Tyr | p.S520Y | Q8IZJ3 | protein_coding | tolerated(0.09) | possibly_damaging(0.481) | TCGA-BR-8680-01 | Stomach | stomach adenocarcinoma | Male | <65 | III/IV | Chemotherapy | oxaliplatin | CR | |
CPAMD8 | SNV | Missense_Mutation | rs775596217 | c.3563C>T | p.Pro1188Leu | p.P1188L | Q8IZJ3 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-CG-4460-01 | Stomach | stomach adenocarcinoma | Female | >=65 | III/IV | Chemotherapy | capecitabine | PD |
CPAMD8 | SNV | Missense_Mutation | rs779294937 | c.3808N>T | p.Arg1270Cys | p.R1270C | Q8IZJ3 | protein_coding | deleterious(0.02) | benign(0.233) | TCGA-CG-4475-01 | Stomach | stomach adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
Page: 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 |
Top |
Related drugs of malignant transformation related genes |
![]() |
(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
Page: 1 |