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Gene: CHL1 |
Gene summary for CHL1 |
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Gene information | Species | Human | Gene symbol | CHL1 | Gene ID | 10752 |
Gene name | cell adhesion molecule L1 like | |
Gene Alias | CALL | |
Cytomap | 3p26.3 | |
Gene Type | protein-coding | GO ID | GO:0000902 | UniProtAcc | O00533 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
10752 | CHL1 | LZE2T | Human | Esophagus | ESCC | 3.08e-04 | 7.85e-01 | 0.082 |
10752 | CHL1 | LZE24T | Human | Esophagus | ESCC | 6.08e-07 | 2.02e-01 | 0.0596 |
10752 | CHL1 | P4T-E | Human | Esophagus | ESCC | 5.55e-26 | 8.04e-01 | 0.1323 |
10752 | CHL1 | P8T-E | Human | Esophagus | ESCC | 2.40e-17 | 4.53e-01 | 0.0889 |
10752 | CHL1 | P9T-E | Human | Esophagus | ESCC | 1.72e-12 | 3.98e-01 | 0.1131 |
10752 | CHL1 | P10T-E | Human | Esophagus | ESCC | 3.16e-19 | 5.06e-01 | 0.116 |
10752 | CHL1 | P11T-E | Human | Esophagus | ESCC | 4.27e-06 | 5.38e-01 | 0.1426 |
10752 | CHL1 | P12T-E | Human | Esophagus | ESCC | 2.27e-09 | 2.56e-01 | 0.1122 |
10752 | CHL1 | P15T-E | Human | Esophagus | ESCC | 2.06e-02 | 1.98e-01 | 0.1149 |
10752 | CHL1 | P22T-E | Human | Esophagus | ESCC | 1.44e-02 | 1.36e-01 | 0.1236 |
10752 | CHL1 | P23T-E | Human | Esophagus | ESCC | 3.68e-04 | 2.47e-01 | 0.108 |
10752 | CHL1 | P26T-E | Human | Esophagus | ESCC | 1.09e-04 | 2.22e-01 | 0.1276 |
10752 | CHL1 | P27T-E | Human | Esophagus | ESCC | 1.19e-16 | 4.60e-01 | 0.1055 |
10752 | CHL1 | P28T-E | Human | Esophagus | ESCC | 2.02e-03 | 1.12e-01 | 0.1149 |
10752 | CHL1 | P30T-E | Human | Esophagus | ESCC | 7.10e-11 | 2.49e-01 | 0.137 |
10752 | CHL1 | P31T-E | Human | Esophagus | ESCC | 3.86e-04 | 1.13e-01 | 0.1251 |
10752 | CHL1 | P39T-E | Human | Esophagus | ESCC | 1.57e-09 | 2.95e-01 | 0.0894 |
10752 | CHL1 | P47T-E | Human | Esophagus | ESCC | 8.66e-03 | 1.81e-01 | 0.1067 |
10752 | CHL1 | P49T-E | Human | Esophagus | ESCC | 1.78e-15 | 1.10e+00 | 0.1768 |
10752 | CHL1 | P54T-E | Human | Esophagus | ESCC | 1.85e-25 | 8.92e-01 | 0.0975 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:001049810 | Cervix | CC | proteasomal protein catabolic process | 111/2311 | 490/18723 | 8.98e-11 | 1.58e-08 | 111 |
GO:004316110 | Cervix | CC | proteasome-mediated ubiquitin-dependent protein catabolic process | 91/2311 | 412/18723 | 1.65e-08 | 1.25e-06 | 91 |
GO:00719007 | Cervix | CC | regulation of protein serine/threonine kinase activity | 75/2311 | 359/18723 | 2.76e-06 | 8.02e-05 | 75 |
GO:005134810 | Cervix | CC | negative regulation of transferase activity | 60/2311 | 268/18723 | 2.77e-06 | 8.02e-05 | 60 |
GO:004593610 | Cervix | CC | negative regulation of phosphate metabolic process | 88/2311 | 441/18723 | 2.92e-06 | 8.27e-05 | 88 |
GO:001056310 | Cervix | CC | negative regulation of phosphorus metabolic process | 88/2311 | 442/18723 | 3.21e-06 | 8.77e-05 | 88 |
GO:004232610 | Cervix | CC | negative regulation of phosphorylation | 77/2311 | 385/18723 | 1.09e-05 | 2.38e-04 | 77 |
GO:00615647 | Cervix | CC | axon development | 89/2311 | 467/18723 | 1.71e-05 | 3.27e-04 | 89 |
GO:000193310 | Cervix | CC | negative regulation of protein phosphorylation | 69/2311 | 342/18723 | 2.29e-05 | 4.01e-04 | 69 |
GO:00516567 | Cervix | CC | establishment of organelle localization | 76/2311 | 390/18723 | 3.17e-05 | 5.21e-04 | 76 |
GO:000646910 | Cervix | CC | negative regulation of protein kinase activity | 47/2311 | 212/18723 | 4.13e-05 | 6.36e-04 | 47 |
GO:00336739 | Cervix | CC | negative regulation of kinase activity | 50/2311 | 237/18723 | 9.22e-05 | 1.21e-03 | 50 |
GO:00074097 | Cervix | CC | axonogenesis | 78/2311 | 418/18723 | 1.14e-04 | 1.43e-03 | 78 |
GO:00162367 | Cervix | CC | macroautophagy | 58/2311 | 291/18723 | 1.40e-04 | 1.70e-03 | 58 |
GO:00105067 | Cervix | CC | regulation of autophagy | 61/2311 | 317/18723 | 2.61e-04 | 2.87e-03 | 61 |
GO:00307057 | Cervix | CC | cytoskeleton-dependent intracellular transport | 40/2311 | 195/18723 | 7.92e-04 | 6.99e-03 | 40 |
GO:00426924 | Cervix | CC | muscle cell differentiation | 69/2311 | 384/18723 | 8.12e-04 | 7.09e-03 | 69 |
GO:00434099 | Cervix | CC | negative regulation of MAPK cascade | 37/2311 | 180/18723 | 1.17e-03 | 9.50e-03 | 37 |
GO:00516541 | Cervix | CC | establishment of mitochondrion localization | 10/2311 | 29/18723 | 1.74e-03 | 1.31e-02 | 10 |
GO:00094109 | Cervix | CC | response to xenobiotic stimulus | 78/2311 | 462/18723 | 2.39e-03 | 1.70e-02 | 78 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
CHL1 | SNV | Missense_Mutation | c.2003N>T | p.Asn668Ile | p.N668I | O00533 | protein_coding | deleterious(0) | probably_damaging(0.953) | TCGA-78-7159-01 | Lung | lung adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
CHL1 | SNV | Missense_Mutation | novel | c.3252A>T | p.Arg1084Ser | p.R1084S | O00533 | protein_coding | tolerated(0.2) | benign(0.084) | TCGA-78-8662-01 | Lung | lung adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | PD |
CHL1 | SNV | Missense_Mutation | novel | c.2408N>A | p.Ala803Asp | p.A803D | O00533 | protein_coding | deleterious(0) | probably_damaging(0.994) | TCGA-97-7546-01 | Lung | lung adenocarcinoma | Female | >=65 | I/II | Targeted Molecular therapy | tarceva | SD |
CHL1 | SNV | Missense_Mutation | c.455C>A | p.Pro152Gln | p.P152Q | O00533 | protein_coding | tolerated(0.42) | benign(0) | TCGA-99-8028-01 | Lung | lung adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
CHL1 | SNV | Missense_Mutation | novel | c.3380A>T | p.Tyr1127Phe | p.Y1127F | O00533 | protein_coding | deleterious(0.01) | probably_damaging(0.999) | TCGA-L9-A444-01 | Lung | lung adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
CHL1 | SNV | Missense_Mutation | c.2155C>G | p.His719Asp | p.H719D | O00533 | protein_coding | deleterious(0) | benign(0.306) | TCGA-L9-A7SV-01 | Lung | lung adenocarcinoma | Male | >=65 | I/II | Chemotherapy | cisplatin | CR | |
CHL1 | SNV | Missense_Mutation | novel | c.2456A>T | p.Tyr819Phe | p.Y819F | O00533 | protein_coding | deleterious(0.01) | probably_damaging(0.999) | TCGA-MN-A4N5-01 | Lung | lung adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
CHL1 | SNV | Missense_Mutation | novel | c.1457N>T | p.Arg486Leu | p.R486L | O00533 | protein_coding | deleterious(0.02) | probably_damaging(0.951) | TCGA-18-3416-01 | Lung | lung squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | PD |
CHL1 | SNV | Missense_Mutation | c.1028T>A | p.Val343Glu | p.V343E | O00533 | protein_coding | deleterious(0) | probably_damaging(0.952) | TCGA-21-5787-01 | Lung | lung squamous cell carcinoma | Male | >=65 | III/IV | Unknown | Unknown | PD | |
CHL1 | SNV | Missense_Mutation | c.1422G>T | p.Gln474His | p.Q474H | O00533 | protein_coding | tolerated(0.34) | possibly_damaging(0.605) | TCGA-21-5787-01 | Lung | lung squamous cell carcinoma | Male | >=65 | III/IV | Unknown | Unknown | PD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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