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Gene: ZFC3H1 |
Gene summary for ZFC3H1 |
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Gene information | Species | Human | Gene symbol | ZFC3H1 | Gene ID | 196441 |
Gene name | zinc finger C3H1-type containing | |
Gene Alias | CCDC131 | |
Cytomap | 12q21.1 | |
Gene Type | protein-coding | GO ID | GO:0006139 | UniProtAcc | O60293 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
196441 | ZFC3H1 | CCI_1 | Human | Cervix | CC | 2.43e-03 | 6.71e-01 | 0.528 |
196441 | ZFC3H1 | CCI_2 | Human | Cervix | CC | 3.77e-16 | 1.39e+00 | 0.5249 |
196441 | ZFC3H1 | CCI_3 | Human | Cervix | CC | 5.12e-16 | 1.13e+00 | 0.516 |
196441 | ZFC3H1 | HTA11_3410_2000001011 | Human | Colorectum | AD | 1.89e-16 | -5.94e-01 | 0.0155 |
196441 | ZFC3H1 | HTA11_2487_2000001011 | Human | Colorectum | SER | 2.72e-07 | -5.84e-01 | -0.1808 |
196441 | ZFC3H1 | HTA11_1938_2000001011 | Human | Colorectum | AD | 3.67e-03 | -4.35e-01 | -0.0811 |
196441 | ZFC3H1 | HTA11_78_2000001011 | Human | Colorectum | AD | 1.43e-02 | -3.81e-01 | -0.1088 |
196441 | ZFC3H1 | HTA11_3361_2000001011 | Human | Colorectum | AD | 5.53e-05 | -5.60e-01 | -0.1207 |
196441 | ZFC3H1 | HTA11_83_2000001011 | Human | Colorectum | SER | 1.19e-02 | -3.75e-01 | -0.1526 |
196441 | ZFC3H1 | HTA11_696_2000001011 | Human | Colorectum | AD | 1.66e-09 | -4.49e-01 | -0.1464 |
196441 | ZFC3H1 | HTA11_866_2000001011 | Human | Colorectum | AD | 6.44e-03 | -3.58e-01 | -0.1001 |
196441 | ZFC3H1 | HTA11_866_3004761011 | Human | Colorectum | AD | 8.33e-12 | -5.24e-01 | 0.096 |
196441 | ZFC3H1 | HTA11_10711_2000001011 | Human | Colorectum | AD | 5.60e-04 | -3.96e-01 | 0.0338 |
196441 | ZFC3H1 | HTA11_7696_3000711011 | Human | Colorectum | AD | 1.59e-04 | -3.48e-01 | 0.0674 |
196441 | ZFC3H1 | HTA11_6818_2000001021 | Human | Colorectum | AD | 2.35e-06 | -5.17e-01 | 0.0588 |
196441 | ZFC3H1 | HTA11_99999970781_79442 | Human | Colorectum | MSS | 8.83e-04 | -3.57e-01 | 0.294 |
196441 | ZFC3H1 | HTA11_99999973899_84307 | Human | Colorectum | MSS | 1.28e-03 | -5.76e-01 | 0.2585 |
196441 | ZFC3H1 | HTA11_99999974143_84620 | Human | Colorectum | MSS | 1.37e-12 | -5.39e-01 | 0.3005 |
196441 | ZFC3H1 | A001-C-207 | Human | Colorectum | FAP | 4.91e-02 | -2.89e-02 | 0.1278 |
196441 | ZFC3H1 | A015-C-203 | Human | Colorectum | FAP | 9.89e-26 | -1.32e-01 | -0.1294 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
ZFC3H1 | SNV | Missense_Mutation | c.3112G>T | p.Gly1038Cys | p.G1038C | O60293 | protein_coding | tolerated(0.05) | benign(0.43) | TCGA-HU-A4GN-01 | Stomach | stomach adenocarcinoma | Male | <65 | I/II | Chemotherapy | mitomycin | PD | |
ZFC3H1 | SNV | Missense_Mutation | c.1402N>G | p.Arg468Gly | p.R468G | O60293 | protein_coding | deleterious(0) | probably_damaging(0.987) | TCGA-VQ-A8P2-01 | Stomach | stomach adenocarcinoma | Male | >=65 | III/IV | Unspecific | Complete Response | ||
ZFC3H1 | SNV | Missense_Mutation | rs759268830 | c.133A>G | p.Ser45Gly | p.S45G | O60293 | protein_coding | tolerated_low_confidence(0.61) | benign(0) | TCGA-VQ-A91E-01 | Stomach | stomach adenocarcinoma | Female | >=65 | III/IV | Chemotherapy | fluorouracil | CR |
ZFC3H1 | insertion | Frame_Shift_Ins | novel | c.807_808insCCTTG | p.Thr270ProfsTer2 | p.T270Pfs*2 | O60293 | protein_coding | TCGA-BR-8486-01 | Stomach | stomach adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | ||
ZFC3H1 | insertion | Frame_Shift_Ins | novel | c.806_807insTT | p.Gln269HisfsTer2 | p.Q269Hfs*2 | O60293 | protein_coding | TCGA-BR-8486-01 | Stomach | stomach adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | ||
ZFC3H1 | deletion | In_Frame_Del | novel | c.444_461delNNNNNNNNNNNNNNNNNN | p.Arg149_Gly154del | p.R149_G154del | O60293 | protein_coding | TCGA-BR-A4IY-01 | Stomach | stomach adenocarcinoma | Male | <65 | I/II | Chemotherapy | oxaliplatin | CR | ||
ZFC3H1 | insertion | Frame_Shift_Ins | novel | c.3249_3250insT | p.Leu1084SerfsTer7 | p.L1084Sfs*7 | O60293 | protein_coding | TCGA-VQ-A8P2-01 | Stomach | stomach adenocarcinoma | Male | >=65 | III/IV | Unspecific | Complete Response | |||
ZFC3H1 | SNV | Missense_Mutation | novel | c.1191C>A | p.Ser397Arg | p.S397R | O60293 | protein_coding | deleterious(0) | probably_damaging(0.991) | TCGA-E8-A436-01 | Thyroid | thyroid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
ZFC3H1 | SNV | Missense_Mutation | novel | c.1190G>C | p.Ser397Thr | p.S397T | O60293 | protein_coding | deleterious(0.01) | probably_damaging(0.971) | TCGA-E8-A436-01 | Thyroid | thyroid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
ZFC3H1 | SNV | Missense_Mutation | novel | c.4855N>A | p.Glu1619Lys | p.E1619K | O60293 | protein_coding | deleterious(0.04) | benign(0.275) | TCGA-EM-A3SX-01 | Thyroid | thyroid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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