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Gene: WDR17 |
Gene summary for WDR17 |
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Gene information | Species | Human | Gene symbol | WDR17 | Gene ID | 116966 |
Gene name | WD repeat domain 17 | |
Gene Alias | WDR17 | |
Cytomap | 4q34.2 | |
Gene Type | protein-coding | GO ID | NA | UniProtAcc | Q8IZU2 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
116966 | WDR17 | HCC1 | Human | Liver | HCC | 5.09e-09 | 8.86e-01 | 0.5336 |
116966 | WDR17 | HCC2 | Human | Liver | HCC | 1.41e-14 | 1.01e+00 | 0.5341 |
116966 | WDR17 | HCC5 | Human | Liver | HCC | 3.01e-14 | 8.14e-01 | 0.4932 |
116966 | WDR17 | HTA12-23-1 | Human | Pancreas | PDAC | 1.27e-03 | 6.03e-01 | 0.3405 |
116966 | WDR17 | HTA12-25-1 | Human | Pancreas | PDAC | 3.33e-03 | 4.07e-01 | 0.313 |
116966 | WDR17 | HTA12-26-1 | Human | Pancreas | PDAC | 2.63e-13 | 7.33e-01 | 0.3728 |
116966 | WDR17 | HTA12-29-1 | Human | Pancreas | PDAC | 9.44e-28 | 6.40e-01 | 0.3722 |
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Tissue | Expression Dynamics | Abbreviation |
Liver | ![]() | HCC: Hepatocellular carcinoma |
NAFLD: Non-alcoholic fatty liver disease |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
WDR17 | SNV | Missense_Mutation | novel | c.3404N>A | p.Pro1135His | p.P1135H | Q8IZU2 | protein_coding | deleterious(0.02) | possibly_damaging(0.826) | TCGA-NC-A5HQ-01 | Lung | lung squamous cell carcinoma | Male | >=65 | III/IV | Chemotherapy | carboplatin | CR |
WDR17 | SNV | Missense_Mutation | novel | c.110N>T | p.Gly37Val | p.G37V | Q8IZU2 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-O2-A52Q-01 | Lung | lung squamous cell carcinoma | Female | <65 | III/IV | Unknown | Unknown | PD |
WDR17 | SNV | Missense_Mutation | novel | c.1940N>G | p.Thr647Ser | p.T647S | Q8IZU2 | protein_coding | tolerated(0.07) | probably_damaging(0.996) | TCGA-O2-A52Q-01 | Lung | lung squamous cell carcinoma | Female | <65 | III/IV | Unknown | Unknown | PD |
WDR17 | deletion | Frame_Shift_Del | c.694delG | p.Asp232ThrfsTer9 | p.D232Tfs*9 | Q8IZU2 | protein_coding | TCGA-44-8119-01 | Lung | lung adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |||
WDR17 | SNV | Missense_Mutation | novel | c.3421N>T | p.Ser1141Cys | p.S1141C | Q8IZU2 | protein_coding | deleterious(0.01) | possibly_damaging(0.728) | TCGA-BA-A6DA-01 | Oral cavity | head & neck squamous cell carcinoma | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
WDR17 | SNV | Missense_Mutation | novel | c.2929A>G | p.Met977Val | p.M977V | Q8IZU2 | protein_coding | tolerated(0.29) | benign(0.003) | TCGA-BA-A6DL-01 | Oral cavity | head & neck squamous cell carcinoma | Male | <65 | I/II | Chemotherapy | carboplatin | CR |
WDR17 | SNV | Missense_Mutation | c.1049N>T | p.Pro350Leu | p.P350L | Q8IZU2 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-CN-5356-01 | Oral cavity | head & neck squamous cell carcinoma | Male | <65 | III/IV | Unknown | Unknown | SD | |
WDR17 | SNV | Missense_Mutation | novel | c.3680N>A | p.Ser1227Tyr | p.S1227Y | Q8IZU2 | protein_coding | deleterious(0.02) | benign(0.031) | TCGA-CN-5356-01 | Oral cavity | head & neck squamous cell carcinoma | Male | <65 | III/IV | Unknown | Unknown | SD |
WDR17 | SNV | Missense_Mutation | novel | c.523G>T | p.Asp175Tyr | p.D175Y | Q8IZU2 | protein_coding | deleterious(0.01) | probably_damaging(0.999) | TCGA-CR-5248-01 | Oral cavity | head & neck squamous cell carcinoma | Male | <65 | I/II | Chemotherapy | oxaliplatin | PD |
WDR17 | SNV | Missense_Mutation | rs141454308 | c.2993N>T | p.Glu998Val | p.E998V | Q8IZU2 | protein_coding | tolerated(0.11) | possibly_damaging(0.541) | TCGA-CR-7364-01 | Oral cavity | head & neck squamous cell carcinoma | Male | >=65 | III/IV | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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