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Gene: SORCS1 |
Gene summary for SORCS1 |
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Gene information | Species | Human | Gene symbol | SORCS1 | Gene ID | 114815 |
Gene name | sortilin related VPS10 domain containing receptor 1 | |
Gene Alias | hSorCS | |
Cytomap | 10q25.1 | |
Gene Type | protein-coding | GO ID | GO:0006810 | UniProtAcc | B3KVZ0 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
114815 | SORCS1 | S014 | Human | Liver | HCC | 6.02e-18 | 7.52e-01 | 0.2254 |
114815 | SORCS1 | S015 | Human | Liver | HCC | 3.17e-08 | 3.87e-01 | 0.2375 |
114815 | SORCS1 | S016 | Human | Liver | HCC | 8.57e-24 | 8.21e-01 | 0.2243 |
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Tissue | Expression Dynamics | Abbreviation |
Liver | ![]() | HCC: Hepatocellular carcinoma |
NAFLD: Non-alcoholic fatty liver disease |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:004819321 | Liver | HCC | Golgi vesicle transport | 217/7958 | 296/18723 | 2.58e-27 | 1.02e-24 | 217 |
GO:000689221 | Liver | HCC | post-Golgi vesicle-mediated transport | 77/7958 | 104/18723 | 6.14e-11 | 2.24e-09 | 77 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
SORCS1 | SNV | Missense_Mutation | novel | c.2219N>T | p.Gly740Val | p.G740V | Q8WY21 | protein_coding | deleterious(0) | probably_damaging(0.924) | TCGA-21-1083-01 | Lung | lung squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
SORCS1 | SNV | Missense_Mutation | novel | c.701A>G | p.Tyr234Cys | p.Y234C | Q8WY21 | protein_coding | deleterious(0.01) | benign(0.142) | TCGA-21-5783-01 | Lung | lung squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
SORCS1 | SNV | Missense_Mutation | c.2164G>T | p.Val722Phe | p.V722F | Q8WY21 | protein_coding | deleterious(0.04) | possibly_damaging(0.67) | TCGA-21-5784-01 | Lung | lung squamous cell carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
SORCS1 | SNV | Missense_Mutation | c.3371N>T | p.Arg1124Met | p.R1124M | Q8WY21 | protein_coding | tolerated(0.06) | probably_damaging(0.99) | TCGA-21-5786-01 | Lung | lung squamous cell carcinoma | Male | <65 | I/II | Unknown | Unknown | PD | |
SORCS1 | SNV | Missense_Mutation | rs569730754 | c.2416G>A | p.Asp806Asn | p.D806N | Q8WY21 | protein_coding | tolerated(0.18) | benign(0.135) | TCGA-21-A5DI-01 | Lung | lung squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
SORCS1 | SNV | Missense_Mutation | c.1456N>T | p.Asp486Tyr | p.D486Y | Q8WY21 | protein_coding | deleterious(0) | probably_damaging(0.971) | TCGA-22-5477-01 | Lung | lung squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | PD | |
SORCS1 | SNV | Missense_Mutation | c.2164G>A | p.Val722Ile | p.V722I | Q8WY21 | protein_coding | tolerated(0.32) | benign(0.023) | TCGA-22-5479-01 | Lung | lung squamous cell carcinoma | Male | <65 | I/II | Chemotherapy | carboplatin | SD | |
SORCS1 | SNV | Missense_Mutation | novel | c.3074T>C | p.Leu1025Pro | p.L1025P | Q8WY21 | protein_coding | tolerated(0.16) | possibly_damaging(0.862) | TCGA-22-5489-01 | Lung | lung squamous cell carcinoma | Male | <65 | I/II | Chemotherapy | taxotere | PD |
SORCS1 | SNV | Missense_Mutation | c.1738N>A | p.Gln580Lys | p.Q580K | Q8WY21 | protein_coding | deleterious(0.03) | benign(0.056) | TCGA-33-4566-01 | Lung | lung squamous cell carcinoma | Male | <65 | I/II | Unknown | Unknown | SD | |
SORCS1 | SNV | Missense_Mutation | c.652N>A | p.Glu218Lys | p.E218K | Q8WY21 | protein_coding | tolerated(0.2) | benign(0.344) | TCGA-33-4566-01 | Lung | lung squamous cell carcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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