GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:0016049110 | Esophagus | ESCC | cell growth | 289/8552 | 482/18723 | 1.29e-10 | 3.77e-09 | 289 |
GO:000155819 | Esophagus | ESCC | regulation of cell growth | 248/8552 | 414/18723 | 2.97e-09 | 6.45e-08 | 248 |
GO:000206420 | Esophagus | ESCC | epithelial cell development | 136/8552 | 220/18723 | 9.50e-07 | 1.21e-05 | 136 |
GO:003367420 | Esophagus | ESCC | positive regulation of kinase activity | 260/8552 | 467/18723 | 7.26e-06 | 7.22e-05 | 260 |
GO:00319294 | Esophagus | ESCC | TOR signaling | 79/8552 | 126/18723 | 8.57e-05 | 6.21e-04 | 79 |
GO:00182124 | Esophagus | ESCC | peptidyl-tyrosine modification | 202/8552 | 378/18723 | 1.34e-03 | 6.39e-03 | 202 |
GO:00320061 | Esophagus | ESCC | regulation of TOR signaling | 63/8552 | 104/18723 | 1.55e-03 | 7.29e-03 | 63 |
GO:00181084 | Esophagus | ESCC | peptidyl-tyrosine phosphorylation | 200/8552 | 375/18723 | 1.60e-03 | 7.45e-03 | 200 |
GO:0002066 | Esophagus | ESCC | columnar/cuboidal epithelial cell development | 29/8552 | 44/18723 | 5.41e-03 | 2.02e-02 | 29 |
GO:00610417 | Liver | NAFLD | regulation of wound healing | 39/1882 | 134/18723 | 5.52e-10 | 1.28e-07 | 39 |
GO:00420607 | Liver | NAFLD | wound healing | 84/1882 | 422/18723 | 6.56e-10 | 1.37e-07 | 84 |
GO:0042730 | Liver | NAFLD | fibrinolysis | 15/1882 | 25/18723 | 1.26e-09 | 2.30e-07 | 15 |
GO:0030195 | Liver | NAFLD | negative regulation of blood coagulation | 21/1882 | 49/18723 | 2.42e-09 | 4.05e-07 | 21 |
GO:1900047 | Liver | NAFLD | negative regulation of hemostasis | 21/1882 | 50/18723 | 3.78e-09 | 5.40e-07 | 21 |
GO:0030193 | Liver | NAFLD | regulation of blood coagulation | 24/1882 | 66/18723 | 9.30e-09 | 1.26e-06 | 24 |
GO:0050819 | Liver | NAFLD | negative regulation of coagulation | 21/1882 | 53/18723 | 1.33e-08 | 1.69e-06 | 21 |
GO:1900046 | Liver | NAFLD | regulation of hemostasis | 24/1882 | 68/18723 | 1.84e-08 | 2.09e-06 | 24 |
GO:0061045 | Liver | NAFLD | negative regulation of wound healing | 26/1882 | 78/18723 | 1.86e-08 | 2.09e-06 | 26 |
GO:19030347 | Liver | NAFLD | regulation of response to wounding | 41/1882 | 167/18723 | 4.70e-08 | 4.58e-06 | 41 |
GO:0050818 | Liver | NAFLD | regulation of coagulation | 24/1882 | 71/18723 | 4.80e-08 | 4.60e-06 | 24 |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
ROS1 | SNV | Missense_Mutation | | c.6860N>C | p.Lys2287Thr | p.K2287T | P08922 | protein_coding | deleterious_low_confidence(0.01) | benign(0.003) | TCGA-EO-A22R-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
ROS1 | SNV | Missense_Mutation | novel | c.5707N>T | p.Asp1903Tyr | p.D1903Y | P08922 | protein_coding | deleterious(0) | probably_damaging(0.998) | TCGA-EO-A22R-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
ROS1 | SNV | Missense_Mutation | novel | c.2559N>C | p.Gln853His | p.Q853H | P08922 | protein_coding | tolerated(0.15) | benign(0.135) | TCGA-EO-A22R-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
ROS1 | SNV | Missense_Mutation | novel | c.1061N>A | p.Ser354Tyr | p.S354Y | P08922 | protein_coding | deleterious(0) | benign(0.246) | TCGA-EO-A22R-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
ROS1 | SNV | Missense_Mutation | novel | c.4495N>C | p.Asn1499His | p.N1499H | P08922 | protein_coding | deleterious(0.04) | benign(0.275) | TCGA-EO-A22U-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
ROS1 | SNV | Missense_Mutation | novel | c.4396N>C | p.Ile1466Leu | p.I1466L | P08922 | protein_coding | tolerated(1) | benign(0) | TCGA-EO-A22U-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
ROS1 | SNV | Missense_Mutation | novel | c.1139N>T | p.Arg380Ile | p.R380I | P08922 | protein_coding | deleterious(0) | possibly_damaging(0.797) | TCGA-EO-A22U-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
ROS1 | SNV | Missense_Mutation | novel | c.4582N>C | p.Ile1528Leu | p.I1528L | P08922 | protein_coding | tolerated(0.22) | probably_damaging(0.93) | TCGA-EO-A22X-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unspecific | Carboplatin | Complete Response |
ROS1 | SNV | Missense_Mutation | rs779854799 | c.4141N>A | p.Ala1381Thr | p.A1381T | P08922 | protein_coding | tolerated(0.57) | benign(0.194) | TCGA-EO-A22X-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unspecific | Carboplatin | Complete Response |
ROS1 | SNV | Missense_Mutation | novel | c.3394N>C | p.Thr1132Pro | p.T1132P | P08922 | protein_coding | deleterious(0) | possibly_damaging(0.898) | TCGA-EO-A22X-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unspecific | Carboplatin | Complete Response |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
6098 | ROS1 | TYROSINE KINASE, CLINICALLY ACTIONABLE, DRUG RESISTANCE, ENZYME, DRUGGABLE GENOME, KINASE, TRANSCRIPTION FACTOR | | Imidazo[1,2-b]pyridazine derivative 2 | | |
6098 | ROS1 | TYROSINE KINASE, CLINICALLY ACTIONABLE, DRUG RESISTANCE, ENZYME, DRUGGABLE GENOME, KINASE, TRANSCRIPTION FACTOR | | ENTRECTINIB | ENTRECTINIB | 28183697 |
6098 | ROS1 | TYROSINE KINASE, CLINICALLY ACTIONABLE, DRUG RESISTANCE, ENZYME, DRUGGABLE GENOME, KINASE, TRANSCRIPTION FACTOR | inhibitor | HESPERADIN | HESPERADIN | 19035792 |
6098 | ROS1 | TYROSINE KINASE, CLINICALLY ACTIONABLE, DRUG RESISTANCE, ENZYME, DRUGGABLE GENOME, KINASE, TRANSCRIPTION FACTOR | | CRIZOTINIB | CRIZOTINIB | 23724914,25733882,25351743,25688157,26372962 |
6098 | ROS1 | TYROSINE KINASE, CLINICALLY ACTIONABLE, DRUG RESISTANCE, ENZYME, DRUGGABLE GENOME, KINASE, TRANSCRIPTION FACTOR | | AZD3463 | | 26372962 |
6098 | ROS1 | TYROSINE KINASE, CLINICALLY ACTIONABLE, DRUG RESISTANCE, ENZYME, DRUGGABLE GENOME, KINASE, TRANSCRIPTION FACTOR | | TPX-0005 | | |
6098 | ROS1 | TYROSINE KINASE, CLINICALLY ACTIONABLE, DRUG RESISTANCE, ENZYME, DRUGGABLE GENOME, KINASE, TRANSCRIPTION FACTOR | inhibitor | CRIZOTINIB | CRIZOTINIB | |
6098 | ROS1 | TYROSINE KINASE, CLINICALLY ACTIONABLE, DRUG RESISTANCE, ENZYME, DRUGGABLE GENOME, KINASE, TRANSCRIPTION FACTOR | | DS6051b | | |
6098 | ROS1 | TYROSINE KINASE, CLINICALLY ACTIONABLE, DRUG RESISTANCE, ENZYME, DRUGGABLE GENOME, KINASE, TRANSCRIPTION FACTOR | | CYC-116 | CYC-116 | |
6098 | ROS1 | TYROSINE KINASE, CLINICALLY ACTIONABLE, DRUG RESISTANCE, ENZYME, DRUGGABLE GENOME, KINASE, TRANSCRIPTION FACTOR | | CRIZOTINIB | CRIZOTINIB | 29596029,23724914,25264305,24875859,25922291,22215748,25688157,26372962,25667280,30980071,29333528 |