![]() |
|||||
|
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() |
Gene: PXDN |
Gene summary for PXDN |
![]() |
Gene information | Species | Human | Gene symbol | PXDN | Gene ID | 7837 |
Gene name | peroxidasin | |
Gene Alias | ASGD7 | |
Cytomap | 2p25.3 | |
Gene Type | protein-coding | GO ID | GO:0001959 | UniProtAcc | Q92626 |
Top |
Malignant transformation analysis |
![]() |
![]() |
Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
7837 | PXDN | LZE7T | Human | Esophagus | ESCC | 1.72e-12 | 5.68e-01 | 0.0667 |
7837 | PXDN | LZE8T | Human | Esophagus | ESCC | 2.47e-02 | 8.15e-02 | 0.067 |
7837 | PXDN | P2T-E | Human | Esophagus | ESCC | 8.46e-39 | 6.84e-01 | 0.1177 |
7837 | PXDN | P8T-E | Human | Esophagus | ESCC | 1.06e-44 | 7.73e-01 | 0.0889 |
7837 | PXDN | P10T-E | Human | Esophagus | ESCC | 9.76e-42 | 7.12e-01 | 0.116 |
7837 | PXDN | P11T-E | Human | Esophagus | ESCC | 5.28e-12 | 6.75e-01 | 0.1426 |
7837 | PXDN | P12T-E | Human | Esophagus | ESCC | 5.08e-29 | 5.21e-01 | 0.1122 |
7837 | PXDN | P15T-E | Human | Esophagus | ESCC | 1.34e-18 | 4.20e-01 | 0.1149 |
7837 | PXDN | P16T-E | Human | Esophagus | ESCC | 2.25e-23 | 3.61e-01 | 0.1153 |
7837 | PXDN | P19T-E | Human | Esophagus | ESCC | 3.67e-11 | 6.46e-01 | 0.1662 |
7837 | PXDN | P21T-E | Human | Esophagus | ESCC | 7.97e-34 | 6.82e-01 | 0.1617 |
7837 | PXDN | P22T-E | Human | Esophagus | ESCC | 1.46e-30 | 3.17e-01 | 0.1236 |
7837 | PXDN | P23T-E | Human | Esophagus | ESCC | 1.56e-03 | 1.84e-01 | 0.108 |
7837 | PXDN | P24T-E | Human | Esophagus | ESCC | 2.24e-07 | 2.81e-01 | 0.1287 |
7837 | PXDN | P26T-E | Human | Esophagus | ESCC | 1.39e-05 | 1.61e-01 | 0.1276 |
7837 | PXDN | P30T-E | Human | Esophagus | ESCC | 6.14e-11 | 6.29e-01 | 0.137 |
7837 | PXDN | P31T-E | Human | Esophagus | ESCC | 3.24e-36 | 5.92e-01 | 0.1251 |
7837 | PXDN | P32T-E | Human | Esophagus | ESCC | 2.27e-20 | 5.06e-01 | 0.1666 |
7837 | PXDN | P40T-E | Human | Esophagus | ESCC | 1.39e-09 | 3.72e-01 | 0.109 |
7837 | PXDN | P42T-E | Human | Esophagus | ESCC | 6.10e-20 | 5.92e-01 | 0.1175 |
Page: 1 2 3 |
![]() |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
Top |
Malignant transformation related pathway analysis |
![]() |
![]() |
Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
![]() |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:0006979111 | Esophagus | ESCC | response to oxidative stress | 303/8552 | 446/18723 | 7.15e-22 | 1.30e-19 | 303 |
GO:00607595 | Esophagus | ESCC | regulation of response to cytokine stimulus | 103/8552 | 162/18723 | 3.14e-06 | 3.53e-05 | 103 |
GO:00019595 | Esophagus | ESCC | regulation of cytokine-mediated signaling pathway | 95/8552 | 150/18723 | 9.48e-06 | 9.04e-05 | 95 |
GO:00301984 | Esophagus | ESCC | extracellular matrix organization | 171/8552 | 301/18723 | 6.08e-05 | 4.67e-04 | 171 |
GO:00430624 | Esophagus | ESCC | extracellular structure organization | 171/8552 | 302/18723 | 7.73e-05 | 5.76e-04 | 171 |
GO:00452294 | Esophagus | ESCC | external encapsulating structure organization | 172/8552 | 304/18723 | 7.80e-05 | 5.80e-04 | 172 |
GO:000963620 | Esophagus | ESCC | response to toxic substance | 150/8552 | 262/18723 | 1.00e-04 | 7.12e-04 | 150 |
GO:007259318 | Esophagus | ESCC | reactive oxygen species metabolic process | 137/8552 | 239/18723 | 1.82e-04 | 1.16e-03 | 137 |
GO:1990748110 | Esophagus | ESCC | cellular detoxification | 70/8552 | 116/18723 | 1.02e-03 | 5.17e-03 | 70 |
GO:00301993 | Esophagus | ESCC | collagen fibril organization | 40/8552 | 61/18723 | 1.35e-03 | 6.44e-03 | 40 |
GO:0097237110 | Esophagus | ESCC | cellular response to toxic substance | 72/8552 | 124/18723 | 3.65e-03 | 1.49e-02 | 72 |
GO:0098869110 | Esophagus | ESCC | cellular oxidant detoxification | 60/8552 | 101/18723 | 3.76e-03 | 1.53e-02 | 60 |
GO:00717115 | Esophagus | ESCC | basement membrane organization | 22/8552 | 31/18723 | 3.90e-03 | 1.58e-02 | 22 |
GO:00850292 | Esophagus | ESCC | extracellular matrix assembly | 29/8552 | 45/18723 | 8.63e-03 | 3.04e-02 | 29 |
GO:000697920 | Oral cavity | OSCC | response to oxidative stress | 273/7305 | 446/18723 | 8.35e-22 | 1.65e-19 | 273 |
GO:00019594 | Oral cavity | OSCC | regulation of cytokine-mediated signaling pathway | 87/7305 | 150/18723 | 1.82e-06 | 2.35e-05 | 87 |
GO:00607594 | Oral cavity | OSCC | regulation of response to cytokine stimulus | 92/7305 | 162/18723 | 3.25e-06 | 3.90e-05 | 92 |
GO:000963618 | Oral cavity | OSCC | response to toxic substance | 137/7305 | 262/18723 | 7.94e-06 | 8.52e-05 | 137 |
GO:007259316 | Oral cavity | OSCC | reactive oxygen species metabolic process | 122/7305 | 239/18723 | 9.73e-05 | 7.34e-04 | 122 |
GO:00192214 | Oral cavity | OSCC | cytokine-mediated signaling pathway | 222/7305 | 472/18723 | 2.02e-04 | 1.35e-03 | 222 |
Page: 1 2 3 4 5 |
![]() |
Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
Page: 1 |
Top |
Cell-cell communication analysis |
![]() |
Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
Page: 1 |
Top |
Single-cell gene regulatory network inference analysis |
![]() |
TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
Page: 1 |
Top |
Somatic mutation of malignant transformation related genes |
![]() |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
PXDN | SNV | Missense_Mutation | novel | c.1186N>T | p.Gly396Trp | p.G396W | Q92626 | protein_coding | deleterious(0.01) | probably_damaging(0.993) | TCGA-55-6981-01 | Lung | lung adenocarcinoma | Female | <65 | III/IV | Chemotherapy | chemo | CR |
PXDN | SNV | Missense_Mutation | novel | c.4112N>T | p.Ser1371Leu | p.S1371L | Q92626 | protein_coding | tolerated(0.36) | benign(0) | TCGA-55-7283-01 | Lung | lung adenocarcinoma | Female | >=65 | III/IV | Chemotherapy | carboplatin | PR |
PXDN | SNV | Missense_Mutation | c.2365N>T | p.Gly789Trp | p.G789W | Q92626 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-55-7994-01 | Lung | lung adenocarcinoma | Male | >=65 | I/II | Chemotherapy | carboplatin | CR | |
PXDN | SNV | Missense_Mutation | c.3027N>T | p.Trp1009Cys | p.W1009C | Q92626 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-55-8507-01 | Lung | lung adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD | |
PXDN | SNV | Missense_Mutation | c.3284A>T | p.His1095Leu | p.H1095L | Q92626 | protein_coding | deleterious(0) | possibly_damaging(0.744) | TCGA-64-1678-01 | Lung | lung adenocarcinoma | Female | >=65 | I/II | Chemotherapy | carboplatin | SD | |
PXDN | SNV | Missense_Mutation | c.1552A>T | p.Thr518Ser | p.T518S | Q92626 | protein_coding | tolerated(0.16) | benign(0.034) | TCGA-64-5775-01 | Lung | lung adenocarcinoma | Male | >=65 | III/IV | Chemotherapy | carboplatin | PD | |
PXDN | SNV | Missense_Mutation | c.4186N>G | p.Ile1396Val | p.I1396V | Q92626 | protein_coding | tolerated(0.33) | benign(0.038) | TCGA-64-5778-01 | Lung | lung adenocarcinoma | Male | <65 | I/II | Targeted Molecular therapy | tarceva | PD | |
PXDN | SNV | Missense_Mutation | c.803G>C | p.Arg268Thr | p.R268T | Q92626 | protein_coding | deleterious(0.01) | benign(0.219) | TCGA-75-5146-01 | Lung | lung adenocarcinoma | Male | Unknown | I/II | Unknown | Unknown | PD | |
PXDN | SNV | Missense_Mutation | novel | c.2542N>T | p.Ser848Cys | p.S848C | Q92626 | protein_coding | deleterious(0) | probably_damaging(0.928) | TCGA-75-6211-01 | Lung | lung adenocarcinoma | Female | Unknown | I/II | Unknown | Unknown | PD |
PXDN | SNV | Missense_Mutation | rs570640127 | c.3592N>T | p.Arg1198Trp | p.R1198W | Q92626 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-78-7146-01 | Lung | lung adenocarcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD |
Page: 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 |
Top |
Related drugs of malignant transformation related genes |
![]() |
(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
Page: 1 |