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Gene: PLXNA1 |
Gene summary for PLXNA1 |
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Gene information | Species | Human | Gene symbol | PLXNA1 | Gene ID | 5361 |
Gene name | plexin A1 | |
Gene Alias | NOV | |
Cytomap | 3q21.3 | |
Gene Type | protein-coding | GO ID | GO:0000902 | UniProtAcc | Q9UIW2 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
5361 | PLXNA1 | LZE2T | Human | Esophagus | ESCC | 3.38e-05 | 5.92e-01 | 0.082 |
5361 | PLXNA1 | LZE7T | Human | Esophagus | ESCC | 2.75e-10 | 4.16e-01 | 0.0667 |
5361 | PLXNA1 | LZE8T | Human | Esophagus | ESCC | 2.28e-02 | 6.11e-02 | 0.067 |
5361 | PLXNA1 | LZE24T | Human | Esophagus | ESCC | 1.44e-07 | 1.45e-01 | 0.0596 |
5361 | PLXNA1 | P1T-E | Human | Esophagus | ESCC | 1.17e-13 | 6.10e-01 | 0.0875 |
5361 | PLXNA1 | P2T-E | Human | Esophagus | ESCC | 7.50e-10 | 2.25e-01 | 0.1177 |
5361 | PLXNA1 | P4T-E | Human | Esophagus | ESCC | 1.62e-04 | 4.13e-02 | 0.1323 |
5361 | PLXNA1 | P5T-E | Human | Esophagus | ESCC | 5.35e-10 | 2.01e-01 | 0.1327 |
5361 | PLXNA1 | P8T-E | Human | Esophagus | ESCC | 4.84e-26 | 5.33e-01 | 0.0889 |
5361 | PLXNA1 | P9T-E | Human | Esophagus | ESCC | 3.54e-06 | 1.35e-01 | 0.1131 |
5361 | PLXNA1 | P10T-E | Human | Esophagus | ESCC | 4.95e-33 | 6.63e-01 | 0.116 |
5361 | PLXNA1 | P11T-E | Human | Esophagus | ESCC | 9.46e-03 | 3.16e-01 | 0.1426 |
5361 | PLXNA1 | P12T-E | Human | Esophagus | ESCC | 7.47e-05 | 1.55e-01 | 0.1122 |
5361 | PLXNA1 | P15T-E | Human | Esophagus | ESCC | 8.77e-10 | 3.45e-01 | 0.1149 |
5361 | PLXNA1 | P16T-E | Human | Esophagus | ESCC | 3.84e-02 | 1.28e-01 | 0.1153 |
5361 | PLXNA1 | P17T-E | Human | Esophagus | ESCC | 1.76e-06 | 3.13e-01 | 0.1278 |
5361 | PLXNA1 | P20T-E | Human | Esophagus | ESCC | 1.21e-07 | 1.90e-01 | 0.1124 |
5361 | PLXNA1 | P21T-E | Human | Esophagus | ESCC | 7.87e-14 | 3.49e-01 | 0.1617 |
5361 | PLXNA1 | P22T-E | Human | Esophagus | ESCC | 2.86e-15 | 2.72e-01 | 0.1236 |
5361 | PLXNA1 | P23T-E | Human | Esophagus | ESCC | 6.60e-04 | 1.18e-01 | 0.108 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:0048732111 | Esophagus | ESCC | gland development | 269/8552 | 436/18723 | 7.81e-12 | 2.95e-10 | 269 |
GO:0016049110 | Esophagus | ESCC | cell growth | 289/8552 | 482/18723 | 1.29e-10 | 3.77e-09 | 289 |
GO:002260420 | Esophagus | ESCC | regulation of cell morphogenesis | 180/8552 | 309/18723 | 5.19e-06 | 5.45e-05 | 180 |
GO:002261216 | Esophagus | ESCC | gland morphogenesis | 78/8552 | 118/18723 | 5.83e-06 | 6.03e-05 | 78 |
GO:003134616 | Esophagus | ESCC | positive regulation of cell projection organization | 201/8552 | 353/18723 | 1.19e-05 | 1.11e-04 | 201 |
GO:001072010 | Esophagus | ESCC | positive regulation of cell development | 172/8552 | 298/18723 | 1.74e-05 | 1.55e-04 | 172 |
GO:005076710 | Esophagus | ESCC | regulation of neurogenesis | 203/8552 | 364/18723 | 6.10e-05 | 4.68e-04 | 203 |
GO:00507697 | Esophagus | ESCC | positive regulation of neurogenesis | 131/8552 | 225/18723 | 9.71e-05 | 6.90e-04 | 131 |
GO:006156415 | Esophagus | ESCC | axon development | 251/8552 | 467/18723 | 2.41e-04 | 1.49e-03 | 251 |
GO:001097516 | Esophagus | ESCC | regulation of neuron projection development | 240/8552 | 445/18723 | 2.48e-04 | 1.53e-03 | 240 |
GO:000836018 | Esophagus | ESCC | regulation of cell shape | 92/8552 | 154/18723 | 3.00e-04 | 1.81e-03 | 92 |
GO:00519606 | Esophagus | ESCC | regulation of nervous system development | 237/8552 | 443/18723 | 5.02e-04 | 2.78e-03 | 237 |
GO:006056010 | Esophagus | ESCC | developmental growth involved in morphogenesis | 131/8552 | 234/18723 | 9.28e-04 | 4.73e-03 | 131 |
GO:00519625 | Esophagus | ESCC | positive regulation of nervous system development | 149/8552 | 272/18723 | 1.50e-03 | 7.06e-03 | 149 |
GO:000740915 | Esophagus | ESCC | axonogenesis | 219/8552 | 418/18723 | 3.14e-03 | 1.31e-02 | 219 |
GO:00507728 | Esophagus | ESCC | positive regulation of axonogenesis | 48/8552 | 79/18723 | 4.93e-03 | 1.89e-02 | 48 |
GO:004308715 | Esophagus | ESCC | regulation of GTPase activity | 183/8552 | 348/18723 | 5.34e-03 | 2.00e-02 | 183 |
GO:004858810 | Esophagus | ESCC | developmental cell growth | 125/8552 | 234/18723 | 1.01e-02 | 3.46e-02 | 125 |
GO:00017639 | Esophagus | ESCC | morphogenesis of a branching structure | 106/8552 | 196/18723 | 1.08e-02 | 3.66e-02 | 106 |
GO:002260422 | Liver | HCC | regulation of cell morphogenesis | 188/7958 | 309/18723 | 4.84e-11 | 1.82e-09 | 188 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa0436016 | Esophagus | ESCC | Axon guidance | 108/4205 | 182/8465 | 5.13e-03 | 1.30e-02 | 6.67e-03 | 108 |
hsa0436017 | Esophagus | ESCC | Axon guidance | 108/4205 | 182/8465 | 5.13e-03 | 1.30e-02 | 6.67e-03 | 108 |
hsa0436014 | Oral cavity | OSCC | Axon guidance | 97/3704 | 182/8465 | 5.59e-03 | 1.33e-02 | 6.76e-03 | 97 |
hsa0436015 | Oral cavity | OSCC | Axon guidance | 97/3704 | 182/8465 | 5.59e-03 | 1.33e-02 | 6.76e-03 | 97 |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
SEMA4A | NRP1_PLXNA1 | SEMA4A_NRP1_PLXNA1 | SEMA4 | CRC | MSI-H |
SEMA3B | NRP1_PLXNA1 | SEMA3B_NRP1_PLXNA1 | SEMA3 | CRC | MSI-H |
SEMA3C | NRP1_PLXNA1 | SEMA3C_NRP1_PLXNA1 | SEMA3 | CRC | MSI-H |
SEMA5A | PLXNA1 | SEMA5A_PLXNA1 | SEMA5 | CRC | MSI-H |
SEMA3A | NRP1_PLXNA1 | SEMA3A_NRP1_PLXNA1 | SEMA3 | HNSCC | OSCC |
SEMA3C | NRP1_PLXNA1 | SEMA3C_NRP1_PLXNA1 | SEMA3 | HNSCC | OSCC |
SEMA3D | NRP1_PLXNA1 | SEMA3D_NRP1_PLXNA1 | SEMA3 | HNSCC | OSCC |
SEMA3C | NRP2_PLXNA1 | SEMA3C_NRP2_PLXNA1 | SEMA3 | HNSCC | OSCC |
SEMA3D | NRP2_PLXNA1 | SEMA3D_NRP2_PLXNA1 | SEMA3 | HNSCC | OSCC |
SEMA3F | NRP2_PLXNA1 | SEMA3F_NRP2_PLXNA1 | SEMA3 | HNSCC | OSCC |
SEMA3G | NRP2_PLXNA1 | SEMA3G_NRP2_PLXNA1 | SEMA3 | HNSCC | OSCC |
SEMA4A | NRP1_PLXNA1 | SEMA4A_NRP1_PLXNA1 | SEMA4 | HNSCC | OSCC |
SEMA5A | PLXNA1 | SEMA5A_PLXNA1 | SEMA5 | HNSCC | OSCC |
SEMA3C | NRP2_PLXNA1 | SEMA3C_NRP2_PLXNA1 | SEMA3 | HNSCC | Precancer |
SEMA3D | NRP2_PLXNA1 | SEMA3D_NRP2_PLXNA1 | SEMA3 | HNSCC | Precancer |
SEMA3F | NRP2_PLXNA1 | SEMA3F_NRP2_PLXNA1 | SEMA3 | HNSCC | Precancer |
SEMA3G | NRP2_PLXNA1 | SEMA3G_NRP2_PLXNA1 | SEMA3 | HNSCC | Precancer |
SEMA6D | PLXNA1 | SEMA6D_PLXNA1 | SEMA6 | HNSCC | Precancer |
SEMA5A | PLXNA1 | SEMA5A_PLXNA1 | SEMA5 | HNSCC | Precancer |
SEMA6D | PLXNA1 | SEMA6D_PLXNA1 | SEMA6 | Lung | AAH |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
PLXNA1 | SNV | Missense_Mutation | rs753918103 | c.3827N>A | p.Arg1276His | p.R1276H | Q9UIW2 | protein_coding | deleterious(0.01) | probably_damaging(0.925) | TCGA-XK-AAIW-01 | Prostate | prostate adenocarcinoma | Male | >=65 | 9 | Unknown | Unknown | PD |
PLXNA1 | SNV | Missense_Mutation | c.5209N>T | p.Arg1737Cys | p.R1737C | Q9UIW2 | protein_coding | deleterious(0.04) | probably_damaging(1) | TCGA-XK-AAIW-01 | Prostate | prostate adenocarcinoma | Male | >=65 | 9 | Unknown | Unknown | PD | |
PLXNA1 | SNV | Missense_Mutation | novel | c.5497N>A | p.Ala1833Thr | p.A1833T | Q9UIW2 | protein_coding | deleterious(0.03) | possibly_damaging(0.788) | TCGA-XK-AAIW-01 | Prostate | prostate adenocarcinoma | Male | >=65 | 9 | Unknown | Unknown | PD |
PLXNA1 | SNV | Missense_Mutation | rs757936424 | c.2312C>T | p.Ser771Leu | p.S771L | Q9UIW2 | protein_coding | deleterious(0.04) | benign(0.038) | TCGA-BR-4361-01 | Stomach | stomach adenocarcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD |
PLXNA1 | SNV | Missense_Mutation | c.5119N>T | p.Arg1707Trp | p.R1707W | Q9UIW2 | protein_coding | deleterious(0) | probably_damaging(0.98) | TCGA-BR-6452-01 | Stomach | stomach adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
PLXNA1 | SNV | Missense_Mutation | c.3644G>A | p.Gly1215Glu | p.G1215E | Q9UIW2 | protein_coding | tolerated(0.06) | probably_damaging(0.956) | TCGA-BR-8361-01 | Stomach | stomach adenocarcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD | |
PLXNA1 | SNV | Missense_Mutation | c.3103N>A | p.Leu1035Ile | p.L1035I | Q9UIW2 | protein_coding | tolerated(0.88) | benign(0.034) | TCGA-BR-8363-01 | Stomach | stomach adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
PLXNA1 | SNV | Missense_Mutation | rs770145599 | c.2639N>T | p.Thr880Met | p.T880M | Q9UIW2 | protein_coding | deleterious(0) | probably_damaging(0.966) | TCGA-BR-8368-01 | Stomach | stomach adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
PLXNA1 | SNV | Missense_Mutation | c.2522A>G | p.His841Arg | p.H841R | Q9UIW2 | protein_coding | tolerated(0.09) | benign(0.062) | TCGA-BR-8372-01 | Stomach | stomach adenocarcinoma | Male | <65 | III/IV | Chemotherapy | etoposide | CR | |
PLXNA1 | SNV | Missense_Mutation | c.4336A>G | p.Thr1446Ala | p.T1446A | Q9UIW2 | protein_coding | tolerated(0.31) | benign(0.202) | TCGA-BR-8372-01 | Stomach | stomach adenocarcinoma | Male | <65 | III/IV | Chemotherapy | etoposide | CR |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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