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Gene: PHF3 |
Gene summary for PHF3 |
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Gene information | Species | Human | Gene symbol | PHF3 | Gene ID | 23469 |
Gene name | PHD finger protein 3 | |
Gene Alias | PHF3 | |
Cytomap | 6q12 | |
Gene Type | protein-coding | GO ID | GO:0006139 | UniProtAcc | B3KP41 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
23469 | PHF3 | HTA11_3410_2000001011 | Human | Colorectum | AD | 2.73e-32 | -8.59e-01 | 0.0155 |
23469 | PHF3 | HTA11_2487_2000001011 | Human | Colorectum | SER | 1.44e-17 | -8.48e-01 | -0.1808 |
23469 | PHF3 | HTA11_2951_2000001011 | Human | Colorectum | AD | 3.07e-04 | -8.65e-01 | 0.0216 |
23469 | PHF3 | HTA11_1938_2000001011 | Human | Colorectum | AD | 1.53e-07 | -5.77e-01 | -0.0811 |
23469 | PHF3 | HTA11_78_2000001011 | Human | Colorectum | AD | 7.99e-03 | -4.83e-01 | -0.1088 |
23469 | PHF3 | HTA11_2112_2000001011 | Human | Colorectum | SER | 1.95e-03 | -8.49e-01 | -0.2196 |
23469 | PHF3 | HTA11_3361_2000001011 | Human | Colorectum | AD | 1.32e-16 | -9.05e-01 | -0.1207 |
23469 | PHF3 | HTA11_83_2000001011 | Human | Colorectum | SER | 9.51e-06 | -5.74e-01 | -0.1526 |
23469 | PHF3 | HTA11_696_2000001011 | Human | Colorectum | AD | 3.83e-24 | -7.08e-01 | -0.1464 |
23469 | PHF3 | HTA11_866_2000001011 | Human | Colorectum | AD | 1.57e-28 | -7.38e-01 | -0.1001 |
23469 | PHF3 | HTA11_1391_2000001011 | Human | Colorectum | AD | 1.02e-03 | -5.04e-01 | -0.059 |
23469 | PHF3 | HTA11_2992_2000001011 | Human | Colorectum | SER | 3.69e-04 | -7.89e-01 | -0.1706 |
23469 | PHF3 | HTA11_5212_2000001011 | Human | Colorectum | AD | 8.81e-03 | -6.45e-01 | -0.2061 |
23469 | PHF3 | HTA11_5216_2000001011 | Human | Colorectum | SER | 1.19e-03 | -8.65e-01 | -0.1462 |
23469 | PHF3 | HTA11_546_2000001011 | Human | Colorectum | AD | 3.53e-04 | -6.53e-01 | -0.0842 |
23469 | PHF3 | HTA11_9341_2000001011 | Human | Colorectum | SER | 5.49e-03 | -9.38e-01 | -0.00410000000000005 |
23469 | PHF3 | HTA11_7862_2000001011 | Human | Colorectum | AD | 1.05e-06 | -8.30e-01 | -0.0179 |
23469 | PHF3 | HTA11_866_3004761011 | Human | Colorectum | AD | 1.80e-18 | -6.83e-01 | 0.096 |
23469 | PHF3 | HTA11_9408_2000001011 | Human | Colorectum | AD | 1.45e-06 | -1.03e+00 | 0.0451 |
23469 | PHF3 | HTA11_8622_2000001021 | Human | Colorectum | SER | 1.18e-03 | -7.61e-01 | 0.0528 |
Page: 1 2 3 4 5 6 7 8 9 10 11 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
PHF3 | SNV | Missense_Mutation | c.451A>G | p.Asn151Asp | p.N151D | Q92576 | protein_coding | deleterious(0) | benign(0.193) | TCGA-78-7166-01 | Lung | lung adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
PHF3 | SNV | Missense_Mutation | rs778781808 | c.3598A>G | p.Thr1200Ala | p.T1200A | Q92576 | protein_coding | tolerated(0.42) | probably_damaging(0.915) | TCGA-86-8279-01 | Lung | lung adenocarcinoma | Male | <65 | I/II | Chemotherapy | etoposide | CR |
PHF3 | SNV | Missense_Mutation | novel | c.703N>T | p.Asp235Tyr | p.D235Y | Q92576 | protein_coding | deleterious_low_confidence(0) | benign(0.157) | TCGA-95-7043-01 | Lung | lung adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | PD |
PHF3 | SNV | Missense_Mutation | c.3025N>T | p.His1009Tyr | p.H1009Y | Q92576 | protein_coding | deleterious(0) | possibly_damaging(0.68) | TCGA-97-A4M0-01 | Lung | lung adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
PHF3 | SNV | Missense_Mutation | rs778125792 | c.4327N>T | p.Leu1443Phe | p.L1443F | Q92576 | protein_coding | deleterious(0) | probably_damaging(0.997) | TCGA-MN-A4N4-01 | Lung | lung adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
PHF3 | SNV | Missense_Mutation | novel | c.3376N>T | p.Ala1126Ser | p.A1126S | Q92576 | protein_coding | deleterious(0.05) | probably_damaging(0.972) | TCGA-MP-A4SV-01 | Lung | lung adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
PHF3 | SNV | Missense_Mutation | c.719N>A | p.Cys240Tyr | p.C240Y | Q92576 | protein_coding | deleterious_low_confidence(0) | benign(0.359) | TCGA-18-3409-01 | Lung | lung squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | PD | |
PHF3 | SNV | Missense_Mutation | c.688N>T | p.Asp230Tyr | p.D230Y | Q92576 | protein_coding | deleterious_low_confidence(0) | benign(0.233) | TCGA-18-5592-01 | Lung | lung squamous cell carcinoma | Male | <65 | I/II | Unknown | Unknown | SD | |
PHF3 | SNV | Missense_Mutation | c.2755G>T | p.Ala919Ser | p.A919S | Q92576 | protein_coding | tolerated(0.26) | benign(0.056) | TCGA-37-3789-01 | Lung | lung squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
PHF3 | SNV | Missense_Mutation | c.2848N>T | p.Val950Leu | p.V950L | Q92576 | protein_coding | tolerated(0.18) | benign(0.014) | TCGA-60-2698-01 | Lung | lung squamous cell carcinoma | Male | <65 | I/II | Chemotherapy | mithramycin | PD |
Page: 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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