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Gene: NBEA |
Gene summary for NBEA |
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Gene information | Species | Human | Gene symbol | NBEA | Gene ID | 26960 |
Gene name | neurobeachin | |
Gene Alias | BCL8B | |
Cytomap | 13q13.3 | |
Gene Type | protein-coding | GO ID | GO:0008104 | UniProtAcc | Q8NFP9 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
26960 | NBEA | HTA11_3410_2000001011 | Human | Colorectum | AD | 1.65e-05 | -3.72e-01 | 0.0155 |
26960 | NBEA | HTA11_2487_2000001011 | Human | Colorectum | SER | 2.40e-02 | -4.03e-01 | -0.1808 |
26960 | NBEA | HTA11_78_2000001011 | Human | Colorectum | AD | 7.92e-04 | -4.49e-01 | -0.1088 |
26960 | NBEA | HTA11_347_2000001011 | Human | Colorectum | AD | 2.43e-06 | -3.82e-01 | -0.1954 |
26960 | NBEA | HTA11_3361_2000001011 | Human | Colorectum | AD | 1.58e-02 | -4.75e-01 | -0.1207 |
26960 | NBEA | HTA11_696_2000001011 | Human | Colorectum | AD | 1.97e-10 | -3.92e-01 | -0.1464 |
26960 | NBEA | HTA11_866_2000001011 | Human | Colorectum | AD | 8.01e-12 | -3.61e-01 | -0.1001 |
26960 | NBEA | HTA11_1391_2000001011 | Human | Colorectum | AD | 2.25e-07 | -4.53e-01 | -0.059 |
26960 | NBEA | HTA11_10711_2000001011 | Human | Colorectum | AD | 3.68e-04 | -4.16e-01 | 0.0338 |
26960 | NBEA | HTA11_7696_3000711011 | Human | Colorectum | AD | 1.86e-03 | -3.24e-01 | 0.0674 |
26960 | NBEA | HTA11_99999970781_79442 | Human | Colorectum | MSS | 4.92e-08 | -3.07e-01 | 0.294 |
26960 | NBEA | HTA11_99999971662_82457 | Human | Colorectum | MSS | 1.33e-07 | -2.74e-01 | 0.3859 |
26960 | NBEA | HTA11_99999974143_84620 | Human | Colorectum | MSS | 3.08e-08 | -3.80e-01 | 0.3005 |
26960 | NBEA | F007 | Human | Colorectum | FAP | 2.05e-05 | -4.90e-01 | 0.1176 |
26960 | NBEA | A002-C-010 | Human | Colorectum | FAP | 1.82e-07 | -2.90e-01 | 0.242 |
26960 | NBEA | A001-C-207 | Human | Colorectum | FAP | 6.65e-10 | -5.23e-01 | 0.1278 |
26960 | NBEA | A015-C-203 | Human | Colorectum | FAP | 5.84e-13 | -1.73e-01 | -0.1294 |
26960 | NBEA | A002-C-201 | Human | Colorectum | FAP | 2.33e-18 | -5.43e-01 | 0.0324 |
26960 | NBEA | A002-C-203 | Human | Colorectum | FAP | 2.84e-15 | -4.75e-01 | 0.2786 |
26960 | NBEA | A001-C-108 | Human | Colorectum | FAP | 1.41e-16 | -4.51e-01 | -0.0272 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
NBEA | SNV | Missense_Mutation | novel | c.8044T>C | p.Cys2682Arg | p.C2682R | Q8NFP9 | protein_coding | deleterious(0.01) | possibly_damaging(0.683) | TCGA-AX-A2HD-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD |
NBEA | SNV | Missense_Mutation | novel | c.5543N>T | p.Ser1848Phe | p.S1848F | Q8NFP9 | protein_coding | deleterious(0.03) | benign(0.11) | TCGA-AX-A2IO-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Chemotherapy | carboplatin | SD |
NBEA | SNV | Missense_Mutation | c.5504N>T | p.Ser1835Ile | p.S1835I | Q8NFP9 | protein_coding | deleterious(0.01) | benign(0.307) | TCGA-B5-A0JY-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | doxorubicin | SD | |
NBEA | SNV | Missense_Mutation | rs866023350 | c.6879N>C | p.Glu2293Asp | p.E2293D | Q8NFP9 | protein_coding | deleterious(0.01) | benign(0.179) | TCGA-B5-A0JY-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | doxorubicin | SD |
NBEA | SNV | Missense_Mutation | c.4739N>A | p.Arg1580His | p.R1580H | Q8NFP9 | protein_coding | deleterious(0) | probably_damaging(0.996) | TCGA-B5-A0K3-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Chemotherapy | carboplatin | PD | |
NBEA | SNV | Missense_Mutation | c.7363G>A | p.Val2455Ile | p.V2455I | Q8NFP9 | protein_coding | tolerated(0.1) | benign(0.003) | TCGA-B5-A0K9-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
NBEA | SNV | Missense_Mutation | c.3032N>T | p.Ser1011Ile | p.S1011I | Q8NFP9 | protein_coding | deleterious_low_confidence(0.04) | benign(0.119) | TCGA-B5-A11E-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
NBEA | SNV | Missense_Mutation | c.5333N>A | p.Ala1778Asp | p.A1778D | Q8NFP9 | protein_coding | tolerated_low_confidence(0.34) | benign(0.039) | TCGA-B5-A11E-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
NBEA | SNV | Missense_Mutation | c.5615N>T | p.Ala1872Val | p.A1872V | Q8NFP9 | protein_coding | deleterious(0.05) | benign(0.444) | TCGA-B5-A11E-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
NBEA | SNV | Missense_Mutation | c.8005N>G | p.Thr2669Ala | p.T2669A | Q8NFP9 | protein_coding | tolerated(0.35) | benign(0.024) | TCGA-B5-A11E-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
26960 | NBEA | KINASE | antidepressants | |||
26960 | NBEA | KINASE | metformin | METFORMIN | 29650774 |
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